DK1390372T3 - 1-oxa-3,9-diaza-spiro '5,5]undecan-2-on-derivater og anvendelse deraf som neurokininreceptorantagonist - Google Patents
1-oxa-3,9-diaza-spiro '5,5]undecan-2-on-derivater og anvendelse deraf som neurokininreceptorantagonistInfo
- Publication number
- DK1390372T3 DK1390372T3 DK02742943T DK02742943T DK1390372T3 DK 1390372 T3 DK1390372 T3 DK 1390372T3 DK 02742943 T DK02742943 T DK 02742943T DK 02742943 T DK02742943 T DK 02742943T DK 1390372 T3 DK1390372 T3 DK 1390372T3
- Authority
- DK
- Denmark
- Prior art keywords
- undecan
- diaza
- oxa
- spiro
- derivatives
- Prior art date
Links
- 229940122540 Neurokinin receptor antagonist Drugs 0.000 title 1
- 239000002462 tachykinin receptor antagonist Substances 0.000 title 1
- KYWIYKKSMDLRDC-UHFFFAOYSA-N undecan-2-one Chemical class CCCCCCCCCC(C)=O KYWIYKKSMDLRDC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01111644 | 2001-05-14 | ||
| PCT/EP2002/004935 WO2002092604A1 (en) | 2001-05-14 | 2002-05-06 | 1-oxa-3,9-diaza-spiro'5,5!undecan-2-ones derivatives and its use as antagonist of the neurikinin receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1390372T3 true DK1390372T3 (da) | 2008-09-15 |
Family
ID=8177412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02742943T DK1390372T3 (da) | 2001-05-14 | 2002-05-06 | 1-oxa-3,9-diaza-spiro '5,5]undecan-2-on-derivater og anvendelse deraf som neurokininreceptorantagonist |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6599900B2 (https=) |
| EP (1) | EP1390372B1 (https=) |
| JP (1) | JP4056887B2 (https=) |
| KR (1) | KR100618063B1 (https=) |
| CN (1) | CN1264847C (https=) |
| AR (1) | AR033631A1 (https=) |
| AT (1) | ATE401333T1 (https=) |
| AU (1) | AU2002342238B2 (https=) |
| BR (1) | BR0209604A (https=) |
| CA (1) | CA2447329C (https=) |
| DE (1) | DE60227657D1 (https=) |
| DK (1) | DK1390372T3 (https=) |
| ES (1) | ES2310206T3 (https=) |
| MX (1) | MXPA03010321A (https=) |
| PT (1) | PT1390372E (https=) |
| WO (1) | WO2002092604A1 (https=) |
| ZA (1) | ZA200308535B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2006132465A (ru) * | 2004-02-10 | 2008-03-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Модуляторы хемокинового рецептора ccr5 |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| DE602006014531D1 (de) * | 2005-03-03 | 2010-07-08 | Janssen Pharmaceutica Nv | Substituierte oxadiazaspiro-ä5.5ü-undecanonderivate und ihre verwendung als neurokininantagonisten |
| NZ556628A (en) | 2005-03-08 | 2009-09-25 | Janssen Pharmaceutica Nv | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists |
| US7470684B2 (en) * | 2007-01-03 | 2008-12-30 | Hoffmann-La Roche Inc. | Spiropiperidine derivatives as NK3 antagonists |
| EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| WO2008119663A1 (en) | 2007-03-29 | 2008-10-09 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| UA121775C2 (uk) | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl |
| EP3571191A1 (en) | 2017-01-20 | 2019-11-27 | Pfizer Inc | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors |
| EP3571202B1 (en) | 2017-01-23 | 2021-06-30 | Pfizer Inc. | Heterocyclic spiro compounds as magl inhibitors |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2131021B (en) * | 1982-11-24 | 1985-12-18 | Erba Farmitalia | Antipsychotic benzoxazines |
| IL111960A (en) * | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| WO1997011940A1 (en) * | 1995-09-29 | 1997-04-03 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
-
2002
- 2002-05-06 CN CNB028094735A patent/CN1264847C/zh not_active Expired - Fee Related
- 2002-05-06 EP EP02742943A patent/EP1390372B1/en not_active Expired - Lifetime
- 2002-05-06 AT AT02742943T patent/ATE401333T1/de not_active IP Right Cessation
- 2002-05-06 KR KR1020037014713A patent/KR100618063B1/ko not_active Expired - Fee Related
- 2002-05-06 PT PT02742943T patent/PT1390372E/pt unknown
- 2002-05-06 DK DK02742943T patent/DK1390372T3/da active
- 2002-05-06 DE DE60227657T patent/DE60227657D1/de not_active Expired - Lifetime
- 2002-05-06 MX MXPA03010321A patent/MXPA03010321A/es active IP Right Grant
- 2002-05-06 ES ES02742943T patent/ES2310206T3/es not_active Expired - Lifetime
