DK1802340T3 - Kombination af rekombinante mycobakterier og et biologisk aktivt middel som en vaccine - Google Patents
Kombination af rekombinante mycobakterier og et biologisk aktivt middel som en vaccine Download PDFInfo
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- DK1802340T3 DK1802340T3 DK05795016.4T DK05795016T DK1802340T3 DK 1802340 T3 DK1802340 T3 DK 1802340T3 DK 05795016 T DK05795016 T DK 05795016T DK 1802340 T3 DK1802340 T3 DK 1802340T3
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Claims (40)
1. Kombination egnet til anvendelse ved en fremgangsmåde til fremkaldelse af en TH1 immunreaktion, hvor kombinationen omfatter en første bestanddel og en separat anden bestanddel, hvor den første bestanddel er en bakteriel celle, som omfatter i det mindste ét rekombinant nukleinsyremolekyle, som koder for et fagolysosomalt undvigelsespeptid eller -polypeptid, hvor den bakterielle celle er en mycobakteriecelle, som er ureasedeficient; og hvor den anden bestanddel er et antigen.
2. Bakteriel celle, som omfatter i det mindste ét rekombinant nukleinsyremolekyle, som koder for et fagolysosomalt undvigelsespeptid eller -polypeptid, hvor den bakterielle celle er en mycobakteriecelle, som er ureasedeficient, til anvendelse som et adjuvans.
3. Kombination ifølge krav 1 og den bakterielle celle ifølge krav 2, til anvendelse som angivet i krav 2, hvor cellen er en Mycobacterium bovis celle.
4. Kombination ifølge ethvert af kravene 1 og 3, og den bakterielle celle ifølge ethvert af kravene 2 til 3, til anvendelse som angivet i krav 2, hvor i det mindste en nukleinsyre i den bakterielle celle, som koder for en cellulær ureaseunderenhed, er inaktiveret.
5. Kombination ifølge krav 4 og den bakterielle celle ifølge krav 4 til anvendelse som angivet i krav 2, hvor i det mindste den sekvens, som koder for den bakterielle urease C underenhed, er inaktiveret.
6. Kombination ifølge ethvert af kravene 1 og 3 til 5, og den bakterielle celle ifølge ethvert af kravene 2 til 5, til anvendelse som angivet i krav 2, hvor det fagolysosomale undvigelsesdomæne er et listeria fagolysosomalt undvigelsesdomæne.
7. Kombination ifølge ethvert af kravene 1 og 3 til 6 og den bakterielle celle ifølge ethvert af kravene 2 til 6 til anvendelse som angivet i krav 2, hvor det fagolysosomale domæne er kodet af et nukleinsyremolekyle valgt fra gruppen omfattende a) en nukleotidsekvens omfattende nukleotid 211-1722 som vist i SEQ. ID. NO. 1; b) en nukleotidsekvens, som koder for den samme aminosyresekvens som sekvensen fra a); og c) en nukleotidsekvens, som hybridiserer, under stringente betingelser, med sekvensen fra a) eller b).
8. Kombination ifølge ethvert af kravene 1 og 3 til 7 og den bakterielle celle ifølge ethvert af kravene 2 til 7, til anvendelse som angivet i krav 2, hvor den bakterielle celle omfatter i det mindste ét rekombinant nukleinsyremolekyle, som koder for et peptid eller polypeptid, som er i stand til at fremkalde en immunreaktion i et pattedyr.
9. Kombination ifølge krav 8 og den bakterielle celle ifølge krav 8 til anvendelse som angivet i krav 2, hvor peptidet eller polypeptidet vælges blandt autoantigener, tumorantigener, virusantigener, parasitantigener, bakterielle antigener og immunogene fragmenter deraf.
10. Kombination ifølge krav 8 eller 9 og den bakterielle celle ifølge krav 8 eller 9, til anvendelse som angivet i krav 2, hvor peptidet eller polypeptidet er en del af et fusionspolypeptid.
