DK173765B1 - Fremgangsmåde til fremstilling af piperyliden-dihydro-dibenzo[a,d]cycloheptener og aza-derivater deraf, samt 8-(halogen/trifluormethyl)-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridiner....... - Google Patents

Fremgangsmåde til fremstilling af piperyliden-dihydro-dibenzo[a,d]cycloheptener og aza-derivater deraf, samt 8-(halogen/trifluormethyl)-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridiner....... Download PDF

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Publication number
DK173765B1
DK173765B1 DK198602209A DK220986A DK173765B1 DK 173765 B1 DK173765 B1 DK 173765B1 DK 198602209 A DK198602209 A DK 198602209A DK 220986 A DK220986 A DK 220986A DK 173765 B1 DK173765 B1 DK 173765B1
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Prior art keywords
compound
substituted
alkyl
dihydro
solution
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DK198602209A
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Danish (da)
English (en)
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DK220986A (da
DK220986D0 (da
Inventor
Frank J Villani
Doris Pickel Schumacher
Jesse Kwok-Keung Wong
Bruce Lee Murphy
Jon Edward Clark
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Schering Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK173765(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/839,016 external-priority patent/US4731447A/en
Priority claimed from US06/838,974 external-priority patent/US4659716A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK220986D0 publication Critical patent/DK220986D0/da
Publication of DK220986A publication Critical patent/DK220986A/da
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Publication of DK173765B1 publication Critical patent/DK173765B1/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK198602209A 1985-05-13 1986-05-13 Fremgangsmåde til fremstilling af piperyliden-dihydro-dibenzo[a,d]cycloheptener og aza-derivater deraf, samt 8-(halogen/trifluormethyl)-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridiner....... DK173765B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73342885A 1985-05-13 1985-05-13
US73342885 1985-05-13
US83897486 1986-03-12
US06/839,016 US4731447A (en) 1985-05-13 1986-03-12 Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US83901686 1986-03-12
US06/838,974 US4659716A (en) 1984-02-15 1986-03-12 Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines

Publications (3)

Publication Number Publication Date
DK220986D0 DK220986D0 (da) 1986-05-13
DK220986A DK220986A (da) 1986-11-14
DK173765B1 true DK173765B1 (da) 2001-09-17

Family

ID=27419175

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198602209A DK173765B1 (da) 1985-05-13 1986-05-13 Fremgangsmåde til fremstilling af piperyliden-dihydro-dibenzo[a,d]cycloheptener og aza-derivater deraf, samt 8-(halogen/trifluormethyl)-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridiner.......

Country Status (15)

Country Link
EP (1) EP0208855B1 (sv)
JP (2) JP2511412B2 (sv)
AR (1) AR241463A1 (sv)
AU (2) AU600665B2 (sv)
CA (1) CA1272480A (sv)
DE (1) DE3677842D1 (sv)
DK (1) DK173765B1 (sv)
ES (1) ES8800679A1 (sv)
FI (2) FI90977C (sv)
HK (1) HK75993A (sv)
HU (1) HU199138B (sv)
IE (1) IE59110B1 (sv)
IL (1) IL78771A (sv)
PT (1) PT82570B (sv)
SG (1) SG69193G (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
NZ228888A (en) * 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US5095022A (en) * 1989-07-04 1992-03-10 Hokuriku Pharmaceutical Co., Ltd. Piperidine derivatives and pharmaceutical compositions comprising the same
ES2080700B1 (es) * 1994-07-27 1996-10-16 Farmihispania S A Nuevo procedimiento para la obtencion de loratadina.
ES2080699B1 (es) * 1994-07-27 1996-10-16 Farmahispania S A Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
CN1047774C (zh) * 1996-09-10 1999-12-29 上海华联制药有限公司 氮杂二苯并环庚烯酮类化合物的制备方法
ATE220546T1 (de) * 1997-04-25 2002-08-15 Schering Plough Kabushiki Kais Augentropfen enthaltend ein loratidinmetabolit
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
WO2000005215A1 (en) * 1998-07-24 2000-02-03 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones
AU3790200A (en) * 1998-11-20 2000-06-13 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
TWI225056B (en) * 1998-12-18 2004-12-11 Schering Corp Process for preparing tricyclic compounds having antihistaminic activity
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
NZ573173A (en) 2006-06-01 2012-03-30 Msd Consumer Care Inc Phenylephrine pharmaceutical formulation and compositions for colonic absorption
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (sv) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
GB1489332A (en) * 1973-10-11 1977-10-19 Beecham Group Ltd Reduced bicyclic pyridone derivatives
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
JPS61501205A (ja) * 1984-02-15 1986-06-19 シェリング・コ−ポレ−ション 8↓−クロル↓−6,11↓−ジヒドロ↓−11↓−(4↓−ピペリジリデン)↓−5H↓−ベンゾ〔5,6〕シクロヘプタ〔1,2−b〕ピリジンおよびその塩、これらの化合物の製造方法、ならびにこれらの化合物を含有する医薬組成物

Also Published As

Publication number Publication date
DK220986A (da) 1986-11-14
FI902315A0 (fi) 1990-05-09
AR241463A1 (es) 1992-07-31
DE3677842D1 (de) 1991-04-11
EP0208855A1 (en) 1987-01-21
DK220986D0 (da) 1986-05-13
FI90977B (sv) 1994-01-14
EP0208855B1 (en) 1991-03-06
FI87648B (fi) 1992-10-30
ES554898A0 (es) 1987-11-16
IL78771A (en) 1990-11-29
AU5702690A (en) 1990-10-04
FI861987A (sv) 1986-11-14
JP2511412B2 (ja) 1996-06-26
CA1272480A (en) 1990-08-07
FI90977C (sv) 1994-04-25
HUT41731A (en) 1987-05-28
IE59110B1 (en) 1994-01-12
JPS61289087A (ja) 1986-12-19
JP2519880B2 (ja) 1996-07-31
SG69193G (en) 1993-08-06
IE861259L (en) 1986-11-13
ES8800679A1 (es) 1987-11-16
AU638019B2 (en) 1993-06-17
PT82570A (en) 1986-06-01
HK75993A (en) 1993-08-06
AU5737486A (en) 1986-12-18
FI861987A0 (sv) 1986-05-13
IL78771A0 (en) 1986-08-31
JPH0859657A (ja) 1996-03-05
PT82570B (pt) 1988-11-30
AU600665B2 (en) 1990-08-23
HU199138B (en) 1990-01-29
FI87648C (sv) 1993-02-10

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired