DK175843B1 - Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet - Google Patents

Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet Download PDF

Info

Publication number
DK175843B1
DK175843B1 DK199001101A DK110190A DK175843B1 DK 175843 B1 DK175843 B1 DK 175843B1 DK 199001101 A DK199001101 A DK 199001101A DK 110190 A DK110190 A DK 110190A DK 175843 B1 DK175843 B1 DK 175843B1
Authority
DK
Denmark
Prior art keywords
polypeptide
asp
polypeptides
alvelolar
surfactant
Prior art date
Application number
DK199001101A
Other languages
Danish (da)
English (en)
Other versions
DK110190A (da
DK110190D0 (da
Inventor
Bradley J Benson
Robert T White
W Schilling James Jr
Douglas Buckley
Robert M Scarborough
Barbara Cordell
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of DK110190D0 publication Critical patent/DK110190D0/da
Publication of DK110190A publication Critical patent/DK110190A/da
Application granted granted Critical
Publication of DK175843B1 publication Critical patent/DK175843B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Seasonings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK199001101A 1987-11-04 1990-05-03 Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet DK175843B1 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11709987A 1987-11-04 1987-11-04
US26644388A 1988-11-01 1988-11-01
PCT/US1988/003899 WO1989004326A1 (en) 1987-11-04 1988-11-02 Alveolar surfactant proteins

Publications (3)

Publication Number Publication Date
DK110190D0 DK110190D0 (da) 1990-05-03
DK110190A DK110190A (da) 1990-07-04
DK175843B1 true DK175843B1 (da) 2005-03-29

Family

ID=26814915

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001101A DK175843B1 (da) 1987-11-04 1990-05-03 Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet

Country Status (9)

Country Link
EP (1) EP0383837B1 (ko)
JP (1) JP2602968B2 (ko)
KR (2) KR960010558B1 (ko)
AT (1) ATE163013T1 (ko)
AU (1) AU625394B2 (ko)
CA (1) CA1340461C (ko)
DK (1) DK175843B1 (ko)
IL (1) IL88293A0 (ko)
WO (1) WO1989004326A1 (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
JPH04501204A (ja) * 1988-08-11 1992-03-05 サイオス　ノバ　インコーポレイテッド 異種タンパク発現を安定させる方法およびそれに使用するベクター
CA2063273C (en) * 1989-07-11 2002-09-24 Bradley J. Benson Surfactant compositions and methods
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
ES2189825T3 (es) * 1993-12-08 2003-07-16 Mitsubishi Pharma Corp Nuevo peptido sintetico, tensioactivo pulmonar que lo contiene y remedio para el sindrome de malestar respiratorio.
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
ATE292800T1 (de) 1998-07-24 2005-04-15 Altana Pharma Ag Immunologische bestimmung des hydrophoben lungensurfaktantproteins sp-c
ATE350399T1 (de) 1999-06-17 2007-01-15 Altana Pharma Ag Surfactant protein c ester
CA2384861A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
ES2346048T3 (es) 2001-10-11 2010-10-08 Nycomed Gmbh Nueva utilizacion de un agente tensioactivo pulmonar.
US6998384B2 (en) 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
US8236750B2 (en) 2004-08-06 2012-08-07 Nycomed Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
EP1841458B9 (en) 2005-01-06 2012-12-12 Discovery Laboratories, Inc. Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia
CA2663795A1 (en) 2006-09-19 2008-03-27 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
BRPI0822826A2 (pt) 2008-06-25 2015-07-07 Braasch Biotech Llc Proteína de fusão de somatostatina deficiente em cloranfenicol acetil trasferase (cat) e seus usos
CN102119033B (zh) 2008-06-25 2015-04-08 布拉施生物技术有限责任公司 用于增强促生长素抑制素免疫原性的组合物和方法
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
WO2016029013A2 (en) 2014-08-21 2016-02-25 Braasch Biotech Llc Methods for improving immunological response in vaccinated animals
DE102016125491A1 (de) 2016-12-22 2018-06-28 Bombardier Transportation Gmbh Zugverband mit mindestens einer Aufhängungsvorrichtung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins

