DK146765C - Fremgangsmaade til isolering af vindolin, catharantin, 3',4'-anhydrovinblastin, vincristin, vinblastin, leurosin, desacetylvinblastin og 4-desacetoxyvinblastin samt n-desmetylvinblastin i til vincristin omdannet form fra toerrede dele af planten vinca rosea l - Google Patents

Fremgangsmaade til isolering af vindolin, catharantin, 3',4'-anhydrovinblastin, vincristin, vinblastin, leurosin, desacetylvinblastin og 4-desacetoxyvinblastin samt n-desmetylvinblastin i til vincristin omdannet form fra toerrede dele af planten vinca rosea l

Info

Publication number
DK146765C
DK146765C DK239178A DK239178A DK146765C DK 146765 C DK146765 C DK 146765C DK 239178 A DK239178 A DK 239178A DK 239178 A DK239178 A DK 239178A DK 146765 C DK146765 C DK 146765C
Authority
DK
Denmark
Prior art keywords
vindolin
velinin
vastlinin
desmetylinine
desacetylvinblastin
Prior art date
Application number
DK239178A
Other languages
English (en)
Other versions
DK239178A (da
DK146765B (da
Inventor
Karola Jovanovics
Gyoergy Fekete
Eszter Dezseri
Lajos Dancsi
Csaba Lorincz
Bela Szarvady
Gyoergy Dobo
Csaba Szantay
Lajos Szabo
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DK239178A publication Critical patent/DK239178A/da
Publication of DK146765B publication Critical patent/DK146765B/da
Application granted granted Critical
Publication of DK146765C publication Critical patent/DK146765C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK239178A 1977-05-31 1978-05-30 Fremgangsmaade til isolering af vindolin, catharantin, 3',4'-anhydrovinblastin, vincristin, vinblastin, leurosin, desacetylvinblastin og 4-desacetoxyvinblastin samt n-desmetylvinblastin i til vincristin omdannet form fra toerrede dele af planten vinca rosea l DK146765C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HURI000638 1977-05-31
HU77RI638A HU178084B (en) 1977-05-31 1977-05-31 New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue

Publications (3)

Publication Number Publication Date
DK239178A DK239178A (da) 1978-12-01
DK146765B DK146765B (da) 1983-12-27
DK146765C true DK146765C (da) 1984-06-04

Family

ID=11001035

Family Applications (1)

Application Number Title Priority Date Filing Date
DK239178A DK146765C (da) 1977-05-31 1978-05-30 Fremgangsmaade til isolering af vindolin, catharantin, 3',4'-anhydrovinblastin, vincristin, vinblastin, leurosin, desacetylvinblastin og 4-desacetoxyvinblastin samt n-desmetylvinblastin i til vincristin omdannet form fra toerrede dele af planten vinca rosea l

Country Status (19)

Country Link
US (1) US4172077A (da)
JP (1) JPS5439100A (da)
AT (1) AT364469B (da)
AU (1) AU515713B2 (da)
BE (1) BE867670A (da)
CA (1) CA1094552A (da)
CH (1) CH640861A5 (da)
DD (1) DD136139A5 (da)
DE (1) DE2823461A1 (da)
DK (1) DK146765C (da)
FR (1) FR2393002A1 (da)
GB (1) GB1602633A (da)
HU (1) HU178084B (da)
IL (1) IL54761A (da)
IT (1) IT1096605B (da)
NL (1) NL7805881A (da)
SE (1) SE437829B (da)
SU (1) SU867313A3 (da)
YU (1) YU129378A (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (da) * 1974-12-30 1978-07-21 Anvar
FR2544318B1 (fr) * 1983-04-14 1985-08-16 Fabre Sa Pierre Procede de preparation de vindoline et de catharanthine
US4778885A (en) * 1986-09-18 1988-10-18 Allelix Inc. Production of alkaloid dimers using ferric ion
US4749787A (en) * 1986-10-23 1988-06-07 Harbor Branch Oceanographic Institution, Inc. Process of isolating vinblastine from the plant catharanthis roseus
US4831133A (en) * 1987-05-01 1989-05-16 Allelix, Inc. Extraction of alkaloids of Catharanthus roseus tissue
US5907044A (en) 1997-07-30 1999-05-25 Degussa Aktiengellschaft Method of isolating 1- N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE)
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2005030237A1 (en) * 2003-09-26 2005-04-07 Señor Rafael Phil. Inc. A pharmaceutical composition comprising catharanthus roseaus, (vinca rosea), its preparation and use thereof
CN100374446C (zh) * 2005-12-19 2008-03-12 东北林业大学 一种从长春花中分离文多灵、长春质碱、长春碱和长春新碱的方法
CN104262362B (zh) * 2014-09-01 2017-02-15 海南希源化工科技有限公司 一种长春碱的提取及纯化方法
CN104370910B (zh) * 2014-12-13 2016-08-31 海南大学 一种文多林的提取及纯化方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3352868A (en) * 1964-04-01 1967-11-14 Lilly Co Eli Dihydrovinblastine
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3225030A (en) * 1965-02-15 1965-12-21 Lilly Co Eli Method of preparing leurosine and vincaleukoblastine
US3422112A (en) * 1968-01-22 1969-01-14 Lilly Co Eli Indolyl vindolines
AT313485B (de) * 1971-09-17 1974-02-25 Richter Gedeon Vegyeszet Verfahren zur selektiven Gewinnung von Vinblastin, Vinleurosin und Vinchristin oder deren Salzen
US3932417A (en) * 1973-10-24 1976-01-13 Eli Lilly And Company Dimeric indole alkaloid purification process

Also Published As

Publication number Publication date
DD136139A5 (de) 1979-06-20
AT364469B (de) 1981-10-27
IT1096605B (it) 1985-08-26
SU867313A3 (ru) 1981-09-23
BE867670A (fr) 1978-09-18
IL54761A0 (en) 1978-07-31
SE437829B (sv) 1985-03-18
ATA391578A (de) 1981-03-15
GB1602633A (en) 1981-11-11
SE7805900L (sv) 1978-12-01
DK239178A (da) 1978-12-01
HU178084B (en) 1982-03-28
DE2823461A1 (de) 1978-12-14
FR2393002B1 (da) 1983-05-20
CA1094552A (en) 1981-01-27
AU3664978A (en) 1979-12-06
IT7824055A0 (it) 1978-05-31
US4172077A (en) 1979-10-23
YU129378A (en) 1983-10-31
FR2393002A1 (fr) 1978-12-29
AU515713B2 (en) 1981-04-16
IL54761A (en) 1981-09-13
DK146765B (da) 1983-12-27
NL7805881A (nl) 1978-12-04
JPS5439100A (en) 1979-03-24
CH640861A5 (de) 1984-01-31

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