DK1395587T3 - Fremgangsmåde til fremstilling af imipenem - Google Patents

Fremgangsmåde til fremstilling af imipenem

Info

Publication number
DK1395587T3
DK1395587T3 DK02730567T DK02730567T DK1395587T3 DK 1395587 T3 DK1395587 T3 DK 1395587T3 DK 02730567 T DK02730567 T DK 02730567T DK 02730567 T DK02730567 T DK 02730567T DK 1395587 T3 DK1395587 T3 DK 1395587T3
Authority
DK
Denmark
Prior art keywords
preparing imipenem
imipenem
preparing
Prior art date
Application number
DK02730567T
Other languages
Danish (da)
English (en)
Inventor
Yatendra Kumar
Neera Tewari
Bishwa Prakash Rai
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of DK1395587T3 publication Critical patent/DK1395587T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK02730567T 2001-05-18 2002-05-15 Fremgangsmåde til fremstilling af imipenem DK1395587T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN594DE2001 2001-05-18
PCT/IB2002/001670 WO2002094828A1 (en) 2001-05-18 2002-05-15 Process for the preparation of imipenem

Publications (1)

Publication Number Publication Date
DK1395587T3 true DK1395587T3 (da) 2009-10-12

Family

ID=11097061

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02730567T DK1395587T3 (da) 2001-05-18 2002-05-15 Fremgangsmåde til fremstilling af imipenem

Country Status (19)

Country Link
US (1) US7462712B2 (no)
EP (1) EP1395587B1 (no)
JP (1) JP2005508860A (no)
KR (1) KR20040002973A (no)
CN (1) CN1694885A (no)
AR (1) AR035978A1 (no)
AT (1) ATE437879T1 (no)
BR (1) BR0209842A (no)
CA (1) CA2447227A1 (no)
DE (1) DE60233130D1 (no)
DK (1) DK1395587T3 (no)
EA (1) EA007252B1 (no)
ES (1) ES2328117T3 (no)
MX (1) MXPA03010498A (no)
NO (1) NO20035136D0 (no)
PL (1) PL370705A1 (no)
PT (1) PT1395587E (no)
WO (1) WO2002094828A1 (no)
ZA (1) ZA200308958B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE437879T1 (de) * 2001-05-18 2009-08-15 Ranbaxy Lab Ltd Verfahren zur herstellung von imipenem
MXPA06001115A (es) * 2003-12-09 2006-04-11 Choongwae Pharm Co Un proceso nuevo para la preparacion de imipenem.
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
WO2010146449A1 (en) * 2009-06-18 2010-12-23 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of imipenam
CN101921274B (zh) * 2010-07-16 2012-09-26 深圳市海滨制药有限公司 一种制备亚胺培南的方法
CN101921275B (zh) * 2010-07-16 2012-09-26 深圳市海滨制药有限公司 一种制备亚胺培南的方法
CN101921273B (zh) * 2010-07-16 2012-09-26 深圳市海滨制药有限公司 一种制备亚胺培南的方法
JP6486835B2 (ja) 2013-01-18 2019-03-20 コデクシス， インコーポレイテッド カルバペネム合成に有用な人口生体触媒
CN110790765B (zh) * 2018-08-02 2022-08-05 江苏瑞科医药科技有限公司 一种亚胺培南的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
US4745188A (en) * 1980-11-21 1988-05-17 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4374772A (en) * 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4640915A (en) * 1982-03-29 1987-02-03 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
US4644061A (en) * 1982-09-28 1987-02-17 Bristol-Myers Company Carbapenem antibiotics
US4782051A (en) * 1985-06-10 1988-11-01 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5672701A (en) * 1990-01-16 1997-09-30 Bristol-Myers Squibb Company 4-substituted alkyl carbapenem antibiotics
AU3904493A (en) * 1992-04-13 1993-11-18 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (no) * 2000-11-03 2004-01-03 Ranbaxy Lab Ltd
ATE437879T1 (de) * 2001-05-18 2009-08-15 Ranbaxy Lab Ltd Verfahren zur herstellung von imipenem
MXPA03010548A (es) * 2001-05-18 2004-05-27 Ranbaxy Lab Ltd Proceso para el aislamiento de imipenem cristalino.
MXPA06001115A (es) * 2003-12-09 2006-04-11 Choongwae Pharm Co Un proceso nuevo para la preparacion de imipenem.

Also Published As

Publication number Publication date
CA2447227A1 (en) 2002-11-28
EA200301224A1 (ru) 2004-12-30
BR0209842A (pt) 2005-01-04
CN1694885A (zh) 2005-11-09
MXPA03010498A (es) 2004-05-27
EP1395587A1 (en) 2004-03-10
US7462712B2 (en) 2008-12-09
EA007252B1 (ru) 2006-08-25
NO20035136D0 (no) 2003-11-18
EP1395587B1 (en) 2009-07-29
PT1395587E (pt) 2009-09-03
ZA200308958B (en) 2004-07-19
KR20040002973A (ko) 2004-01-07
AR035978A1 (es) 2004-07-28
DE60233130D1 (de) 2009-09-10
ES2328117T3 (es) 2009-11-10
EP1395587A4 (en) 2004-09-15
JP2005508860A (ja) 2005-04-07
WO2002094828A1 (en) 2002-11-28
US20040220168A1 (en) 2004-11-04
PL370705A1 (en) 2005-05-30
ATE437879T1 (de) 2009-08-15

Similar Documents

Publication Publication Date Title
DK1303478T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1277722T3 (da) Fremgangsmåde til fremstilling af methanol
DK1182261T3 (da) Fremgangsmåde til frembringelse af basisk aminosyre
DK1293507T3 (da) Fremgangsmåde til fremstilling af krystaller
DK1412459T3 (da) Fremgangsmåde til fremstilling af mellemdestillater
DK1252824T3 (da) Fremgangsmåde til forbedring af knoglemineralisering
DK2058243T3 (da) Fremgangsmåde til fremstilling af drikke
DK1226188T3 (da) Fremgangsmåde til fremstilling af mannichaddukter, som indeholder polyisobutenphenol
DK2135957T3 (da) Fremgangsmåde til fremstilling af glucaner
DK1296935T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1309545T3 (da) Fremgangsmåde til fremstilling af alkylarylsulfonater
DK1380121T3 (da) Fremgangsmåde til fremstilling af oxazolidinoner
DK1385826T3 (da) Fremgangsmåde til fremstilling af (S)-(+)- og (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azapin-5-carboxamid
DK1536685T3 (da) Fremgangsmåde til fremstilling af pasta-ekstruderede sulfonamidsammensætninger
DK1353923T3 (da) Forbedret fremgangsmåde til syntese af carbapenem
DK1335995T3 (da) Fremgangsmåde til fremstilling af en fordampningskilde
DK1572613T3 (da) Fremgangsmåde til fremstilling af benzophenoner
DK1575941T3 (da) Fremgangsmåde til fremstilling af (S)-pantoprazol
DK1395587T3 (da) Fremgangsmåde til fremstilling af imipenem
DK1326836T3 (da) Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-methylpyridin
DK1578720T3 (da) Fremgangsmåde til fremstilling af gamma-cyhalothrin
ITMI20021031A1 (it) Procedimento per preparare policarbonato-polioli
NO20035137D0 (no) Fremgangsmåte til isolering av krystallinsk imipenem
DK1368483T3 (da) Fremgangsmåde til fremstilling af polypeptider
DK1385806T3 (da) Ettrinsfremgangsmåde til fremstilling af trimethoxytoluen