DK1778618T3 - Synthesis of triethylenetetramines - Google Patents
Synthesis of triethylenetetraminesInfo
- Publication number
- DK1778618T3 DK1778618T3 DK05805036.0T DK05805036T DK1778618T3 DK 1778618 T3 DK1778618 T3 DK 1778618T3 DK 05805036 T DK05805036 T DK 05805036T DK 1778618 T3 DK1778618 T3 DK 1778618T3
- Authority
- DK
- Denmark
- Prior art keywords
- triethylenetetramines
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/76—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by nitration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/09—Diamines
- C07C211/10—Diaminoethanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/13—Amines containing three or more amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58908004P | 2004-07-19 | 2004-07-19 | |
PCT/IB2005/052421 WO2006027705A2 (en) | 2004-07-19 | 2005-07-19 | Synthesis of triethylenetetramines |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1778618T3 true DK1778618T3 (en) | 2014-03-10 |
Family
ID=36036723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05805036.0T DK1778618T3 (en) | 2004-07-19 | 2005-07-19 | Synthesis of triethylenetetramines |
Country Status (8)
Country | Link |
---|---|
US (8) | US7582796B2 (en) |
EP (1) | EP1778618B1 (en) |
AU (1) | AU2005281353A1 (en) |
CA (3) | CA2875095C (en) |
DK (1) | DK1778618T3 (en) |
ES (1) | ES2449066T3 (en) |
PT (1) | PT1778618E (en) |
WO (1) | WO2006027705A2 (en) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2478997C (en) | 2002-03-08 | 2013-12-17 | Protemix Corporation Limited | Use of copper chelating tetraamines for the treatment of cardiovascular disease and heart failure |
JP2006503014A (en) | 2002-08-20 | 2006-01-26 | プロテミックス コーポレイション リミティド | Dosage forms and related treatments |
CA2875095C (en) | 2004-07-19 | 2019-09-03 | Philera New Zealand Limited | Synthesis of triethylenetetramines |
CA3018698A1 (en) * | 2005-11-09 | 2007-05-18 | Philera New Zealand Limited | Treatment of mitochondria-related diseases and improvement of age-related metabolic deficits |
WO2008104579A1 (en) * | 2007-03-01 | 2008-09-04 | Basf Se | Method for producing ethylenediamine diacetonitrile |
CN101675025B (en) * | 2007-03-01 | 2015-04-08 | 巴斯夫欧洲公司 | Method for producing tetraethylenepentamine |
KR20090122435A (en) | 2007-03-01 | 2009-11-30 | 바스프 에스이 | Novel method for producing teta by means of eddn |
US7960591B2 (en) * | 2007-03-01 | 2011-06-14 | Basf Se | Method for producing triethylenetetramine |
US7880036B2 (en) * | 2007-03-01 | 2011-02-01 | Basf Se | Production method for ethyleneamine mixtures |
EP2350212A4 (en) * | 2008-11-07 | 2012-05-23 | Huntsman Petrochemical Llc | Polyaminoacetonitriles, their methods of preparation and use |
WO2010146009A1 (en) | 2009-06-18 | 2010-12-23 | Basf Se | Methyl-substituted teta compounds |
US8309179B2 (en) * | 2009-09-28 | 2012-11-13 | Rohm And Haas Electronics Materials Llc | Selenium/group 1b ink and methods of making and using same |
KR20130037667A (en) | 2010-03-02 | 2013-04-16 | 바스프 에스이 | The use of linear triethylentetramine as curing agent for epoxy resins |
DE102011083324A1 (en) * | 2011-09-23 | 2013-03-28 | Henkel Ag & Co. Kgaa | Oral and dental care and cleaning products with polyamines |
CN102924289B (en) * | 2012-11-07 | 2014-11-12 | 广东奥尔诚药业有限公司 | Synthetic process of hydrochloric acid trientine |
WO2014131674A2 (en) | 2013-03-01 | 2014-09-04 | Basf Se | Amine composition |