11. Kombination ifølge krav 10 og den bakterielle celle ifølge krav 10 til anvendelse som angivet i krav 2, hvorfusionspolypeptidet omfatter a) i det mindste ét domæne fra et polypeptid, hvor polypeptiddomænet er i stand til at fremkalde en immunreaktion i et pattedyr, og b) et fagolysosomalt undvigelsesdomæne.
12. Kombination ifølge krav 11 og den bakterielle celle ifølge krav 11 til anvendelse som angivet i krav 2, hvor polypeptidet er det polypeptid, som er angivet i krav 8 eller dele deraf.
13. Kombination ifølge krav 11 eller 12 og den bakterielle celle ifølge krav 11 eller 12 til anvendelse som angivet i krav 2, hvor det fagolysosomale undvigelsesdomæne er et domæne af det fagolysosomale undvigelsesdomæne som angivet i ethvert af kravene 1 til 10.
14. Kombination ifølge ethvert af kravene 1 og 3 til 13 og den bakterielle celle ifølge ethvert af kravene 2 til 13 til anvendelse som angivet i krav 2, hvor den bakterielle celle er rBCGAureC:Hly.
15. Kombination ifølge ethvert af kravene 1 og 3 til 14, hvor antigenet vælges fra gruppen omfattende en immunogen tumorcelle, en eukaryotisk celle, som udtrykker et tumorassocieret antigen, en eukaryotisk celle, som udtrykker et tumorspecifikt antigen, og en celle, som udtrykker et parasitantigen.
16. Kombination ifølge krav 15, hvor tumorcellen er en immunogen tumor og hvor tumorcellen fortrinsvis vælges fra gruppen omfattende melanomceller, nyre-carcinomceller, brysttumorceller, hjernetumorceller, prostatatumorceller, ikke-småcellet lungecancer, coloncarcinom og hoved- og halspladecelletumor. 17 Kombination ifølge ethvert af kravene 15 til 16, hvor cellen er en allogen celle og er HLA-klasse 1 tilpasset.
18. Kombination ifølge krav 15, hvor parasitantigenet er gp190/MSP1 protein af plasmodium, fotrinsvis Plasmodium falciparum, eller et fragment deraf, som er i stand til at fremkalde en immunreaktion i et pattedyr.
19. Kombination ifølge ethvert af kravene 1 og 3 til 14, hvor antigenet er gp190/MSP1 protein af plasmodium, fortrinsvis Plasmodium falciparum, eller et fragment deraf som er i stand til at fremkalde en immunreaktion i et pattedyr.
20. Kombination ifølge ethvert af kravene 1 og 3 til 14, hvor antigenet er human cytomegalovirus.
21. Kombination ifølge ethvert af kravene 1 og 3 til 14, hvor antigenet er en viral partikel eller adskillige deraf, fortrinsvis frigivet efter infektion af pattedyrsceller med human cytomegalovirus, hvorved partiklerne (a) er omgivet af en lipidmembran i hvilken virale glycoproteiner er indlejrede, og (b) indeholder hverken virale DNA eller kapsider.
22. Kombination ifølge krav 21, hvor partiklerne indeholder et fusionsprotein omfattende én ellere flere dele af T-celle-antigenet pp65 (UL83) og én eller flere dele af ét eller flere proteiner, som ikke er pp65.
23. Kombination ifølge krav 22, hvor T-celle-antigenet pp65 er fusioneret med én eller flere dele af et glycoprotein af den humane cytomegalovirus, hvorved glycoproteinet vælges fra gruppen omfattende HCMV glycoproteinet gH, HCMV proteinet IE-i (ppUL123) og HCMV glycoproteinet gB.
24. Kombination ifølge krav 22, hvor T-celle-antigenet er fusioneret med én eller flere dele af et protein, som er en del af et humant patogen, som er forskelligt fra HCMV.
