DK150069C - Analogifremgangsmaade til fremstilling af n-(2-pyridyl)-2-methyl-4-acyloxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxider - Google Patents

Analogifremgangsmaade til fremstilling af n-(2-pyridyl)-2-methyl-4-acyloxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxider

Info

Publication number
DK150069C
DK150069C DK013082A DK13082A DK150069C DK 150069 C DK150069 C DK 150069C DK 013082 A DK013082 A DK 013082A DK 13082 A DK13082 A DK 13082A DK 150069 C DK150069 C DK 150069C
Authority
DK
Denmark
Prior art keywords
benzothiazine
dioxides
acyloxy
carboxamide
pyridyl
Prior art date
Application number
DK013082A
Other languages
English (en)
Other versions
DK13082A (da
DK150069B (da
Inventor
Joseph George Lombardino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK13082A publication Critical patent/DK13082A/da
Publication of DK150069B publication Critical patent/DK150069B/da
Application granted granted Critical
Publication of DK150069C publication Critical patent/DK150069C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK013082A 1981-01-15 1982-01-14 Analogifremgangsmaade til fremstilling af n-(2-pyridyl)-2-methyl-4-acyloxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxider DK150069C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22516281 1981-01-15
US06/225,162 US4309427A (en) 1981-01-15 1981-01-15 Benzothiazine dioxide derivatives

Publications (3)

Publication Number Publication Date
DK13082A DK13082A (da) 1982-07-16
DK150069B DK150069B (da) 1986-12-01
DK150069C true DK150069C (da) 1987-10-19

Family

ID=22843790

Family Applications (1)

Application Number Title Priority Date Filing Date
DK013082A DK150069C (da) 1981-01-15 1982-01-14 Analogifremgangsmaade til fremstilling af n-(2-pyridyl)-2-methyl-4-acyloxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxider

Country Status (9)

Country Link
US (1) US4309427A (da)
EP (1) EP0057059B1 (da)
JP (1) JPS57139076A (da)
DE (1) DE3260051D1 (da)
DK (1) DK150069C (da)
GR (1) GR75137B (da)
HK (1) HK65286A (da)
IE (1) IE51830B1 (da)
MY (1) MY8600632A (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474955A (en) * 1981-06-17 1984-10-02 Vincenzo Iannella Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester
GT198276334A (es) * 1981-08-03 1984-01-10 Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina.
US4376204A (en) * 1981-10-05 1983-03-08 Pfizer Inc. 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam
IT1168064B (it) * 1981-11-12 1987-05-20 Prodotti Antibiotici Spa Composto ad azione antinfiammatoria
IT8219486A0 (it) * 1982-02-05 1982-02-05 Chiesi Farma Spa Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche.
SU1306476A3 (ru) * 1982-06-17 1987-04-23 Пфайзер,Инк (Фирма) Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида
EP0098422B1 (de) * 1982-07-07 1987-12-09 Siegfried Aktiengesellschaft Verfahren zur Herstellung von 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazin-3-carboxamid 1,1-dioxid
IT1206525B (it) * 1982-12-10 1989-04-27 Zionale S R L A Roma Preparato anti-infiammatorio nonsteroideo, per il trattamento delle affezioni artroreumatiche e metodo per la sua preparazione
JPS608282A (ja) * 1983-06-27 1985-01-17 キエシ・フアルマチエウチチ・エツセ・ピ・ア ４―ピバロイルオキシ―２―メチル―２ｈ―１，２―ベンゾチアジン―３―〔ｎ―（２―ピリジル）―カルボキサミド〕―１，１―ジオキシドおよびそれを有効成分とする医薬
IT1194522B (it) * 1983-12-16 1988-09-22 Prodotti Antibiotici Spa Metodo di sintesi di derivanti benzotiazinici
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
US4683306A (en) * 1984-07-13 1987-07-28 Yuhan Corporation Co., Ltd. Process for the preparation of 3,4-dihydro-2-substituted-2H-1,2-thiazine-carboxylic acid 1,1-dioxide derivatives
IT1196307B (it) * 1984-10-22 1988-11-16 Chiesi Farma Spa Formulazioni farmaceutiche acquose di piroxicam monoidrato
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
WO1987006933A1 (en) * 1986-05-16 1987-11-19 Pfizer Inc. Benzothiazine dioxide derivatives
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
GB9824023D0 (en) * 1998-11-03 1998-12-30 Isis Innovation Surface functionalisation
WO2010100410A1 (en) 2009-03-02 2010-09-10 Oxford Advanced Surfaces Ltd Chemical agents capable of forming covalent 3-d networks

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3862319A (en) * 1971-02-09 1975-01-21 Pfizer Benzothiazine dioxides as anti-thromobotic agents
US3925371A (en) * 1974-09-23 1975-12-09 Mcneilab Inc Benzothiazine-1,1-dioxides
US4074048A (en) * 1976-05-10 1978-02-14 Warner-Lambert Company Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides

Also Published As

Publication number Publication date
DK13082A (da) 1982-07-16
GR75137B (da) 1984-07-13
US4309427A (en) 1982-01-05
IE820054L (en) 1982-07-15
JPS57139076A (en) 1982-08-27
IE51830B1 (en) 1987-04-01
EP0057059A1 (en) 1982-08-04
MY8600632A (en) 1986-12-31
EP0057059B1 (en) 1984-03-07
HK65286A (en) 1986-09-12
JPS6330309B2 (da) 1988-06-17
DK150069B (da) 1986-12-01
DE3260051D1 (en) 1984-04-12

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