DK1280799T3 - Orthosubstituerede anthranilsyreamider og anvendelse heraf som lægemidler - Google Patents
Orthosubstituerede anthranilsyreamider og anvendelse heraf som lægemidlerInfo
- Publication number
- DK1280799T3 DK1280799T3 DK01940416T DK01940416T DK1280799T3 DK 1280799 T3 DK1280799 T3 DK 1280799T3 DK 01940416 T DK01940416 T DK 01940416T DK 01940416 T DK01940416 T DK 01940416T DK 1280799 T3 DK1280799 T3 DK 1280799T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid amides
- anthranilic acid
- orthosubstituted
- drugs
- ortho
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10023486A DE10023486C1 (de) | 2000-05-09 | 2000-05-09 | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
PCT/EP2001/005214 WO2001085719A1 (de) | 2000-05-09 | 2001-05-08 | Ortho substituierte anthranilsäureamide und deren verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1280799T3 true DK1280799T3 (da) | 2004-05-10 |
Family
ID=7641923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01940416T DK1280799T3 (da) | 2000-05-09 | 2001-05-08 | Orthosubstituerede anthranilsyreamider og anvendelse heraf som lægemidler |
Country Status (31)
Country | Link |
---|---|
US (2) | US7081468B2 (ru) |
EP (1) | EP1280799B1 (ru) |
JP (1) | JP2003532725A (ru) |
KR (1) | KR20020094024A (ru) |
CN (1) | CN1237062C (ru) |
AT (1) | ATE258174T1 (ru) |
AU (2) | AU7400101A (ru) |
BG (1) | BG107261A (ru) |
BR (1) | BR0110621A (ru) |
CA (1) | CA2407852A1 (ru) |
CZ (1) | CZ20023677A3 (ru) |
DE (2) | DE10023486C1 (ru) |
DK (1) | DK1280799T3 (ru) |
EE (1) | EE04938B1 (ru) |
ES (1) | ES2214424T3 (ru) |
HK (1) | HK1056728A1 (ru) |
HR (1) | HRP20020977B1 (ru) |
HU (1) | HUP0301954A2 (ru) |
IL (2) | IL152578A0 (ru) |
MX (1) | MXPA02010915A (ru) |
NO (1) | NO323541B1 (ru) |
NZ (1) | NZ521700A (ru) |
PL (1) | PL358204A1 (ru) |
PT (1) | PT1280799E (ru) |
RU (1) | RU2264399C2 (ru) |
SK (1) | SK15882002A3 (ru) |
TR (1) | TR200400912T4 (ru) |
UA (1) | UA73187C2 (ru) |
WO (1) | WO2001085719A1 (ru) |
YU (1) | YU82702A (ru) |
ZA (1) | ZA200209896B (ru) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10023486C1 (de) * | 2000-05-09 | 2002-03-14 | Schering Ag | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
DE10023484A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US20030134836A1 (en) * | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
TW200306819A (en) * | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
CA2493026C (en) * | 2002-07-31 | 2011-05-24 | Schering Aktiengesellschaft | Vegfr-2 and vegfr-3 inhibitory anthranilamide pyridines |
US7615565B2 (en) | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
EP1628661A2 (en) * | 2003-06-05 | 2006-03-01 | Vertex Pharmaceuticals Incorporated | Modulators of vr1 receptor |
DE10327719A1 (de) * | 2003-06-13 | 2005-01-20 | Schering Ag | VEGFR-2 und VEGFR-3 Inhibitorische Anthranylamidpyridone |
US7202260B2 (en) * | 2003-06-13 | 2007-04-10 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones |
US7652135B2 (en) | 2003-09-23 | 2010-01-26 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
DE102004009238A1 (de) * | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | Arylamid-Derivate |
DE102004011720B4 (de) * | 2004-03-10 | 2008-04-03 | Bayer Schering Pharma Aktiengesellschaft | Radiohalogenierte Benzamidderivate und deren Verwendung in der Tumordiagnostik und Tumortherapie |
US7427390B2 (en) * | 2004-03-10 | 2008-09-23 | Schering Ag | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy |
US7906533B2 (en) | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
EP1657241A1 (en) * | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
CA2629964A1 (en) * | 2005-11-30 | 2007-06-07 | Astellas Pharma Inc. | 2-aminobenzamide derivative |
SG11201605486WA (en) | 2014-01-13 | 2016-08-30 | Aurigene Discovery Tech Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
WO2015193846A1 (en) * | 2014-06-20 | 2015-12-23 | Aurigene Discovery Technologies Limited | Substituted indazole compounds as irak4 inhibitors |
PL3600270T3 (pl) | 2017-03-31 | 2023-09-25 | Aurigene Oncology Limited | Związki i kompozycje do leczenia zaburzeń hematologicznych |
