DK2268308T3 - Vaccine til beskyttelse mod lawsonia intracellularis - Google Patents
Vaccine til beskyttelse mod lawsonia intracellularis Download PDFInfo
- Publication number
- DK2268308T3 DK2268308T3 DK09753743.5T DK09753743T DK2268308T3 DK 2268308 T3 DK2268308 T3 DK 2268308T3 DK 09753743 T DK09753743 T DK 09753743T DK 2268308 T3 DK2268308 T3 DK 2268308T3
- Authority
- DK
- Denmark
- Prior art keywords
- vaccine
- carbohydrate
- lawsonia intracellularis
- cells
- containing composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (4)
- VACCINE TIL BESKYTTELSE MOD LAWSONIA TNTRACELT,ITT .ARTS PATENTKRAV1. Ikke-levende carbohydratholdig sammensætning, hvor carbohydratet også findes levende i Lawsonia intracellularis-ceWet i association med den ydre membran af disse celler, til anvendelse som en vaccine til beskytttelse mod en infektion med Lawsonia intracellularis, ved systemisk administration af vaccinen, hvor den carbohydratholdige sammensætning er materiale, der resultererer i destruktion af Lawsonia intracellularis- bakterier, og hvor den carbohydratholdige sammensætning indeholder hele celler af destruerede Lawsonia intracellularis-baktaå&t.
- 2. Ikke-levende carbohydratholdig sammensætning til anvendelse ifølge krav 1, kendetegnet ved, at vaccinen omfatter en olie-i-vand-adjuvans, der indeholder oliedråber af submikrometerstørrelse.
- 3. Ikke-levende carbohydratholdig sammensætning til anvendelse ifølge krav 2, kendetegnet ved, at adjuvansen omfatter dråber af biologisk nedbrydelig olie og dråber af mineralolie, hvor dråberne af biologisk nedbrydelig olie har en gennemsnitlig størrelse, der adskiller sig fra den gennemsnitlige størrelse af dråberne af mineralolie.
- 4. Ikke-levende carbohydratholdig sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at vaccinen endvidere omfatter antigener af Mycoplasma hyopneumoniae og svine-circovirus.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4616108P | 2008-04-18 | 2008-04-18 | |
| EP08154764 | 2008-04-18 | ||
| US11175608P | 2008-11-06 | 2008-11-06 | |
| EP08105738 | 2008-11-06 | ||
| PCT/EP2009/054516 WO2009144088A2 (en) | 2008-04-18 | 2009-04-16 | Vaccine for protection against lawsonia intracellulars |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2268308T3 true DK2268308T3 (da) | 2018-05-22 |
Family
ID=41212183
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09753743.5T DK2268308T3 (da) | 2008-04-18 | 2009-04-16 | Vaccine til beskyttelse mod lawsonia intracellularis |
| DK18154850.4T DK3351267T3 (da) | 2008-04-18 | 2009-04-16 | Vaccine til beskyttelse mod lawsonia intracellularis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18154850.4T DK3351267T3 (da) | 2008-04-18 | 2009-04-16 | Vaccine til beskyttelse mod lawsonia intracellularis |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20110033496A1 (da) |
| EP (3) | EP3708186A1 (da) |
| JP (2) | JP6026106B2 (da) |
| CN (1) | CN102006883A (da) |
| BR (2) | BRPI0909769A2 (da) |
| CA (1) | CA2717969C (da) |
| DK (2) | DK2268308T3 (da) |
| ES (1) | ES2666671T3 (da) |
| FR (1) | FR21C1002I1 (da) |
| HU (2) | HUE038294T2 (da) |
| PL (2) | PL2268308T3 (da) |
| TW (1) | TWI551295B (da) |
| WO (1) | WO2009144088A2 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI551295B (zh) * | 2008-04-18 | 2016-10-01 | 英特威特國際股份有限公司 | 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗 |
| ES2606131T3 (es) | 2009-11-09 | 2017-03-22 | Intervet International B.V. | Método para cultivar bacterias Lawsonia intracellularis en células McCoy infectadas de forma persistente |
| KR101837768B1 (ko) | 2011-05-25 | 2018-03-12 | 건국대학교 산학협력단 | 돼지 증식성 회장염을 진단하기 위한 단백질 및 그 응용 |
| US10130699B2 (en) | 2013-12-03 | 2018-11-20 | Intervet Inc. | Vaccine against Lawsonia intracellularis and porcine circovirus 2 |
| CN110354258A (zh) | 2013-12-03 | 2019-10-22 | 英特维特国际股份有限公司 | 抗猪圆环病毒2型的疫苗 |
| WO2015082465A1 (en) * | 2013-12-03 | 2015-06-11 | Intervet International B.V. | Swine vaccine against prrs and lawsonia intracellularis |
