DK1789019T3 - Pulvere indeholdende hidtil ukendte oligosaccharidblandinger og fremgangsmåder til fremstilling af disse - Google Patents

Pulvere indeholdende hidtil ukendte oligosaccharidblandinger og fremgangsmåder til fremstilling af disse

Info

Publication number
DK1789019T3
DK1789019T3 DK05745334T DK05745334T DK1789019T3 DK 1789019 T3 DK1789019 T3 DK 1789019T3 DK 05745334 T DK05745334 T DK 05745334T DK 05745334 T DK05745334 T DK 05745334T DK 1789019 T3 DK1789019 T3 DK 1789019T3
Authority
DK
Denmark
Prior art keywords
saccharose
linked
processes
preparation
glu
Prior art date
Application number
DK05745334T
Other languages
English (en)
Inventor
Patrick Garidel
Wolfgang Friess
Richard Fuhrherr
Stefan Bassarab
Karoline Bechtold-Peters
Torsten Schultz-Fademrecht
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1789019T3 publication Critical patent/DK1789019T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK05745334T 2004-05-10 2005-05-04 Pulvere indeholdende hidtil ukendte oligosaccharidblandinger og fremgangsmåder til fremstilling af disse DK1789019T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004022928A DE102004022928A1 (de) 2004-05-10 2004-05-10 Pulver enthaltend neuartige Oligosacharidgemische und Verfahren zu deren Herstellung
PCT/EP2005/004808 WO2005113007A2 (de) 2004-05-10 2005-05-04 Pulver enthaltend neuartige oligosaccharidgemische und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DK1789019T3 true DK1789019T3 (da) 2008-05-26

Family

ID=35335878

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05745334T DK1789019T3 (da) 2004-05-10 2005-05-04 Pulvere indeholdende hidtil ukendte oligosaccharidblandinger og fremgangsmåder til fremstilling af disse

Country Status (10)

Country Link
EP (1) EP1789019B1 (da)
JP (1) JP2007536315A (da)
KR (1) KR20070043709A (da)
AT (1) ATE383850T1 (da)
CA (1) CA2564332A1 (da)
DE (2) DE102004022928A1 (da)
DK (1) DK1789019T3 (da)
ES (1) ES2299032T3 (da)
TW (1) TW200605897A (da)
WO (1) WO2005113007A2 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
DE102006053375A1 (de) * 2006-11-10 2008-05-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mischung von Pulvern
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
JP5670421B2 (ja) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング コンポーネント表面のコーティング方法
EP2432531B1 (de) 2009-05-18 2019-03-06 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
JP5715640B2 (ja) 2009-11-25 2015-05-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP2726495B1 (en) 2011-06-28 2019-03-06 Leukocare Ag Method for preventing the unfolding of a (poly)peptide and/or inducing the (re-)folding of a (poly)peptide
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
PL3139984T3 (pl) 2014-05-07 2021-11-08 Boehringer Ingelheim International Gmbh Nebulizator
CN106232166B (zh) 2014-05-07 2020-04-14 勃林格殷格翰国际有限公司 喷雾器
CN106255554B (zh) 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途
WO2016067252A1 (en) 2014-10-31 2016-05-06 Glaxosmithkline Intellectual Property Development Limited Powder formulation
JP7170329B2 (ja) 2016-09-16 2022-11-14 ロイコケア・アクチェンゲゼルシャフト 処理中の生物医薬製品の安定化のための新規な方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
JPH0776527A (ja) * 1993-06-28 1995-03-20 Hayashibara Biochem Lab Inc 半固形製剤とその製造方法
EP0745382B1 (en) * 1994-01-31 2003-11-12 Yamanouchi Pharmaceutical Co. Ltd. Intraorally soluble compressed molding and process for producing the same
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US6258341B1 (en) * 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
US6299871B1 (en) * 1998-07-24 2001-10-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases
ES2281458T3 (es) * 2000-12-21 2007-10-01 Nektar Therapeutics Composiciones de polvo estables en almacenamiento del receptor de interleucina 4.
BR0311645A (pt) * 2002-06-07 2005-02-22 Dzucker Ag Mannheim Ochsenfurt Isomalte de galactosila - procedimento para sua produção e emprego

Also Published As

Publication number Publication date
ATE383850T1 (de) 2008-02-15
DE502005002596D1 (de) 2008-03-06
CA2564332A1 (en) 2005-12-01
EP1789019B1 (de) 2008-01-16
WO2005113007A3 (de) 2006-08-03
ES2299032T3 (es) 2008-05-16
DE102004022928A1 (de) 2005-12-08
TW200605897A (en) 2006-02-16
KR20070043709A (ko) 2007-04-25
JP2007536315A (ja) 2007-12-13
EP1789019A2 (de) 2007-05-30
WO2005113007A2 (de) 2005-12-01

Similar Documents

Publication Publication Date Title
DK1789019T3 (da) Pulvere indeholdende hidtil ukendte oligosaccharidblandinger og fremgangsmåder til fremstilling af disse
TW200605917A (en) Spray-dried powder comprising at least one 1,4 o-linked saccharose-derivative and methods for their preparation
WO2001062737A3 (en) Amino pyrazole derivatives useful for the treatment of obesity and other disorders
NZ527157A (en) Compositions for delivering bisphosphonates
EA200702217A1 (ru) Безводные кристаллические формы n-[1-(2-этоксиэтил)-5-(n-этил-n-метиламино)-7-(4-метилпиридин-2-иламино)-1h-пиразоло[4,3-d]пиримидин-3-карбонил]метансульфонамида
DK1320531T3 (da) Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
WO2002074247A8 (en) Pharmaceutical formulations for sustained release
EP2374812A3 (en) 4-amino-4-oxobutanoyl Peptides as Inhibitors of Viral Replication
HK1088840A1 (en) Stable analogs of glp-1 glp-1
TW200517106A (en) Sustained release pharmaceutical compositions
EA200801275A1 (ru) Стабилизированные составы карбоната лантана
WO2003086303A3 (en) Farnesoid x-activated receptor agonists
CA2412161A1 (en) Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones
TW200605905A (en) 1,4 o-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
EP1093372A4 (en) CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF INHIBITING PEPTIDE RELEASE $ g (b) -AMYLOID AND / OR ITS SYNTHESIS USING THE SAME
WO2008128775A3 (en) Stabilised pharmaceutical composition containing pregabaline
EP1619180A4 (en) CASR ANTAGONIST
DK1140031T3 (da) Farmaceutisk sammensætning til kontrolleret frigivelse med tilidinmesylat som aktivt stof
DK1641820T3 (da) Fra RasGap afledt peptid til selektiv at dræbe kræftceller
EP1600441A3 (en) Novel crystalline form of lercanidipin hydrochloride and processes for its preparation
BR0306928A (pt) Composições farmacêuticas estáveis compreendendo inibidores de enzimas conversoras de angiotensina (ace)
WO2007087026A3 (en) Solid-state form of amg 706 and pharmaceutical compositions thereof
WO2007000770A3 (en) Protein kinase c inhibitors for prevention of insulin resistance and type 2 diabetes
WO2007011958A3 (en) Intraoral dosage forms of glucagon
WO2001074790A3 (en) Novel compounds for enhancing chemotherapy