ATE914T1 - HETEROCYCLIC SPIRO-LINKED AMIDINES, THEIR STEREOISOMERS AND OPTICAL ISOMERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. - Google Patents

HETEROCYCLIC SPIRO-LINKED AMIDINES, THEIR STEREOISOMERS AND OPTICAL ISOMERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.

Info

Publication number
ATE914T1
ATE914T1 AT80100835T AT80100835T ATE914T1 AT E914 T1 ATE914 T1 AT E914T1 AT 80100835 T AT80100835 T AT 80100835T AT 80100835 T AT80100835 T AT 80100835T AT E914 T1 ATE914 T1 AT E914T1
Authority
AT
Austria
Prior art keywords
alkoxy
substituted
nitrogen atom
hydrogen
alkyl
Prior art date
Application number
AT80100835T
Other languages
German (de)
Inventor
Manfred Dr. Foersch
Wolfgang Dr. Schaub
Hermann Dr. Gerhards
Harry Maurice Dr. Geyer
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Application granted granted Critical
Publication of ATE914T1 publication Critical patent/ATE914T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/05—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Abstract

Heterocyclic, spiro-linked amidines of the formula I <IMAGE> I and their physiologically acceptable salts, in which (a) n is 1 or 2; (b) R1 and R2 are hydrogen or alkyl radicals which, together with the nitrogen atom, can form a 5-, 6- or 7-membered ring which can be substituted by C1-C3-alkyl, C1-C2-alkoxy, hydroxyl or C1-C4-alkoxy-carbonyl groups and in which one of the carbon atoms can also be replaced by an oxygen, sulfur or nitrogen atom, it being possible for the nitrogen atom to be substituted by hydrogen, by the formyl group or by a phenyl radical, which can in turn be monosubstituted or polysubstituted by a C1 to C4-alkyl group or an alkoxy, methylenedioxy, hydroxyl, halogen, nitro or amino group, or it being possible for the nitrogen atom to be substituted by a C1-C4-alkyl group, or in which R1 represents hydrogen and R2 represents a C5-C8-cycloalkyl radical which can be substituted by C1-C4-dialkylamino groups; (c) R3 is hydrogen or methyl and (d) R 4 denotes a phenyl radical which is optionally monosubstituted or polysubstituted by C1-C4-alkyl, C1-C4-alkoxy, methylenedioxy, hydroxyl, halogen, cyano, nitro, trifluoromethyl, amino, C2-C5-acylamino or mono- or di-C1-C4-alkylamino groups, or a thiophene radical, their stereoisomers and optical isomers, processes for their preparation and antidepressive medicaments containing these compounds.
AT80100835T 1979-02-23 1980-02-20 HETEROCYCLIC SPIRO-LINKED AMIDINES, THEIR STEREOISOMERS AND OPTICAL ISOMERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. ATE914T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792907070 DE2907070A1 (en) 1979-02-23 1979-02-23 HETEROCYCLIC SPIRO-LINKED AMIDINE AND METHOD FOR THE PRODUCTION THEREOF
EP80100835A EP0014996B1 (en) 1979-02-23 1980-02-20 Heterocyclic spiro-amidines, their stereoisomers and optical isomers, methods for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
ATE914T1 true ATE914T1 (en) 1982-05-15

Family

ID=6063739

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80100835T ATE914T1 (en) 1979-02-23 1980-02-20 HETEROCYCLIC SPIRO-LINKED AMIDINES, THEIR STEREOISOMERS AND OPTICAL ISOMERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.

Country Status (11)

Country Link
US (1) US4277470A (en)
EP (1) EP0014996B1 (en)
JP (1) JPS55120563A (en)
AT (1) ATE914T1 (en)
AU (1) AU534240B2 (en)
CA (1) CA1140930A (en)
DE (2) DE2907070A1 (en)
DK (1) DK77280A (en)
ES (5) ES488706A1 (en)
IL (1) IL59441A0 (en)
ZA (1) ZA801041B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
SE9904121D0 (en) 1999-11-15 1999-11-15 Gustaf Jederstroem Hydrophobic biomolecular structure

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2911409A (en) * 1955-07-18 1959-11-03 Upjohn Co 2-spiro-substituted pyrrolidines
US2931805A (en) * 1958-11-10 1960-04-05 Smith Kline French Lab Spiro [bicyclo [2. 2. 1] heptane-2, 2'-alkylenimines]

Also Published As

Publication number Publication date
DE3060314D1 (en) 1982-06-09
EP0014996B1 (en) 1982-04-28
ES488706A1 (en) 1980-09-16
CA1140930A (en) 1983-02-08
ES488704A1 (en) 1980-09-16
JPS55120563A (en) 1980-09-17
AU534240B2 (en) 1984-01-12
ES488702A1 (en) 1980-09-16
ES488703A1 (en) 1980-09-16
US4277470A (en) 1981-07-07
EP0014996A1 (en) 1980-09-03
ZA801041B (en) 1981-03-25
ES488705A1 (en) 1980-09-16
DK77280A (en) 1980-08-24
DE2907070A1 (en) 1980-09-04
AU5580680A (en) 1980-08-28
IL59441A0 (en) 1980-05-30

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee