DK2144626T3 - Tuberculosis vaccine and method of using same - Google Patents
Tuberculosis vaccine and method of using same Download PDFInfo
- Publication number
- DK2144626T3 DK2144626T3 DK08745627.3T DK08745627T DK2144626T3 DK 2144626 T3 DK2144626 T3 DK 2144626T3 DK 08745627 T DK08745627 T DK 08745627T DK 2144626 T3 DK2144626 T3 DK 2144626T3
- Authority
- DK
- Denmark
- Prior art keywords
- composition
- mycobacterium
- tuberculosis
- host
- vaccine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 19
- 229960002109 tuberculosis vaccine Drugs 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims description 50
- 241000186359 Mycobacterium Species 0.000 claims description 33
- 201000008827 tuberculosis Diseases 0.000 claims description 22
- 239000002671 adjuvant Substances 0.000 claims description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 230000028993 immune response Effects 0.000 claims description 19
- 230000002685 pulmonary effect Effects 0.000 claims description 13
- 230000001681 protective effect Effects 0.000 claims description 11
- 239000000443 aerosol Substances 0.000 claims description 10
- 238000002255 vaccination Methods 0.000 claims description 10
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 9
- 230000005855 radiation Effects 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 239000013592 cell lysate Substances 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 22
- 201000010099 disease Diseases 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 13
- 239000000427 antigen Substances 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 210000004072 lung Anatomy 0.000 description 13
- 210000001744 T-lymphocyte Anatomy 0.000 description 11
- 208000015181 infectious disease Diseases 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- 244000052616 bacterial pathogen Species 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 238000011282 treatment Methods 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000004224 protection Effects 0.000 description 6
- 230000036039 immunity Effects 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000011859 microparticle Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- -1 poly(lactic acid) Polymers 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 210000004443 dendritic cell Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000002779 inactivation Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000002480 immunoprotective effect Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 229940071648 metered dose inhaler Drugs 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000008520 organization Effects 0.000 description 3
- 230000007420 reactivation Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 102000009016 Cholera Toxin Human genes 0.000 description 2
- 108010049048 Cholera Toxin Proteins 0.000 description 2
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 208000031998 Mycobacterium Infections Diseases 0.000 description 2
- 241000187494 Mycobacterium xenopi Species 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000008156 Ringer's lactate solution Substances 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- 230000030741 antigen processing and presentation Effects 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000016396 cytokine production Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 229940112141 dry powder inhaler Drugs 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 229960001438 immunostimulant agent Drugs 0.000 description 2