IL274248B2 (en) | 2017-10-31 | 2024-06-01 | Curis Inc | Compounds and preparations for the treatment of hematological disorders |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409668A (en) * | 1964-11-07 | 1968-11-05 | Palazzo Giuseppe | Substituted anthranilamides and process for the preparation thereof |
FR2689508B1 (fr) * | 1992-04-01 | 1994-06-17 | Fournier Ind & Sante | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
UA71587C2 (ru) * | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Translated By PlajАМИДЫ АНТРАНИЛОВОЙ КИСЛОТЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕЧЕБНЫХ СРЕДСТВ |
GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
DE10023486C1 (de) * | 2000-05-09 | 2002-03-14 | Schering Ag | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
DE10023484A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
KR20030094395A (ko) * | 2001-05-08 | 2003-12-11 | 쉐링 악티엔게젤샤프트 | Vegfr-2 및 vegfr-3의 억제제로서의 선택적안트라닐아미드 피리딘 아미드 |
US20040039019A1 (en) * | 2002-06-19 | 2004-02-26 | Schering Ag | Selected anthranilaminde pyridinamides and their use as pharmaceutical agents |
US7517894B2 (en) * | 2002-07-31 | 2009-04-14 | Bayer Schering Pharma Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
US7615565B2 (en) * | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
US7202260B2 (en) * | 2003-06-13 | 2007-04-10 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones |
EP1773397A2 (en) * | 2004-07-19 | 2007-04-18 | Thia Medica AS | Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities |
EP1657241A1 (en) * | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US7906533B2 (en) * | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
US20060266770A1 (en) * | 2005-05-26 | 2006-11-30 | Fitzgerald Robert M | Portable dispensers comprising a mobile dispenser and mobile storage cartridge |
-
2000
- 2000-05-09 DE DE10023486A patent/DE10023486C1/de not_active Expired - Fee Related
-
2001
- 2001-05-08 RU RU2002131887/04A patent/RU2264399C2/ru not_active IP Right Cessation
- 2001-05-08 IL IL15257801A patent/IL152578A0/xx unknown
- 2001-05-08 AU AU7400101A patent/AU7400101A/xx active Pending
- 2001-05-08 PT PT01940416T patent/PT1280799E/pt unknown
- 2001-05-08 JP JP2001582320A patent/JP2003532725A/ja active Pending
- 2001-05-08 CA CA002407852A patent/CA2407852A1/en not_active Abandoned
- 2001-05-08 DE DE50101364T patent/DE50101364D1/de not_active Expired - Fee Related
- 2001-05-08 ES ES01940416T patent/ES2214424T3/es not_active Expired - Lifetime
- 2001-05-08 PL PL01358204A patent/PL358204A1/xx unknown
- 2001-05-08 US US10/275,480 patent/US7081468B2/en not_active Expired - Fee Related
- 2001-05-08 BR BR0110621-0A patent/BR0110621A/pt not_active IP Right Cessation
- 2001-05-08 YU YU82702A patent/YU82702A/sh unknown
- 2001-05-08 CN CNB018091369A patent/CN1237062C/zh not_active Expired - Fee Related
- 2001-05-08 CZ CZ20023677A patent/CZ20023677A3/cs unknown
- 2001-05-08 KR KR1020027014966A patent/KR20020094024A/ko active IP Right Grant
- 2001-05-08 EP EP01940416A patent/EP1280799B1/de not_active Expired - Lifetime
- 2001-05-08 SK SK1588-2002A patent/SK15882002A3/sk unknown
- 2001-05-08 WO PCT/EP2001/005214 patent/WO2001085719A1/de active IP Right Grant
- 2001-05-08 MX MXPA02010915A patent/MXPA02010915A/es active IP Right Grant
- 2001-05-08 EE EEP200200625A patent/EE04938B1/xx not_active IP Right Cessation
- 2001-05-08 HU HU0301954A patent/HUP0301954A2/hu unknown
- 2001-05-08 AT AT01940416T patent/ATE258174T1/de not_active IP Right Cessation
- 2001-05-08 DK DK01940416T patent/DK1280799T3/da active
- 2001-05-08 TR TR2004/00912T patent/TR200400912T4/xx unknown
- 2001-05-08 AU AU2001274001A patent/AU2001274001B2/en not_active Ceased
- 2001-05-08 NZ NZ521700A patent/NZ521700A/en unknown
- 2001-08-05 UA UA2002129865A patent/UA73187C2/uk unknown
-
2002
- 2002-10-31 IL IL152578A patent/IL152578A/en not_active IP Right Cessation
- 2002-11-08 NO NO20025358A patent/NO323541B1/no unknown
- 2002-11-08 BG BG107261A patent/BG107261A/bg unknown
- 2002-12-05 ZA ZA200209896A patent/ZA200209896B/en unknown
- 2002-12-09 HR HR20020977A patent/HRP20020977B1/xx not_active IP Right Cessation
-
2003
- 2003-12-13 HK HK03109101A patent/HK1056728A1/xx not_active IP Right Cessation
-
2005
- 2005-09-06 US US11/218,423 patent/US20060014747A1/en not_active Abandoned
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