DK128891B - Cycloalkylmethylaminobenzophenon-derivater til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-pheny-1H-1,4-benzodiazepin-2(3H)-oner. - Google Patents

Cycloalkylmethylaminobenzophenon-derivater til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-pheny-1H-1,4-benzodiazepin-2(3H)-oner.

Info

Publication number
DK128891B
DK128891B DK76565AA DK76565A DK128891B DK 128891 B DK128891 B DK 128891B DK 76565A A DK76565A A DK 76565AA DK 76565 A DK76565 A DK 76565A DK 128891 B DK128891 B DK 128891B
Authority
DK
Denmark
Prior art keywords
cycloalkylmethylaminobenzophenone
cycloalkylmethyl
benzodiazepin
pheny
intermediates
Prior art date
Application number
DK76565AA
Other languages
English (en)
Inventor
Millan F Mc
I Pattison
Original Assignee
Warner Lambert Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262221A external-priority patent/US3192199A/en
Application filed by Warner Lambert Pharmaceutical filed Critical Warner Lambert Pharmaceutical
Publication of DK128891B publication Critical patent/DK128891B/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/30Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C07D243/32Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings containing a phthalimide or hydrogenated phthalimide ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK76565AA 1963-03-01 1965-02-12 Cycloalkylmethylaminobenzophenon-derivater til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-pheny-1H-1,4-benzodiazepin-2(3H)-oner. DK128891B (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US262221A US3192199A (en) 1963-03-01 1963-03-01 Process for the production of 1-cycloalkyl derivatives of 1, 4-benzodiazepine
US427141A US3304313A (en) 1963-03-01 1965-01-21 2-(nu-phthalimidoacetyl-nu-cycloalkylmethyl)-aminobenzophenone derivatives
US427079A US3284503A (en) 1963-03-01 1965-01-21 2-cycloalkylmethylamino-benzhydrols and benzophenones

Publications (1)

Publication Number Publication Date
DK128891B true DK128891B (da) 1974-07-22

Family

ID=27401492

Family Applications (5)

Application Number Title Priority Date Filing Date
DK101064AA DK116511B (da) 1963-03-01 1964-02-28 Fremgangsmåde til fremstilling af substituerede 1,4-benzodiazepinforbindelser.
DK76565AA DK128891B (da) 1963-03-01 1965-02-12 Cycloalkylmethylaminobenzophenon-derivater til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-pheny-1H-1,4-benzodiazepin-2(3H)-oner.
DK76765AA DK129003B (da) 1963-03-01 1965-02-12 2-Cycloalkylcarbonylamidoforbindelser til anvendelse som mellemprodukter ved fremstilling af 1-cyloalkylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-oner.
DK76465AA DK117069B (da) 1963-03-01 1965-02-12 Phthalimidoacetylforbindelser til anvendelse som mellemprodukter ved fremstillingen af 5-phenyl-1H-1,4-benzodiazepin-2(3H)-oner.
DK76665AA DK129001B (da) 1963-03-01 1965-02-12 Cycloalkylmethylaminobenzhydrolforbindelser til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-oner.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK101064AA DK116511B (da) 1963-03-01 1964-02-28 Fremgangsmåde til fremstilling af substituerede 1,4-benzodiazepinforbindelser.

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK76765AA DK129003B (da) 1963-03-01 1965-02-12 2-Cycloalkylcarbonylamidoforbindelser til anvendelse som mellemprodukter ved fremstilling af 1-cyloalkylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-oner.
DK76465AA DK117069B (da) 1963-03-01 1965-02-12 Phthalimidoacetylforbindelser til anvendelse som mellemprodukter ved fremstillingen af 5-phenyl-1H-1,4-benzodiazepin-2(3H)-oner.
DK76665AA DK129001B (da) 1963-03-01 1965-02-12 Cycloalkylmethylaminobenzhydrolforbindelser til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-oner.

Country Status (9)

Country Link
US (2) US3304313A (da)
BE (1) BE644425A (da)
BR (1) BR6457222D0 (da)
CH (3) CH446357A (da)
DE (1) DE1229098B (da)
DK (5) DK116511B (da)
FR (1) FR1394287A (da)
GB (2) GB1040163A (da)
SE (4) SE326177B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925364A (en) * 1967-09-22 1975-12-09 Sumitomo Chemical Co Benzodiazepine derivatives
US3549623A (en) * 1968-11-14 1970-12-22 Warner Lambert Pharmaceutical 7-r1-1-(r2)-3-hydroxy-5-phenyl-1h-1,4-benzodiazepin-2(3h)-one
US3691157A (en) * 1970-08-12 1972-09-12 Rodney Ian Fryer Preparation of 7-substituted-1-(2-diethylaminoethyl)-5-(2-halophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-ones
USRE31071E (en) * 1971-12-09 1982-11-02 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler 6-Aza-3H-1,4-benzodiazepines
US4008223A (en) * 1971-12-09 1977-02-15 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler 6-Aza-3H-1,4-benzodiazepines
KR900003529B1 (ko) * 1985-07-29 1990-05-21 오르토 파마슈티컬 코포레이션 2-아실-3,4-디알콕시아닐린의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993062A (en) * 1959-10-22 1961-07-18 Dow Chemical Co Carboxamides of nu-pentachlorophenylethylenediamine
US3153093A (en) * 1961-11-22 1964-10-13 Abbott Lab Amino derivatives of nu-cyclopropylbenzylamines
US3152179A (en) * 1963-03-22 1964-10-06 Searle & Co 2-(hydroxy/oxy)-nu, nu-di (lower alkyl)-5-(6-methoxy-2-naphthyl) cyclopentane-acetamides and congeners

