DK2049482T3 - Positivt ladede, vandopløselige prodrugs af aryl- og heteroaryleddikesyrer med meget hurtig hudpenetrationshastighed - Google Patents
Positivt ladede, vandopløselige prodrugs af aryl- og heteroaryleddikesyrer med meget hurtig hudpenetrationshastighed Download PDFInfo
- Publication number
- DK2049482T3 DK2049482T3 DK06795612.8T DK06795612T DK2049482T3 DK 2049482 T3 DK2049482 T3 DK 2049482T3 DK 06795612 T DK06795612 T DK 06795612T DK 2049482 T3 DK2049482 T3 DK 2049482T3
- Authority
- DK
- Denmark
- Prior art keywords
- diethylaminoethyl
- acoh
- acetate
- compound
- chlorobenzoyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Claims (14)
1. Forbindelse valgt blandt gruppen bestående af: Diethylaminoethyl 1 -(p-chlorobenzoyl)-5-methoxy-2-methylindol 3-acetat.AcOH, Diethylaminoethyl (Z)-5-fluoro-2-methyl-1 -[(4-methylsulfinyl) phenylmethylen]-1 H-inden-3-acetat.AcOH, Diethylaminoethyl 1 -methyl-5-(4-methylbenzoyl)-1 H-pyrrol-2-acetat.AcOH, Diethylaminoethyl 5-(4-Chlorobenzoyl)-1,4-dimethyl-1 H-pyrrol-2-acetat.AcOH, Diethylaminoethyl 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3 ,4-b]indol-1-acetat.AcOH, Diethylaminoethyl 2-amino-3-benzoylbenzenacetat.AcOH, Diethylaminoethyl 2-amino-3-(4-bromo-benzoyl)benzenacetat.AcOH, Diethylaminoethyl 3-chloro-4-(2-propenyloxy)benzenacetat.AcOH, Diethylaminoethyl 2-(2,4-dichlorophenoxy)benzenacetat.AcOH, Diethylaminoethyl 1 -(4-chlorobenzoyl-5-methoxy-2-methyl-1 H-indol-3-acetoxy acetat. AcO H, Diethylaminoethyl 4-(4-chlorophenyl)-2-phenyl-5-thiazolacetat.AcOH, Diethylaminoethyl 3 -(4-chlorophenyl)-1-phenyl-1 H-pyrazol-4-acetat.AcOH, Diethylaminoethyl [(1-benzyl- 1H-indazol-3-yl)oxy]acetat.AcOH, Diethylaminoethyl 6-methoxyl-2-naphthalen-2-acetat.AcOH, og Diethylaminoethyl p-isobutylphenylacetat.AcOH.
2. Fremgangsmåde til fremstilling af en forbindelse ifølge krav 1, hvor syrehalogenider eller blandede anhydrider af tolmetin, zomepirac, etodolac, amfenac, bromofenac, alclofenac, fenclofenac, acemetacin, fentiazac, indomethacin, sulindac, lonazolac, bendazac, 6MNA eller ibufenac reageres med forbindelser med den almene struktur (3)
Struktur 3 hvor R3 i struktur 3 repræsenterer ethyl; R4 repræsenterer ethyl; X repræsenterer O; og n = 2.
3. Fremgangsmåde til fremstilling af en forbindelse ifølge krav 1, hvor tolmetin, zomepirac, etodolac, amfenac, bromofenac, alclofenac, fenclofenac, acemetacin, fentiazac, indomethacin, sulindac, lonazolac, bendazac, 6MNA eller ibufenac reageres med en forbindelse med den almene struktur (3)
Struktur 3 hvor R3 i struktur 3 repræsenterer ethyl; R4 repræsenterer ethyl; X repræsenterer O; og n = 2, ved at anvende koblingsreagenser.
4. Fremgangsmåde ifølge krav 3, hvor koblingsreagenserne er valgt blandt gruppen bestående af Ν,Ν'-Dicyclohexylcarbodiimid, N, N'-Diisopropyl-carbodiimid, 0-(Benzotriazol-1 -yl)-N,N,N',N'-tetramethyluronium tetrafluoroborat, 0-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluorophosphat og Benzotriazol-1-yl-oxy-tris (dimethylamino)phosphoniumhexafluorophosphat.
