DK189786A - 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse - Google Patents
4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse Download PDFInfo
- Publication number
- DK189786A DK189786A DK189786A DK189786A DK189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- substituted
- aminoalkylidene
- isoxazolones
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
g 7
hvor R betyder hydrogen eller Cj^-alkyl, og R
betyder C1-4-alkyl eller phenyl-(Cj^)-alkyl, eller hvor R® og R^ tilsammen danner en alkylenkæde med 3 til 7 methylengrupper, som eventuelt er substitueret med C1_4-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller hvor en CH2“gruppe eventuelt
Q Q
er erstattet med 0, S eller N-R , hvor R betyder hydrogen, Cj^-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller R3 og R4 sammen med ' nitrogenatomet danner en mættet eller umættet, monoeller bicyclisk ring med ialt 4 til 10 ringled, der foruden nitrogenatornet som yderligere heteroatom kan indeholde et oxygenatom, et svovlatom eller et nitrogenatom, og som eventuelt er substitueret med C^_4~alkyl,
Cj_4-alkoxycarbonyl, carbamoyl, cinnamyl, phenyl, som eventuelt kan være substitueret med halogen, C1_4-alkyl, C1_4-alkoxy eller trifluormethyl, eller roed gruppen -(CH,) -CH3 R9m, hvor y er 0 til 3, m er A “ 1 eller 2, og R7 er en phenylgruppe, som kan være substitueret med halogen, C^_4-alkyl, C^_4-alkoxy eller trifluormethyl, med undtagelse af forbindelser, hvor R^ 2 3 4 og R betyder hydrogen, og R og R betyder methyl, samt fysiologisk acceptable syreadditionssalte kan fremstilles på flere måder.
Forbindelserne (I) er anvendelige til behandling af cognitive dysfunktioner.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853515093 DE3515093A1 (de) | 1985-04-26 | 1985-04-26 | 4-aminoalkylidensubstituierte 3-aryl-5(4h)-isoxazolone, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DE3515093 | 1985-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK189786D0 DK189786D0 (da) | 1986-04-24 |
| DK189786A true DK189786A (da) | 1986-10-27 |
Family
ID=6269184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK189786A DK189786A (da) | 1985-04-26 | 1986-04-24 | 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0199323A3 (da) |
| JP (1) | JPS61251674A (da) |
| KR (1) | KR860008171A (da) |
| AU (1) | AU5671486A (da) |
| DE (1) | DE3515093A1 (da) |
| DK (1) | DK189786A (da) |
| ES (1) | ES8704484A1 (da) |
| FI (1) | FI861729A (da) |
| GR (1) | GR861100B (da) |
| HU (1) | HU194193B (da) |
| IL (1) | IL78616A0 (da) |
| PT (1) | PT82454B (da) |
| ZA (1) | ZA863112B (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0367393A3 (en) * | 1988-10-31 | 1991-03-27 | Takeda Chemical Industries, Ltd. | New heterocyclic compounds, production and use thereof |
| JP3122465B2 (ja) * | 1991-03-28 | 2001-01-09 | エフ．ホフマン ― ラ ロシュ アーゲー | 光スクリーニング剤 |
| GB2274282B (en) * | 1993-01-19 | 1996-08-14 | Erba Carlo Spa | Piperazine-and piperidine-isoxazole derivatives |
-
1985
- 1985-04-26 DE DE19853515093 patent/DE3515093A1/de not_active Withdrawn
-
1986
- 1986-04-21 EP EP86105468A patent/EP0199323A3/de not_active Withdrawn
- 1986-04-24 HU HU861710A patent/HU194193B/hu unknown
- 1986-04-24 AU AU56714/86A patent/AU5671486A/en not_active Abandoned
- 1986-04-24 DK DK189786A patent/DK189786A/da not_active Application Discontinuation
- 1986-04-24 FI FI861729A patent/FI861729A/fi not_active Application Discontinuation
- 1986-04-24 ES ES554312A patent/ES8704484A1/es not_active Expired
- 1986-04-24 PT PT82454A patent/PT82454B/pt unknown
- 1986-04-25 KR KR1019860003198A patent/KR860008171A/ko not_active Application Discontinuation
- 1986-04-25 ZA ZA863112A patent/ZA863112B/xx unknown
- 1986-04-25 IL IL78616A patent/IL78616A0/xx unknown
- 1986-04-25 GR GR861100A patent/GR861100B/el unknown
- 1986-04-25 JP JP61094974A patent/JPS61251674A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HU194193B (en) | 1988-01-28 |
| IL78616A0 (en) | 1986-08-31 |
| KR860008171A (ko) | 1986-11-12 |
| ES8704484A1 (es) | 1987-04-01 |
| ZA863112B (en) | 1987-06-24 |
| GR861100B (en) | 1986-08-19 |
| DK189786D0 (da) | 1986-04-24 |
| AU5671486A (en) | 1986-10-30 |
| PT82454A (de) | 1986-05-01 |
| ES554312A0 (es) | 1987-04-01 |
| FI861729A0 (fi) | 1986-04-24 |
| PT82454B (de) | 1988-04-29 |
| EP0199323A3 (de) | 1987-10-28 |
| FI861729A (fi) | 1986-10-27 |
| DE3515093A1 (de) | 1986-10-30 |
| JPS61251674A (ja) | 1986-11-08 |
| HUT41749A (en) | 1987-05-28 |
| EP0199323A2 (de) | 1986-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |