DK1656095T3 - N,n-dihalogengenerede aminosyrer og derivater - Google Patents

N,n-dihalogengenerede aminosyrer og derivater Download PDF

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Publication number
DK1656095T3
DK1656095T3 DK04801985.5T DK04801985T DK1656095T3 DK 1656095 T3 DK1656095 T3 DK 1656095T3 DK 04801985 T DK04801985 T DK 04801985T DK 1656095 T3 DK1656095 T3 DK 1656095T3
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solution
composition
dichloro
amino acid
derivative
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DK04801985.5T
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English (en)
Inventor
Lu Wang
Jane Yang
Mansour Bassiri
Ramin Najafi
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Novabay Pharmaceuticals Inc
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Publication of DK1656095T3 publication Critical patent/DK1656095T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/02Compounds containing nitrogen-to-halogen bonds
    • C07C239/04N-halogenated amines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04Sulfonic acids; Derivatives thereof
    • A01N41/08Sulfonic acid halides; alpha-Hydroxy-sulfonic acids; Amino-sulfonic acids; Thiosulfonic acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (13)

1. Sammensætning med bakteriedræbende, antibakteriel, infektionshæmmende, antimikrobiel, desinficerende, antifungal, sporedræbende og antiviral aktivitet, der omfatter en N,N-dihalogen-aminosyre udvalgt fra gruppen bestående af N,N-dichlor-2,2-dirmethyltaurin, Ν,Ν-dichlor-1,1,2,2-tetramethyltaurin, N,N-dibrom-2,2-dimethyltaurin, N,N-dibrom-l,l,2,2-tetramethyltaurin, N,N-dichlor-3,3-dimethylhomotaurin eller et derivat deraf; hvilket derivat er udvalgt ffa gruppen bestående af farmaceutisk acceptable salte og estere med Ci-C6-alkanoler.
2. Sammensætning ifølge krav 1, hvor sammensætningen omfatter en farmaceutisk acceptabel bærer.
3. Sammensætning ifølge krav 1, der har et pH-forhold på mellem 2 til 7, eller 3,0 til 6,0, eller 3,0 til 5,0 eller 3,5.
4. Sammensætning ifølge krav 1, hvilken sammensætning er isotonisk og fysiologisk afbalanceret.
5. Sammensætning ifølge krav 1, hvor Ν,Ν-dihalogenaminosyren er udvalgt fra gruppen bestående af N,N-dichlor-2,2-dimethyltaurin, Ν,Ν-dichlor-1,1,2,2-tetramethyltaurin, N,N-dibrom-2,2- dimethyltaurin, N,N-dibrom-l,l,2,2-tetramethyltaurin og N,N-dichlor-3,3-dimethylhomotaurin. 6. Ν,Ν-dihalogenaminosyre udvalgt fra gruppen bestående af N,N-dichlor-2,2-dimethyltaurin, Ν,Ν- dichlor- 1,1,2,2-tetramethyltaurin, N,N-dibrom-2,2-dimethyltaurin, N,N-dibrom-l, 1,2,2- tetramethyltaurin, N,N-dichlor-3,3-dimethylhomotaurin eller et derivat deraf, hvor derivatet er udvalgt fra gruppen bestående af farmaceutisk acceptable salte og estere med Ci-C6-alkanoler. 7. Ν,Ν-dihalogenaminosyre ifølge krav 6, der er N,N-dichlor-2,2-dimethyltaurin; eller et farmaceutisk acceptabelt salt deraf.
8. Sammensætning, der omfatter en Ν,Ν-dihalogenaminosyre ifølge krav 6 eller et derivat deraf, hvilket derivat er udvalgt fra gruppen bestående af farmaceutisk acceptable salte og estere med C1-C6-alkanoler til anvendelse i medicin.
9. Anvendelse af en Ν,Ν-dihalogen-aminosyre ifølge et hvilket som helst af kravene 6 til 8 i fremstillingen af en bakteriedræbende, antibakteriel, infektionshæmmende, antimikrobiel, sporedræbende, desinficerende, antifungal og antiviral aktivitetssammensætning eller i fremstillingen af en medikamentsammensætning til bakteriedræbende, antibakteriel, infektionshæmmende, antimikrobiel, sporedræbende, desinficerende, antifungal og antiviral anvendelse.
10. Fremgangsmåde til desinfektion ved kontrol med eller forebyggelse af væksten af bakterier, mikrober, sporer, fungi eller vira, hvilken fremgangsmåde omfatter påføring af en effektiv mængde af en sammensætning ifølge krav 1 til et område, rum eller materiale, der kræver kontrol eller forebyggelse af vækst eller proliferation, forudsat at fremgangsmåden ikke anvendes som en fremgangsmåde til behandling af menneske- eller dyrekroppen ved terapi.
11. Fremgangsmåde ifølge krav 10, hvor sammensætningens pH er på mellem 2 til 7, 3,0 til 6,8, eller 3,0 til 6,0 eller 3,0 til 5,0 eller 3,5.
12. Fremgangsmåde ifølge krav 10, hvor Ν,Ν-dihalogenaminosyren eller derivatet deraf fremstilles in situ.
13. Fremgangsmåde ifølge krav 10, hvor materialet, der skal behandles, er udvalgt fra fødevarer, dyrefoder, kirurgiske instrumenter, kirurgisk udstyr, medicinske anordninger og udstyr, der anvendes til sådanne formål.
14. Sammensætning ifølge krav 8, der har en koncentration af Ν,Ν-dihalogenaminosyren eller dets derivat på mellem 0,1 og 100 eller 0,3 til 50 mM og et pH-område på mellem 2 til 7, 3 til 4,8, 3,0 til 4,5 eller 3,5 til 4,5 eller 3,5.
15. Sammensætning ifølge krav 8 i stabiliseret form, hvilken sammensætning har en koncentration af Ν,Ν-dihalogenaminosyren eller dets derivat på mellem 0,1 og 100 eller 0,1 til 50 mM og et pH-forhold på mellem 2 til 7, 3 til 6, 3 til 4,8, 3 til 4,5 eller 3,5 til 4,5 eller på 3,5.
DK04801985.5T 2003-08-18 2004-08-17 N,n-dihalogengenerede aminosyrer og derivater DK1656095T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49620703P 2003-08-18 2003-08-18
PCT/US2004/026603 WO2005020896A2 (en) 2003-08-18 2004-08-17 N,n-dihalogenated amino acids and derivatives