5. Fremgangsmåde til fremstilling af en forbindelse ifølge krav 1, hvor metalsalte, organiske basiske salte eller immobiliserede basiske salte af tolmetin, zomepirac, etodolac, amfenac, bromofenac, alclofenac, fenclofenac, acemetacin, fentiazac, indomethacin, sulindac, lonazolac, bendazac, 6MNA, ibufenac og beslægtede forbindelser reageres med forbindelser med den almene struktur 4,
Struktur 4 hvor R2 i struktur 4 repræsenterer H, R3 repræsenterer ethyl; R4 repræsenterer ethyl; Z repræsenterer halogen eller p-toluensulphonyl, A' repræsenterer en hvilken som helst negativ ion og n = 2.
6. Sammensætning indeholdende mindst en forbindelse ifølge krav 1.
7. Forbindelse ifølge krav 1 eller farmaceutisk sammensætning ifølge krav 6 til anvendelse i en fremgangsmåde til behandling af en lidelse, der kan behandles med et ikke-steroidt, antiinflammatorisk middel (NSAIA), valgt blandt gruppen bestående af smerte fra tandpine, hovedpine og arthritis og anden inflammatorisk smerte, feber, cancer, dysmenorré, strålingsinduceret opkastning, diabetisk neuropati og akut migrænehovedpine, hæmofil artropati, knogletab og solskoldning hos mennesker eller dyr.
8. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor anvendelserne omfatter indgift af forbindelsen eller sammensætningen transdermalt i en hvilken som helst del af kroppen for at opnå terapeutisk effektive plasmaniveauer af forbindelsen.
9. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor lidelsen, der kan behandles med NSAIA, er valgt blandt gruppen bestående af hovedpine, tandpine og muskelsmerte samt arthritis og anden inflammatorisk smerte, og omfattende indgift i det betændte område af en terapeutisk effektiv mængde af forbindelsen eller sammensætningen.
10. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor lidelsen, der kan behandles med NSAIA, er valgt blandt gruppen bestående af akne, solskoldning eller andre hudlidelser, hvor forbindelsen eller sammensætningen indgives transdermalt og er i form af en opløsning, spray, lotion, salve, emulsion eller gel.
11. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor lidelsen, der kan behandles med NSAIA, er astma, hvor forbindelsen eller sammensætningen indgives ved at spraye gennem munden eller næsen eller andre dele af kroppen.
12. Forbindelse eller sammensætning til anvendelse ifølge krav 7, hvor lidelsen, der kan behandles med NSAIA, er valgt blandt gruppen bestående af øjenbetændelsessygdomme, okulær smerte efter hornhindekirurgi, glaucoma og ørebetændelses- og/eller øresmertelidelser (otitis).
13. Transdermalt terapeutisk indgiftssystem omfattende mindst en forbindelse ifølge krav 1 som en aktiv ingrediens til anvendelse i en fremgangsmåde til behandling af lidelser, der kan behandles med NSAIA, hos mennesker eller dyr.
