DK1539815T3 - Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf - Google Patents

Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf

Info

Publication number
DK1539815T3
DK1539815T3 DK03750910T DK03750910T DK1539815T3 DK 1539815 T3 DK1539815 T3 DK 1539815T3 DK 03750910 T DK03750910 T DK 03750910T DK 03750910 T DK03750910 T DK 03750910T DK 1539815 T3 DK1539815 T3 DK 1539815T3
Authority
DK
Denmark
Prior art keywords
ace
applications
crystal structure
converting enzyme
angiotensin converting
Prior art date
Application number
DK03750910T
Other languages
Danish (da)
English (en)
Inventor
Ravi Acharya
Edward Sturrock
Original Assignee
Univ Bath
Univ Cape Town
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bath, Univ Cape Town filed Critical Univ Bath
Application granted granted Critical
Publication of DK1539815T3 publication Critical patent/DK1539815T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK03750910T 2002-09-12 2003-09-12 Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf DK1539815T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221169.6A GB0221169D0 (en) 2002-09-12 2002-09-12 Crystal
PCT/GB2003/003966 WO2004024765A1 (fr) 2002-09-12 2003-09-12 Structure de cristal d'une enzyme de conversion de l'angiotensine (ace) et ses utilisations

Publications (1)

Publication Number Publication Date
DK1539815T3 true DK1539815T3 (da) 2009-05-11

Family

ID=9943936

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03750910T DK1539815T3 (da) 2002-09-12 2003-09-12 Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf

Country Status (11)

Country Link
US (3) US7704319B2 (fr)
EP (1) EP1539815B1 (fr)
AT (1) ATE421975T1 (fr)
AU (1) AU2003269128B8 (fr)
CA (1) CA2507621C (fr)
DE (1) DE60326048D1 (fr)
DK (1) DK1539815T3 (fr)
GB (1) GB0221169D0 (fr)
SI (1) SI1539815T1 (fr)
WO (1) WO2004024765A1 (fr)
ZA (1) ZA200502088B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600406D0 (en) 2006-01-10 2006-02-15 Univ Bath Crystal
WO2010028236A1 (fr) * 2008-09-05 2010-03-11 Avila Therapeutics, Inc. Algorithme pour concevoir des inhibiteurs irréversibles
KR20120093220A (ko) 2009-09-16 2012-08-22 아빌라 테라퓨틱스, 인크. 단백질 키나아제 컨쥬게이트 및 인히비터
CN102812167A (zh) 2009-12-30 2012-12-05 阿维拉制药公司 蛋白的配体-介导的共价修饰
WO2012162856A1 (fr) * 2011-06-01 2012-12-06 Novo Nordisk A/S Cristal de récepteur de cytokine
CN113876353A (zh) * 2016-06-20 2022-01-04 蝴蝶网络有限公司 引导超声装置的操作者定位超声装置的方法、系统和介质

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947575A (en) 1969-06-30 1976-03-30 E. R. Squibb & Sons, Inc. Peptides as argiotensin converting enzyme inhibitors
US3832337A (en) 1970-07-28 1974-08-27 Squibb & Sons Inc Peptide enzyme inhibitors
US3891616A (en) 1974-04-17 1975-06-24 Squibb & Sons Inc Hypotensive {62 -homoaminoacid nonapeptides
ES441743A1 (es) * 1974-10-19 1977-03-16 Hoechst Ag Procedimiento para la obtencion de fibras e hilos de moda- crilico protegido contra las llamas con termoestabilidad me-jorada.
US4052511A (en) 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4053651A (en) 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
FR2649412B1 (fr) * 1989-07-05 1995-10-20 Inst Nat Sante Rech Med Acide nucleique codant pour l'enzyme de conversion de l'angiotensine (eca) testiculaire humaine, et ses applications, notamment pour le depistage in vitro de cette enzyme dans l'organisme
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
JPH03251543A (ja) 1990-02-26 1991-11-11 Unitika Ltd アンジオテンシン変換酵素阻害剤
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO2003092607A2 (fr) * 2002-05-01 2003-11-13 Vertex Pharmaceuticals Incorporated Structure cristalline de la proteine aurora-2 et poches de liaison associees
US20040033532A1 (en) * 2002-08-08 2004-02-19 Ehlers Mario R. W. Use of three-dimensional crystal structure coordinates to design and synthesize domain-selective inhibitors for angiotensin-converting enzyme (ACE)
AU2003276877A1 (en) * 2002-09-09 2004-03-29 Millenium Pharmaceuticals, Inc. Crystal structure of angiotensin-converting enzyme-related carboxypeptidase

Also Published As

Publication number Publication date
ATE421975T1 (de) 2009-02-15
US7704319B2 (en) 2010-04-27
WO2004024765A8 (fr) 2006-01-05
AU2003269128B8 (en) 2010-02-25
US7901507B2 (en) 2011-03-08
US20060174816A1 (en) 2006-08-10
AU2003269128A1 (en) 2004-04-30
WO2004024765A1 (fr) 2004-03-25
US8594947B2 (en) 2013-11-26
AU2003269128B2 (en) 2009-10-29
CA2507621C (fr) 2020-02-25
ZA200502088B (en) 2008-02-27
SI1539815T1 (sl) 2009-06-30
CA2507621A1 (fr) 2004-03-25
EP1539815A1 (fr) 2005-06-15
US20100160180A1 (en) 2010-06-24
EP1539815B1 (fr) 2009-01-28
DE60326048D1 (de) 2009-03-19
US20090142822A1 (en) 2009-06-04
GB0221169D0 (en) 2002-10-23

Similar Documents

Publication Publication Date Title
NO20044597L (no) Kjemiske forbindelser
DE602004006433D1 (de) Pyrrol-substituierte indole als inhibitoren von pai-1
PA8564901A1 (es) Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
DK1553975T3 (da) Optimerede Fc-varianter og fremgangsmåder til generering heraf.
DK1663298T3 (da) Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner
BR0206601A (pt) Composição adesiva
MX2007007030A (es) Enzimas para procesamiento de almidon.
TW200621253A (en) 2-amido-thiazole-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
DK1605969T3 (da) Peptider som inhiberer angiotensin-omdannende enzym
GB2430677A8 (en) Novel antigenbinding polypeptides and their uses
NO20074807L (no) Fast farmasoytisk doseringsformulering
DK1794173T3 (da) Amplifikationsblokker indeholdende interkalaterende nukleinsyrer (INA) indeholdende interkalaterende pseudonukleotider (IPN)
NO20062649L (no) Biarylsulfonamider og metoder for anvendelse av disse
NO20055838D0 (no) Aktive varianter av IL-18 bindende protein og medisinske anvendelser derav
ATE511393T1 (de) Transdermale fentanylapplikation
ATE412649T1 (de) Substituierte heteroarylbenzofuransäuren
EA200601743A1 (ru) Выделенный полипептид реналазы и его применение
NO20044448L (no) Nye forbindelser
DK1539815T3 (da) Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf
PA8577701A1 (es) Polipeptido t20 pegilado
EA200602155A1 (ru) Новая комбинация ингибитора iтока синусового узла и ингибитора ангиотензинпревращающего фермента и фармацевтические композиции, её содержащие
DE602006017359D1 (de) Substrat für die rpn-11-enzymaktivität
EA200800411A1 (ru) Новая кристаллическая форма периндоприлэрбумина
NO20051301L (no) Proteintyrosinforfataseinhibitorer
TW200621718A (en) Novel co-crystals