KR101546208B1 - 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐 - Google Patents

동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐 Download PDF

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Publication number
KR101546208B1
KR101546208B1 KR1020147030750A KR20147030750A KR101546208B1 KR 101546208 B1 KR101546208 B1 KR 101546208B1 KR 1020147030750 A KR1020147030750 A KR 1020147030750A KR 20147030750 A KR20147030750 A KR 20147030750A KR 101546208 B1 KR101546208 B1 KR 101546208B1
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South Korea
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nozzle
sample
fluid
conduit
port
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20140146163A (ko
Inventor
잔 헨릭 아덴크재어-라르센
데이비드 키 디에트리치
칼 안드레아스 그람
앤드류 엠. 리치
피터 밀러
에릭 제이. 텔페얀
미켈 타닝
데이비드 비. 휘트
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지이 헬쓰케어 리미티드
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44Sample treatment involving radiation, e.g. heat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00Dissolving
    • B01F21/20Dissolving using flow mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38Diluting, dispersing or mixing samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0289Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/10Devices for withdrawing samples in the liquid or fluent state
    • G01N2001/1006Dispersed solids
    • G01N2001/1012Suspensions
    • G01N2001/1025Liquid suspensions; Slurries; Mud; Sludge
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38Diluting, dispersing or mixing samples
    • G01N2001/383Diluting, dispersing or mixing samples collecting and diluting in a flow of liquid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Fluid Mechanics (AREA)
  • Clinical Laboratory Science (AREA)
  • Veterinary Medicine (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polarising Elements (AREA)
KR1020147030750A 2007-08-28 2008-08-27 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐 Expired - Fee Related KR101546208B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96832007P 2007-08-28 2007-08-28
US60/968,320 2007-08-28
PCT/EP2008/061197 WO2009027422A2 (en) 2007-08-28 2008-08-27 Nozzle for a polarizer for dynamic nuclear spin polarisation (dnp)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107004444A Division KR20100055443A (ko) 2007-08-28 2008-08-27 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐

Publications (2)

Publication Number Publication Date
KR20140146163A KR20140146163A (ko) 2014-12-24
KR101546208B1 true KR101546208B1 (ko) 2015-08-20

Family

ID=40130844

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020147030750A Expired - Fee Related KR101546208B1 (ko) 2007-08-28 2008-08-27 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐
KR1020107004444A Withdrawn KR20100055443A (ko) 2007-08-28 2008-08-27 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020107004444A Withdrawn KR20100055443A (ko) 2007-08-28 2008-08-27 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐

Country Status (13)

