DK1492881T3 - Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanaler - Google Patents
Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanalerInfo
- Publication number
- DK1492881T3 DK1492881T3 DK03727297T DK03727297T DK1492881T3 DK 1492881 T3 DK1492881 T3 DK 1492881T3 DK 03727297 T DK03727297 T DK 03727297T DK 03727297 T DK03727297 T DK 03727297T DK 1492881 T3 DK1492881 T3 DK 1492881T3
- Authority
- DK
- Denmark
- Prior art keywords
- light
- controlled ion
- direct light
- ion channels
- biological
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/405—Assays involving biological materials from specific organisms or of a specific nature from algae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Magnetic Treatment Devices (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10216005A DE10216005A1 (de) | 2002-04-11 | 2002-04-11 | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
PCT/EP2003/003799 WO2003084994A2 (de) | 2002-04-11 | 2003-04-11 | Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1492881T3 true DK1492881T3 (da) | 2009-02-16 |
Family
ID=28684950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03727297T DK1492881T3 (da) | 2002-04-11 | 2003-04-11 | Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanaler |
Country Status (8)
Country | Link |
---|---|
US (3) | US7824869B2 (da) |
EP (2) | EP2055714B1 (da) |
AT (1) | ATE412063T1 (da) |
AU (1) | AU2003233968A1 (da) |
DE (2) | DE10216005A1 (da) |
DK (1) | DK1492881T3 (da) |
ES (1) | ES2315495T3 (da) |
WO (1) | WO2003084994A2 (da) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
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DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
US20190321651A1 (en) * | 2005-07-22 | 2019-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | System for Optical Stimulation of Target Cells |
US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US10052497B2 (en) * | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US20090093403A1 (en) | 2007-03-01 | 2009-04-09 | Feng Zhang | Systems, methods and compositions for optical stimulation of target cells |
US8906360B2 (en) * | 2005-07-22 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated cation channel and uses thereof |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
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WO2008086470A1 (en) * | 2007-01-10 | 2008-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US8401609B2 (en) * | 2007-02-14 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
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US20140324138A1 (en) * | 2007-05-09 | 2014-10-30 | Massachusetts Institute Of Technology | Wirelessly-powered illumination of biological tissue |
US9138596B2 (en) * | 2007-08-22 | 2015-09-22 | Cardiac Pacemakers, Inc. | Optical depolarization of cardiac tissue |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
KR20100136550A (ko) | 2008-04-18 | 2010-12-28 | 노파르티스 포르슝스티프퉁 쯔바이크니덜라쑹 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 | 실명을 치료하기 위한 신규의 치료 도구 및 방법 |
DE102008020152B4 (de) * | 2008-04-22 | 2012-04-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
ES2608498T3 (es) | 2008-04-23 | 2017-04-11 | The Board Of Trustees Of The Leland Stanford Junior University | Sistemas, métodos y composiciones para la estimulación óptica de células diana |
EP2315833B8 (en) | 2008-05-20 | 2015-05-27 | Eos Neuroscience, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
EP2294208B1 (en) | 2008-05-29 | 2013-05-08 | The Board of Trustees of The Leland Stanford Junior University | Cell line, system and method for optical control of secondary messengers |
ES2612052T3 (es) | 2008-06-17 | 2017-05-11 | The Board Of Trustees Of The Leland Stanford Junior University | Dispositivos para la estimulación óptica de células diana, utilizando un elemento de transmisión óptica |
