DK179986A - Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling - Google Patents

Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling Download PDF

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Publication number
DK179986A
DK179986A DK179986A DK179986A DK179986A DK 179986 A DK179986 A DK 179986A DK 179986 A DK179986 A DK 179986A DK 179986 A DK179986 A DK 179986A DK 179986 A DK179986 A DK 179986A
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DK
Denmark
Prior art keywords
variety
preparation
cis
quinolizin
trans
Prior art date
Application number
DK179986A
Other languages
Danish (da)
English (en)
Other versions
DK179986D0 (da
Inventor
Csaba Szantay
Ferenc Soti
Maria Incze
Zsuzsanna Balogh
Zsolt Szombatelyi
Egon Karpati
Bela Kiss
Katalin Csomor
Istvan Laszlovszky
Erzsebet Lapis
Lilla Forgacs
Csaba Kuthi
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK179986D0 publication Critical patent/DK179986D0/da
Publication of DK179986A publication Critical patent/DK179986A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK179986A 1985-04-19 1986-04-18 Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling DK179986A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU851517A HU194220B (en) 1985-04-19 1985-04-19 Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof

Publications (2)

Publication Number Publication Date
DK179986D0 DK179986D0 (da) 1986-04-18
DK179986A true DK179986A (da) 1986-10-20

Family

ID=10954837

Family Applications (1)

Application Number Title Priority Date Filing Date
DK179986A DK179986A (da) 1985-04-19 1986-04-18 Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling

Country Status (10)

Country Link
US (1) US4843080A (xx)
EP (1) EP0202774A3 (xx)
JP (1) JPS61249985A (xx)
AU (1) AU587025B2 (xx)
CA (1) CA1301171C (xx)
DK (1) DK179986A (xx)
FI (1) FI861642A (xx)
HU (1) HU194220B (xx)
IL (1) IL78536A0 (xx)
ZA (1) ZA862942B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194221B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
JPH0368582A (ja) * 1989-06-08 1991-03-25 Duphar Internatl Res Bv Ｎ―オキソ―テトラヒドロ―β―カルボリンおよびその製造方法
WO2014124219A1 (en) 2013-02-08 2014-08-14 General Mills, Inc. Reduced sodium food product

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3478051A (en) * 1967-03-17 1969-11-11 Sandoz Ag Azecino- and azonino(5,4-b)indoles
HU174502B (hu) * 1976-12-30 1980-01-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh oktagidro-indolo/2,3-a/-khinolizina
ZA786426B (en) * 1977-11-25 1979-10-31 Scras New indulo(2,3-a)quinolizidines,preparation and therapeutic use
GB2009749B (en) * 1977-11-25 1982-04-28 Scras Indolo(1,3-a)quinolizidines
HU178700B (en) * 1978-02-10 1982-06-28 Richter Gedeon Vegyeszet Process for preparing 1,1-disubstituted octahydro-indolo/2,3-a/-quinolizines
HU178402B (en) * 1978-08-01 1982-04-28 Richter Gedeon Vegyeszet New process for producing okrahydro-indolo-square bracket-2,3-a-square bracket closed-quinolysines
HU177732B (en) * 1978-12-15 1981-12-28 Richter Gedeon Vegyeszet Process for producing 10-bromo-vincamine and acid additional salts thereof,and 10-bromo-14-epivincamine
US4353911A (en) * 1979-07-20 1982-10-12 Andre Buzas Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
US4358452A (en) * 1980-05-09 1982-11-09 John Wyeth & Brother Limited N-[1,2,3,4,6,7,12,12 α-octahydro-2H-indolo(2,3α)-quinolizinyl-2β-yl]alkane and benzyl sulfonamides and anti-hypertensive use thereof
HU185305B (en) * 1981-08-23 1985-01-28 Richter Gedeon Vegyeszet Process for preparing vincine and apovincine
HU182380B (en) * 1981-09-30 1983-12-28 Richter Gedeon Vegyeszet Process for producing esters of vincaminic acid
DE3175900D1 (en) * 1981-11-18 1987-03-12 Thal Claude Indoloquinolizine derivatives, process for their preparation and their therapeutic use
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
HU194221B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound

Also Published As

Publication number Publication date
DK179986D0 (da) 1986-04-18
EP0202774A2 (en) 1986-11-26
AU5638186A (en) 1986-10-23
HU194220B (en) 1988-01-28
FI861642A (fi) 1986-10-20
FI861642A0 (fi) 1986-04-18
EP0202774A3 (en) 1989-03-15
CA1301171C (en) 1992-05-19
JPS61249985A (ja) 1986-11-07
HUT40650A (en) 1987-01-28
AU587025B2 (en) 1989-08-03
ZA862942B (en) 1987-03-25
IL78536A0 (en) 1986-08-31
US4843080A (en) 1989-06-27

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