DK2183610T3 - Nozzle for Dynamic Core Spin Polarization (DNP) Polarizer - Google Patents
Nozzle for Dynamic Core Spin Polarization (DNP) Polarizer Download PDFInfo
- Publication number
- DK2183610T3 DK2183610T3 DK08803264.4T DK08803264T DK2183610T3 DK 2183610 T3 DK2183610 T3 DK 2183610T3 DK 08803264 T DK08803264 T DK 08803264T DK 2183610 T3 DK2183610 T3 DK 2183610T3
- Authority
- DK
- Denmark
- Prior art keywords
- sample
- nozzle
- dissolution
- conduit
- dissolution medium
- Prior art date
Links
- 230000010287 polarization Effects 0.000 title description 13
- NCYVXEGFNDZQCU-UHFFFAOYSA-N nikethamide Chemical compound CCN(CC)C(=O)C1=CC=CN=C1 NCYVXEGFNDZQCU-UHFFFAOYSA-N 0.000 title 1
- 239000012738 dissolution medium Substances 0.000 claims description 80
- 239000012530 fluid Substances 0.000 claims description 49
- 238000004891 communication Methods 0.000 claims description 21
- 239000002609 medium Substances 0.000 claims 3
- 239000000523 sample Substances 0.000 description 104
- 238000004090 dissolution Methods 0.000 description 74
- 239000000243 solution Substances 0.000 description 22
- 239000000463 material Substances 0.000 description 21
- 238000000034 method Methods 0.000 description 17
- 238000003032 molecular docking Methods 0.000 description 16
- 239000007787 solid Substances 0.000 description 14
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 12
- 239000012520 frozen sample Substances 0.000 description 11
- 239000002253 acid Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 229940107700 pyruvic acid Drugs 0.000 description 6
- 238000011144 upstream manufacturing Methods 0.000 description 6
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229940076788 pyruvate Drugs 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 239000012062 aqueous buffer Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 229910001369 Brass Inorganic materials 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 239000010951 brass Substances 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F21/00—Dissolving
- B01F21/20—Dissolving using flow mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N2001/1006—Dispersed solids
- G01N2001/1012—Suspensions
- G01N2001/1025—Liquid suspensions; Slurries; Mud; Sludge
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/383—Diluting, dispersing or mixing samples collecting and diluting in a flow of liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Fluid Mechanics (AREA)
- Clinical Laboratory Science (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polarising Elements (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96832007P | 2007-08-28 | 2007-08-28 | |
| PCT/EP2008/061197 WO2009027422A2 (en) | 2007-08-28 | 2008-08-27 | Nozzle for a polarizer for dynamic nuclear spin polarisation (dnp) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2183610T3 true DK2183610T3 (en) | 2016-06-27 |
Family
ID=40130844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08803264.4T DK2183610T3 (en) | 2007-08-28 | 2008-08-27 | Nozzle for Dynamic Core Spin Polarization (DNP) Polarizer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110036453A1 (https=) |
| EP (1) | EP2183610B1 (https=) |
| JP (1) | JP5405466B2 (https=) |
| KR (2) | KR101546208B1 (https=) |
| CN (2) | CN101790692A (https=) |
| AU (1) | AU2008292171B2 (https=) |
| BR (1) | BRPI0816131A2 (https=) |
| CA (1) | CA2697955A1 (https=) |
| DK (1) | DK2183610T3 (https=) |
| ES (1) | ES2576582T3 (https=) |
| MX (1) | MX2010002195A (https=) |
| RU (2) | RU2475770C2 (https=) |
| WO (1) | WO2009027422A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9587215B2 (en) | 2014-08-07 | 2017-03-07 | General Electric Company | Devices, systems and methods for automated transfer of a sample |
| US9632066B2 (en) | 2015-04-09 | 2017-04-25 | Ut-Battelle, Llc | Open port sampling interface |
| US10060838B2 (en) | 2015-04-09 | 2018-08-28 | Ut-Battelle, Llc | Capture probe |
| US10481222B2 (en) * | 2017-07-24 | 2019-11-19 | General Electric Company | Fluid path insert for a cryogenic cooling system |
| US11125657B2 (en) | 2018-01-30 | 2021-09-21 | Ut-Battelle, Llc | Sampling probe |
| US12134099B2 (en) | 2021-06-01 | 2024-11-05 | Invetech Ip Llc | Needle-less access vial and cap for the aseptic sampling and storage of liquids |
| KR102794718B1 (ko) | 2022-05-16 | 2025-04-14 | 전남대학교산학협력단 | 하이브리드 신호서열을 포함하는 재조합 벡터 및 이를 이용한 인간 인슐린 유사 성장인자-1의 분비 생산방법 |
| CN116223554B (zh) * | 2023-05-09 | 2023-08-04 | 中国科学院精密测量科学与技术创新研究院 | 一种用于dDNP探针分子多通道代谢示踪检测的装置和方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB103769A (en) * | 1916-07-26 | 1917-02-08 | William Edward Silverthorne | Improvements in and relating to Pour Outs for Bottles and the like. |