SG191604A1 (en) | 2008-06-17 | 2013-07-31 | Univ Leland Stanford Junior | Apparatus and methods for controlling cellular development |
WO2010006049A1 (en) | 2008-07-08 | 2010-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
EP2547762B1 (en) | 2010-03-17 | 2018-04-25 | The Board of Trustees of the Leland Stanford Junior University | Light-sensitive ion-passing molecules |
GB2492719A (en) | 2010-04-05 | 2013-01-09 | Eos Neuroscience Inc | Methods and compositions for decreasing chronic pain |
WO2011140279A1 (en) | 2010-05-04 | 2011-11-10 | Wayne State University | Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
US9207237B2 (en) | 2010-08-23 | 2015-12-08 | President And Fellows Of Harvard College | Systems, methods, and workflows for optogenetics analysis |
WO2012027358A1 (en) | 2010-08-23 | 2012-03-01 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
MX347453B (es) * | 2010-09-08 | 2017-04-27 | Max-Planck-Gesellschaft Zur Förderung Der Wss E V | Canalrodopsina 2 mutante. |
US8932562B2 (en) | 2010-11-05 | 2015-01-13 | The Board Of Trustees Of The Leland Stanford Junior University | Optically controlled CNS dysfunction |
EP2635108B1 (en) | 2010-11-05 | 2019-01-23 | The Board of Trustees of the Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
CN103313752B (zh) | 2010-11-05 | 2016-10-19 | 斯坦福大学托管董事会 | 用于光遗传学方法的光的上转换 |
AU2011323235B2 (en) | 2010-11-05 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of reward-related behaviors |
EP2635111B1 (en) | 2010-11-05 | 2018-05-23 | The Board of Trustees of the Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
JP6328424B6 (ja) | 2010-11-05 | 2018-07-11 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 記憶機能の制御および特性化 |
US20120214188A1 (en) * | 2010-11-12 | 2012-08-23 | Nathan Klapoetke | Light-activated ion channel molecules and uses thereof |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
US8973531B2 (en) * | 2010-12-09 | 2015-03-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Automated continuous zooplankton culture system |
PL3254703T3 (pl) | 2011-04-22 | 2020-10-05 | The Regents Of The University Of California | Wiriony wirusa towarzyszącego adenowirusom z różnymi kapsydami i sposoby ich zastosowania |
US9163094B2 (en) | 2011-09-27 | 2015-10-20 | Massachusetts Institute Of Technology | Light-activated fusion proteins and uses therefor |
ES2660114T3 (es) | 2011-11-12 | 2018-03-20 | Massachusetts Institute Of Technology | Canalrodopsinas para el control óptico de células |
CN104093833B (zh) | 2011-12-16 | 2017-11-07 | 斯坦福大学托管董事会 | 视蛋白多肽及其使用方法 |
EP2817068B1 (en) | 2012-02-21 | 2017-04-12 | The Board of Trustees of the Leland Stanford Junior University | Compositions for treating neurogenic disorders of the pelvic floor |
US10947281B2 (en) | 2012-03-05 | 2021-03-16 | Wayne State University | Identification of channelrhodopsin-2 (ChR2) mutations and methods of use |
US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
ES2742492T3 (es) | 2013-03-15 | 2020-02-14 | Univ Leland Stanford Junior | Control optogenético del estado conductual |
US10220092B2 (en) | 2013-04-29 | 2019-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
WO2015023782A1 (en) | 2013-08-14 | 2015-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for controlling pain |
EP3102290A1 (en) | 2014-02-07 | 2016-12-14 | Massachusetts Institute Of Technology | Blue light-activated ion channel molecules and uses thereof |
CA2946514C (en) | 2014-04-22 | 2023-08-29 | Q-State Biosciences, Inc. | Optogenetic analysis of compounds |
CA2947771A1 (en) | 2014-06-18 | 2015-12-23 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
US10882892B2 (en) | 2014-08-05 | 2021-01-05 | Massachusetts Institute Of Technology | Channelrhodopsin variants and uses thereof |