Country Link
US (1) US20110036453A1 (https=)
EP (1) EP2183610B1 (https=)
JP (1) JP5405466B2 (https=)
KR (2) KR101546208B1 (https=)
CN (2) CN101790692A (https=)
AU (1) AU2008292171B2 (https=)
BR (1) BRPI0816131A2 (https=)
CA (1) CA2697955A1 (https=)
DK (1) DK2183610T3 (https=)
ES (1) ES2576582T3 (https=)
MX (1) MX2010002195A (https=)
RU (2) RU2475770C2 (https=)
WO (1) WO2009027422A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9587215B2 (en) 2014-08-07 2017-03-07 General Electric Company Devices, systems and methods for automated transfer of a sample
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US10481222B2 (en) * 2017-07-24 2019-11-19 General Electric Company Fluid path insert for a cryogenic cooling system
US11125657B2 (en) 2018-01-30 2021-09-21 Ut-Battelle, Llc Sampling probe
US12134099B2 (en) 2021-06-01 2024-11-05 Invetech Ip Llc Needle-less access vial and cap for the aseptic sampling and storage of liquids
KR102794718B1 (ko) 2022-05-16 2025-04-14 전남대학교산학협력단 하이브리드 신호서열을 포함하는 재조합 벡터 및 이를 이용한 인간 인슐린 유사 성장인자-1의 분비 생산방법
CN116223554B (zh) * 2023-05-09 2023-08-04 中国科学院精密测量科学与技术创新研究院 一种用于dDNP探针分子多通道代谢示踪检测的装置和方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB103769A (en) * 1916-07-26 1917-02-08 William Edward Silverthorne Improvements in and relating to Pour Outs for Bottles and the like.
US2842465A (en) * 1955-12-06 1958-07-08 Jack Danciger Method for cleaning tires
FR1187261A (fr) * 1957-11-25 1959-09-09 Canule perforatrice pour dispositif de transfusion ou de perfusion et permettant de prélever un liquide dans un flacon obturé par un bouchon
AR206690A1 (es) * 1973-07-05 1976-08-13 Ime Ltd Dispositivo de traspaso de fluido
CA1010382A (en) * 1973-08-29 1977-05-17 Beckman Instruments Gas stream cleaning system
US4296786A (en) * 1979-09-28 1981-10-27 The West Company Transfer device for use in mixing a primary solution and a secondary or additive substance
DE3278622D1 (en) * 1981-10-23 1988-07-14 Univ Birmingham Liquid dispenser
US4419233A (en) * 1981-11-18 1983-12-06 Baker Marvin E Chlorinator for a swimming pool
JPS60104270U (ja) * 1983-12-16 1985-07-16 三菱重工業株式会社 氷融解装置
US4769159A (en) * 1986-02-18 1988-09-06 Ecolab Inc. Institutional softener containing cationic surfactant and organic acid
US5400923A (en) * 1988-06-20 1995-03-28 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
JPH0350531A (ja) * 1989-07-19 1991-03-05 Fujitsu Ltd 半導体集光装置
US5076315A (en) * 1990-07-23 1991-12-31 King Joseph A Dispersal valve and canister
JP3331089B2 (ja) * 1995-05-15 2002-10-07 理学電機株式会社 試料冷却ノズル
US5653871A (en) * 1996-04-24 1997-08-05 Everpure, Inc. Filter assembly with O-ring protection
EP1324690A1 (en) * 2000-07-13 2003-07-09 Medi-Physics, Inc. DIAGNOSTIC PROCEDURES USING ?129 XE SPECTROSCOPY CHARACTERISTIC CHEMICAL SHIFT TO DETECT PATHOLOGY i IN VIVO /i
GB0022341D0 (en) * 2000-09-12 2000-10-25 Nycomed Imaging As Method
DK1330659T3 (da) * 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
WO2004109121A1 (en) * 2003-05-30 2004-12-16 E-Z Flo Injection Systems, Inc. Hose-end chemical delivery system
US20070145164A1 (en) * 2005-12-22 2007-06-28 Nordson Corporation Jetting dispenser with multiple jetting nozzle outlets
JP5013907B2 (ja) * 2007-03-06 2012-08-29 英明 藤原 偏極希ガスの製造方法
US20080240998A1 (en) * 2007-03-28 2008-10-02 Urbahn John A Fluid path system for dissolution and transport of a hyperpolarized material
US7633290B1 (en) * 2008-09-09 2009-12-15 General Electric Company Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent

Also Published As

Publication number Publication date
EP2183610A2 (en) 2010-05-12
JP5405466B2 (ja) 2014-02-05
DK2183610T3 (en) 2016-06-27
EP2183610B1 (en) 2016-03-23
WO2009027422A3 (en) 2009-09-03
CN101790692A (zh) 2010-07-28
WO2009027422A2 (en) 2009-03-05
MX2010002195A (es) 2010-08-02
BRPI0816131A2 (pt) 2017-06-13
CA2697955A1 (en) 2009-03-05
CN104076308A (zh) 2014-10-01
US20110036453A1 (en) 2011-02-17
RU2609497C2 (ru) 2017-02-02
AU2008292171B2 (en) 2014-06-05
KR20140146163A (ko) 2014-12-24
AU2008292171A1 (en) 2009-03-05
AU2008292171A2 (en) 2010-04-29
JP2010537213A (ja) 2010-12-02
RU2010105972A (ru) 2011-10-10
RU2475770C2 (ru) 2013-02-20
KR20100055443A (ko) 2010-05-26
RU2012148805A (ru) 2014-05-20
ES2576582T3 (es) 2016-07-08

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