- 239000003022 immunostimulating agent Substances 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 230000015788 innate immune response Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 210000001533 respiratory mucosa Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 229940031626 subunit vaccine Drugs 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940021747 therapeutic vaccine Drugs 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QZCJOXAIQXPLNS-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8,8a-octadecafluoronaphthalene 4-(2-aminoethyl)benzene-1,2-diol Chemical compound NCCc1ccc(O)c(O)c1.FC1(F)C(F)(F)C(F)(F)C2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C2(F)C1(F)F QZCJOXAIQXPLNS-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000037164 Collema parvum Species 0.000 description 1
- 241001134763 Corynebacterium flavescens Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 101710088335 Diacylglycerol acyltransferase/mycolyltransferase Ag85A Proteins 0.000 description 1
- 206010013453 Disseminated tuberculosis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241001467553 Mycobacterium africanum Species 0.000 description 1
- 241000545499 Mycobacterium avium-intracellulare Species 0.000 description 1
- 241000186366 Mycobacterium bovis Species 0.000 description 1
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 1
- 241001312372 Mycobacterium canettii Species 0.000 description 1
- 241000187478 Mycobacterium chelonae Species 0.000 description 1
- 206010071401 Mycobacterium chelonae infection Diseases 0.000 description 1
- 241000187911 Mycobacterium farcinogenes Species 0.000 description 1
- 241000186365 Mycobacterium fortuitum Species 0.000 description 1
- 241000186363 Mycobacterium kansasii Species 0.000 description 1
- 241000186362 Mycobacterium leprae Species 0.000 description 1
- 241000908167 Mycobacterium lepraemurium Species 0.000 description 1
- 241000187492 Mycobacterium marinum Species 0.000 description 1
- 241000187481 Mycobacterium phlei Species 0.000 description 1
- 241000187468 Mycobacterium senegalense Species 0.000 description 1
- 241000187489 Mycobacterium simiae Species 0.000 description 1
- 241000187480 Mycobacterium smegmatis Species 0.000 description 1
- 241000187477 Mycobacterium thermoresistibile Species 0.000 description 1
- 241001646725 Mycobacterium tuberculosis H37Rv Species 0.000 description 1
- 108700035964 Mycobacterium tuberculosis HsaD Proteins 0.000 description 1
- 241001302239 Mycobacterium tuberculosis complex Species 0.000 description 1
- 241000187917 Mycobacterium ulcerans Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000026681 Paratuberculosis Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 208000032942 Vaccine-Preventable disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 210000002588 alveolar type II cell Anatomy 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2s)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 description 1
- BMLSTPRTEKLIPM-UHFFFAOYSA-I calcium;potassium;disodium;hydrogen carbonate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].OC([O-])=O BMLSTPRTEKLIPM-UHFFFAOYSA-I 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000000139 costimulatory effect Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000000521 hyperimmunizing effect Effects 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000003071 memory t lymphocyte Anatomy 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229940055036 mycobacterium phlei Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002006 poly(N-vinylimidazole) polymer Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920002721 polycyanoacrylate Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920002620 polyvinyl fluoride Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 210000002978 thoracic duct Anatomy 0.000 description 1
- 238000004613 tight binding model Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92330107P | 2007-04-12 | 2007-04-12 | |
| PCT/US2008/060065 WO2008128065A2 (en) | 2007-04-12 | 2008-04-11 | Tuberculosis vaccine and method of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2144626T3 true DK2144626T3 (en) | 2015-02-09 |
Family
