DK139974B - Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel. - Google Patents
Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel.Info
- Publication number
- DK139974B DK139974B DK603371AA DK603371A DK139974B DK 139974 B DK139974 B DK 139974B DK 603371A A DK603371A A DK 603371AA DK 603371 A DK603371 A DK 603371A DK 139974 B DK139974 B DK 139974B
- Authority
- DK
- Denmark
- Prior art keywords
- dihydrothebain
- thebain
- dihydrocodeinone
- reduction
- preparation
- Prior art date
Links
- 239000003638 chemical reducing agent Substances 0.000 title 1
- RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical compound N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 title 1
- 229910000071 diazene Inorganic materials 0.000 title 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title 1
- 229960000240 hydrocodone Drugs 0.000 title 1
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 title 1
- QKQQEIVDLRUZRP-UHFFFAOYSA-N northebaine Natural products COC1=CC=C2C(NCC3)CC4=CC=C(OC)C5=C4C23C1O5 QKQQEIVDLRUZRP-UHFFFAOYSA-N 0.000 title 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5892670 | 1970-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK139974B true DK139974B (da) | 1979-05-28 |
| DK139974C DK139974C (en:Method) | 1979-12-10 |
Family
ID=10482707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK603371AA DK139974B (da) | 1970-12-11 | 1971-12-09 | Fremgangsmåde til fremstilling af 8,14-dihydrothebain eller dihydrocodeinon ud fra thebain ved reduktion under anvendelse af diimin dannet som ustabilt mellemprodukt som reduktionsmiddel. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US3812132A (en:Method) |
| JP (1) | JPS5511678B1 (en:Method) |
| AU (1) | AU459401B2 (en:Method) |
| BE (1) | BE776304A (en:Method) |
| CA (1) | CA958412A (en:Method) |
| CH (1) | CH556340A (en:Method) |
| CS (1) | CS176251B2 (en:Method) |
| DE (1) | DE2159348A1 (en:Method) |
| DK (1) | DK139974B (en:Method) |
| FR (1) | FR2117924B1 (en:Method) |
| GB (1) | GB1317210A (en:Method) |
| HU (1) | HU164465B (en:Method) |
| IL (1) | IL38268A (en:Method) |
| NL (1) | NL175622C (en:Method) |
| PL (1) | PL81441B1 (en:Method) |
| SE (1) | SE388422B (en:Method) |
| YU (1) | YU39064B (en:Method) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59142770A (ja) * | 1983-02-02 | 1984-08-16 | Trio Kenwood Corp | カセツトテ−プレコ−ダの駆動機構 |
| GB2429206A (en) * | 2004-07-09 | 2007-02-21 | Tasmanian Alkaloids Pty Ltd | Process for the synthesis of hydromorphone |
| US20080125592A1 (en) * | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| WO2008048711A1 (en) | 2006-10-17 | 2008-04-24 | Penick Corporation | Process for preparing oxymorphone |
| GB0624880D0 (en) * | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
| US9131649B2 (en) * | 2008-03-07 | 2015-09-15 | Tasmanian Alkaloids Pty. Ltd | Papaver somniferum strain with high concentration of thebaine |
| US8541647B2 (en) | 2008-05-29 | 2013-09-24 | Tasmania Alkaloids Pty, Ltd. | Papaver somniferum with high concentration of codeine |
| AU2010298514B2 (en) * | 2009-09-22 | 2014-11-20 | SpecGx LLC | Methods for producing hydrocodone, hydromorphone or a derivative thereof |
| CA2802294C (en) | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| JP5736040B2 (ja) | 2010-06-11 | 2015-06-17 | ローズ テクノロジーズ | Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
| US9120800B2 (en) | 2013-08-02 | 2015-09-01 | Johnson Matthey Public Limited Company | Process for the preparation of oxymorphone alkaloid and oxymorphone salts |
| US9273060B2 (en) | 2014-03-05 | 2016-03-01 | Johnson Matthey Public Limited Company | Processes for making hydrocodone, hydromorphone and their derivatives |
| WO2015134003A1 (en) | 2014-03-05 | 2015-09-11 | Johnson Matthey Public Limited Company | Processes for making hydrocodone, hydromorphone and their derivatives |
| US10155771B2 (en) | 2015-11-04 | 2018-12-18 | Noramco, Inc. | Selective reduction of morphinan alkaloids |
-
1970
- 1970-12-11 GB GB5892670A patent/GB1317210A/en not_active Expired
-
1971
- 1971-11-24 PL PL1971151754A patent/PL81441B1/pl unknown
- 1971-11-30 IL IL38268A patent/IL38268A/en unknown
- 1971-11-30 CA CA128,915A patent/CA958412A/en not_active Expired
- 1971-11-30 DE DE19712159348 patent/DE2159348A1/de not_active Withdrawn
- 1971-12-02 US US00204298A patent/US3812132A/en not_active Expired - Lifetime
- 1971-12-03 AU AU36469/71A patent/AU459401B2/en not_active Expired
- 1971-12-06 BE BE776304A patent/BE776304A/xx not_active IP Right Cessation
- 1971-12-07 FR FR7143867A patent/FR2117924B1/fr not_active Expired
- 1971-12-07 JP JP9899371A patent/JPS5511678B1/ja active Pending
- 1971-12-09 YU YU03086/71A patent/YU39064B/xx unknown
- 1971-12-09 DK DK603371AA patent/DK139974B/da unknown
- 1971-12-09 CS CS8571A patent/CS176251B2/cs unknown
- 1971-12-10 SE SE7115886A patent/SE388422B/xx unknown
- 1971-12-10 CH CH1811571A patent/CH556340A/xx not_active IP Right Cessation
- 1971-12-10 HU HUMA2294A patent/HU164465B/hu unknown
- 1971-12-13 NL NLAANVRAGE7117082,A patent/NL175622C/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE776304A (fr) | 1972-06-06 |
| CS176251B2 (en:Method) | 1977-06-30 |
| IL38268A0 (en) | 1972-01-27 |
| GB1317210A (en) | 1973-05-16 |
| HU164465B (en:Method) | 1974-02-28 |
| YU308671A (en) | 1982-06-30 |
| PL81441B1 (en:Method) | 1975-08-30 |
| IL38268A (en) | 1974-11-29 |
| FR2117924B1 (en:Method) | 1975-02-07 |
| DE2159348A1 (de) | 1972-06-15 |
| US3812132A (en) | 1974-05-21 |
| NL175622C (nl) | 1984-12-03 |
| FR2117924A1 (en:Method) | 1972-07-28 |
| CA958412A (en) | 1974-11-26 |
| YU39064B (en) | 1984-04-30 |
| NL175622B (nl) | 1984-07-02 |
| AU3646971A (en) | 1973-06-07 |
| CH556340A (de) | 1974-11-29 |
| AU459401B2 (en) | 1975-03-27 |
| SE388422B (sv) | 1976-10-04 |
| NL7117082A (en:Method) | 1972-06-13 |
| DK139974C (en:Method) | 1979-12-10 |
| JPS5511678B1 (en:Method) | 1980-03-26 |
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