DK1719503T3 - Anvendelse af stivelse med fraspaltede sidekæder i ekstrudering/sfæronisering af farmaceutiske pellets - Google Patents

Anvendelse af stivelse med fraspaltede sidekæder i ekstrudering/sfæronisering af farmaceutiske pellets

Info

Publication number
DK1719503T3
DK1719503T3 DK06008756T DK06008756T DK1719503T3 DK 1719503 T3 DK1719503 T3 DK 1719503T3 DK 06008756 T DK06008756 T DK 06008756T DK 06008756 T DK06008756 T DK 06008756T DK 1719503 T3 DK1719503 T3 DK 1719503T3
Authority
DK
Denmark
Prior art keywords
starch
spheronization
extrusion
side chains
pharmaceutical pellets
Prior art date
Application number
DK06008756T
Other languages
English (en)
Inventor
Aleksandra Dukic
Chris Vervaet
Jean Paul Remon
Paul A Altieri
Paul B Foreman
Original Assignee
Nat Starch Chem Invest
Univ Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Starch Chem Invest, Univ Gent filed Critical Nat Starch Chem Invest
Application granted granted Critical
Publication of DK1719503T3 publication Critical patent/DK1719503T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Grain Derivatives (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Jellies, Jams, And Syrups (AREA)
DK06008756T 2005-05-02 2006-04-27 Anvendelse af stivelse med fraspaltede sidekæder i ekstrudering/sfæronisering af farmaceutiske pellets DK1719503T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67718205P 2005-05-02 2005-05-02
US11/410,375 US8318230B2 (en) 2005-05-02 2006-04-25 Use of debranched starch in extrusion-spheronization pharmaceutical pellets

Publications (1)

Publication Number Publication Date
DK1719503T3 true DK1719503T3 (da) 2009-03-23

Family

ID=36716950

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06008756T DK1719503T3 (da) 2005-05-02 2006-04-27 Anvendelse af stivelse med fraspaltede sidekæder i ekstrudering/sfæronisering af farmaceutiske pellets

Country Status (9)

Country Link
US (1) US8318230B2 (da)
EP (1) EP1719503B1 (da)
JP (1) JP4970839B2 (da)
AT (1) ATE415947T1 (da)
AU (1) AU2006201779A1 (da)
DE (1) DE602006003935D1 (da)
DK (1) DK1719503T3 (da)
ES (1) ES2318607T3 (da)
MY (1) MY139086A (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090062233A1 (en) 2007-08-09 2009-03-05 Xin Ji Modified starch material of biocompatible hemostasis
CN104888263B (zh) * 2008-01-14 2018-11-30 北京环球利康科技有限公司 生物相容性止血、防粘连、促愈合、外科封闭的变性淀粉材料
WO2010021559A1 (en) * 2008-08-22 2010-02-25 Medmat Innovation - Materiais Médicos, Lda. Hydroxyapatite and bioglass-based pellets, production process and applications of thereof
CN102202648B (zh) * 2008-10-23 2014-07-23 汉高公司 包含脱支淀粉的阴道小丸
JP2012508713A (ja) * 2008-11-17 2012-04-12 ビーエーエスエフ ソシエタス・ヨーロピア デンプン含有顆粒製剤
US8194138B2 (en) * 2008-12-17 2012-06-05 Getac Technology Corporation Portable electronic device and camera module thereof
US20100159777A1 (en) * 2008-12-18 2010-06-24 Kimberly-Clark Worldwide, Inc. Thermoplastic Starch Formed from an Enzymatically Debranched Starch
EP2509445B1 (en) * 2009-12-10 2019-01-23 Dow Global Technologies LLC Process for preparing stable starch dispersions
CN103040787A (zh) * 2012-12-24 2013-04-17 蚌埠丰原涂山制药有限公司 一种阿奇霉素胶囊剂及其制备方法
JP6578778B2 (ja) * 2014-08-19 2019-09-25 大正製薬株式会社 固形組成物
US20180079831A1 (en) * 2015-04-22 2018-03-22 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Novel Process
EP3459527B1 (en) * 2017-09-20 2022-11-23 Tillotts Pharma Ag Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization
TWI727188B (zh) * 2018-07-19 2021-05-11 大豐膠囊工業股份有限公司 解支酶改質澱粉，其製備方法及其於硬空膠囊製造上的應用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same
CA2032385A1 (en) 1990-12-17 1992-06-18 Chung Wai-Chiu Enzymatically debranched starches as tablet excipients
JPH0749378B2 (ja) * 1990-12-27 1995-05-31 ナショナル スターチ アンド ケミカル インベストメント ホールディング コーポレイション タブレット賦形剤としての酵素的に枝切りされたデンプン
CA2064394C (en) 1991-05-03 1996-10-22 Norman Lacourse Extruded foods containing high amylose starch
US5281276A (en) * 1992-03-25 1994-01-25 National Starch And Chemical Investment Holding Corporation Process for making amylase resistant starch from high amylose starch
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
US5725676A (en) 1993-07-30 1998-03-10 National Starch And Chemical Investment Holding Corporation Thermally inhibited starches and flours and process for their production
US5830884A (en) * 1995-01-18 1998-11-03 National Starch And Chemical Investment Holding Corporation Pharmaceutical products containing thermally-inhibited starches
US6054302A (en) 1996-05-06 2000-04-25 National Starch And Chemical Investment Holding Corporation High solids, single phase process for preparing enzyme-converted starches
CA2211778A1 (en) 1997-08-14 1999-02-14 Francois Carriere Preparation of pregelatinized high amylose starch and debranched starch useful as an excipient for controlled release of active agents
IT1298574B1 (it) * 1998-02-06 2000-01-12 Vectorpharma Int Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
US20030215499A1 (en) * 2002-05-14 2003-11-20 Yong-Cheng Shi Use of completely linear short chain alpha-glucans as a pharmaceutical excipient
JP4170062B2 (ja) * 2002-10-21 2008-10-22 フロイント産業株式会社 固形剤
GB2409204A (en) * 2003-12-19 2005-06-22 Reckitt Benckiser Nv Plasticized thermoplastic polymer

Also Published As

Publication number Publication date
US20060246192A1 (en) 2006-11-02
JP4970839B2 (ja) 2012-07-11
AU2006201779A1 (en) 2006-11-16
US8318230B2 (en) 2012-11-27
EP1719503B1 (en) 2008-12-03
ATE415947T1 (de) 2008-12-15
JP2006312630A (ja) 2006-11-16
EP1719503A1 (en) 2006-11-08
ES2318607T3 (es) 2009-05-01
MY139086A (en) 2009-08-28
DE602006003935D1 (de) 2009-01-15

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