ID=39523390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08745627.3T DK2144626T3 (en) | 2007-04-12 | 2008-04-11 | Tuberculosis vaccine and method of using same |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8394389B2 (https=) |
| EP (1) | EP2144626B8 (https=) |
| JP (2) | JP5713672B2 (https=) |
| AU (1) | AU2008240181B2 (https=) |
| CA (1) | CA2682870C (https=) |
| CY (1) | CY1117290T1 (https=) |
| DK (1) | DK2144626T3 (https=) |
| ES (1) | ES2531018T3 (https=) |
| HR (1) | HRP20150177T1 (https=) |
| HU (1) | HUE024427T2 (https=) |
| PL (1) | PL2144626T3 (https=) |
| PT (1) | PT2144626E (https=) |
| SI (1) | SI2144626T1 (https=) |
| WO (1) | WO2008128065A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20150177T1 (hr) | 2007-04-12 | 2015-04-10 | Mico Bio, Inc. | Cjepivo protiv tuberkuloze i postupak upotrebe tog cjepiva |
| WO2012137072A1 (en) | 2011-04-06 | 2012-10-11 | Biovaxim Limited | Therapeutic vaccine compositions inducing tolerance to hiv for treating hiv infections in humans |
| AP2013007166A0 (en) | 2011-04-06 | 2013-10-31 | Univ Paris Descartes Inst De Rech Pour Le Dev Ird | Pharmaceutical compositions for preventing and/or treating an HIV disease in humans |
| MX2013012165A (es) * | 2011-04-20 | 2014-06-11 | Mico Bio Inc | Composicion y metodo para mejorar una respuesta inmune. |
| ES2438690B1 (es) * | 2012-06-15 | 2015-01-16 | Fundació Institut Per A La Investigació En Ciències De La Salut "Germans Trias I Pujol" (Igtp) Unitat De Tuberculosi Experimental | Micobacterias inactivadas para su uso por vía oral en la prevención de la tuberculosis |
| EP2679232A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria vaccination |
| EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
| US9388400B2 (en) | 2012-06-29 | 2016-07-12 | Lysando Ag | Composition for use in mycobacteria diagnosis |
| KR101615186B1 (ko) | 2014-03-07 | 2016-04-25 | 연세대학교 산학협력단 | 결핵 백신의 면역효과 증강용 조성물 및 면역효과 증진 방법 |
| KR101631054B1 (ko) * | 2015-12-31 | 2016-06-16 | 중앙대학교 산학협력단 | 마이코박테리아 유래 CFP-10 또는 Ag85B에 특이적으로 결합하는 항체 또는 그의 항원 결합 단편 |
| US10279031B2 (en) * | 2016-05-11 | 2019-05-07 | Phibro Animal Health Corporation | Composition comprising antigens and a mucosal adjuvant and a method for using |
| WO2018006939A1 (en) | 2016-07-05 | 2018-01-11 | Universidad De Zaragoza | Inactivated tuberculosis vaccine |
| CN108743931B (zh) * | 2018-05-02 | 2022-08-16 | 成都威斯克生物医药有限公司 | 抗结核病疫苗及其制备方法和用途 |
| ES2962407T3 (es) | 2018-12-04 | 2024-03-18 | Sabiotec Spin Off S L | Inmunoestimulante para su uso contra patógenos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8404280D0 (en) * | 1984-02-17 | 1984-03-21 | Stanford J L | Biological preparations |
| US4724114A (en) | 1984-04-23 | 1988-02-09 | Kimberly-Clark Corporation | Selective layering of superabsorbents in meltblown substrates |
| SE9900495D0 (sv) * | 1999-02-12 | 1999-02-12 | Pharmatrix Ab | Vaccine composition |
| DE60226175T2 (de) | 2001-11-14 | 2009-07-09 | Novavax, Inc. | Mycobakterieller impfstoff |
| BR0303367A (pt) * | 2002-03-08 | 2004-07-20 | Bakulesh Mafatlal Khamar | Células de mycobacterium w, veìculo farmaceuticamente aceitável, preservativo, ruptura de mycobacterium w, extração de solvente, enzimas usadas para a extração enzimática de células de mycobacterium w, adjuvante, composição farmacêutica, tensoativo, e, concentração de tensoativo do processo de fabricar uma composição farmacêutica para a administração de tuberculose |
| CA2612900C (en) * | 2005-06-23 | 2016-08-09 | Claus Aagaard | Improved tuberculosis vaccines |
| HRP20150177T1 (hr) | 2007-04-12 | 2015-04-10 | Mico Bio, Inc. | Cjepivo protiv tuberkuloze i postupak upotrebe tog cjepiva |
-
2008
- 2008-04-11 HR HRP20150177AT patent/HRP20150177T1/hr unknown
- 2008-04-11 PL PL08745627T patent/PL2144626T3/pl unknown
- 2008-04-11 HU HUE08745627A patent/HUE024427T2/en unknown
- 2008-04-11 CA CA2682870A patent/CA2682870C/en not_active Expired - Fee Related
