DK1569634T3 - Anvendelse af en PPAR-agonist og metformin til behandling af fedme - Google Patents

Anvendelse af en PPAR-agonist og metformin til behandling af fedme

Info

Publication number
DK1569634T3
DK1569634T3 DK03780062T DK03780062T DK1569634T3 DK 1569634 T3 DK1569634 T3 DK 1569634T3 DK 03780062 T DK03780062 T DK 03780062T DK 03780062 T DK03780062 T DK 03780062T DK 1569634 T3 DK1569634 T3 DK 1569634T3
Authority
DK
Denmark
Prior art keywords
metformin
obesity
treatment
ppar agonist
agonist
Prior art date
Application number
DK03780062T
Other languages
Danish (da)
English (en)
Inventor
Jean-Louis Junien
Alan Edgar
Evelyne Chaput
Original Assignee
Fournier Lab Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Ireland Ltd filed Critical Fournier Lab Ireland Ltd
Application granted granted Critical
Publication of DK1569634T3 publication Critical patent/DK1569634T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK03780062T 2002-11-28 2003-11-26 Anvendelse af en PPAR-agonist og metformin til behandling af fedme DK1569634T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02292940A EP1424070A1 (en) 2002-11-28 2002-11-28 Combination of a PPAR alpha agonist and metformin for decreasing the serum triglycerides
PCT/EP2003/013302 WO2004047831A2 (en) 2002-11-28 2003-11-26 Use of a pparalpha agonist and metformin for decreasing the serum triglycerides

Publications (1)

Publication Number Publication Date
DK1569634T3 true DK1569634T3 (da) 2007-09-10

Family

ID=32241358

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03780062T DK1569634T3 (da) 2002-11-28 2003-11-26 Anvendelse af en PPAR-agonist og metformin til behandling af fedme

Country Status (22)

Country Link
US (2) US20060142397A1 (zh)
EP (2) EP1424070A1 (zh)
JP (1) JP2006508995A (zh)
CN (1) CN1777417B (zh)
AT (1) ATE362362T1 (zh)
AU (1) AU2003288175B2 (zh)
BR (1) BR0316810A (zh)
CA (1) CA2507894C (zh)
CY (1) CY1106749T1 (zh)
DE (1) DE60313886T2 (zh)
DK (1) DK1569634T3 (zh)
EA (1) EA009772B1 (zh)
ES (1) ES2287546T3 (zh)
HK (1) HK1077755A1 (zh)
MA (1) MA27553A1 (zh)
MX (1) MXPA05005707A (zh)
NO (1) NO20052549L (zh)
PT (1) PT1569634E (zh)
SI (1) SI1569634T1 (zh)
TN (1) TNSN05148A1 (zh)
WO (1) WO2004047831A2 (zh)
ZA (1) ZA200504345B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
EP1457206A1 (en) * 2003-03-13 2004-09-15 Fournier Laboratories Ireland Limited Combined use of a fibrate and orlistat for the treatment of obesity
EP1559419A1 (en) * 2004-01-23 2005-08-03 Fournier Laboratories Ireland Limited Pharmaceutical formulations comprising metformin and a fibrate, and processes for their obtention
FR2896160B1 (fr) * 2006-01-13 2008-04-25 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agonistes du ppar alpha.
WO2010132580A2 (en) * 2009-05-12 2010-11-18 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
WO2011159917A2 (en) 2010-06-16 2011-12-22 The Administrators Of The Tulane Educational Fund Growth hormone secretatogue receptor antagonists and uses thereof
FR3050112B1 (fr) * 2016-04-15 2020-09-04 Soc Civ Immobiliere Gecinq Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques
CN107496397A (zh) * 2016-06-14 2017-12-22 重庆安格龙翔医药科技有限公司 一种二甲双胍与非诺贝酸的复合物及其制剂
FR3056908B1 (fr) * 2016-09-30 2019-04-19 Nashpharm Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
CN111374093A (zh) * 2018-12-28 2020-07-07 高倩 超级肥胖小鼠的构建与鉴定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT323195B (de) * 1973-03-16 1975-06-25 Hurka Wilhelm Verfahren zur herstellung neuer salze von biguaniden
FR2275199A1 (fr) * 1974-06-19 1976-01-16 Cerpha (chloro-4 phenoxy) isobutyrate de dimethylbiguanide, son procede de preparation et medicaments contenant ce produit comme principe actif
US5190970A (en) * 1990-10-19 1993-03-02 E. R. Squibb & Sons, Inc. Method for preventing onset of or treating Type II diabetes employing a cholesterol lowering drug alone or in combination with an ace inhibitor
US5739106A (en) * 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
WO1997027847A1 (en) * 1996-02-02 1997-08-07 Merck & Co., Inc. Method of treating diabetes and related disease states
EP0930882A2 (en) * 1996-08-02 1999-07-28 Institut Pasteur De Lille Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
FR2774591B1 (fr) * 1998-02-12 2000-05-05 Lipha Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
US5942500A (en) * 1998-04-27 1999-08-24 Perry; Stephen C. Dietary composition to reduce dietary fats
FR2796940B1 (fr) * 1999-07-26 2005-04-08 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
US6498193B2 (en) * 1999-12-22 2002-12-24 Trustees Of Dartmouth College Treatment for complications of type 2 diabetes
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
US20030092736A1 (en) * 2001-05-30 2003-05-15 Cheng Peter T. Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
WO2004034968A2 (en) * 2002-08-20 2004-04-29 The Regents Of The University Of California Combination therapy for controlling appetites

Also Published As

Publication number Publication date
CA2507894C (en) 2011-01-04
CA2507894A1 (en) 2004-06-10
DE60313886T2 (de) 2008-01-17
MA27553A1 (fr) 2005-10-03
AU2003288175B2 (en) 2008-11-13
BR0316810A (pt) 2005-10-18
ZA200504345B (en) 2006-08-30
WO2004047831A2 (en) 2004-06-10
US20060142397A1 (en) 2006-06-29
US20100144874A1 (en) 2010-06-10
ES2287546T3 (es) 2007-12-16
CN1777417A (zh) 2006-05-24
HK1077755A1 (en) 2006-02-24
CY1106749T1 (el) 2012-05-23
WO2004047831A3 (en) 2005-02-24
MXPA05005707A (es) 2005-07-26
JP2006508995A (ja) 2006-03-16
AU2003288175A1 (en) 2004-06-18
EP1569634A2 (en) 2005-09-07
NO20052549L (no) 2005-06-10
PT1569634E (pt) 2007-08-22
EP1424070A1 (en) 2004-06-02
SI1569634T1 (sl) 2007-10-31
TNSN05148A1 (fr) 2007-05-14
ATE362362T1 (de) 2007-06-15
EA009772B1 (ru) 2008-04-28
DE60313886D1 (de) 2007-06-28
EP1569634B1 (en) 2007-05-16
CN1777417B (zh) 2010-10-06
EP1569634B8 (en) 2007-08-29
EA200500691A1 (ru) 2005-12-29

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