DK138638B - Indanderivater til anvendelse som mellemprodukter ved fremstilling af 19-nor-steroider. - Google Patents

Indanderivater til anvendelse som mellemprodukter ved fremstilling af 19-nor-steroider.

Info

Publication number
DK138638B
DK138638B DK525269AA DK525269A DK138638B DK 138638 B DK138638 B DK 138638B DK 525269A A DK525269A A DK 525269AA DK 525269 A DK525269 A DK 525269A DK 138638 B DK138638 B DK 138638B
Authority
DK
Denmark
Prior art keywords
steroids
intermediates
preparation
indane derivatives
indane
Prior art date
Application number
DK525269AA
Other languages
Danish (da)
English (en)
Other versions
DK138638C (OSRAM
Inventor
Zoltan George Hajos
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to DK228371A priority Critical patent/DK150473C/da
Priority to DK154372A priority patent/DK142053B/da
Publication of DK138638B publication Critical patent/DK138638B/da
Application granted granted Critical
Publication of DK138638C publication Critical patent/DK138638C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/26—Saturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK525269AA 1968-10-04 1969-10-02 Indanderivater til anvendelse som mellemprodukter ved fremstilling af 19-nor-steroider. DK138638B (da)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK228371A DK150473C (da) 1968-10-04 1971-05-12 Racemiske eller optisk aktive perhydroindaner til anvendelse som mellemprodukter ved fremstillingen af 19-nor-steroider
DK154372A DK142053B (da) 1968-10-04 1972-03-29 Fremgangsmåde til fremstilling af racemiske eller optisk aktive indan- eller perhydronaphthalenderivater.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US765023A US3897460A (en) 1968-10-04 1968-10-04 3{62 -Tertiarybutoxy-decahydro-benz{8 E{9 indenes

Publications (2)

Publication Number Publication Date
DK138638B true DK138638B (da) 1978-10-09
DK138638C DK138638C (OSRAM) 1979-03-19

Family

ID=25072426

Family Applications (2)

Application Number Title Priority Date Filing Date
DK525269AA DK138638B (da) 1968-10-04 1969-10-02 Indanderivater til anvendelse som mellemprodukter ved fremstilling af 19-nor-steroider.
DK525169AA DK129282B (da) 1968-10-04 1969-10-02 Fremgangsmåde til fremstilling af indanderivater.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK525169AA DK129282B (da) 1968-10-04 1969-10-02 Fremgangsmåde til fremstilling af indanderivater.

Country Status (13)

Country Link
US (1) US3897460A (OSRAM)
JP (2) JPS5227157B1 (OSRAM)
AT (3) AT291233B (OSRAM)
BE (2) BE739719A (OSRAM)
BR (3) BR6912946D0 (OSRAM)
CH (1) CH527785A (OSRAM)
DE (2) DE1949793A1 (OSRAM)
DK (2) DK138638B (OSRAM)
ES (4) ES372174A1 (OSRAM)
FR (2) FR2019927A1 (OSRAM)
GB (4) GB1224587A (OSRAM)
NL (2) NL172231C (OSRAM)
SE (5) SE365495B (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979458A (en) * 1967-12-04 1976-09-07 Syntex Corporation Production of unsaturated carbocyclic ketones
US3975440A (en) * 1970-01-21 1976-08-17 Hoffmann-La Roche Inc. Asymmetric synthesis of organic compounds
DE2409597C2 (de) * 1974-02-25 1983-12-29 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Bicycloalkan-Carbonsäuren
DE2320285C2 (de) * 1973-04-18 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Bicycloalkan-Carbonsäuren
CH583167A5 (OSRAM) * 1973-04-18 1976-12-31 Schering Ag
US3971809A (en) * 1973-07-02 1976-07-27 Hoffmann-La Roche Inc. 3A,4,7,7A-Tetrahydro-4-phenylethyl-7a-alkyl-5(6H)-indanones and process for the preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019252A (en) * 1959-06-18 1962-01-30 Lab Francais Chimiotherapie Process for the preparation of novel derivatives of cyclopentanonaphthalene and products obtained thereby
US3117979A (en) * 1960-01-22 1964-01-14 Roussel Uclaf Esters of 10beta-substituted 4, 5-seco-delta9(11)-19-nor-androstene-17beta-ol-3, 5-dines, intermediates and process
BE657260A (OSRAM) * 1962-03-06
FR1364556A (fr) * 1962-03-06 1964-06-26 Roussel Uclaf Nouveau procédé de synthèse de stéroïdes et de composés apparentés et produits utilisés dans ce procédé