- 2002-05-06 JP JP2002589488A patent/JP4056887B2/ja not_active Expired - Fee Related
- 2002-05-06 AU AU2002342238A patent/AU2002342238B2/en not_active Ceased
- 2002-05-06 WO PCT/EP2002/004935 patent/WO2002092604A1/en not_active Ceased
- 2002-05-06 CA CA002447329A patent/CA2447329C/en not_active Expired - Fee Related
- 2002-05-06 BR BR0209604-8A patent/BR0209604A/pt not_active IP Right Cessation
- 2002-05-10 AR ARP020101705A patent/AR033631A1/es unknown
- 2002-05-10 US US10/143,431 patent/US6599900B2/en not_active Expired - Fee Related
-
2003
- 2003-10-31 ZA ZA200308535A patent/ZA200308535B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1390372B1 (en) | 2008-07-16 |
| CA2447329C (en) | 2009-07-28 |
| KR100618063B1 (ko) | 2006-08-30 |
| MXPA03010321A (es) | 2004-02-17 |
| ES2310206T3 (es) | 2009-01-01 |
| CA2447329A1 (en) | 2002-11-21 |
| DE60227657D1 (de) | 2008-08-28 |
| AU2002342238B2 (en) | 2007-01-25 |
| CN1264847C (zh) | 2006-07-19 |
| WO2002092604A1 (en) | 2002-11-21 |
| JP2004534758A (ja) | 2004-11-18 |
| EP1390372A1 (en) | 2004-02-25 |
| US6599900B2 (en) | 2003-07-29 |
| KR20030094405A (ko) | 2003-12-11 |
| ZA200308535B (en) | 2005-01-31 |
| AR033631A1 (es) | 2003-12-26 |
| JP4056887B2 (ja) | 2008-03-05 |
| CN1507449A (zh) | 2004-06-23 |
| ATE401333T1 (de) | 2008-08-15 |
| PT1390372E (pt) | 2008-08-25 |
| BR0209604A (pt) | 2004-03-23 |
| US20030004163A1 (en) | 2003-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE381565T1 (de) | 1,3,8-triaza-spiro 4,5 decan-4-onderivative als neurokininrezeptorantagonisten | |
| NO20041560L (no) | 1,6-nafthyridinderivater som antidiabetiske midler | |
| NO20042373L (no) | Nye 1,2,4-tiadiazoliumderivater som melanokortinreseptormodulatorer | |
| NO20043064L (no) | 1-alkyl-1-azoniabisyklo [2.2.2] oktankarbamatderivater og anvendelse av disse som muskarine reseptorantagonister | |
| NO20021719L (no) | 6-posisjon substituerte indoliner, fremstilling og anvendelse derav som medikament | |
| NO20011503L (no) | Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, deres fremstilling og anvendelse som anorektiske legemidler | |
| DE60214428D1 (de) | 1, 4-dihydro-1, 4-diphenylpyridin-derivate | |
| NO20015113L (no) | Nye forbindelser, deres fremstilling og anvendelse | |
| ATE302782T1 (de) | Substituierte 1-oxa-2,8-diaza-spiro(4,5)dec-2-en- derivate als arzneimittel gegen schmerz | |
| DK1083171T3 (da) | Pyrazolinderivater, deres fremstilling og anvendelse som medikamenter | |
| DK1095025T3 (da) | Benzimidazoler, deres fremstilling og deres anvendelse som lægemidler | |
| NO20005146L (no) | Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter | |
| NO996115D0 (no) | Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister | |
| DK1004592T3 (da) | Nye erythromycinderivater, deres fremstilling og deres anvendelse som medikamenter | |
| DK1390372T3 (da) | 1-oxa-3,9-diaza-spiro '5,5]undecan-2-on-derivater og anvendelse deraf som neurokininreceptorantagonist | |
| NO20014050D0 (no) | 1-aryl-1,3,5-triazin-4-tion-2,6-dioner, fremstilling derav og anvendelse derav som herbicider | |
| DK1147139T3 (da) | Vandig copolymerisatdespersion, fremgangsmåde til fremstilling deraf såvel som anvendelse deraf | |
| NO20004271D0 (no) | Benzylpiperazinyl- og benzylpiperidinyl etanonderivater, deres fremstilling og deres anvendelse som dopamin D4 reseptorantagonister | |
| NO20013709D0 (no) | Nye N-triazolylmetyl-piperazinderivater som neurokininreseptorantagonister | |
| DK1523473T3 (da) | Indolinderivater substitueret i position 6, deres fremstilling og anvendelse som lægemiddel. | |
| DK1296961T3 (da) | 1,4-diazepan-2,5-dionderivater og anvendelse deraf som NK-1-receptorantagonister | |
| DK1185525T3 (da) | 4-heterocyclylsulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidinderivater, fremstilling deraf samt anvendelse deraf som endothelinreceptorantagonister | |
| DK1532141T3 (da) | 2-pyrrolidin-2-yl-[1,3,4]-oxadiazol-derivater og anvendelse deraf som antidepressiv | |
| DK1189932T3 (da) | Nye echinocandinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som svampebekæmpelsesmidler | |
| DK1157020T3 (da) | Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-oler, fremgangsmåder til deres fremstilling og deres anvendelse som lægemiddel |