US20160084057A1 (en) * | 2014-09-24 | 2016-03-24 | Baker Hughes Incorporated | Concentric coil tubing deployment for hydraulic fracture application |
CN104387336B (en) * | 2014-10-24 | 2016-04-27 | 上海应用技术学院 | Isosorbide-5-Nitrae, the preparation method of 7,10-tetraazacyclododecanand and nanofiltration membrane thereof |
CN106278907B (en) * | 2014-12-17 | 2019-06-21 | 四川科瑞德凯华制药有限公司 | A kind of Syprine Hydrochloride compound |
JP6889116B2 (en) | 2015-02-03 | 2021-06-18 | カドモン ファーマシューティカルズ,リミティド ライアビリティ カンパニー | Stable trientine preparation |
EP3350154B1 (en) * | 2015-09-18 | 2021-02-17 | Emcure Pharmaceuticals Limited | An improved process for preparation of trientine dihydrochloride |
WO2017049529A1 (en) | 2015-09-24 | 2017-03-30 | Innolife Co., Ltd. | A pharmaceutical composition comprising a copper chelating tetramine and the use thereof |
WO2017213524A1 (en) * | 2016-06-10 | 2017-12-14 | Garth Cooper | Treatment of neurodegenerative disorders |
CN108203423A (en) * | 2016-12-20 | 2018-06-26 | 中国医学科学院药物研究所 | Cumarin Mannich base and its purposes in neurodegenerative disease is prevented |
WO2018193482A1 (en) * | 2017-04-22 | 2018-10-25 | Biophore India Pharmaceuticals Pvt. Ltd. | Improved method for the synthesis of 1,2-ethanediamine, n, n'-bis(2-aminoethyl)-dihydrochloride(trientine dihydrochloride) |
WO2019073427A1 (en) * | 2017-10-12 | 2019-04-18 | Piramal Enterprises Limited | A process for the preparation of trientine dihydrochloride |
WO2019106123A1 (en) * | 2017-12-01 | 2019-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of triethylenetetramine (teta) for the therapeutic induction of autophagy |
CA3096423A1 (en) | 2018-05-04 | 2019-11-07 | Gmp-Orphan Sa | Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use |
CN109459518A (en) * | 2018-12-26 | 2019-03-12 | 环境保护部南京环境科学研究所 | The extraction and detection method of lipid in organism liver organization |
US10799459B1 (en) | 2019-05-17 | 2020-10-13 | Xspray Microparticles Ab | Rapidly disintegrating solid oral dosage forms containing dasatinib |
EP3982943A4 (en) * | 2019-06-17 | 2023-07-05 | Philera New Zealand Ltd. | Combination treatments for central nervous system disorders |
KR102489293B1 (en) * | 2020-10-15 | 2023-01-17 | (주) 에프엔지리서치 | High purification of technical grade triethylenetetramine |
CN117157064A (en) * | 2021-03-05 | 2023-12-01 | 菲勒拉新西兰有限责任公司 | Treatment of copper disorders |
TWI819502B (en) | 2022-02-23 | 2023-10-21 | 裕捷股份有限公司 | Triethylenetetramine tetrahydrochloride and its preparation method and composition |
CN116675607A (en) * | 2022-02-23 | 2023-09-01 | 裕捷股份有限公司 | Triethylenetetramine tetrahydrochloride and preparation method and composition thereof |
US20230364031A1 (en) * | 2022-04-19 | 2023-11-16 | Garth Cooper | Treatment of brain copper disorders |
WO2024018394A1 (en) * | 2022-07-19 | 2024-01-25 | Biophore India Pharmaceuticals Pvt. Ltd | A process for the preparation of crystalline form a of n, n'-bis(2-aminoethyl)-1,2-ethanediamine tetrahydrochloride |
US20240043370A1 (en) * | 2022-08-07 | 2024-02-08 | Philera New Zealand Ltd. | Method for triethylenetetramine purification |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US159364A (en) * | 1875-02-02 | Improvement in cisterns | ||
US9534A (en) * | 1853-01-11 | haydbn | ||
US159489A (en) * | 1875-02-02 | Improvement in flat-iron heaters | ||
US3791988A (en) | 1972-03-23 | 1974-02-12 | Hoffmann La Roche | Diagnostic test for glucose |
PL105793B1 (en) * | 1977-11-24 | 1979-10-31 | METHOD OF OBTAINING SALTS OF DICARBOXYLIC ACIDS AND POLYAMINE | |
