DK2004814T3 - Gruppe af nye enantioselektive mikrobielle nitrilhydrataser med bred substratspecificitet - Google Patents

Gruppe af nye enantioselektive mikrobielle nitrilhydrataser med bred substratspecificitet

Info

Publication number
DK2004814T3
DK2004814T3 DK07724055.4T DK07724055T DK2004814T3 DK 2004814 T3 DK2004814 T3 DK 2004814T3 DK 07724055 T DK07724055 T DK 07724055T DK 2004814 T3 DK2004814 T3 DK 2004814T3
Authority
DK
Denmark
Prior art keywords
pair
polynucleotides
group
polynucleotide
substrate specificity
Prior art date
Application number
DK07724055.4T
Other languages
English (en)
Inventor
Sabine Lutz-Wahl
Martina Hensel
Marcus Waelz
Juergen Eck
Klaus Liebeton
Lutz Fischer
Christian Ewert
Original Assignee
B R A I N Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B R A I N Ag filed Critical B R A I N Ag
Application granted granted Critical
Publication of DK2004814T3 publication Critical patent/DK2004814T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK07724055.4T 2006-04-07 2007-04-05 Gruppe af nye enantioselektive mikrobielle nitrilhydrataser med bred substratspecificitet DK2004814T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06007383A EP1842907A1 (en) 2006-04-07 2006-04-07 A group of novel enantioselective microbial nitrile hydratases with broad substrate specificity
PCT/EP2007/003114 WO2007115797A2 (en) 2006-04-07 2007-04-05 A group of novel enantioselective microbial nitrile hydratases with broad substrate specificity

Publications (1)

Publication Number Publication Date
DK2004814T3 true DK2004814T3 (da) 2010-12-06

Family

ID=36699317

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10009308.7T DK2261327T3 (da) 2006-04-07 2007-04-05 Nye enantioselektive mikrobielle nitrilhydrataser med bred substratspecificitet
DK07724055.4T DK2004814T3 (da) 2006-04-07 2007-04-05 Gruppe af nye enantioselektive mikrobielle nitrilhydrataser med bred substratspecificitet

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10009308.7T DK2261327T3 (da) 2006-04-07 2007-04-05 Nye enantioselektive mikrobielle nitrilhydrataser med bred substratspecificitet

Country Status (7)

Country Link
US (1) US8470576B2 (da)
EP (3) EP1842907A1 (da)
AT (1) ATE480617T1 (da)
CA (1) CA2648557C (da)
DE (1) DE602007009069D1 (da)
DK (2) DK2261327T3 (da)
WO (1) WO2007115797A2 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103635574B (zh) 2011-06-07 2016-04-13 三菱丽阳株式会社 改良型腈水合酶
AU2015203203B2 (en) * 2011-06-07 2017-06-08 Mitsubishi Chemical Corporation Improved nitrile hydratase
CN104862296B (zh) * 2015-04-22 2017-12-12 江南大学 一种比酶活和稳定性提高的融合型腈水合酶
US11098299B2 (en) * 2016-12-28 2021-08-24 Mitsui Chemicals, Inc. Mutant nitrile hydratase, nucleic acid coding said mutant nitrile hydratase, expression vector and transformant including said nucleic acid, production method for said mutant nitrile hydratase, and production method for amide compound
KR20200135010A (ko) 2019-05-24 2020-12-02 (주)아모레퍼시픽 메이크업 상태를 평가하는 방법
US20230159452A1 (en) * 2020-04-24 2023-05-25 Pharmazell Gmbh Regioselective oxidation of heterocyclic alpha-amino amides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133411A (en) 1966-07-26 2000-10-17 The United States Of America As Represented By The Secretary Of The Navy Slurry mixture forming an additive for producing a hydrodynamic drag reduction aqueous polymer solution
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
AU627648B2 (en) 1990-02-28 1992-08-27 Teruhiko Beppu Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
US5593871A (en) 1990-09-20 1997-01-14 E. I. Du Pont De Nemours And Company Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles
JPH06303971A (ja) 1993-04-16 1994-11-01 Mitsubishi Kasei Corp ニトリルヒドラターゼ活性を有する新規なタンパク質およびそれをコードする遺伝子ならびに該遺伝子を含有する形質転換体によるニトリル類からアミド類の製造方法
JP3119468B2 (ja) 1994-11-09 2000-12-18 三菱レイヨン株式会社 光学活性なα−ヒドロキシ酸またはα−ヒドロキシアミドの製造法
AU7514896A (en) 1995-10-06 1997-04-28 E.I. Du Pont De Nemours And Company Nucleic acid fragments encoding stereospecific nitrile hydratase and amidase enzymes and recombinant microorganisms expressing those enzymes useful for the production of chiral amides and acides
JP3408737B2 (ja) 1998-03-16 2003-05-19 三井化学株式会社 ニトリルヒドラターゼの活性化に関与するタンパク質及びそれをコードする遺伝子
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US20020137153A1 (en) * 2000-10-04 2002-09-26 Ramer Sandra W. Enantioselective production of amino carboxylic acids
JP2002325587A (ja) 2001-03-02 2002-11-12 Daicel Chem Ind Ltd ニトリルヒドラターゼ、およびアミドの製造方法
JP2004194588A (ja) 2002-12-19 2004-07-15 Mitsui Chemicals Inc 新規なニトリルヒドラターゼ
DE102004013842A1 (de) 2004-03-20 2005-10-13 Degussa Ag Nitrilhydratasen aus Metagenombibliotheken
DE102004013824A1 (de) 2004-03-20 2005-10-13 Degussa Ag Nitrilhydratasen aus Rhodococcus opacus

Also Published As

Publication number Publication date
US8470576B2 (en) 2013-06-25
EP2004814B1 (en) 2010-09-08
WO2007115797A3 (en) 2008-03-06
EP1842907A1 (en) 2007-10-10
EP2261327A2 (en) 2010-12-15
CA2648557C (en) 2017-01-03
EP2261327A3 (en) 2011-03-16
CA2648557A1 (en) 2007-10-18
DE602007009069D1 (de) 2010-10-21
DK2261327T3 (da) 2014-01-13
EP2261327B1 (en) 2013-11-20
EP2004814A2 (en) 2008-12-24
US20100047863A1 (en) 2010-02-25
ATE480617T1 (de) 2010-09-15
WO2007115797A2 (en) 2007-10-18

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