- 2008-04-11 DK DK08745627.3T patent/DK2144626T3/en active
- 2008-04-11 AU AU2008240181A patent/AU2008240181B2/en not_active Ceased
- 2008-04-11 PT PT08745627T patent/PT2144626E/pt unknown
- 2008-04-11 EP EP08745627.3A patent/EP2144626B8/en not_active Not-in-force
- 2008-04-11 US US12/595,006 patent/US8394389B2/en not_active Expired - Fee Related
- 2008-04-11 ES ES08745627T patent/ES2531018T3/es active Active
- 2008-04-11 SI SI200831389T patent/SI2144626T1/sl unknown
- 2008-04-11 WO PCT/US2008/060065 patent/WO2008128065A2/en not_active Ceased
- 2008-04-11 JP JP2010503240A patent/JP5713672B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-11 US US13/764,241 patent/US8932608B2/en not_active Expired - Fee Related
-
2014
- 2014-10-17 JP JP2014212560A patent/JP2015038130A/ja active Pending
- 2014-12-05 US US14/561,774 patent/US9636391B2/en not_active Expired - Fee Related
-
2015
- 2015-03-02 CY CY20151100215T patent/CY1117290T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8932608B2 (en) | 2015-01-13 |
| EP2144626B8 (en) | 2015-02-18 |
| EP2144626A2 (en) | 2010-01-20 |
| CA2682870A1 (en) | 2008-10-23 |
| AU2008240181B2 (en) | 2014-01-09 |
| PT2144626E (pt) | 2015-03-03 |
| AU2008240181A1 (en) | 2008-10-23 |
| SI2144626T1 (sl) | 2015-04-30 |
| US20130273110A1 (en) | 2013-10-17 |
| WO2008128065A2 (en) | 2008-10-23 |
| CY1117290T1 (el) | 2017-04-26 |
| US9636391B2 (en) | 2017-05-02 |
| JP2015038130A (ja) | 2015-02-26 |
| US8394389B2 (en) | 2013-03-12 |
| WO2008128065A3 (en) | 2008-12-18 |
| JP2010523711A (ja) | 2010-07-15 |
| US20100112007A1 (en) | 2010-05-06 |
| CA2682870C (en) | 2016-08-09 |
| EP2144626B1 (en) | 2014-12-03 |
| JP5713672B2 (ja) | 2015-05-07 |
| HRP20150177T1 (hr) | 2015-04-10 |
| ES2531018T3 (es) | 2015-03-09 |
| US20150258187A1 (en) | 2015-09-17 |
| PL2144626T3 (pl) | 2015-09-30 |
| HUE024427T2 (en) | 2016-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2144626T3 (en) | Tuberculosis vaccine and method of using same | |
| JP2010523711A5 (https=) | ||
| Salvin et al. | Brief communication: tumor suppression by a lymphokine released into the circulation of mice with delayed hypersensitivity | |
| Stylianou et al. | Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges | |
| Tyne et al. | TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines | |
| RU2526910C2 (ru) | Профилактическая вакцина от туберкулеза | |
| Liu et al. | Maintenance and recall of memory T cell populations against tuberculosis: Implications for vaccine design | |
| JP6655549B2 (ja) | 免疫応答を誘導するための新規方法 | |
| Ha et al. | Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination | |
| Touray et al. | Protective RNA nanovaccines against Mycobacterium avium subspecies hominissuis | |
| Giri et al. | Is intranasal vaccination a feasible solution for tuberculosis? | |
| Carpenter et al. | Mucosal delivery of microparticle encapsulated ESAT-6 induces robust cell-mediated responses in the lung milieu | |
| ES2335177B1 (es) | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. | |
| DK2341928T3 (en) | MYCOBACTERIUM TUBERCULOSIS VACCINE | |
| CN104582721B (zh) | 用于防止结核病的口服灭活分枝杆菌 | |
| CN104411326B (zh) | 抗哮喘的mtb‑c疫苗 | |
| AU2014201218A1 (en) | Tuberculosis vaccine and method of using same | |
| Garcia-Contreras et al. | Inhaled vaccines for the prevention of tuberculosis | |
| Neustrup | Nanoparticles and microfluidics for future tuberculosis accines | |
| KR20250131865A (ko) | 면역증강제를 포함하는 결핵 예방용 mRNA 백신 조성물 | |
| Sarim Imam et al. | Pulmonary Vaccine Delivery Systems: A Novel Approach for Immunization | |
| Lu | Aerosol delivery of recombinant antigen 85B in microparticle vaccine systems for protection against tuberculosis | |
| BCG and new tuberculosis vaccines | ||
| ZHAO | Primary Study on the Action of Genome DNA of Mycobacterium Bovis-Bacille Calmette-Guerin for Macrophage Activation in Mice | |
| HK1138786B (en) | Prophylactic tuberculosis vaccine |