CS197093B1 (en) * | 1978-06-16 | 1980-04-30 | Ivo Kuhr | Process for preparing pure dihydtochloride of triethylentetramine |
IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4323558A (en) | 1979-09-10 | 1982-04-06 | Nelson Research & Development Co. | Topical trien containing pharmaceutical compositions and methods of use |
US4371374A (en) | 1980-11-17 | 1983-02-01 | The Rockefeller University | Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine |
JPS57144215A (en) | 1981-03-02 | 1982-09-06 | Nippon Nousan Kogyo Kk | Composition for improving lipometabolism |
DE3217071A1 (en) | 1982-05-06 | 1983-11-10 | Rüdiger Dr. 6365 Rosbach Gröning | Pharmaceutical composition for oral administration with improved bioavailability of the active substances |
US4758583A (en) | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
US5852009A (en) | 1984-03-19 | 1998-12-22 | The Rockefeller University | Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon |
US4665192A (en) | 1984-03-19 | 1987-05-12 | The Rockefeller University | 2-(2-furoyl)-4(5)-2(furanyl)-1H-imidazole |
US4578583A (en) | 1984-04-03 | 1986-03-25 | The Babcock & Wilcox Company | Solid state ultraviolet flame detector |
JPH01500589A (en) | 1986-03-21 | 1989-03-01 | ユーラシアム ラボラトリーズ インコーポレーテツド | pharmaceutical composition |
CH667590A5 (en) | 1986-07-24 | 1988-10-31 | Inpharzam Int Sa | WATER-SOLUBLE EFFERVESCENT PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CISTEIN. . |
CH666814A5 (en) | 1986-07-24 | 1988-08-31 | Inpharzam Int Sa | WATER-SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CISTEIN. |
US4866090A (en) | 1988-01-07 | 1989-09-12 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
EP0331014A3 (en) | 1988-03-02 | 1991-10-23 | THERA - Patent Verwaltungs-GmbH | Use of ace inhibitors in diabetes prophylaxis |
JPH01294631A (en) | 1988-05-19 | 1989-11-28 | Sanwa Kagaku Kenkyusho Co Ltd | Remedy and preventive for diabetic disease, food and drink and table luxury |
US5077313A (en) | 1988-11-25 | 1991-12-31 | Gert Lubec | Process for inhibiting pathological collagen cross-linking in diabetes patients |
CA2026686A1 (en) | 1989-10-30 | 1991-05-01 | Werner Tschollar | Method for preventing onset of type ii diabetes employing an ace inhibitor |
US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
ES2106318T3 (en) | 1991-12-06 | 1997-11-01 | North Shore Univ Hospital | METHOD TO REDUCE INFECTIONS RELATED TO MEDICAL DEVICES. |
US5246970A (en) | 1991-12-16 | 1993-09-21 | Washington University | Method of inhibiting nitric oxide formation |
JP3157622B2 (en) | 1992-06-05 | 2001-04-16 | 株式会社ミツカングループ本社 | Fructosylamine deglycase, method for producing the same, and method for quantifying amadori compound using the enzyme |
JPH07118148A (en) | 1993-10-26 | 1995-05-09 | Tsumura & Co | Preventive for hepatoma |
US5420120A (en) | 1993-12-17 | 1995-05-30 | Alcon Laboratories, Inc. | Anti-inflammatory glucocorticoid compounds for topical ophthalmic use |
WO1995017900A1 (en) | 1993-12-30 | 1995-07-06 | Arcturus Pharmaceutical Corporation | Methods for the treatment of the central nervous system or eye involving pathogenic oxidation pathways |
US5854271A (en) | 1994-05-02 | 1998-12-29 | Cytos Pharmaceuticals, L.L.C. | Effective method for the amelioration and prevention of tissue and cellular damage |
WO1996012483A1 (en) | 1994-10-25 | 1996-05-02 | Washington University | Method of inhibiting nitric oxide formation |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US5906996A (en) | 1996-08-21 | 1999-05-25 | Murphy; Michael A. | Tetramine treatment of neurological disorders |