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DK1656095T3 true DK1656095T3 (da) 2014-03-10

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US (2) US7462361B2 (da)
EP (2) EP2725008A1 (da)
JP (1) JP4994033B2 (da)
KR (1) KR101057609B1 (da)
CN (1) CN1902158B (da)
AR (1) AR047757A1 (da)
AU (1) AU2004268546B2 (da)
BR (1) BRPI0413660A (da)
CA (1) CA2535926C (da)
DK (1) DK1656095T3 (da)
ES (1) ES2444845T3 (da)
HK (1) HK1103713A1 (da)
IL (1) IL173726A (da)
MX (1) MXPA06001898A (da)
NZ (1) NZ545654A (da)
PL (1) PL1656095T3 (da)
PT (1) PT1656095E (da)
SG (1) SG149043A1 (da)
SI (1) SI1656095T1 (da)
TW (1) TWI376364B (da)
WO (1) WO2005020896A2 (da)

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MXPA06001898A (es) 2006-05-31
KR101057609B1 (ko) 2011-08-18
WO2005020896A2 (en) 2005-03-10
AU2004268546A1 (en) 2005-03-10
JP2007502826A (ja) 2007-02-15
US20090023812A1 (en) 2009-01-22
US7462361B2 (en) 2008-12-09
WO2005020896A3 (en) 2006-10-05
CN1902158B (zh) 2011-04-06
EP1656095A2 (en) 2006-05-17
BRPI0413660A (pt) 2006-10-24
US20050065115A1 (en) 2005-03-24
EP1656095B1 (en) 2014-01-01
CA2535926A1 (en) 2005-03-10
SI1656095T1 (sl) 2014-04-30
CN1902158A (zh) 2007-01-24
PT1656095E (pt) 2014-03-11
CA2535926C (en) 2012-10-09
IL173726A (en) 2013-06-27
US7893109B2 (en) 2011-02-22
JP4994033B2 (ja) 2012-08-08
PL1656095T3 (pl) 2014-04-30
EP2725008A1 (en) 2014-04-30
TWI376364B (en) 2012-11-11
TW200520749A (en) 2005-07-01
AR047757A1 (es) 2006-02-22
HK1103713A1 (da) 2007-12-28
EP1656095A4 (en) 2007-11-28
AU2004268546B2 (en) 2011-12-08
IL173726A0 (en) 2006-07-05
SG149043A1 (en) 2009-01-29
KR20060065701A (ko) 2006-06-14
ES2444845T3 (es) 2014-02-27
NZ545654A (en) 2009-12-24

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