Also Published As

Publication number Publication date
GB1040162A (en) 1966-08-24
DK116511B (da) 1970-01-19
DK129003B (da) 1974-08-05
CH459209A (de) 1968-07-15
SE326177B (da) 1970-07-20
FR1394287A (fr) 1965-04-02
BR6457222D0 (pt) 1973-07-17
DK117069B (da) 1970-03-16
SE326178B (da) 1970-07-20
CH466272A (de) 1968-12-15
DK129001B (da) 1974-08-05
SE320376B (da) 1970-02-09
BE644425A (da) 1964-06-27
DE1229098B (de) 1966-11-24
US3284503A (en) 1966-11-08
US3304313A (en) 1967-02-14
SE326179B (da) 1970-07-20
GB1040163A (en) 1966-08-24
CH446357A (de) 1967-11-15

Similar Documents

Publication Publication Date Title
DK125133B (da) Aza-dibenzo-[a,d]-cyclohepten-derivater til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 5-substituerede aza-dibenzo-cycloheptener.
DK125849B (da) α-Benzyliden-β,β-dialkoxy-propionitriler til anvendelse som mellemprodukt ved fremstilling af 2,4-diamino-5-benzylpyrimidiner.
DK116441B (da) Fremgangsmåde til fremstilling af 10,11-dihydro-dibenzo-(b,f)-thiepinderivater.
DK128891B (da) Cycloalkylmethylaminobenzophenon-derivater til anvendelse som mellemprodukter ved fremstillingen af 1-cycloalkylmethyl-5-pheny-1H-1,4-benzodiazepin-2(3H)-oner.
DK106185C (da) Fremgangsmåde til fremstilling af 17α-acyloxy-4,6-pregnadien-20-oner.
DK120752B (da) Fremgangsmåde til fremstilling af 5-aryl-3H-1,4-benzodiazepin-4-oxider.
DK107168C (da) Fremgangsmåde til fremstilling af 5-aryl-3H-1,4-benzodiazepin-2(1H)-oner.
DK136115B (da) Ketaler af 3,5,17-trioxo-13beta-alkyl-4,5-secogonaner til anvendelse som mellemprodukter ved fremstillingen af 19-nor-steroider.
DK122960B (da) Quinazolinderivater til anvendelse som mellemprodukter ved fremstillingen af 1,4-benzodiazepin-4-oxider.
DK138638B (da) Indanderivater til anvendelse som mellemprodukter ved fremstilling af 19-nor-steroider.
DK106328C (da) Fremgangsmåde til fremstilling af 17α-alkoxy-16-methylen-3,20-diketopregnanderivater.
DK121759B (da) Analogifremgangsmåde til fremstilling af 3-oxo-7α-methylgona-4,9-diener.
DK123650B (da) Analogifremgangsmåde til fremstilling af D-threo-1-phenyl-2-amino-1,3-propandiolderivater.
DK116736B (da) Fremgangsmåde til fremstilling af 5-chlor-2,3-pyridindiol.
DK116595B (da) Fremgangsmåde til fremstilling af 2-mercapto-4,6-bis-amino-s-triazinderivater.
DK128896B (da) 8-Hydroxy-13-alkylgona-1,3,5(10),9(11)-tetraener til anvendelse som mellemprodukter ved fremstillingen af 13-alkylgona-1,3,5(10),7-teraener.
DK114204B (da) Fremgangsmåde til fremstilling af carboxamidoalkyl-1,3-benzoxaziner.
DK117956B (da) Fremgangsmåde til fremstilling af 3-oxogona-4,9-diener.
DK120346B (da) Fremgangsmåde til fremstilling af 5-aryl-7-nitro-3H-1, 4-benzodiazepin-2(1H)-oner.
DK138370B (da) Fremgangsmåde til fremstilling af 1-methyl-7-halogen-2,3-dihyro-5-phenyl-1,4-benzodiazepiner.
DK118818B (da) Fremgangsmåde til fremstilling af 3-keto-4,6-bisdehydro-9β,10α-steroider.
DK134671B (da) Benzophenonderivater til anvendelse som mellemprodukter ved fremstilling af 1,4-benzodiazepinderivater.
DK134907B (da) 2-Amino-alfa-phenylbenzylidenaminforbindelser til anvendelse som mellemprodukter ved fremstilling af 5-phenyl-1,4-benzodiazepiner.
DK114902B (da) Fremgangsmåde til fremstilling af O,S-disubstituerede thiol-thiaminderivater.
DK109871C (da) Fremgangsmåde til fremstilling af 2-aminometyl-3,4-dihydro-2H-pyraner eller derivater deraf.