EP1007048A4 (en) | 1997-03-11 | 2004-09-22 | Gen Hospital Corp | Identification of agents for use in the treatment of alzheimer's disease |
US5811446A (en) | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
US20050085555A1 (en) | 1997-08-21 | 2005-04-21 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
US20030013772A1 (en) | 2000-02-23 | 2003-01-16 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
US6576672B1 (en) | 1998-08-21 | 2003-06-10 | Michael A. Murphy | Polyamine treatment of neurological disorders |
US5980914A (en) | 1997-08-22 | 1999-11-09 | P.N. Gerolymatos S.A. | Clioquinol for the treatment of Parkinson's disease |
US6821954B2 (en) | 1997-09-18 | 2004-11-23 | Auckland Uniservices Limited | Compounds and uses thereof in treating bone disorders |
US5972985A (en) | 1997-11-03 | 1999-10-26 | Cytos Pharmaceuticals, Llc | Histidine containing nutriceutical compositions |
AU754681B2 (en) | 1998-02-04 | 2002-11-21 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
US6323218B1 (en) | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
US6147070A (en) | 1998-06-05 | 2000-11-14 | Facchini; Francesco | Methods and compositions for controlling iron stores to treat and cure disease states |
EP1234585A3 (en) | 1998-09-04 | 2004-01-21 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
WO2000018392A1 (en) | 1998-09-25 | 2000-04-06 | Glycox Corporation Limited | Fructosamine oxidase: antagonists and inhibitors |
AU772616B2 (en) | 1998-09-25 | 2004-05-06 | Protemix Corporation Limited | Fructosamine oxidase assay: methods and materials |
JP2000204037A (en) | 1999-01-12 | 2000-07-25 | Tsumura & Co | Therapeutic agent for amyotrophic lateral sclerosis |
US6309380B1 (en) | 1999-01-27 | 2001-10-30 | Marian L. Larson | Drug delivery via conformal film |
US20030166561A1 (en) | 1999-06-18 | 2003-09-04 | Cooper Garth J. S. | Peptide |
CN1296384C (en) | 1999-06-18 | 2007-01-24 | 普罗特米克斯发现有限公司 | Peptide having preptin functionality |
US20030050434A1 (en) | 1999-06-18 | 2003-03-13 | Cooper Garth J.S. | Peptide |
DE60129427T3 (en) | 2000-05-11 | 2014-07-24 | The Procter & Gamble Company | HIGHLY CONCENTRATED LAUNDRY SPRAY COMPOSITIONS AND COMPOUNDS CONTAINING THEM |
FR2810035B1 (en) * | 2000-06-13 | 2004-04-16 | Air Liquide | PROCESS FOR THE PREPARATION OF TETRAAZA MACROCYCLES AND NEW COMPOUNDS |
EP1370254B1 (en) | 2000-12-01 | 2008-01-16 | Radical Vision Therapeutics Inc. | Copper chelators for treating ocular inflammation |
US7754765B2 (en) | 2000-12-01 | 2010-07-13 | Radical Vision Therapeutics Inc | Copper chelators for treating ocular inflammation |
US6545016B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
NZ528509A (en) | 2001-03-30 | 2005-09-30 | Protemix Discovery Ltd | Phosphoprotein target for insulin and its antagonists |
AU2002354951A1 (en) | 2001-07-19 | 2003-03-03 | Dmi Biosciences, Inc. | Use of copper chelators to inhibit the inactivation of protein c |
CA2471833A1 (en) | 2001-11-26 | 2003-06-05 | Protemix Corporation Limited | Methods of compositions for normalizing lipid levels in mammalian tissues |
US20040038861A1 (en) | 2001-11-26 | 2004-02-26 | Cooper Garth J. S. | Methods and compositions for normalizing lipid levels in mammalian tissues |
AU2003207441A1 (en) | 2002-01-03 | 2003-07-24 | Duke University | Methods of modulating localization and physiological function of ip3 receptors |
CN1886423A (en) | 2002-01-18 | 2006-12-27 | 普罗特米克斯公司 | Glycoisoforms of adiponectin and uses thereof |
EP1465982A4 (en) | 2002-01-25 | 2006-06-07 | Gamida Cell Ltd | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
CA2473102A1 (en) | 2002-01-29 | 2003-07-29 | Protemix Corporation Limited | Suppression of cytotoxic protein conformers |
US20050074756A1 (en) | 2002-03-01 | 2005-04-07 | Cooper Garth James Smith | FALP proteins |
AU2003222513A1 (en) | 2002-03-08 | 2003-09-22 | Protemix Corporation Limited | Preventing and/or treating vascular disease, cardiomyopathy and/or associated heart failure |
CA2478997C (en) | 2002-03-08 | 2013-12-17 | Protemix Corporation Limited | Use of copper chelating tetraamines for the treatment of cardiovascular disease and heart failure |
WO2003082259A1 (en) | 2002-04-03 | 2003-10-09 | Puleva Biotech, S.A. | Natural phenolic products and derivatives thereof for protection against neurodegenerative diseases |
AU2003222533A1 (en) | 2002-04-29 | 2003-11-17 | Protemix Corporation Limited | Proteins with deglycating activities and methods of using same |
WO2003099223A2 (en) | 2002-05-24 | 2003-12-04 | The Regents Of The University Of Michigan | Copper lowering treatment of inflammatory and fibrotic diseases |
EP1539131A4 (en) | 2002-07-23 | 2009-07-08 | Univ Michigan | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
US7189865B2 (en) | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
US20060116318A1 (en) | 2002-08-01 | 2006-06-01 | Jillian Cornish | Preptin methods of use |
US20040142393A1 (en) | 2002-08-01 | 2004-07-22 | Cooper Garth James Smith | Methods of use of compounds with preptin function |
CA2494308A1 (en) | 2002-08-01 | 2004-02-12 | Protemix Corporation Limited | Methods of use of compounds with preptin function |
JP2006503014A (en) | 2002-08-20 | 2006-01-26 | プロテミックス コーポレイション リミティド | Dosage forms and related treatments |
WO2004017957A1 (en) | 2002-08-20 | 2004-03-04 | Protemix Corporation Limited | Preventing and/or treating cardiovascular disease and/or associated heart failure |
WO2004056861A2 (en) | 2002-12-23 | 2004-07-08 | Protemix Corporation Limited | Glycoisoforms of adiponectin and uses thereof |
US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
US20070185072A1 (en) | 2003-03-21 | 2007-08-09 | Christophe Boldron | Nitrogeneous polycyclic derivatives useful as chelators of metal ions and their applications |
WO2004087160A1 (en) | 2003-04-03 | 2004-10-14 | Prana Biotechnology Ltd | Treatment of neurological conditions |
WO2004100884A2 (en) | 2003-05-07 | 2004-11-25 | Dmi Biosciences, Inc. | Oral care methods and products |
US7176239B2 (en) | 2003-07-11 | 2007-02-13 | Suming Wang | Methods and compositions for treatment of Ataxia-telangeictasia |
WO2005040205A1 (en) | 2003-10-28 | 2005-05-06 | Protemix Discovery Limited | Peptides with anti-obesity activity and other related uses |
DE20316977U1 (en) | 2003-11-03 | 2005-03-17 | Neoperl Gmbh | backflow preventer |
CA2550505A1 (en) | 2003-12-19 | 2005-06-30 | Protemix Corporation Limited | Copper antagonist compounds |
CA2875095C (en) | 2004-07-19 | 2019-09-03 | Philera New Zealand Limited | Synthesis of triethylenetetramines |
WO2006068516A1 (en) | 2004-12-20 | 2006-06-29 | Protemix Corporation Limited | Implantable medical devices coated with or containing copper chelating compounds |
-
2005
- 2005-07-19 CA CA2875095A patent/CA2875095C/en not_active Expired - Fee Related