Also Published As

Publication number Publication date
JPH03502095A (ja) 1991-05-16
EP0383837A4 (en) 1991-09-11
CA1340461C (en) 1999-03-23
EP0383837B1 (en) 1998-02-04
KR900700505A (ko) 1990-08-13
IL88293A0 (en) 1989-06-30
ATE163013T1 (de) 1998-02-15
KR960010558B1 (ko) 1996-08-02
EP0383837A1 (en) 1990-08-29
DK110190A (da) 1990-07-04
DK110190D0 (da) 1990-05-03
JP2602968B2 (ja) 1997-04-23
WO1989004326A1 (en) 1989-05-18
AU625394B2 (en) 1992-07-09
AU2797989A (en) 1989-06-01

Similar Documents

Publication Publication Date Title
DK175843B1 (da) Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet
ATE140963T1 (de) Verfahren zur herstellung von sekretierten rezeptoranalogen
NO177678C (no) Fremgangsmåte for fremstilling av et terapeutisk aktivt, rekombinant protein som har ASP-aktivitet, ekspresjonssystem samt DNA som koder for nevnte protein
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
NO831317L (no) Fremgangsmaate for fremstilling av funksjonelle menneske-urokinase proteiner.
FI104255B1 (fi) Menetelmä ihmisen seerumialbumiinin N-terminaalifragmentteja sisältävien fuusioproteiinien valmistamiseksi
DK521386A (da) Fremgangsmaade til bestemmelse af aminosyre-sekvensen af et polypeptid, som er komplementaert til et peptid eller protein eller en del heraf, samt middel til brug ved fremgangsmaaden
DE68929546D1 (de) Menschlicher Fc-gamma-Rezeptor III
DK672788D0 (da) Rekombinant-dna-vektorer til direkte udtrykkelse af aktiveret humant protein c
DK165506C (da) Proteinpraeparat med koagulationsaktivitet samt fremgangsmaade til fremstilling deraf
DE3750342D1 (de) Menschliches gamma-interferon-spezifisches Rezeptorprotein, Antikörper gegen dieses Protein, Verfahren zur Herstellung dieses Proteins und dieses Antikörpers und dieses Protein und diesen Antikörper enthaltende Zusammensetzungen.
DK156592A (da) Human-h1-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet og fremgangsmaade til sammenfoejning af a- og b-kaederne i human-h1-relaxin
DK645887D0 (da) Gamma-hesteinterferon, fremgangsmaade til fremstilling af, samt anvendelse af en saadan forbindelse
DK611386A (da) Recombinant humant fsh, fremgangsmaade til fremstilling deraf og vektorer og celler til anvendelse ved fremgangsmaaden
DK11187A (da) Dna-sekvenser der koder for proteiner med husi-type i inhibitorers biologiske aktivitet, biotekniske fremgangsmaader til fremstilling af proteinerne o g farmaceutiske praeparater der indeholder dem
CA2083177A1 (en) Alveolar surfactant proteins
ES8706827A1 (es) Procedimiento para preparar polipeptidos.
NO922421L (no) Collagenbindende protein, samt fremstilling derav
ES2194012T3 (es) Epitopo p1a1 y p1a2 de la gpiii a de plaquetas, su preparacion y uso.
GB2171703B (en) Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
DK470689A (da) Hidtil ukendte dna-sekvenser, der koder for protein-derivater, som tillader hoej udtrykkelse af rekombinante proteiner med ringe molekylevaegt
DE68917520D1 (de) Verfahren und Systeme zur Herstellung von HIV-Antigenen.
DK652889D0 (da) Fremgangsmaade til fremstilling af et protein eller polypeptid
NO179453C (no) Fremgangsmåte for fremstilling av terapeutisk aktivt amphiregulin, vertscelle som produserer proteinet, rekombinant vektor inneholdt i vertscellen, samt nukleotidsekvens som koder for proteiner med amphiregulinaktivitet
FI934079A (fi) Menetelmä fuusioproteiinin valmistamiseksi

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK