DK137279B - Fremgangsmåde til fremstilling af dobbeltsalte af S-adenosyl-L-methionin med svovlsyre og p-toluensulfonsyre. - Google Patents
Fremgangsmåde til fremstilling af dobbeltsalte af S-adenosyl-L-methionin med svovlsyre og p-toluensulfonsyre.Info
- Publication number
- DK137279B DK137279B DK342974AA DK342974A DK137279B DK 137279 B DK137279 B DK 137279B DK 342974A A DK342974A A DK 342974AA DK 342974 A DK342974 A DK 342974A DK 137279 B DK137279 B DK 137279B
- Authority
- DK
- Denmark
- Prior art keywords
- adenosyl
- methionine
- preparation
- double salts
- sulfuric acid
- Prior art date
Links
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 title 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 title 2
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical class O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2589573 | 1973-06-27 | ||
| IT2314874A IT1022036B (it) | 1974-05-24 | 1974-05-24 | Processo per la preparazione di sali enzimatici |
| LU79038A LU79038A1 (fr) | 1973-06-27 | 1978-02-09 | Procede de preparation de sels enzymatiques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK342974A DK342974A (da) | 1975-03-17 |
| DK137279B true DK137279B (da) | 1978-02-13 |
| DK137279C DK137279C (da) | 1978-07-17 |
Family
ID=27273344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK342974AA DK137279B (da) | 1973-06-27 | 1974-06-26 | Fremgangsmåde til fremstilling af dobbeltsalte af S-adenosyl-L-methionin med svovlsyre og p-toluensulfonsyre. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3954726A (da) |
| JP (1) | JPS5235727B2 (da) |
| AR (1) | AR202219A1 (da) |
| AT (1) | AT347604B (da) |
| BE (1) | BE816915A (da) |
| CA (1) | CA1024088A (da) |
| CH (1) | CH592686A5 (da) |
| DD (1) | DD112451A5 (da) |
| DE (1) | DE2430999C2 (da) |
| DK (1) | DK137279B (da) |
| FI (1) | FI60218C (da) |
| FR (1) | FR2234891B1 (da) |
| GB (1) | GB1443587A (da) |
| HK (1) | HK31680A (da) |
| IE (1) | IE39517B1 (da) |
| LU (1) | LU79038A1 (da) |
| NL (1) | NL176276C (da) |
| RO (1) | RO64135A (da) |
| SE (1) | SE408712B (da) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR221676A1 (es) * | 1974-07-12 | 1981-03-13 | Bioresearch Sas | Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico |
| DE2646269A1 (de) * | 1975-10-16 | 1977-04-28 | Yamasa Shoyu Kk | Stabilisierte s-adenosyl-l-methionin- zubereitung und verfahren zur herstellung derselben |
| GB2001976B (en) * | 1977-08-03 | 1982-03-10 | Yamasa Shoyu Kk | S-adenosyl-l-methionine compositions and production thereof |
| JPS5428808A (en) * | 1977-08-03 | 1979-03-03 | Yamasa Shoyu Co Ltd | Composition containing s-adenoyl-l-methionine and its preparation |
| GB2064523B (en) * | 1979-12-04 | 1983-06-29 | Kanegafuchi Chemical Ind | Stable composition of s-adenosyl-l-methionine |
| IT1137640B (it) | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| US4376116A (en) * | 1981-09-01 | 1983-03-08 | Research Corporation | Polyamine biosynthesis inhibitors |
| IT1139974B (it) * | 1981-09-11 | 1986-09-24 | Bioresearch Srl | Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo |
| JPS59196408U (ja) * | 1983-06-16 | 1984-12-27 | 株式会社 永幸 | 筒形容器 |
| IT1169773B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
| IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
| US4794174A (en) * | 1987-02-10 | 1988-12-27 | Southern Research Institute | 5'deoxy-5'-substituted adenosines |
| ATE80165T1 (de) * | 1987-10-09 | 1992-09-15 | Vincenzo Zappia | Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten. |
| JPH02290896A (ja) * | 1989-04-28 | 1990-11-30 | Fuji Kagaku Kogyo Kk | 新規なｓ―アデノシルメチオニン誘導体 |
| JPH0576192U (ja) * | 1991-08-27 | 1993-10-15 | 株式会社河合楽器製作所 | 小型電子機器におけるマイクロフオンの保持機構 |
| JP3491938B2 (ja) * | 1993-12-13 | 2004-02-03 | キヤノン株式会社 | Ｄｎａの回収方法 |
| IT1318535B1 (it) * | 2000-05-25 | 2003-08-27 | Chementecno Srl | Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. |
| US6759395B2 (en) * | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
| US6649753B2 (en) | 2001-06-07 | 2003-11-18 | Orchid Chemicals & Pharmaceuticals Ltd. | Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation |
| WO2002102823A1 (en) * | 2001-06-14 | 2002-12-27 | Orchid Chemicals & Pharmaceuticals Limited | Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation |
| US20050272687A1 (en) * | 2004-06-08 | 2005-12-08 | Hebert Rolland F | Stable S-adenosyl-l-methionine |
| FR2884421B1 (fr) | 2005-04-15 | 2007-08-10 | Virbac Sa | Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie |
| AU2006237346B2 (en) * | 2005-04-20 | 2011-04-07 | Basf Plant Science Gmbh | Expression cassettes for seed-preferential expression in plants |
| US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