| JP2018504424A (ja) * | 2015-02-04 | 2018-02-15 | インターベット インターナショナル ベー． フェー． | 豚における無症候性ローソニア感染症に対する使用のためのワクチン |
| JP2018504423A (ja) * | 2015-02-04 | 2018-02-15 | インターベット インターナショナル ベー． フェー． | 豚における無症候性ローソニア感染症に対する使用のためのワクチン |
| JP6906511B2 (ja) * | 2015-10-22 | 2021-07-21 | インターベット インターナショナル ベー． フェー． | ローソニア・イントラセルラリス感染から生じる障害に対してｍｄａ陽性動物を防御するためのワクチン |
| JP6655414B2 (ja) | 2016-02-15 | 2020-02-26 | 株式会社デンソー | 排気浄化システム |
| US20200323975A1 (en) | 2017-12-04 | 2020-10-15 | Intervet Inc. | Vaccination with replicon particles and oil adjuvant |
| EP3727444A1 (en) | 2017-12-18 | 2020-10-28 | Intervet International B.V. | Swine influenza a virus vaccine |
| US10792352B2 (en) | 2018-02-28 | 2020-10-06 | Boehringer Ingelheim Vetmedica Gmbh | Method for reducing skatole and/or indole in animals |
| US20230277649A1 (en) | 2020-06-19 | 2023-09-07 | Intervet Inc. | Swine influenza a virus vaccine comprising two distinct rna replicon particles |
| CN115768785A (zh) | 2020-06-19 | 2023-03-07 | 英特维特国际股份有限公司 | 包含含有编码病毒的不同神经氨酸酶抗原的第一、第二和第三核酸序列的核酸构建体的甲型猪流感病毒疫苗 |
| EP4168041A1 (en) | 2020-06-19 | 2023-04-26 | Intervet International B.V. | Swine influenza a virus vaccine comprising a nucleic acid construct having a specific order of genes |
| WO2021255221A1 (en) | 2020-06-19 | 2021-12-23 | Intervet International B.V. | Swine influenza a virus vaccine comprising a nucleic acid construct encoding antigens of specific virus lineages |
| WO2023072805A1 (en) | 2021-10-25 | 2023-05-04 | Intervet International B.V. | A vaccine for the protection of piglets against swine influenza a virus infection |
| AU2022375120A1 (en) | 2021-11-01 | 2024-04-11 | Boehringer Ingelheim Vetmedica Gmbh | Immunogenic gel compositions |
| WO2024068637A1 (en) | 2022-09-27 | 2024-04-04 | Intervet International B.V. | A method of culturing lawsonia intracellularis bacteria |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0382271B1 (en) | 1989-02-04 | 1994-12-21 | Akzo Nobel N.V. | Tocols as adjuvant in vaccine |
| FR2649012B1 (fr) | 1989-07-03 | 1991-10-25 | Seppic Sa | Emulsions multiphasiques injectables |
| US5885823A (en) | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| NZ322398A (en) * | 1995-11-30 | 2000-02-28 | Pig Res & Dev Corp | Vaccine compositions comprising non-pathogenic form of Lawsonia intracellularis, nucleic acid sequences thereof and treatment of intestinal disease |
| NZ515363A (en) * | 1999-05-13 | 2003-07-25 | Pfizer Prod Inc | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
| EP1094070A3 (en) | 1999-10-22 | 2002-01-09 | Pfizer Products Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| JP2004529854A (ja) | 2000-09-29 | 2004-09-30 | アリゾナ・ボード・オブ・リージエンツ・オン・ビハーフ・オブ・ザ・ユニバーシテイー・オブ・アリゾナ | 増殖性回腸炎のための改善されたワクチン及びその作製と使用の方法 |
| EP1586646B1 (en) | 2000-12-20 | 2011-03-09 | Intervet International BV | Lawsonia intracellularis vaccine |
| SG144909A1 (en) | 2003-07-25 | 2008-08-28 | Boehringer Ingelheim Vetmed | Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof |
| EP1709067B1 (en) | 2004-01-22 | 2010-06-09 | Intervet International BV | Lawsonia intracellularis subunit vaccines |
| KR20070008625A (ko) * | 2004-04-05 | 2007-01-17 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
| EP2305294B1 (en) * | 2004-09-22 | 2015-04-01 | GlaxoSmithKline Biologicals SA | Immunogenic composition for use in vaccination against staphylococcei |
| US20070212373A1 (en) | 2004-12-08 | 2007-09-13 | Akzo Nobel N.V. | Lawsonia Intracellularis 26 Kd Subunit Vaccine |
| US8834891B2 (en) * | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| US8398994B2 (en) * | 2005-07-15 | 2013-03-19 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia vaccine and methods of use thereof |
| US20080248061A1 (en) | 2005-09-09 | 2008-10-09 | Intervet International B.V. | Pcv-2 Vaccine |
| BRPI0708522A2 (pt) | 2006-03-03 | 2011-05-31 | Merial Ltd | vacina de mycoplasma hyopneumoniae |
