DK1875239T3 - Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi - Google Patents

Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi

Info

Publication number
DK1875239T3
DK1875239T3 DK06751892.8T DK06751892T DK1875239T3 DK 1875239 T3 DK1875239 T3 DK 1875239T3 DK 06751892 T DK06751892 T DK 06751892T DK 1875239 T3 DK1875239 T3 DK 1875239T3
Authority
DK
Denmark
Prior art keywords
imaging probe
candidate
library
click chemistry
identifying
Prior art date
Application number
DK06751892.8T
Other languages
Danish (da)
English (en)
Inventor
Hartmuth C Kolb
Vani P Mocharla
Joseph C Walsh
Original Assignee
Siemens Medical Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions filed Critical Siemens Medical Solutions
Application granted granted Critical
Publication of DK1875239T3 publication Critical patent/DK1875239T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK06751892.8T 2005-04-27 2006-04-27 Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi DK1875239T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67529005P 2005-04-27 2005-04-27
PCT/US2006/016428 WO2006116736A2 (fr) 2005-04-27 2006-04-27 Procede chimique in situ de criblage de sondes d'imagerie moleculaire de haute affinite

Publications (1)

Publication Number Publication Date
DK1875239T3 true DK1875239T3 (da) 2012-01-23

Family

ID=36954603

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06751892.8T DK1875239T3 (da) 2005-04-27 2006-04-27 Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi

Country Status (9)

Country Link
US (1) US20060269942A1 (fr)
EP (1) EP1875239B1 (fr)
JP (1) JP4790012B2 (fr)
KR (1) KR100973156B1 (fr)
AT (1) ATE527542T1 (fr)
CA (1) CA2606477C (fr)
DK (1) DK1875239T3 (fr)
ES (1) ES2375495T3 (fr)
WO (1) WO2006116736A2 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071718B2 (en) 2004-12-22 2011-12-06 General Electric Company Selective radiolabeling of biomolecules
US8158590B2 (en) 2005-08-05 2012-04-17 Syntarga B.V. Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
ATE519114T1 (de) 2006-03-14 2011-08-15 Univ Basel Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten
US20100022481A1 (en) * 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
JP2010523599A (ja) * 2007-04-05 2010-07-15 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド クリックケミストリーを使用した炭酸脱水酵素−ｉｘのための分子イメージングプローブの開発
BRPI0906797A2 (pt) 2008-01-09 2015-07-14 Molecular Insight Pharm Inc Inibidores de anidrase carbônica ix
WO2009105746A2 (fr) * 2008-02-22 2009-08-27 University Of South Florida Triazoles et leurs procédés de production
CA2728733A1 (fr) 2008-06-18 2009-12-23 California Institute Of Technology Agents de capture multiligands et compositions, procedes et systemes associes
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
EP2361098B1 (fr) * 2008-10-31 2019-08-28 The General Hospital Corporation Compositions et procédés d'administration d'une substance à une cible biologique
EP2706057B1 (fr) 2008-12-05 2016-04-20 Molecular Insight Pharmaceuticals, Inc. Dérivés de bis(imidazolyl) et complexes de radionucleides
CA2752884A1 (fr) * 2009-02-27 2010-09-02 Genentech, Inc. Procedes et compositions pour le marquage des proteines
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
CA2756137C (fr) 2009-03-23 2015-11-24 Siemens Medical Solutions Usa, Inc. Agents d'imagerie pour detecter des troubles neurologiques
BR112012000209B8 (pt) 2009-06-15 2021-07-27 Molecular Insight Pharm Inc heterodímeros de ácido glutâmico e seus processos de preparação
EP3483610A1 (fr) * 2009-11-09 2019-05-15 University Of Washington Center For Commercialization Points de polymère chromophore fonctionnalisé et leurs bioconjugués
WO2012074840A2 (fr) 2010-11-22 2012-06-07 The General Hospital Corporation Compositions et procédés d'imagerie in vivo
EP2966061B1 (fr) * 2011-03-04 2017-05-03 Life Technologies Corporation Composés et procédés de conjugaison de biomolécules
WO2012121746A2 (fr) 2011-03-09 2012-09-13 The General Hospital Corporation Imagerie de la masse des cellules bêta
US10796494B2 (en) 2011-06-06 2020-10-06 Microsoft Technology Licensing, Llc Adding attributes to virtual representations of real-world objects
EP2800471A4 (fr) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc Complexe métalliques de poly (carboxyl) amine contenant des ligands ayant une affinité pour l'anhydrase carbonique ix
EP2888253A4 (fr) * 2012-08-24 2016-01-06 Univ Texas Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies
BR112015003729A2 (pt) * 2012-08-24 2018-06-05 Univ Texas composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um paciente
US9902705B2 (en) 2012-10-24 2018-02-27 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
HUE035739T2 (en) 2013-01-14 2018-05-28 Molecular Insight Pharm Inc Triazine-based radiopharmaceuticals and radiological imaging agents
WO2014182704A2 (fr) 2013-05-06 2014-11-13 The General Hospital Corporation Sondes d'activation bio-orthogonales
ES2726648T3 (es) 2014-02-25 2019-10-08 Univ Texas Sales de moduladores heterocíclicos de la actividad del HIF para el tratamiento de enfermedades
WO2016085659A1 (fr) * 2014-11-24 2016-06-02 Battelle Memorial Institute Procédé et système de précipitation de l'activité chromatine
JP2022505714A (ja) * 2018-10-24 2022-01-14 エイピーエイ－ アドバンスト・テクノロジーズ・リミテッド 腫瘍細胞の選択的イメージングのための融合性リポソーム

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
US5519931A (en) * 1994-03-16 1996-05-28 Syncor International Corporation Container and method for transporting a syringe containing radioactive material
HUP9900426A3 (en) * 1995-05-01 2001-12-28 Univ Pittsburgh Pittsburgh Amyloid binding azoderivatives, preparation thereof and use of these compounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6210655B1 (en) * 1997-06-18 2001-04-03 University Of Medicine & Dentistry Of Nj Site-specific 13C-enriched reagents for diagnostic medicine by magnetic resonance imaging
US6558903B1 (en) * 1999-06-30 2003-05-06 Millennium Pharmaceuticals, Inc. Kinases and uses thereof
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US6808308B2 (en) * 2001-05-25 2004-10-26 Scanwell Systems Removable shielding for use during neurological examinations on a whole body pet scanner
CA2478981A1 (fr) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification d'inhibiteurs de kinase
DK2226316T3 (en) * 2002-05-30 2016-04-11 Scripps Research Inst Copper catalyzed ligation of azides and acetylenes
ATE354096T1 (de) 2002-12-23 2007-03-15 Astex Therapeutics Ltd Synthese und screening von liganden mit hilfe von röntgenkristallographie
US20060067879A1 (en) * 2004-09-27 2006-03-30 Schuller Hildegard M Diagnosis of diseases associated with COX-2 expression

Also Published As

Publication number Publication date
JP2008541014A (ja) 2008-11-20
WO2006116736A3 (fr) 2007-02-01
EP1875239B1 (fr) 2011-10-05
KR100973156B1 (ko) 2010-07-30
EP1875239A2 (fr) 2008-01-09
CA2606477C (fr) 2013-05-28
ES2375495T3 (es) 2012-03-01
CA2606477A1 (fr) 2006-11-02
ATE527542T1 (de) 2011-10-15
WO2006116736A2 (fr) 2006-11-02
KR20080003441A (ko) 2008-01-07
JP4790012B2 (ja) 2011-10-12
US20060269942A1 (en) 2006-11-30

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