25. Kombination ifølge krav 24, hvor patogenet vælges fra gruppen omfattende HIV-1, HBV, HCV og influenza.
26. Kombination ifølge krav 21 til 25, hvor partiklen(lerne) indeholder dele af i det mindste to glycoproteiner, som er varianter af et bestemt glycoprotein fra forskellige HCMV-stammer.
27. Kombination ifølge krav 26, hvor én eller flere af varianterne af det bestemte HCMV glycoprotein er varienten af HCMV Towne-stammen, og den anden er varianten af HCMV Ad 169 stammen.
28. Kombination ifølge ethvert af kravene 21 til 27, hvor de mammale celler er fibroblaster, fortrinsvis forhudsfibroblaster.
29. Kombination ifølge ethvert af kravene 21 til 28, hvor partiklen er et dense body.
30. Kombination ifølge ethvert af kravene 1 og 3 til 14, hvor antigenet er et dense body, fortrinsvis et dense body af HCMV, eller et dense body i overensstemmelse med krav 29.
31. Farmaceutisk sammensætning, hvor sammensætningen omfatter en kombination i overensstemmelse med ethvert af kravene 1 til 30 og en farmaceutisk acceptabel bærer.
32. Anvendelse af en kombination i overensstemmelse med ethvert af kravene 1 og 3 til 30 eller af en farmaceutisk sammensætning i overensstemmelse med krav 31, til fremstilling af et medikament til behandling og/eller forebyggelse af en sygdom valgt fra gruppen omfattende cancer og infektionssygdomme.
33. Anvendelse i overensstemmelse med krav 32, hvor canceren er en immunogen tumor og mere foretrukkent valgt fra gruppen omfattende prostatacancer, melanom, nyrecarcinom, brysttumor, hjernetumor, ikke-småcellet lungecancer, coloncarcinom, og hoved- og halspladecelletumor.
34. Anvendelse ifølge krav 32, hvor infektionssygdommen er malaria.
35. Anvendelse ifølge krav 34, hvor antigenet er gp190/MSP1 protein af plasmodium, eller et fragment deraf, som er i stand til at fremkalde en immunreaktion i et pattedyr.
36. Anvendelse ifølge krav 32, hvor infektionssygdommen er HCMV infektion.
37. Anvendelse ifølge krav 36, hvor antigenet er et dense body som angivet i ethvert af de foregående krav.
38. Anvendelse af en kombination i overensstemmelse med ethvert af kravene 1 og 3 til 30 til fremstilling af en terapeutisk og/eller profylaktisk vaccine for fremkaldelse en TH1 immunreaktion.
39. Kombination ifølge ethvert af kravene 1 og 3 til 30 eller den farmaceutiske sammensætning ifølge krav 31, til anvendelse ved en fremgangsmåde til behandling af en patient, som lider af en sygdom og har behov for en sådan behandling, omfattende indgivelse af kombinationen ifølge ethvert af kravene 1 og 3 til 30 eller den farmaceutiske sammensætning i overensstemmelse med krav 31.
40. Kombination og farmaceutisk sammensætning i overensstemmelse krav 39, hvor sygdommen vælges fra gruppen omfattende cancer og infektionssygdomme.
