HK1089446A1 - Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands - Google Patents

Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands

Info

Publication number
HK1089446A1
HK1089446A1 HK06111339A HK06111339A HK1089446A1 HK 1089446 A1 HK1089446 A1 HK 1089446A1 HK 06111339 A HK06111339 A HK 06111339A HK 06111339 A HK06111339 A HK 06111339A HK 1089446 A1 HK1089446 A1 HK 1089446A1
Authority
HK
Hong Kong
Prior art keywords
pyrimidines
triazolo
imidazo
receptor ligands
benzodiazepine receptor
Prior art date
Application number
HK06111339A
Other languages
English (en)
Inventor
Linghong Xie
Bingsong Han
Yuelian Xu
George Maynard
Bertrand L Chenard
Kenneth Shaw
Yang Gao
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of HK1089446A1 publication Critical patent/HK1089446A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK06111339A 2003-07-25 2006-10-17 Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands HK1089446A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49000603P 2003-07-25 2003-07-25
US54308304P 2004-02-09 2004-02-09
PCT/US2004/023794 WO2005012306A2 (en) 2003-07-25 2004-07-23 Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands

Publications (1)

Publication Number Publication Date
HK1089446A1 true HK1089446A1 (en) 2006-12-01

Family

ID=34118813

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06111339A HK1089446A1 (en) 2003-07-25 2006-10-17 Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands

Country Status (21)

Country Link
US (2) US7271170B2 (xx)
EP (1) EP1648899B1 (xx)
JP (1) JP2007500130A (xx)
KR (1) KR20060098425A (xx)
AR (1) AR045117A1 (xx)
AT (1) ATE350382T1 (xx)
AU (1) AU2004261591A1 (xx)
BR (1) BRPI0412908A (xx)
CA (1) CA2537331A1 (xx)
CY (1) CY1107565T1 (xx)
DE (1) DE602004004143T2 (xx)
DK (1) DK1648899T3 (xx)
ES (1) ES2278345T3 (xx)
HK (1) HK1089446A1 (xx)
IL (1) IL173265A0 (xx)
MX (1) MXPA06000887A (xx)
NZ (1) NZ544262A (xx)
PL (1) PL1648899T3 (xx)
PT (1) PT1648899E (xx)
TW (1) TW200524937A (xx)
WO (1) WO2005012306A2 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482366B2 (en) * 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
JP2007501272A (ja) * 2003-05-05 2007-01-25 ニューロジェン・コーポレーション 置換イミダゾロピラジンおよびトリアゾロピラジン誘導体類:gabaaレセプタリガンド類
WO2006093911A2 (en) * 2005-03-02 2006-09-08 Neurogen Corporation Thiazolylmethyl and oxazolylmethyl heteroaryl derivatives
EP1928237A4 (en) 2005-09-02 2011-03-09 Abbott Lab NEW HETEROCYCLES BASED ON IMIDAZO
JP2010523716A (ja) * 2007-04-11 2010-07-15 サイプレス バイオサイエンシズ,インク. ベンゾジアゼピン受容体拮抗薬を用いるダウン症候群の治療
US8546394B2 (en) 2007-04-17 2013-10-01 Bristol-Myers Squibb Company Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US544057A (en) * 1895-08-06 Bill and letter file
WO2000059905A1 (en) * 1999-04-02 2000-10-12 Neurogen Corporation ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS
US6737242B1 (en) 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9929687D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
AU2001270297A1 (en) * 2000-06-30 2002-01-14 Neurogen Corporation 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
GB0027561D0 (en) * 2000-11-10 2000-12-27 Merck Sharp & Dohme Therapeutic agents
US6900215B2 (en) * 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
TWI248936B (en) * 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
US7030128B2 (en) * 2001-03-23 2006-04-18 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for GABA receptors
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
JP2005531548A (ja) 2002-05-02 2005-10-20 ニューロジェン コーポレイション 置換イミダゾール誘導体:gabaa受容体リガンド
US6982268B2 (en) 2002-05-08 2006-01-03 Neurogen Corporation Substituted imidazolylmethyl pyridine and pyrazine derivatives GABAA receptor ligands
ATE333455T1 (de) 2002-05-17 2006-08-15 Neurogen Corp Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden
CN100579579C (zh) 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
ES2268488T3 (es) 2002-11-08 2007-03-16 Neurogen Corporation Derivados de 4-imidazol-1-ilmetil-pirimidina como ligandos para receptores de gabaa.
JP2007501272A (ja) 2003-05-05 2007-01-25 ニューロジェン・コーポレーション 置換イミダゾロピラジンおよびトリアゾロピラジン誘導体類:gabaaレセプタリガンド類

Also Published As

Publication number Publication date
DE602004004143T2 (de) 2007-10-11
ES2278345T3 (es) 2007-08-01
EP1648899B1 (en) 2007-01-03
US20050038043A1 (en) 2005-02-17
DE602004004143D1 (de) 2007-02-15
KR20060098425A (ko) 2006-09-18
JP2007500130A (ja) 2007-01-11
NZ544262A (en) 2009-06-26
PL1648899T3 (pl) 2007-06-29
WO2005012306A2 (en) 2005-02-10
CY1107565T1 (el) 2013-03-13
WO2005012306A3 (en) 2005-04-14
AR045117A1 (es) 2005-10-19
IL173265A0 (en) 2006-06-11
EP1648899A2 (en) 2006-04-26
PT1648899E (pt) 2007-03-30
US20080139580A1 (en) 2008-06-12
US7271170B2 (en) 2007-09-18
TW200524937A (en) 2005-08-01
ATE350382T1 (de) 2007-01-15
CA2537331A1 (en) 2005-02-10
AU2004261591A1 (en) 2005-02-10
BRPI0412908A (pt) 2006-09-26
MXPA06000887A (es) 2006-04-19
DK1648899T3 (da) 2007-04-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110723