DK194682A - Fremgangsmaade til fremstilling af 3-amino-2-hydroxypropoxy-chromonderivater - Google Patents
Fremgangsmaade til fremstilling af 3-amino-2-hydroxypropoxy-chromonderivater Download PDFInfo
- Publication number
- DK194682A DK194682A DK194682A DK194682A DK194682A DK 194682 A DK194682 A DK 194682A DK 194682 A DK194682 A DK 194682A DK 194682 A DK194682 A DK 194682A DK 194682 A DK194682 A DK 194682A
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxypropoxy
- preparing
- chromonderivatives
- amino
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
hvori og R^ er som ovenfor, i nærværelse af et opløsningsmiddel og en base til fremstilling af et epoxid med formlen 2 hvor H er erstattet med
, hvoref ter epoxidet omsættes med en amin R^Nl·^, hvor R^ er som ovenfor i et alkoholisk opløsningsmiddel ved forhøjede temperaturer, hvorefter der eventuelt omdannes til syreadditionssalte .
Forbindelserne er lægemidler med antihypertensiv virkning.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25940381A | 1981-05-01 | 1981-05-01 | |
US25940381 | 1981-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK194682A true DK194682A (da) | 1982-11-02 |
Family
ID=22984803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK194682A DK194682A (da) | 1981-05-01 | 1982-04-30 | Fremgangsmaade til fremstilling af 3-amino-2-hydroxypropoxy-chromonderivater |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0064165B1 (da) |
JP (1) | JPS57185277A (da) |
KR (1) | KR830010095A (da) |
AT (1) | ATE27700T1 (da) |
AU (1) | AU552925B2 (da) |
CA (1) | CA1188311A (da) |
DE (1) | DE3276531D1 (da) |
DK (1) | DK194682A (da) |
FI (1) | FI821514L (da) |
NO (1) | NO821446L (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
US7635779B2 (en) * | 2004-10-15 | 2009-12-22 | Council Of Scientific & Industrial Research | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents |
EP2057137B1 (en) | 2006-08-09 | 2013-10-23 | Council of Scientific and Industrial Research | S-(+)-7-[3-n-substituted amino-2-hydroxypropoxy]flavones |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1054091B (de) * | 1958-05-30 | 1959-04-02 | Chemiewerk Homburg Ag | Verfahren zur Herstellung von N-substituierten 2-Phenyl-7-aminoalkoxy-chromonen |
FR1320300A (fr) * | 1962-03-15 | 1963-03-08 | Cassella Farbwerke Mainkur Ag | Procédé de préparation de dérivés de la 3-phényl-7-hydroxy-chromone |
GB1058822A (en) * | 1963-07-30 | 1967-02-15 | Ici Ltd | 3-amino-2-hydroxypropoxy heterocyclic derivatives |
-
1982
- 1982-02-23 CA CA000396888A patent/CA1188311A/en not_active Expired
- 1982-02-26 AU AU80952/82A patent/AU552925B2/en not_active Ceased
- 1982-04-06 EP EP82102950A patent/EP0064165B1/en not_active Expired
- 1982-04-06 AT AT82102950T patent/ATE27700T1/de not_active IP Right Cessation
- 1982-04-06 DE DE8282102950T patent/DE3276531D1/de not_active Expired
- 1982-04-26 JP JP57068884A patent/JPS57185277A/ja active Pending
- 1982-04-29 FI FI821514A patent/FI821514L/fi not_active Application Discontinuation
- 1982-04-30 KR KR1019820001907A patent/KR830010095A/ko unknown
- 1982-04-30 NO NO821446A patent/NO821446L/no unknown
- 1982-04-30 DK DK194682A patent/DK194682A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR830010095A (ko) | 1983-12-26 |
AU552925B2 (en) | 1986-06-26 |
FI821514A0 (fi) | 1982-04-29 |
FI821514L (fi) | 1982-11-02 |
AU8095282A (en) | 1982-11-04 |
ATE27700T1 (de) | 1987-06-15 |
JPS57185277A (en) | 1982-11-15 |
NO821446L (no) | 1982-11-02 |
EP0064165B1 (en) | 1987-06-10 |
EP0064165A1 (en) | 1982-11-10 |
CA1188311A (en) | 1985-06-04 |
DE3276531D1 (en) | 1987-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHS | Application shelved for other reasons than non-payment |