DK189786A - 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse - Google Patents

4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse Download PDF

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Publication number
DK189786A
DK189786A DK189786A DK189786A DK189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A
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compounds
substituted
aminoalkylidene
isoxazolones
aryl
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DK189786A
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DK189786D0 (da
Inventor
Alfred Kreutzberger
Karl Kolter
Peter Below
Franz Hock
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Hoechst Ag
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Publication of DK189786D0 publication Critical patent/DK189786D0/da
Publication of DK189786A publication Critical patent/DK189786A/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

Figure DK189786AD00021
g 7
hvor R betyder hydrogen eller Cj^-alkyl, og R
betyder C1-4-alkyl eller phenyl-(Cj^)-alkyl, eller hvor R® og R^ tilsammen danner en alkylenkæde med 3 til 7 methylengrupper, som eventuelt er substitueret med C1_4-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller hvor en CH2“gruppe eventuelt
Q Q
er erstattet med 0, S eller N-R , hvor R betyder hydrogen, Cj^-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller R3 og R4 sammen med ' nitrogenatomet danner en mættet eller umættet, monoeller bicyclisk ring med ialt 4 til 10 ringled, der foruden nitrogenatornet som yderligere heteroatom kan indeholde et oxygenatom, et svovlatom eller et nitrogenatom, og som eventuelt er substitueret med C^_4~alkyl,
Cj_4-alkoxycarbonyl, carbamoyl, cinnamyl, phenyl, som eventuelt kan være substitueret med halogen, C1_4-alkyl, C1_4-alkoxy eller trifluormethyl, eller roed gruppen -(CH,) -CH3 R9m, hvor y er 0 til 3, m er A “ 1 eller 2, og R7 er en phenylgruppe, som kan være substitueret med halogen, C^_4-alkyl, C^_4-alkoxy eller trifluormethyl, med undtagelse af forbindelser, hvor R^ 2 3 4 og R betyder hydrogen, og R og R betyder methyl, samt fysiologisk acceptable syreadditionssalte kan fremstilles på flere måder.
Forbindelserne (I) er anvendelige til behandling af cognitive dysfunktioner.
DK189786A 1985-04-26 1986-04-24 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse DK189786A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853515093 DE3515093A1 (de) 1985-04-26 1985-04-26 4-aminoalkylidensubstituierte 3-aryl-5(4h)-isoxazolone, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3515093 1985-04-26

Publications (2)

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DK189786D0 DK189786D0 (da) 1986-04-24
DK189786A true DK189786A (da) 1986-10-27

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DK189786A DK189786A (da) 1985-04-26 1986-04-24 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse

Country Status (13)

Country Link
EP (1) EP0199323A3 (da)
JP (1) JPS61251674A (da)
KR (1) KR860008171A (da)
AU (1) AU5671486A (da)
DE (1) DE3515093A1 (da)
DK (1) DK189786A (da)
ES (1) ES8704484A1 (da)
FI (1) FI861729A (da)
GR (1) GR861100B (da)
HU (1) HU194193B (da)
IL (1) IL78616A0 (da)
PT (1) PT82454B (da)
ZA (1) ZA863112B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021439A (en) * 1988-10-31 1991-06-04 Takeda Chemical Industries, Ltd. Cerebral function ameliorating agents related to Tan-950 A
AU653010B2 (en) * 1991-03-28 1994-09-15 Dsm Ip Assets B.V. Light screening agent
GB2274282B (en) * 1993-01-19 1996-08-14 Erba Carlo Spa Piperazine-and piperidine-isoxazole derivatives

Also Published As

Publication number Publication date
FI861729A0 (fi) 1986-04-24
ES8704484A1 (es) 1987-04-01
PT82454A (de) 1986-05-01
EP0199323A2 (de) 1986-10-29
ES554312A0 (es) 1987-04-01
KR860008171A (ko) 1986-11-12
GR861100B (en) 1986-08-19
PT82454B (de) 1988-04-29
ZA863112B (en) 1987-06-24
AU5671486A (en) 1986-10-30
HUT41749A (en) 1987-05-28
HU194193B (en) 1988-01-28
JPS61251674A (ja) 1986-11-08
DE3515093A1 (de) 1986-10-30
IL78616A0 (en) 1986-08-31
FI861729A (fi) 1986-10-27
DK189786D0 (da) 1986-04-24
EP0199323A3 (de) 1987-10-28

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