14. Transdermalt terapeutisk indgiftssystem ifølge krav 13, hvor systemet er en bandage eller et plaster omfattende et matrixlag, der indeholder aktivt stof, og et impermeabelt støttelag, eller hvor systemet er et aktivt stof reservoir, der har en permeabel bund, der vender mod huden.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/052732 WO2008017903A1 (en) | 2006-08-08 | 2006-08-08 | Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2049482T3 true DK2049482T3 (da) | 2016-02-01 |
Family
ID=39032656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06795612.8T DK2049482T3 (da) | 2006-08-08 | 2006-08-08 | Positivt ladede, vandopløselige prodrugs af aryl- og heteroaryleddikesyrer med meget hurtig hudpenetrationshastighed |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP2990402A1 (da) |
CN (1) | CN101506160A (da) |
DK (1) | DK2049482T3 (da) |
ES (1) | ES2559781T3 (da) |
HU (1) | HUE028425T2 (da) |
PL (1) | PL2049482T3 (da) |
PT (1) | PT2049482E (da) |
WO (1) | WO2008017903A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
PL2084124T3 (pl) | 2006-10-02 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę |
CN101541743A (zh) | 2006-11-08 | 2009-09-23 | 于崇曦 | 多肽及相关化合物的透皮给药系统 |
ES2633020T3 (es) | 2006-12-10 | 2017-09-18 | Yu, Chongxi-Techfields Biochem | Sistemas de administración transdérmica de antibióticos betalactámicos |
CA2674822C (en) | 2007-01-15 | 2017-08-01 | Chongxi Yu | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
EP2115140B8 (en) | 2007-01-31 | 2017-01-25 | Chongxi Yu | Positively charged water-soluble prodrugs of 1H-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates |
JP2010529101A (ja) * | 2007-06-04 | 2010-08-26 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するnsaiaプロドラッグ及びその新規医薬使用 |
JP2012511027A (ja) | 2008-12-04 | 2012-05-17 | チョンシー ユー | 高透過性組成物およびその用途 |
CN108084246A (zh) | 2009-05-08 | 2018-05-29 | 上海泰飞尔生化技术有限公司 | 多肽和多肽相关化合物的高穿透力前药组合物 |
US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
CN102557976B (zh) * | 2010-12-15 | 2015-06-10 | 辽宁盛京制药有限公司 | 溴芬酸有机盐及其制备方法、其组合物及用途 |
KR102332837B1 (ko) | 2012-05-16 | 2021-12-01 | 테크필즈 파마 코., 엘티디. | 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물 |
CN105143174B (zh) * | 2013-03-15 | 2021-01-12 | 苏州泰飞尔医药有限公司 | 治疗帕金森疾病的新型高穿透力药物及其药物组合物 |
JP5997658B2 (ja) * | 2013-05-08 | 2016-09-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するnsaiaプロドラッグ及びその新規医薬使用 |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
EP3687972A4 (en) * | 2017-09-28 | 2021-09-29 | Medicon Pharmaceuticals, Inc. | ANTI-INFLAMMATORY, ANTITUMOROUS AND ANTIANGIOGENIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF MANUFACTURING AND USING THEREOF |
CA3096700C (en) | 2018-04-26 | 2023-08-22 | Adt Pharmaceuticals, Llc | Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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FR1593024A (da) * | 1968-09-18 | 1970-05-25 | ||
IT1090782B (it) * | 1977-11-30 | 1985-06-26 | Menarini Sas | 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi |
US5192753A (en) | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
KR100213465B1 (ko) | 1996-11-01 | 1999-08-02 | 최좌진 | 케토프로펜 패취 조성물 |
US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
MXPA00012844A (es) | 1998-07-07 | 2004-05-21 | Transdermal Technologies Inc | Composiciones para la liberacion transdermica rapida y sin irritacion de agentes farmaceuticamente activos y metodos para formular tales composiciones y liberar los mismos. |
IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
-
2006
- 2006-08-08 HU HUE06795612A patent/HUE028425T2/en unknown
- 2006-08-08 PT PT67956128T patent/PT2049482E/pt unknown
- 2006-08-08 CN CNA2006800555598A patent/CN101506160A/zh active Pending
- 2006-08-08 ES ES06795612.8T patent/ES2559781T3/es active Active
- 2006-08-08 PL PL06795612T patent/PL2049482T3/pl unknown
- 2006-08-08 EP EP15190570.0A patent/EP2990402A1/en active Pending
- 2006-08-08 WO PCT/IB2006/052732 patent/WO2008017903A1/en active Application Filing
- 2006-08-08 EP EP06795612.8A patent/EP2049482B1/en not_active Not-in-force
- 2006-08-08 DK DK06795612.8T patent/DK2049482T3/da active
Also Published As
Publication number | Publication date |
---|---|
ES2559781T3 (es) | 2016-02-15 |
WO2008017903A1 (en) | 2008-02-14 |
CN101506160A (zh) | 2009-08-12 |
HUE028425T2 (en) | 2016-12-28 |
EP2049482B1 (en) | 2015-10-21 |
PL2049482T3 (pl) | 2016-04-29 |
EP2990402A1 (en) | 2016-03-02 |
EP2049482A1 (en) | 2009-04-22 |
EP2049482A4 (en) | 2010-05-26 |
PT2049482E (pt) | 2016-02-24 |
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