| EP2476434A1 (en) * | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| WO2007116032A1 (en) | 2006-04-10 | 2007-10-18 | Intervet International B.V. | Vaccine against mycoplasma prrsv |
| US8470336B2 (en) * | 2006-05-25 | 2013-06-25 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of young animals against Lawsonia intracellularis infections |
| MX2008015164A (es) | 2006-05-30 | 2008-12-12 | Intervet Int Bv | Vacuna contra organismos de tipo rickettsia. |
| TWI449533B (zh) | 2008-04-18 | 2014-08-21 | Intervet Int Bv | 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａ ｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅ ｃｉｒｃｏ ｖｉｒｕｓ）用疫苗 |
| TWI551295B (zh) * | 2008-04-18 | 2016-10-01 | 英特威特國際股份有限公司 | 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗 |
| JP2018504424A (ja) | 2015-02-04 | 2018-02-15 | インターベット インターナショナル ベー． フェー． | 豚における無症候性ローソニア感染症に対する使用のためのワクチン |
-
2009
- 2009-03-30 TW TW098110510A patent/TWI551295B/zh active
- 2009-04-16 ES ES09753743.5T patent/ES2666671T3/es active Active
- 2009-04-16 DK DK09753743.5T patent/DK2268308T3/da active
- 2009-04-16 JP JP2011504462A patent/JP6026106B2/ja active Active
- 2009-04-16 US US12/988,083 patent/US20110033496A1/en not_active Abandoned
- 2009-04-16 EP EP20167953.7A patent/EP3708186A1/en active Pending
- 2009-04-16 CN CN2009801136792A patent/CN102006883A/zh active Pending
- 2009-04-16 DK DK18154850.4T patent/DK3351267T3/da active
- 2009-04-16 PL PL09753743T patent/PL2268308T3/pl unknown
- 2009-04-16 BR BRPI0909769-4A patent/BRPI0909769A2/pt not_active Application Discontinuation
- 2009-04-16 WO PCT/EP2009/054516 patent/WO2009144088A2/en active Application Filing
- 2009-04-16 PL PL18154850T patent/PL3351267T3/pl unknown
- 2009-04-16 EP EP18154850.4A patent/EP3351267B1/en active Active
- 2009-04-16 HU HUE09753743A patent/HUE038294T2/hu unknown
- 2009-04-16 EP EP09753743.5A patent/EP2268308B1/en active Active
- 2009-04-16 CA CA2717969A patent/CA2717969C/en active Active
- 2009-04-16 BR BR122019000869-8A patent/BR122019000869B1/pt active IP Right Grant
-
2012
- 2012-10-22 US US13/657,210 patent/US8597662B2/en active Active
-
2013
- 2013-07-17 US US13/944,234 patent/US9198963B2/en active Active
-
2015
- 2015-08-11 JP JP2015158693A patent/JP6138875B2/ja active Active
-
2020
- 2020-11-25 HU HUS2000047C patent/HUS2000047I1/hu unknown
-
2021
- 2021-01-18 FR FR21C1002C patent/FR21C1002I1/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3351267A1 (en) | 2018-07-25 |
| JP6026106B2 (ja) | 2016-11-16 |
| ES2666671T3 (es) | 2018-05-07 |
| US20130302372A1 (en) | 2013-11-14 |
| PL3351267T3 (pl) | 2020-11-30 |
| WO2009144088A2 (en) | 2009-12-03 |
| CN102006883A (zh) | 2011-04-06 |
| CA2717969C (en) | 2016-06-07 |
| US9198963B2 (en) | 2015-12-01 |
| HUE038294T2 (hu) | 2018-10-29 |
| JP2016026154A (ja) | 2016-02-12 |
| US20130045228A1 (en) | 2013-02-21 |
| WO2009144088A3 (en) | 2010-05-06 |
| BR122019000869B1 (pt) | 2023-11-07 |
| EP3708186A1 (en) | 2020-09-16 |
| US8597662B2 (en) | 2013-12-03 |
| EP2268308A2 (en) | 2011-01-05 |
| US20110033496A1 (en) | 2011-02-10 |
| EP3351267B1 (en) | 2020-08-05 |
| PL2268308T3 (pl) | 2018-07-31 |
| TWI551295B (zh) | 2016-10-01 |
| FR21C1002I1 (fr) | 2021-03-05 |
| DK3351267T3 (da) | 2020-09-21 |
| TW201002342A (en) | 2010-01-16 |
| HUS2000047I1 (hu) | 2020-12-28 |
| JP6138875B2 (ja) | 2017-05-31 |
| CA2717969A1 (en) | 2009-12-03 |
| EP2268308B1 (en) | 2018-03-14 |
| JP2011516600A (ja) | 2011-05-26 |
| BRPI0909769A2 (pt) | 2015-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2268308T3 (da) | Vaccine til beskyttelse mod lawsonia intracellularis | |
| DK2291195T3 (da) | Vaccine til beskyttelse mod lawsonia intracellularis, mycoplasma hyopneumoniae og porcin circovirus | |
| BRPI0613039A2 (pt) | vacina contra lawsonia e mÉtodos de uso desta | |
| RU2523561C2 (ru) | Вакцина для защиты от lawsonia intracellularis | |
| ES2802748T3 (es) | Vacuna para la protección frente a Lawsonia intracellularis |