| US2842465A (en) * | 1955-12-06 | 1958-07-08 | Jack Danciger | Method for cleaning tires |
| FR1187261A (fr) * | 1957-11-25 | 1959-09-09 | Canule perforatrice pour dispositif de transfusion ou de perfusion et permettant de prélever un liquide dans un flacon obturé par un bouchon | |
| AR206690A1 (es) * | 1973-07-05 | 1976-08-13 | Ime Ltd | Dispositivo de traspaso de fluido |
| CA1010382A (en) * | 1973-08-29 | 1977-05-17 | Beckman Instruments | Gas stream cleaning system |
| US4296786A (en) * | 1979-09-28 | 1981-10-27 | The West Company | Transfer device for use in mixing a primary solution and a secondary or additive substance |
| DE3278622D1 (en) * | 1981-10-23 | 1988-07-14 | Univ Birmingham | Liquid dispenser |
| US4419233A (en) * | 1981-11-18 | 1983-12-06 | Baker Marvin E | Chlorinator for a swimming pool |
| JPS60104270U (ja) * | 1983-12-16 | 1985-07-16 | 三菱重工業株式会社 | 氷融解装置 |
| US4769159A (en) * | 1986-02-18 | 1988-09-06 | Ecolab Inc. | Institutional softener containing cationic surfactant and organic acid |
| US5400923A (en) * | 1988-06-20 | 1995-03-28 | Helena Laboratories Corporation | Apparatus for discharging contents of a sealed container |
| JPH0350531A (ja) * | 1989-07-19 | 1991-03-05 | Fujitsu Ltd | 半導体集光装置 |
| US5076315A (en) * | 1990-07-23 | 1991-12-31 | King Joseph A | Dispersal valve and canister |
| JP3331089B2 (ja) * | 1995-05-15 | 2002-10-07 | 理学電機株式会社 | 試料冷却ノズル |
| US5653871A (en) * | 1996-04-24 | 1997-08-05 | Everpure, Inc. | Filter assembly with O-ring protection |
| EP1324690A1 (en) * | 2000-07-13 | 2003-07-09 | Medi-Physics, Inc. | DIAGNOSTIC PROCEDURES USING ?129 XE SPECTROSCOPY CHARACTERISTIC CHEMICAL SHIFT TO DETECT PATHOLOGY i IN VIVO /i |
| GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
| DK1330659T3 (da) * | 2000-11-03 | 2006-12-18 | Amersham Health As | Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser |
| WO2004109121A1 (en) * | 2003-05-30 | 2004-12-16 | E-Z Flo Injection Systems, Inc. | Hose-end chemical delivery system |
| US20070145164A1 (en) * | 2005-12-22 | 2007-06-28 | Nordson Corporation | Jetting dispenser with multiple jetting nozzle outlets |
| JP5013907B2 (ja) * | 2007-03-06 | 2012-08-29 | 英明 藤原 | 偏極希ガスの製造方法 |
| US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US7633290B1 (en) * | 2008-09-09 | 2009-12-15 | General Electric Company | Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent |
-
2008
- 2008-08-27 JP JP2010522353A patent/JP5405466B2/ja not_active Expired - Fee Related
- 2008-08-27 DK DK08803264.4T patent/DK2183610T3/en active
- 2008-08-27 KR KR1020147030750A patent/KR101546208B1/ko not_active Expired - Fee Related
- 2008-08-27 BR BRPI0816131A patent/BRPI0816131A2/pt not_active IP Right Cessation
- 2008-08-27 MX MX2010002195A patent/MX2010002195A/es active IP Right Grant
- 2008-08-27 RU RU2010105972/28A patent/RU2475770C2/ru not_active IP Right Cessation
- 2008-08-27 US US12/675,815 patent/US20110036453A1/en not_active Abandoned
- 2008-08-27 EP EP08803264.4A patent/EP2183610B1/en not_active Not-in-force
- 2008-08-27 CN CN200880105546A patent/CN101790692A/zh active Pending
- 2008-08-27 CN CN201410294250.0A patent/CN104076308A/zh active Pending
- 2008-08-27 CA CA2697955A patent/CA2697955A1/en not_active Abandoned
- 2008-08-27 AU AU2008292171A patent/AU2008292171B2/en not_active Ceased
- 2008-08-27 WO PCT/EP2008/061197 patent/WO2009027422A2/en not_active Ceased
- 2008-08-27 KR KR1020107004444A patent/KR20100055443A/ko not_active Withdrawn
- 2008-08-27 ES ES08803264.4T patent/ES2576582T3/es active Active
-
2012
- 2012-11-07 RU RU2012148805A patent/RU2609497C2/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2183610A2 (en) | 2010-05-12 |
| JP5405466B2 (ja) | 2014-02-05 |
| EP2183610B1 (en) | 2016-03-23 |
| WO2009027422A3 (en) | 2009-09-03 |
| CN101790692A (zh) | 2010-07-28 |
| WO2009027422A2 (en) | 2009-03-05 |
| MX2010002195A (es) | 2010-08-02 |
| BRPI0816131A2 (pt) | 2017-06-13 |
| CA2697955A1 (en) | 2009-03-05 |
| KR101546208B1 (ko) | 2015-08-20 |
| CN104076308A (zh) | 2014-10-01 |
| US20110036453A1 (en) | 2011-02-17 |
| RU2609497C2 (ru) | 2017-02-02 |
| AU2008292171B2 (en) | 2014-06-05 |
| KR20140146163A (ko) | 2014-12-24 |
| AU2008292171A1 (en) | 2009-03-05 |
| AU2008292171A2 (en) | 2010-04-29 |
| JP2010537213A (ja) | 2010-12-02 |
| RU2010105972A (ru) | 2011-10-10 |
| RU2475770C2 (ru) | 2013-02-20 |
| KR20100055443A (ko) | 2010-05-26 |
| RU2012148805A (ru) | 2014-05-20 |
| ES2576582T3 (es) | 2016-07-08 |
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