41. Fremgangsmåde til fremstilling af en farmaceutisk sammensætning i overensstemmelse med krav 31, omfattende følgende trin tilvejebringelse, som en første bestanddel, af en bakteriel celle, som omfatter i det mindste ét rekombinant nukleinsyremolekyle, som koder for et fagolyso-somalt undvigelsespeptid eller -polypeptid, hvor den bakterielle celle er en mycobakteriecelle, som er ureasedeficient; - tilvejebringelse, som en anden bestanddel, af et antigen; og formulering af den første bestanddel og den anden bestanddel til en farmaceutisk sammensætning
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04025096A EP1649869A1 (en) | 2004-10-21 | 2004-10-21 | Combination of a recombinant mycobacterium and a biologically active agent as a vaccine |
| PCT/EP2005/011127 WO2006045468A1 (en) | 2004-10-21 | 2005-10-16 | Combination of a recombinant mycobacterium and a biologically active agent as a vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1802340T3 true DK1802340T3 (da) | 2014-12-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05795016.4T DK1802340T3 (da) | 2004-10-21 | 2005-10-16 | Kombination af rekombinante mycobakterier og et biologisk aktivt middel som en vaccine |
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| US (1) | US9078844B2 (da) |
| EP (2) | EP1649869A1 (da) |
| JP (1) | JP4836957B2 (da) |
| KR (1) | KR101300905B1 (da) |
| CN (1) | CN101048178B (da) |
| AU (1) | AU2005298976A1 (da) |
| BR (1) | BRPI0517003B1 (da) |
| CA (1) | CA2584321C (da) |
| DK (1) | DK1802340T3 (da) |
| ES (1) | ES2524921T3 (da) |
| HK (1) | HK1106929A1 (da) |
| MX (1) | MX2007004734A (da) |
| PL (1) | PL1802340T3 (da) |
| PT (1) | PT1802340E (da) |
| RU (1) | RU2495677C2 (da) |
| SI (1) | SI1802340T1 (da) |
| UA (1) | UA101140C2 (da) |
| WO (1) | WO2006045468A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200704765B (en) | 2004-12-01 | 2008-09-25 | Aeras Global Tb Vaccine Found | Recombinant BCG strains with enhanced ability to escape the endosome |
| EP2244720A4 (en) * | 2008-01-11 | 2013-01-16 | Us Gov Health & Human Serv | POLYPEPTIDE VACCINE AND VACCINE STRATEGY AGAINST MYCOBACTERIUM |
| SG188595A1 (en) * | 2010-09-20 | 2013-04-30 | Vakzine Projekt Man Gmbh | Recombinant mycobacterium as vaccine for use in humans |
| MX345575B (es) * | 2010-12-21 | 2017-02-03 | Max-Planck-Gesellschaft Zur Förderung Der Wss E V | Micobacteria recombinante como vacuna. |
| WO2013039069A1 (ja) | 2011-09-13 | 2013-03-21 | 日本ビーシージー製造株式会社 | 新規な組換えｂｃｇワクチン |
| EP3090757A1 (en) | 2015-05-04 | 2016-11-09 | Vakzine Projekt Management GmbH | Recombinant mycobacterium as an immunotherapeutic agent for the treatment of cancer |
| US20230218684A1 (en) * | 2020-03-30 | 2023-07-13 | North Carolina State University | Engineered bacteria for use in vaccine compositions |
| CN113499439B (zh) * | 2021-07-20 | 2023-03-17 | 上海市肺科医院 | 结核菌UreC蛋白在制备抗结核分枝杆菌药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69433110T2 (de) | 1993-02-17 | 2004-06-03 | Sloan-Kettering Institute For Cancer Research | Allogenes vakzin und synthesemethode für selbiges |
| US20050169900A1 (en) * | 1993-02-17 | 2005-08-04 | Sloan Kettering Institute For Cancer Research | Allogeneic vaccine and methods to synthesize same |
| DE19640817A1 (de) * | 1996-10-02 | 1998-05-14 | Hermann Prof Dr Bujard | Rekombinantes Herstellungsverfahren für ein vollständiges Malaria-Antigen gp190/MSP 1 |
