DK1648899T3 - Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander - Google Patents

Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander

Info

Publication number
DK1648899T3
DK1648899T3 DK04779031T DK04779031T DK1648899T3 DK 1648899 T3 DK1648899 T3 DK 1648899T3 DK 04779031 T DK04779031 T DK 04779031T DK 04779031 T DK04779031 T DK 04779031T DK 1648899 T3 DK1648899 T3 DK 1648899T3
Authority
DK
Denmark
Prior art keywords
imidazopyrimidines
triazolopyrimidines
receptor ligands
benzodiazepine receptor
benzodiazepine
Prior art date
Application number
DK04779031T
Other languages
Danish (da)
English (en)
Inventor
Bingsong Han
Kenneth Shaw
George Maynard
Yang Gao
Linghong Xie
Yuelian Xu
Bertrand L Chenard
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of DK1648899T3 publication Critical patent/DK1648899T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK04779031T 2003-07-25 2004-07-23 Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander DK1648899T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49000603P 2003-07-25 2003-07-25
US54308304P 2004-02-09 2004-02-09
PCT/US2004/023794 WO2005012306A2 (fr) 2003-07-25 2004-07-23 Imidazo-pyrimidines et triazolo-pyrimidines: ligands de recepteur de benzodiazepine

Publications (1)

Publication Number Publication Date
DK1648899T3 true DK1648899T3 (da) 2007-04-02

Family

ID=34118813

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04779031T DK1648899T3 (da) 2003-07-25 2004-07-23 Imidazopyrimidiner og triazolopyrimidiner: benzodiazepinreceptorligander

Country Status (21)

Country Link
US (2) US7271170B2 (fr)
EP (1) EP1648899B1 (fr)
JP (1) JP2007500130A (fr)
KR (1) KR20060098425A (fr)
AR (1) AR045117A1 (fr)
AT (1) ATE350382T1 (fr)
AU (1) AU2004261591A1 (fr)
BR (1) BRPI0412908A (fr)
CA (1) CA2537331A1 (fr)
CY (1) CY1107565T1 (fr)
DE (1) DE602004004143T2 (fr)
DK (1) DK1648899T3 (fr)
ES (1) ES2278345T3 (fr)
HK (1) HK1089446A1 (fr)
IL (1) IL173265A0 (fr)
MX (1) MXPA06000887A (fr)
NZ (1) NZ544262A (fr)
PL (1) PL1648899T3 (fr)
PT (1) PT1648899E (fr)
TW (1) TW200524937A (fr)
WO (1) WO2005012306A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482366B2 (en) * 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1619948A4 (fr) * 2003-05-05 2007-02-14 Neurogen Corp Derives d'imidazolopyrazine et de triazolopyrazine substitues: des ligands des recepteurs gabaa
WO2006093911A2 (fr) * 2005-03-02 2006-09-08 Neurogen Corporation Derives heteroaryles de thiazolylmethyl et d'oxazolylmethyl
TW200800213A (en) 2005-09-02 2008-01-01 Abbott Lab Novel imidazo based heterocycles
EP2146576A4 (fr) * 2007-04-11 2013-01-16 Cypress Bioscience Inc Traitement du syndrome de down au moyen d'antagonistes des récepteurs des benzodiazépines
CN101687873A (zh) * 2007-04-17 2010-03-31 百时美施贵宝公司 具有稠合杂环的11β-羟基类固醇Ⅰ型脱氢酶抑制剂
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US544057A (en) * 1895-08-06 Bill and letter file
DE60014339T8 (de) * 1999-04-02 2006-04-27 Neurogen Corp., Branford Aryl- und heteroaryl-kondensierte aminoalkyl-imidazol-derivate: selektive modulatoren der gabaa-rezeptoren
US6737242B1 (en) 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9929687D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
AU2001270297A1 (en) * 2000-06-30 2002-01-14 Neurogen Corporation 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
GB0027561D0 (en) * 2000-11-10 2000-12-27 Merck Sharp & Dohme Therapeutic agents
US6900215B2 (en) * 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
TWI248936B (en) * 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
JP2004531499A (ja) * 2001-03-23 2004-10-14 メルク シャープ エンド ドーム リミテッド Ｇａｂａ受容体用リガンドとしてのイミダゾ−ピリミジン誘導体
IL159811A0 (en) * 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
GB0128499D0 (en) 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
AU2003245259A1 (en) 2002-05-02 2003-11-17 Neurogen Corporation Substituted imidazole derivatives: gabaa receptor ligands
EP1501825A2 (fr) 2002-05-08 2005-02-02 Neurogen Corporation Imidazolylmethyl pyridine substituee et derives de pyrazine: les ligands des recepteurs gaba a
JP2006502974A (ja) 2002-05-17 2006-01-26 ニューロジェン コーポレイション 置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド
CN100579579C (zh) 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
ATE335732T1 (de) 2002-11-08 2006-09-15 Neurogen Corp 4-imidazol-1-ylmethylpyrimidinderivate als liganden für gabaa-rezeptoren
EP1619948A4 (fr) 2003-05-05 2007-02-14 Neurogen Corp Derives d'imidazolopyrazine et de triazolopyrazine substitues: des ligands des recepteurs gabaa

Also Published As

Publication number Publication date
JP2007500130A (ja) 2007-01-11
PL1648899T3 (pl) 2007-06-29
IL173265A0 (en) 2006-06-11
MXPA06000887A (es) 2006-04-19
EP1648899A2 (fr) 2006-04-26
ES2278345T3 (es) 2007-08-01
AR045117A1 (es) 2005-10-19
EP1648899B1 (fr) 2007-01-03
BRPI0412908A (pt) 2006-09-26
US20050038043A1 (en) 2005-02-17
TW200524937A (en) 2005-08-01
WO2005012306A3 (fr) 2005-04-14
KR20060098425A (ko) 2006-09-18
PT1648899E (pt) 2007-03-30
US20080139580A1 (en) 2008-06-12
WO2005012306A2 (fr) 2005-02-10
CA2537331A1 (fr) 2005-02-10
DE602004004143T2 (de) 2007-10-11
DE602004004143D1 (de) 2007-02-15
NZ544262A (en) 2009-06-26
HK1089446A1 (en) 2006-12-01
ATE350382T1 (de) 2007-01-15
US7271170B2 (en) 2007-09-18
AU2004261591A1 (en) 2005-02-10
CY1107565T1 (el) 2013-03-13

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