DK2303895T3 - Thiazolyl AND OXAZOLYLISOQUINOLINONER AND methods of use thereof - Google Patents
Thiazolyl AND OXAZOLYLISOQUINOLINONER AND methods of use thereof Download PDFInfo
- Publication number
- DK2303895T3 DK2303895T3 DK09767711.6T DK09767711T DK2303895T3 DK 2303895 T3 DK2303895 T3 DK 2303895T3 DK 09767711 T DK09767711 T DK 09767711T DK 2303895 T3 DK2303895 T3 DK 2303895T3
- Authority
- DK
- Denmark
- Prior art keywords
- thiazolo
- isoquinolin
- hydroxy
- pharmaceutically acceptable
- compound according
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 44
- 125000000335 thiazolyl group Chemical group 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 125
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- 239000001257 hydrogen Substances 0.000 claims description 35
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- 125000002947 alkylene group Chemical group 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 24
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- 238000011282 treatment Methods 0.000 claims description 24
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
- 229910052736 halogen Inorganic materials 0.000 claims description 22
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- -1 (dimethylamino) methyl [1,3] thiazolo [5,4-c] isoquinolin-5 (4H) -one Chemical compound 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Landscapes
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- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7385708P | 2008-06-19 | 2008-06-19 | |
| PCT/US2009/047767 WO2009155402A1 (en) | 2008-06-19 | 2009-06-18 | Thiazolyl- and oxazolyl-isoquinolinones and methods for using them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2303895T3 true DK2303895T3 (en) | 2015-01-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09767711.6T DK2303895T3 (en) | 2008-06-19 | 2009-06-18 | Thiazolyl AND OXAZOLYLISOQUINOLINONER AND methods of use thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8299090B2 (https=) |
| EP (2) | EP2896626A1 (https=) |
| JP (2) | JP5564495B2 (https=) |
| AR (1) | AR072265A1 (https=) |
| AU (1) | AU2009260060B2 (https=) |
| CA (1) | CA2728454C (https=) |
| DK (1) | DK2303895T3 (https=) |
| ES (1) | ES2530815T3 (https=) |
| HK (1) | HK1212698A1 (https=) |
| SA (1) | SA109300394B1 (https=) |
| TW (1) | TWI471329B (https=) |
| WO (1) | WO2009155402A1 (https=) |
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| SA109300394B1 (ar) * | 2008-06-19 | 2013-01-22 | ويث | ثيازوليل- وأوكسازوليل- أيزوكوينولينونات وطرق لاستخدامها |
| WO2009155413A1 (en) | 2008-06-19 | 2009-12-23 | Wyeth | Thienyl- and furanyl-isoquinolinones and methods for using them |
| JP2014520776A (ja) | 2011-07-04 | 2014-08-25 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用 |
| ES2562903T3 (es) * | 2011-07-13 | 2016-03-09 | Santen Pharmaceutical Co., Ltd | Nuevo compuesto que tiene actividad inhibidora de PARP |
| AU2016296905B2 (en) | 2015-07-23 | 2018-07-05 | Centre National De La Recherche Scientifique | Use of a combination of Dbait molecule and parp inhibitors to treat cancer |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| CA3092779A1 (en) | 2018-03-13 | 2019-09-19 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN121398822A (zh) | 2023-06-21 | 2026-01-23 | 四方生物科学有限公司 | 用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合 |
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|---|---|---|---|---|
| DE2963332D1 (en) * | 1978-05-26 | 1982-09-02 | Lepetit Spa | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, cns-depressant and anti-anxiety agents and pharmaceutical compositions thereof |
| ITMI20002358A1 (it) * | 2000-10-31 | 2002-05-01 | Flavio Moroni | Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi |
| AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| TW200412959A (en) | 2002-11-22 | 2004-08-01 | Mitsubishi Pharma Corp | Isoquinoline compounds and medicinal use thereof |
| US7696255B2 (en) | 2005-08-01 | 2010-04-13 | Wietek Holding Gmbh | Process for the recycling of plastics |
| EP2069351B1 (en) | 2006-06-20 | 2015-10-28 | AbbVie Inc. | Pyrazoloquinazolinones as parp inhibitors |
| SA109300394B1 (ar) * | 2008-06-19 | 2013-01-22 | ويث | ثيازوليل- وأوكسازوليل- أيزوكوينولينونات وطرق لاستخدامها |
| WO2009155413A1 (en) | 2008-06-19 | 2009-12-23 | Wyeth | Thienyl- and furanyl-isoquinolinones and methods for using them |
-
2009
- 2009-06-17 SA SA109300394A patent/SA109300394B1/ar unknown
- 2009-06-18 ES ES09767711T patent/ES2530815T3/es active Active
- 2009-06-18 JP JP2011514801A patent/JP5564495B2/ja not_active Expired - Fee Related
- 2009-06-18 AU AU2009260060A patent/AU2009260060B2/en not_active Ceased
- 2009-06-18 EP EP14185672.4A patent/EP2896626A1/en not_active Withdrawn
- 2009-06-18 DK DK09767711.6T patent/DK2303895T3/en active
- 2009-06-18 CA CA2728454A patent/CA2728454C/en active Active
- 2009-06-18 WO PCT/US2009/047767 patent/WO2009155402A1/en not_active Ceased
- 2009-06-18 US US12/487,247 patent/US8299090B2/en not_active Expired - Fee Related
- 2009-06-18 EP EP09767711.6A patent/EP2303895B1/en active Active
- 2009-06-19 AR ARP090102266A patent/AR072265A1/es active IP Right Grant
- 2009-06-19 TW TW98120713A patent/TWI471329B/zh not_active IP Right Cessation
-
2012
- 2012-10-18 US US13/655,082 patent/US8906935B2/en active Active
-
2014
- 2014-03-28 JP JP2014067493A patent/JP2014122242A/ja not_active Withdrawn
- 2014-11-07 US US14/535,877 patent/US9265769B2/en active Active
-
2016
- 2016-01-21 HK HK16100665.6A patent/HK1212698A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2303895A1 (en) | 2011-04-06 |
| AU2009260060A1 (en) | 2009-12-23 |
| AR072265A1 (es) | 2010-08-18 |
| WO2009155402A1 (en) | 2009-12-23 |
| US20150133443A1 (en) | 2015-05-14 |
| HK1212698A1 (en) | 2016-06-17 |
| EP2303895B1 (en) | 2014-09-24 |
| US8906935B2 (en) | 2014-12-09 |
| JP2011525185A (ja) | 2011-09-15 |
| TWI471329B (zh) | 2015-02-01 |
| US8299090B2 (en) | 2012-10-30 |
| AU2009260060B2 (en) | 2015-01-22 |
| JP2014122242A (ja) | 2014-07-03 |
| US20130059843A1 (en) | 2013-03-07 |
| TW201002725A (en) | 2010-01-16 |
| CA2728454A1 (en) | 2009-12-23 |
| HK1156310A1 (en) | 2012-06-08 |
| JP5564495B2 (ja) | 2014-07-30 |
| US9265769B2 (en) | 2016-02-23 |
| US20090318442A1 (en) | 2009-12-24 |
| ES2530815T3 (es) | 2015-03-05 |
| CA2728454C (en) | 2017-01-17 |
| SA109300394B1 (ar) | 2013-01-22 |
| EP2896626A1 (en) | 2015-07-22 |
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