DK141120B - Analogifremgangsmåde til fremstilling af terapeutisk aktive amidoximderivater eller salte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af terapeutisk aktive amidoximderivater eller salte deraf. Download PDF

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Publication number
DK141120B
DK141120B DK256768AA DK256768A DK141120B DK 141120 B DK141120 B DK 141120B DK 256768A A DK256768A A DK 256768AA DK 256768 A DK256768 A DK 256768A DK 141120 B DK141120 B DK 141120B
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Prior art keywords
group
formula
salts
general formula
compound
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Application number
DK256768AA
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Danish (da)
English (en)
Other versions
DK141120C (de
Inventor
Kalman Harsanyi
Pal Kiss
Laszlo Tardos
Kalman Takacs
Zsuzsa Relle
Eva Milak
Dezsoe Korbinats
Csaba Goenczy
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
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Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of DK141120B publication Critical patent/DK141120B/da
Application granted granted Critical
Publication of DK141120C publication Critical patent/DK141120C/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK256768AA 1967-06-06 1968-05-31 Analogifremgangsmåde til fremstilling af terapeutisk aktive amidoximderivater eller salte deraf. DK141120B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUCI000714 1967-06-06
HUCI000714 1967-06-06

Publications (2)

Publication Number Publication Date
DK141120B true DK141120B (da) 1980-01-21
DK141120C DK141120C (de) 1980-07-14

Family

ID=10994338

Family Applications (1)

Application Number Title Priority Date Filing Date
DK256768AA DK141120B (da) 1967-06-06 1968-05-31 Analogifremgangsmåde til fremstilling af terapeutisk aktive amidoximderivater eller salte deraf.

Country Status (17)

Country Link
US (1) US3673188A (de)
AT (1) AT277234B (de)
BE (1) BE716174A (de)
BR (1) BR6899612D0 (de)
CA (1) CA925869A (de)
CH (1) CH526539A (de)
CS (1) CS168502B2 (de)
DE (1) DE1670497C3 (de)
DK (1) DK141120B (de)
FI (1) FI52857C (de)
FR (1) FR7892M (de)
GB (1) GB1187348A (de)
IL (1) IL29976A (de)
NL (1) NL139238B (de)
NO (1) NO127054B (de)
SE (1) SE335128B (de)
YU (1) YU33285B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948928A (en) * 1972-03-17 1976-04-06 Dainippon Pharmaceutical Co., Ltd. 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable acid addition salts thereof
US3907822A (en) * 1973-06-11 1975-09-23 Squibb & Sons Inc Anti-inflammatory (2-benzimidazoylthio)alkylamidoximes
US4112111A (en) * 1975-02-26 1978-09-05 Sandoz Ltd. Indolinylguanidines
US4048176A (en) * 1976-07-23 1977-09-13 Morton-Norwich Products, Inc. 2-(3-Methyl-4-phenyl-1,2,3,4-tetrahydro-2-isoquinolyl)-acetamidoxime dihydrochloride
FR2506767A1 (fr) 1981-05-26 1982-12-03 Synthelabo Derives heterocycliques d'amidoximes, leur preparation et leur application en therapeutique
HU190377B (en) * 1982-03-12 1986-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing theophyllinyl-alkyl-oxadiazoles
EP0225726B1 (de) * 1985-11-08 1991-04-17 Glaxo Group Limited Indolderivate
WO1988000695A1 (en) * 1986-07-24 1988-01-28 Quest Systems, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
AU4858596A (en) * 1995-09-15 1997-04-01 Torrey Pines Institute For Molecular Studies Synthesis of quinazolinone libraries

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3150135A (en) * 1962-11-13 1964-09-22 Fmc Corp Preparation of oximes
US3354174A (en) * 1964-02-19 1967-11-21 Sterling Drug Inc 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines
US3472872A (en) * 1964-02-19 1969-10-14 Sterling Drug Inc Indolyl-lower-alkyl-amidoximes
US3420847A (en) * 1964-02-19 1969-01-07 Sterling Drug Inc Pyrrolyl-lower-alkyl-amidoximes
US3539576A (en) * 1967-07-17 1970-11-10 American Home Prod 1,2,3,7,8,12b-hexahydrobenzo(1,2)cyclohepta(3,4,5 - d,e) isoquinolinomethyleneamidoximes and esters thereof
US3505336A (en) * 1968-05-06 1970-04-07 Sterling Drug Inc 3,4-dihydro-2-(1h)-isoquinolinecarboxamidoximes and lower-alkanoates

Also Published As

Publication number Publication date
NL139238B (nl) 1973-07-16
DE1670497B2 (de) 1973-05-24
DK141120C (de) 1980-07-14
GB1187348A (en) 1970-04-08
DE1670497C3 (de) 1973-12-20
CH526539A (de) 1972-08-15
NO127054B (de) 1973-04-30
BE716174A (de) 1968-11-04
YU128568A (en) 1976-03-31
FI52857C (fi) 1977-12-12
BR6899612D0 (pt) 1973-05-10
NL6807919A (de) 1968-12-09
AT277234B (de) 1969-12-10
US3673188A (en) 1972-06-27
CA925869A (en) 1973-05-08
FR7892M (de) 1970-05-04
IL29976A0 (en) 1968-07-25
SE335128B (de) 1971-05-17
CS168502B2 (de) 1976-06-29
DE1670497A1 (de) 1972-01-27
FI52857B (de) 1977-08-31
IL29976A (en) 1971-11-29
YU33285B (en) 1976-08-31

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