| ITRM20050344A1 (it) * | 2005-06-30 | 2007-01-01 | Luca Maria De | Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi. |
| JP5071112B2 (ja) * | 2006-01-17 | 2012-11-14 | 三菱瓦斯化学株式会社 | Ｓ−アデノシル−ｌ−メチオニンの安定化法及び安定化された組成物 |
| ITMI20060629A1 (it) | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| US20090197824A1 (en) * | 2008-01-31 | 2009-08-06 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| AU2008210327B2 (en) * | 2007-01-31 | 2011-06-16 | Methylation Sciences International Srl | Extended release pharmaceutical formulations of S-adenosylmethionine |
| US20090088404A1 (en) * | 2007-01-31 | 2009-04-02 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| ITMI20071374A1 (it) * | 2007-07-10 | 2009-01-11 | Gnosis Spa | Sali stabili di s-adenosilmetionina e processo per il loro ottenimento. |
| US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
| EP2189154A1 (en) | 2008-11-25 | 2010-05-26 | Gnosis S.p.A. | Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof |
| IT1393331B1 (it) * | 2009-02-09 | 2012-04-20 | Graal S R L | Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same) |
| US20110027342A1 (en) | 2009-07-28 | 2011-02-03 | Msi Methylation Sciences, Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
| US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| WO2014113609A1 (en) | 2013-01-16 | 2014-07-24 | Hebert Sam-E Llc | Stable indole-3-propionate salts of s-adenosyl-l-methionine |
| WO2014163150A1 (ja) * | 2013-04-05 | 2014-10-09 | ライオン株式会社 | 内服組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642772A (en) * | 1968-09-04 | 1972-02-15 | Boehringer Mannheim Gmbh | Process for preparing s-adenosyl homocysteine |
| DE1803978C2 (de) * | 1968-10-18 | 1985-05-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin |
| IE37913B1 (en) * | 1972-08-02 | 1977-11-09 | Bioresearch Sas | Salt of s-adenosyl-l-methionine |
-
1974
- 1974-06-20 IE IE1295/74A patent/IE39517B1/xx unknown
- 1974-06-24 US US05/482,153 patent/US3954726A/en not_active Expired - Lifetime
- 1974-06-24 GB GB2788874A patent/GB1443587A/en not_active Expired
- 1974-06-25 FR FR7422056A patent/FR2234891B1/fr not_active Expired
- 1974-06-26 DD DD179487A patent/DD112451A5/xx unknown
- 1974-06-26 BE BE145935A patent/BE816915A/xx not_active IP Right Cessation
- 1974-06-26 FI FI1954/74A patent/FI60218C/fi active
- 1974-06-26 CH CH877074A patent/CH592686A5/xx not_active IP Right Cessation
- 1974-06-26 AR AR254406A patent/AR202219A1/es active
- 1974-06-26 DK DK342974AA patent/DK137279B/da unknown
- 1974-06-26 SE SE7408388A patent/SE408712B/xx not_active IP Right Cessation
- 1974-06-27 AT AT532574A patent/AT347604B/de not_active IP Right Cessation
- 1974-06-27 NL NLAANVRAGE7408688,A patent/NL176276C/xx not_active IP Right Cessation
- 1974-06-27 CA CA203,583A patent/CA1024088A/en not_active Expired
- 1974-06-27 JP JP49072882A patent/JPS5235727B2/ja not_active Expired
- 1974-06-27 RO RO7400085149A patent/RO64135A/ro unknown
- 1974-06-27 DE DE2430999A patent/DE2430999C2/de not_active Expired
-
1978
- 1978-02-09 LU LU79038A patent/LU79038A1/xx unknown
-
1980
- 1980-06-12 HK HK316/80A patent/HK31680A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LU79038A1 (fr) | 1978-06-26 |
| IE39517B1 (en) | 1978-10-25 |
| FR2234891A1 (da) | 1975-01-24 |
| US3954726A (en) | 1976-05-04 |
| FR2234891B1 (da) | 1977-03-11 |
| FI195474A (da) | 1974-12-28 |
| BE816915A (fr) | 1974-10-16 |
| IE39517L (en) | 1974-12-27 |
| SE7408388L (da) | 1974-12-30 |
| DK342974A (da) | 1975-03-17 |
| DD112451A5 (da) | 1975-04-12 |
| SE408712B (sv) | 1979-07-02 |
| NL176276B (nl) | 1984-10-16 |
| DE2430999C2 (de) | 1982-06-09 |
| NL176276C (nl) | 1985-03-18 |
| GB1443587A (en) | 1976-07-21 |
| DE2430999A1 (de) | 1975-01-16 |
| FI60218B (fi) | 1981-08-31 |
| NL7408688A (da) | 1974-12-31 |
| CH592686A5 (da) | 1977-11-15 |
| JPS5076215A (da) | 1975-06-21 |
| JPS5235727B2 (da) | 1977-09-10 |
| RO64135A (fr) | 1978-11-15 |
| AU7068974A (en) | 1976-01-08 |
| HK31680A (en) | 1980-06-20 |
| FI60218C (fi) | 1981-12-10 |
| AT347604B (de) | 1979-01-10 |
| ATA532574A (de) | 1978-05-15 |
| AR202219A1 (es) | 1975-05-23 |
| CA1024088A (en) | 1978-01-10 |
| DK137279C (da) | 1978-07-17 |
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| DK123527B (da) | Fremgangsmåde til fremstilling af lumilysergsyrederivater. | |
| DK137834B (da) | Analogifremgangsmåde til fremstilling af triazolobenzodiazepinderivater eller syreadditionssalte deraf. | |
| DK138450B (da) | Fremgangsmåde til fremstilling af arylamino-2-imidazoliner og syreadditionssalte deraf. | |
| DK130830B (da) | Analogifremgangsmåde til fremstilling af diphenylmethoxyethylaminer eller syreadditionssalte deraf. |