| EP0902086A1 (en) * | 1997-08-22 | 1999-03-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tuberculosis vaccine |
| DE19910044A1 (de) | 1999-03-08 | 2000-09-14 | Bodo Plachter | Virale Partikel, die nach Infektion durch humanes Cytomegalovirus freigesetzt werden und ihre Verwendung als Impfstoff |
| CA2367447A1 (en) * | 1999-03-15 | 2000-09-21 | Graham Stephen Le Gros | Treatment of asthma |
| PL1618128T3 (pl) * | 2003-04-23 | 2010-12-31 | Max Planck Gesellschaft | Szczepionka przeciwko gruźlicy o ulepszonej skuteczności |
| US7670788B2 (en) * | 2006-06-01 | 2010-03-02 | Allergan, Inc. | Determining and reducing immunoresistance to a Botulinum toxin therapy using Botulinum toxin B peptides |
| US7855268B2 (en) * | 2006-06-01 | 2010-12-21 | Allergan, Inc. | Tolerogizing compositions comprising botulinum toxin type B peptides |
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2004
- 2004-10-21 EP EP04025096A patent/EP1649869A1/en not_active Withdrawn
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2005
- 2005-10-16 MX MX2007004734A patent/MX2007004734A/es active IP Right Grant
- 2005-10-16 JP JP2007537177A patent/JP4836957B2/ja active Active
- 2005-10-16 EP EP05795016.4A patent/EP1802340B1/en active Active
- 2005-10-16 CN CN2005800363269A patent/CN101048178B/zh active Active
- 2005-10-16 RU RU2007118675/10A patent/RU2495677C2/ru active
- 2005-10-16 ES ES05795016.4T patent/ES2524921T3/es active Active
- 2005-10-16 DK DK05795016.4T patent/DK1802340T3/da active
- 2005-10-16 PL PL05795016T patent/PL1802340T3/pl unknown
- 2005-10-16 PT PT57950164T patent/PT1802340E/pt unknown
- 2005-10-16 US US11/577,498 patent/US9078844B2/en active Active
- 2005-10-16 CA CA2584321A patent/CA2584321C/en active Active
- 2005-10-16 BR BRPI0517003-6A patent/BRPI0517003B1/pt active IP Right Grant
- 2005-10-16 KR KR1020077009076A patent/KR101300905B1/ko active IP Right Grant
- 2005-10-16 AU AU2005298976A patent/AU2005298976A1/en not_active Abandoned
- 2005-10-16 SI SI200531915T patent/SI1802340T1/sl unknown
- 2005-10-16 WO PCT/EP2005/011127 patent/WO2006045468A1/en active Application Filing
- 2005-10-16 UA UAA200704420A patent/UA101140C2/ru unknown
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2008
- 2008-01-18 HK HK08100658.5A patent/HK1106929A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080292656A1 (en) | 2008-11-27 |
| KR20070068398A (ko) | 2007-06-29 |
| PT1802340E (pt) | 2014-12-09 |
| KR101300905B1 (ko) | 2013-08-27 |
| CA2584321C (en) | 2021-06-15 |
| JP2008517013A (ja) | 2008-05-22 |
| PL1802340T3 (pl) | 2015-03-31 |
| HK1106929A1 (en) | 2008-03-20 |
| AU2005298976A1 (en) | 2006-05-04 |
| RU2495677C2 (ru) | 2013-10-20 |
| WO2006045468A1 (en) | 2006-05-04 |
| UA101140C2 (ru) | 2013-03-11 |
| CA2584321A1 (en) | 2006-05-04 |
| SI1802340T1 (sl) | 2015-01-30 |
| US9078844B2 (en) | 2015-07-14 |
| EP1802340B1 (en) | 2014-09-03 |
| RU2007118675A (ru) | 2008-11-27 |
| CN101048178B (zh) | 2012-09-05 |
| EP1649869A1 (en) | 2006-04-26 |
| BRPI0517003B1 (pt) | 2021-10-13 |
| BRPI0517003A (pt) | 2008-09-30 |
| JP4836957B2 (ja) | 2011-12-14 |
| CN101048178A (zh) | 2007-10-03 |
| EP1802340A1 (en) | 2007-07-04 |
| MX2007004734A (es) | 2007-07-13 |
| ES2524921T3 (es) | 2014-12-15 |
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