- 2005-07-19 DK DK05805036.0T patent/DK1778618T3/en active
- 2005-07-19 AU AU2005281353A patent/AU2005281353A1/en not_active Abandoned
- 2005-07-19 CA CA3050047A patent/CA3050047A1/en not_active Abandoned
- 2005-07-19 PT PT58050360T patent/PT1778618E/en unknown
- 2005-07-19 US US11/184,761 patent/US7582796B2/en active Active - Reinstated
- 2005-07-19 ES ES05805036.0T patent/ES2449066T3/en active Active
- 2005-07-19 EP EP05805036.0A patent/EP1778618B1/en not_active Not-in-force
- 2005-07-19 WO PCT/IB2005/052421 patent/WO2006027705A2/en active Application Filing
- 2005-07-19 CA CA2577634A patent/CA2577634C/en not_active Expired - Fee Related
-
2009
- 2009-07-21 US US12/460,616 patent/US8067641B2/en active Active
-
2011
- 2011-10-07 US US13/269,399 patent/US8394992B2/en not_active Expired - Fee Related
-
2013
- 2013-01-25 US US13/750,617 patent/US8912362B2/en not_active Expired - Fee Related
-
2014
- 2014-10-31 US US14/529,671 patent/US20150057466A1/en not_active Abandoned
-
2015
- 2015-06-10 US US14/736,074 patent/US9556123B2/en active Active
-
2017
- 2017-05-03 US US15/385,427 patent/US20170226064A1/en not_active Abandoned
-
2019
- 2019-08-08 US US16/535,453 patent/US11795150B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US11795150B2 (en) | 2023-10-24 |
US20130345311A1 (en) | 2013-12-26 |
PT1778618E (en) | 2014-03-04 |
WO2006027705A3 (en) | 2006-07-13 |
EP1778618B1 (en) | 2013-12-25 |
EP1778618A4 (en) | 2008-07-16 |
US9556123B2 (en) | 2017-01-31 |
AU2005281353A1 (en) | 2006-03-16 |
CA2875095C (en) | 2019-09-03 |
US8912362B2 (en) | 2014-12-16 |
US8394992B2 (en) | 2013-03-12 |
US20170226064A1 (en) | 2017-08-10 |
US20150057466A1 (en) | 2015-02-26 |
CA2577634C (en) | 2015-07-07 |
CA2577634A1 (en) | 2006-03-16 |
CA2875095A1 (en) | 2006-03-16 |
EP1778618A2 (en) | 2007-05-02 |
US20160102060A1 (en) | 2016-04-14 |
US20100173994A1 (en) | 2010-07-08 |
ES2449066T3 (en) | 2014-03-18 |
US20060041170A1 (en) | 2006-02-23 |
US20120029203A1 (en) | 2012-02-02 |
CA3050047A1 (en) | 2006-03-16 |
US8067641B2 (en) | 2011-11-29 |
US20200148647A1 (en) | 2020-05-14 |
US7582796B2 (en) | 2009-09-01 |
WO2006027705A2 (en) | 2006-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1778618T3 (en) | Synthesis of triethylenetetramines | |
DK2377869T3 (en) | Synthesis of Bortezomib | |
DK1802579T3 (en) | Derivatives of 3-arylaminopyridine | |
DK1992697T3 (en) | Preparation of TNFR-Fc | |
DK1720866T3 (en) | Course of action | |
DK1931315T3 (en) | Depot formulations of nalbufin | |
DK1658295T3 (en) | Regioselective synthesis of CCI-779 | |
ATE414693T1 (en) | NOVEL CIS-IMIDAZOLINES | |
DK1937071T3 (en) | Crystalline modifications of pyraclostrobin | |
DK1940465T3 (en) | New use of anti-IL-1beta antibodies | |
DK2371818T3 (en) | Hydroxybenzoate salts of methanicotine compounds | |
DK1879844T3 (en) | Preparation of sodium deformate | |
DK1587542T3 (en) | Use of anti-CD100 antibodies | |
NO20055643D0 (en) | Preparation of lodixanol | |
DK1763520T3 (en) | Use of trisubstituted benzopyranones | |
DK2081675T3 (en) | Synthesis of biodiesel | |
DE502005005664D1 (en) | Chronograph | |
DK1516540T3 (en) | Use of vitamin D compounds | |
NO20043305D0 (en) | Preparation of lodixanol | |
DK1730109T3 (en) | Synthesis of pyrrole-2-carbonitriles | |
FR2877833B1 (en) | CORRECTEUR OF LORDOSES | |
DK2301576T3 (en) | Therapeutic use of anti-CS1 antibodies | |
DK1787450T3 (en) | Selection of information | |
SE0402103D0 (en) | Novel compounds | |
ITVR20040028A1 (en) | STRUCTURE OF LONGHERONE |