US10077463B2 (en) | 2015-01-15 | 2018-09-18 | President And Fellows Of Harvard College | Optical selection of cells |
US10048275B2 (en) | 2015-03-13 | 2018-08-14 | Q-State Biosciences, Inc. | Cardiotoxicity screening methods |
JP2018509909A (ja) | 2015-03-19 | 2018-04-12 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 陰イオンチャネルロドプシンの組成物及び使用方法 |
EP3298448A4 (en) | 2015-05-21 | 2019-03-27 | Q-State Biosciences, Inc. | OPTOGENETIC MICROSCOPE |
WO2016209654A1 (en) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
EP3350330B1 (en) | 2015-09-15 | 2022-06-22 | Friedrich Miescher Institute for Biomedical Research | Novel therapeutical tools and methods for treating blindness by targeting photoreceptors |
CA3025975A1 (en) | 2016-04-29 | 2017-11-02 | Gensight Biologics Sa | Optogenetic visual restoration using chrimson |
US20190209708A1 (en) | 2016-05-17 | 2019-07-11 | Friedrich Miescher Institute For Biomedical Research | Novel therapeutic tools and methods for treating blindness |
WO2017207761A1 (en) | 2016-06-03 | 2017-12-07 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Mutant light-inducible ion channel of chrimson |
KR20190020702A (ko) * | 2016-06-03 | 2019-03-04 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | 채널로돕신의 돌연변이 광-유도성 이온 채널 |
EP3570895A1 (en) | 2017-01-17 | 2019-11-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
KR20200103634A (ko) | 2017-10-20 | 2020-09-02 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 치료적으로 유효한 양의 재조합 aav9- 유도 벡터의 망막하 전달을 포함하는 대상체의 원추 광수용체 내 관심의 폴리뉴클레오티드를 발현하는 방법 |
KR102048458B1 (ko) * | 2018-01-26 | 2019-11-25 | 한국과학기술연구원 | 테트라셀미스를 포함하는 눈 건강 개선용 조성물 |
EP4223768A1 (en) | 2022-02-04 | 2023-08-09 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2580277B1 (fr) * | 1985-04-15 | 1988-06-10 | Oreal | Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant |
CA1322439C (en) * | 1988-03-28 | 1993-09-28 | Junji Ohyama | Ion permeable membrane and ion transport method by utilizing said membrane |
JP3128386B2 (ja) | 1993-04-07 | 2001-01-29 | 三洋電機株式会社 | 神経モデル素子 |
US7144733B2 (en) * | 2001-08-16 | 2006-12-05 | Sloan-Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
-
2002
- 2002-04-11 DE DE10216005A patent/DE10216005A1/de not_active Ceased
-
2003
- 2003-04-11 US US10/510,628 patent/US7824869B2/en active Active
- 2003-04-11 WO PCT/EP2003/003799 patent/WO2003084994A2/de not_active Application Discontinuation
- 2003-04-11 AT AT03727297T patent/ATE412063T1/de active
- 2003-04-11 AU AU2003233968A patent/AU2003233968A1/en not_active Abandoned
- 2003-04-11 ES ES03727297T patent/ES2315495T3/es not_active Expired - Lifetime
- 2003-04-11 DE DE50310674T patent/DE50310674D1/de not_active Expired - Lifetime
- 2003-04-11 EP EP08016563.2A patent/EP2055714B1/de not_active Expired - Lifetime
- 2003-04-11 DK DK03727297T patent/DK1492881T3/da active
- 2003-04-11 EP EP03727297A patent/EP1492881B1/de not_active Expired - Lifetime
-
2010
- 2010-05-18 US US12/781,962 patent/US8202699B2/en not_active Expired - Lifetime
-
2012
- 2012-04-23 US US13/453,154 patent/US8647870B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US8647870B2 (en) | 2014-02-11 |
DE10216005A1 (de) | 2003-10-30 |
AU2003233968A8 (en) | 2003-10-20 |
US8202699B2 (en) | 2012-06-19 |
EP1492881A2 (de) | 2005-01-05 |
WO2003084994A2 (de) | 2003-10-16 |
EP2055714A2 (de) | 2009-05-06 |
US20110086421A1 (en) | 2011-04-14 |
US7824869B2 (en) | 2010-11-02 |
EP2055714B1 (de) | 2014-05-07 |
DE50310674D1 (de) | 2008-12-04 |
ATE412063T1 (de) | 2008-11-15 |
EP1492881B1 (de) | 2008-10-22 |
EP2055714A3 (de) | 2009-08-12 |
US20130017597A1 (en) | 2013-01-17 |
AU2003233968A1 (en) | 2003-10-20 |
ES2315495T3 (es) | 2009-04-01 |
US20050202398A1 (en) | 2005-09-15 |
WO2003084994A3 (de) | 2004-02-05 |
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