Also Published As

Publication number Publication date
BR6912947D0 (pt) 1973-02-15
NL6914988A (OSRAM) 1970-04-07
BE739719A (OSRAM) 1970-04-02
GB1224588A (en) 1971-03-10
DE1949800C2 (de) 1982-04-15
GB1224587A (en) 1971-03-10
SE365495B (OSRAM) 1974-03-25
ES400148A1 (es) 1974-12-16
FR2019927A1 (OSRAM) 1970-07-10
ES400147A1 (es) 1974-12-16
SE389332B (sv) 1976-11-01
AT291233B (de) 1971-07-12
NL172231C (nl) 1983-08-01
DK138638C (OSRAM) 1979-03-19
FR2019928A1 (OSRAM) 1970-07-10
ES372173A1 (es) 1971-09-16
CH527785A (de) 1972-09-15
AT291232B (de) 1971-07-12
AT296276B (de) 1972-02-10
BR6912946D0 (pt) 1973-02-15
DE1949800A1 (de) 1970-05-06
DE1949793A1 (de) 1970-05-06
BE739718A (OSRAM) 1970-04-02
GB1244918A (en) 1971-09-02
SE389336B (sv) 1976-11-01
NL6914989A (OSRAM) 1970-04-07
JPS5227157B1 (OSRAM) 1977-07-19
DK129282C (OSRAM) 1975-02-10
SE387935B (sv) 1976-09-20
SE365196B (OSRAM) 1974-03-18
JPS52102259A (en) 1977-08-27
DK129282B (da) 1974-09-23
NL172231B (nl) 1983-03-01
GB1244919A (en) 1971-09-02
BR6912949D0 (pt) 1973-02-15
US3897460A (en) 1975-07-29
ES372174A1 (es) 1971-09-16

Similar Documents

Publication Publication Date Title
DK125849B (da) α-Benzyliden-β,β-dialkoxy-propionitriler til anvendelse som mellemprodukt ved fremstilling af 2,4-diamino-5-benzylpyrimidiner.
DK128327B (da) Anvendelse af tetraacylerede glycoluriler som aktivatører til perforbindelser.
DK130117B (da) Isoxazolderivater til anvendelse som mellemprodukter til fremstilling af farmakologisk virksomme 13β-alkylgon-4-en-3-oner.
DK124473B (da) Fremgangsmåde til fremstilling af cyclopropanderivater.
DK120194B (da) Fremgangsmåde til fremstilling af azirindinderivater.
DK136115B (da) Ketaler af 3,5,17-trioxo-13beta-alkyl-4,5-secogonaner til anvendelse som mellemprodukter ved fremstillingen af 19-nor-steroider.
DK124887B (da) Isoxazolderivater til anvendelse ved fremstillingen af 3-aminoisoxazoler.
DK129282B (da) Fremgangsmåde til fremstilling af indanderivater.
DK128891B (da) Cycloalkylmethylaminobenzophenon-derivater til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-pheny-1H-1,4-benzodiazepin-2(3H)-oner.
DK125476B (da) N-(2-tetrahydrofuryl)-methylphtalimid til anvendelse som mellemprodukt ved fremstilling af 2-aminomethylpyrrolidiner.
DK122960B (da) Quinazolinderivater til anvendelse som mellemprodukter ved fremstillingen af 1,4-benzodiazepin-4-oxider.
DK120598B (da) Analogifremgangsmåde til fremstilling af furazanderivater.
DK126789B (da) 2-(5-Nitro-2-tienyl)-4-klorkinazolinforbindelser til anvendelse som mellemprodukter ved fremstilling af de tilsvarende 4-aminosubstituerede forbindelser.
DK125285B (da) Analogifremgangsmåde til fremstilling af furazanderivater.
DK128678B (da) Carbobenzoamid-kasugamycin-derivater til anvendelse som mellemprodukter ved fremstilligen af biologisk aktive kasugamycin-derivater, samt fremgangsmåde til fremstilling af carbobenzoamid-kasugamycin-derivaterne.
DK140630B (da) Indanonderivater til anvendelse som mellemprodukter ved fremstillingen af 19-norsteroider eller 9beta, 10alfa-steroider.
DK128896B (da) 8-Hydroxy-13-alkylgona-1,3,5(10),9(11)-tetraener til anvendelse som mellemprodukter ved fremstillingen af 13-alkylgona-1,3,5(10),7-teraener.
DK129230B (da) Forbindelser til anvendelse som herbicider.
DK140589B (da) Tricycliske forbindelser til anvendelse som mellemprodukter ved fremstilling af 19-norsteroider eller 9beta, 10alfa-steroider.
DK135586B (da) Substituerede 2-benzyl-4-piperidinoler til anvendelse som mellemprodukter ved fremstilling af benzomorphaner.
DK134670B (da) Beta-ketoforbindelser til anvendelse som mellemprodukter ved fremstilling af 19-norsteroider eller 19-nor-9beta,10alfa-steroider.
DK127504B (da) 13β-ethyl-gon-4-en-3-oner til anvendelse som mellemprodukter ved fremstillingen af de tilsvarende 17α- eller 17β-acetylforbindelser.
DK123602B (da) Analogifremgangsmåde til fremstilling af sulfonamider.
DK127779B (da) β-Bromalkylisocyanater til anvendelse som mellemprodukter ved fremstillingen af 2-oxazolidoner eller 2-amino-2-oxazoliner.
DK133146C (da) Tetrafluorpropylether til anvendelse som mellemprodukt ved fremstillingen af difluormethyl-1,2,2,3,3-pentafluorpropylether

Legal Events

Date Code Title Description
PBP Patent lapsed