DK189786A - 4-AMINOALKYLIDENE SUBSTITUTED 3-ARYL-5 (4H) -ISOXAZOLONES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR USE - Google Patents

4-AMINOALKYLIDENE SUBSTITUTED 3-ARYL-5 (4H) -ISOXAZOLONES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR USE Download PDF

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Publication number
DK189786A
DK189786A DK189786A DK189786A DK189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A
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compounds
substituted
aminoalkylidene
isoxazolones
aryl
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DK189786A
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Danish (da)
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DK189786D0 (en
Inventor
Alfred Kreutzberger
Karl Kolter
Peter Below
Franz Hock
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Hoechst Ag
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Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK189786D0 publication Critical patent/DK189786D0/en
Publication of DK189786A publication Critical patent/DK189786A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

Figure DK189786AD00021

g 7g 7

hvor R betyder hydrogen eller Cj^-alkyl, og Rwherein R is hydrogen or C1-6 alkyl, and R

betyder C1-4-alkyl eller phenyl-(Cj^)-alkyl, eller hvor R® og R^ tilsammen danner en alkylenkæde med 3 til 7 methylengrupper, som eventuelt er substitueret med C1_4-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller hvor en CH2“gruppe eventueltmeans C 1-4 alkyl or phenyl (C 1-4) alkyl, or wherein R 2 and R 2 together form an alkylene chain of 3 to 7 methylene groups optionally substituted with C 1-4 alkyl or phenyl optionally substituted with C C 1-4 alkyl, C 1-4 alkoxy, halogen, nitro or trifluoromethyl, or wherein a CH

Q QQ Q

er erstattet med 0, S eller N-R , hvor R betyder hydrogen, Cj^-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller R3 og R4 sammen med ' nitrogenatomet danner en mættet eller umættet, monoeller bicyclisk ring med ialt 4 til 10 ringled, der foruden nitrogenatornet som yderligere heteroatom kan indeholde et oxygenatom, et svovlatom eller et nitrogenatom, og som eventuelt er substitueret med C^_4~alkyl,is replaced by O, S or NR, wherein R is hydrogen, C1-4 alkyl or phenyl optionally substituted with C1-4 alkyl, C1-4 alkoxy, halogen, nitro or trifluoromethyl, or R3 and R4 together with the nitrogen atom forms a saturated or unsaturated mono or bicyclic ring having a total of 4 to 10 ring members, which may contain, in addition to the nitrogen atom as an additional heteroatom, an oxygen atom, a sulfur atom or a nitrogen atom, and which is optionally substituted with C 1-4 alkyl,

Cj_4-alkoxycarbonyl, carbamoyl, cinnamyl, phenyl, som eventuelt kan være substitueret med halogen, C1_4-alkyl, C1_4-alkoxy eller trifluormethyl, eller roed gruppen -(CH,) -CH3 R9m, hvor y er 0 til 3, m er A “ 1 eller 2, og R7 er en phenylgruppe, som kan være substitueret med halogen, C^_4-alkyl, C^_4-alkoxy eller trifluormethyl, med undtagelse af forbindelser, hvor R^ 2 3 4 og R betyder hydrogen, og R og R betyder methyl, samt fysiologisk acceptable syreadditionssalte kan fremstilles på flere måder.C 1-4 alkoxycarbonyl, carbamoyl, cinnamyl, phenyl which may be optionally substituted by halogen, C 1-4 alkyl, C 1-4 alkoxy or trifluoromethyl, or the red group - (CH 2) -CH 3 R 9m where y is 0 to 3, m is A "1 or 2, and R 7 is a phenyl group which may be substituted by halogen, C 1-4 alkyl, C 1-4 alkoxy or trifluoromethyl, with the exception of compounds wherein R 2 23 4 and R are hydrogen, and R and R is methyl, as well as physiologically acceptable acid addition salts can be prepared in several ways.

Forbindelserne (I) er anvendelige til behandling af cognitive dysfunktioner.Compounds (I) are useful in the treatment of cognitive dysfunctions.

DK189786A 1985-04-26 1986-04-24 4-AMINOALKYLIDENE SUBSTITUTED 3-ARYL-5 (4H) -ISOXAZOLONES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR USE DK189786A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853515093 DE3515093A1 (en) 1985-04-26 1985-04-26 4-AMINOALKYLIDE-SUBSTITUTED 3-ARYL-5 (4H) -ISOXAZOLONE, METHOD FOR THE PRODUCTION THEREOF, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND THEIR USE
DE3515093 1985-04-26

Publications (2)

Publication Number Publication Date
DK189786D0 DK189786D0 (en) 1986-04-24
DK189786A true DK189786A (en) 1986-10-27

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DK189786A DK189786A (en) 1985-04-26 1986-04-24 4-AMINOALKYLIDENE SUBSTITUTED 3-ARYL-5 (4H) -ISOXAZOLONES, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR USE

Country Status (13)

Country Link
EP (1) EP0199323A3 (en)
JP (1) JPS61251674A (en)
KR (1) KR860008171A (en)
AU (1) AU5671486A (en)
DE (1) DE3515093A1 (en)
DK (1) DK189786A (en)
ES (1) ES8704484A1 (en)
FI (1) FI861729A (en)
GR (1) GR861100B (en)
HU (1) HU194193B (en)
IL (1) IL78616A0 (en)
PT (1) PT82454B (en)
ZA (1) ZA863112B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021439A (en) * 1988-10-31 1991-06-04 Takeda Chemical Industries, Ltd. Cerebral function ameliorating agents related to Tan-950 A
EP0532725B1 (en) * 1991-03-28 1997-01-29 Givaudan-Roure (International) S.A. Isoxazole derivatives as light screening agent
GB2274282B (en) * 1993-01-19 1996-08-14 Erba Carlo Spa Piperazine-and piperidine-isoxazole derivatives

Also Published As

Publication number Publication date
DK189786D0 (en) 1986-04-24
HU194193B (en) 1988-01-28
PT82454A (en) 1986-05-01
ES554312A0 (en) 1987-04-01
JPS61251674A (en) 1986-11-08
HUT41749A (en) 1987-05-28
FI861729A (en) 1986-10-27
EP0199323A2 (en) 1986-10-29
PT82454B (en) 1988-04-29
EP0199323A3 (en) 1987-10-28
FI861729A0 (en) 1986-04-24
AU5671486A (en) 1986-10-30
GR861100B (en) 1986-08-19
ES8704484A1 (en) 1987-04-01
DE3515093A1 (en) 1986-10-30
KR860008171A (en) 1986-11-12
IL78616A0 (en) 1986-08-31
ZA863112B (en) 1987-06-24

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