DK127060B - Analogifremgangsmåde til fremstilling af terapeutisk værdifulde 0-benzyloximderivater af 1-o-formyl-eller 1-o-acetyl-phenoxy-2-hydroxy 3-isopropylaminopropan eller ikke toksiske syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af terapeutisk værdifulde 0-benzyloximderivater af 1-o-formyl-eller 1-o-acetyl-phenoxy-2-hydroxy 3-isopropylaminopropan eller ikke toksiske syreadditionssalte deraf.

Info

Publication number
DK127060B
DK127060B DK224468AA DK224468A DK127060B DK 127060 B DK127060 B DK 127060B DK 224468A A DK224468A A DK 224468AA DK 224468 A DK224468 A DK 224468A DK 127060 B DK127060 B DK 127060B
Authority
DK
Denmark
Prior art keywords
isopropylaminopropane
benzyloxime
formyl
phenoxy
acetyl
Prior art date
Application number
DK224468AA
Other languages
English (en)
Inventor
Kenneth Robert Harry Wooldridge
Berkeley Basil
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of DK127060B publication Critical patent/DK127060B/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK224468AA 1967-05-16 1968-05-14 Analogifremgangsmåde til fremstilling af terapeutisk værdifulde 0-benzyloximderivater af 1-o-formyl-eller 1-o-acetyl-phenoxy-2-hydroxy 3-isopropylaminopropan eller ikke toksiske syreadditionssalte deraf. DK127060B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2273567 1967-05-16
GB5851667 1967-12-22

Publications (1)

Publication Number Publication Date
DK127060B true DK127060B (da) 1973-09-17

Family

ID=26256090

Family Applications (1)

Application Number Title Priority Date Filing Date
DK224468AA DK127060B (da) 1967-05-16 1968-05-14 Analogifremgangsmåde til fremstilling af terapeutisk værdifulde 0-benzyloximderivater af 1-o-formyl-eller 1-o-acetyl-phenoxy-2-hydroxy 3-isopropylaminopropan eller ikke toksiske syreadditionssalte deraf.

Country Status (17)

Country Link
US (1) US3875149A (da)
AT (2) AT286262B (da)
BE (1) BE715205A (da)
CH (1) CH489467A (da)
DE (1) DE1768468A1 (da)
DK (1) DK127060B (da)
ES (1) ES353917A1 (da)
FR (2) FR7616M (da)
GB (1) GB1231783A (da)
IE (1) IE32174B1 (da)
IL (1) IL30001A (da)
IS (1) IS860B6 (da)
MT (1) MTP557B (da)
NL (1) NL6806946A (da)
NO (1) NO125183B (da)
SE (1) SE369894B (da)
SU (2) SU443509A3 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1501632A (en) * 1974-06-28 1978-02-22 Cm Ind Aromatic ketones having cardiovascular activity
US4201790A (en) * 1975-06-20 1980-05-06 May & Baker Limited Benzophenone derivatives
JPS58116450A (ja) * 1981-12-29 1983-07-11 Nippon Soda Co Ltd ５−フエニルシクロヘキセノン誘導体、その製造方法及び選択的除草剤
DE3237400A1 (de) * 1982-10-08 1984-04-12 Bayer Ag, 5090 Leverkusen Substituierte 1-hydroxyethyl-triazolyl-derivate
DE3309595A1 (de) * 1983-03-17 1984-09-20 Basf Ag, 6700 Ludwigshafen Neue aminopropanolderivate von 1-(2-hydroxy-phenyl)-3-phenyl-propanolen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
FI832377A0 (fi) * 1983-06-29 1983-06-29 Star Oy Ab Nytt foerfarande foer framstaellning av (r)-, (s)-eller (r,s)-1-(4'-alkylamido-2'-acetyl) fenoxi-3-alkylamino-2-propanoler
ATE165085T1 (de) * 1987-09-29 1998-05-15 Banyu Pharma Co Ltd N-acylaminosäurederivate und deren verwendung
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
JP5070797B2 (ja) * 2005-12-08 2012-11-14 Ｊｎｃ株式会社 側方オキシラン化合物およびその重合体
JP5571387B2 (ja) 2007-01-11 2014-08-13 クリティカル・アウトカム・テクノロジーズ・インコーポレイテッド 癌の治療のための化合物および方法
WO2009079797A1 (en) 2007-12-26 2009-07-02 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
CA2730890C (en) 2008-07-17 2018-05-15 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
CA2999435A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2774766A (en) * 1954-09-08 1956-12-18 Hoffmann La Roche Basic ethers
BE754604A (fr) * 1969-08-08 1971-02-08 Boehringer Sohn Ingelheim Le 1-(2-nitrilophenoxy)-2-hydroxy-3-ethyl-aminopropane et ses sels

Also Published As

Publication number Publication date
ES353917A1 (es) 1969-10-16
AT286262B (de) 1970-12-10
BE715205A (fr) 1968-11-18
IS1741A7 (is) 1968-11-17
NO125183B (da) 1972-07-31
CH489467A (fr) 1970-04-30
SE369894B (da) 1974-09-23
DE1768468A1 (de) 1971-07-01
AT289826B (de) 1971-03-15
US3875149A (en) 1975-04-01
IE32174B1 (en) 1973-05-02
IL30001A0 (en) 1968-07-25
IS860B6 (is) 1974-05-22
SU449484A3 (ru) 1974-11-05
FR1570087A (fr) 1969-06-06
SU443509A3 (ru) 1974-09-15
NL6806946A (da) 1968-11-18
FR7616M (fr) 1970-01-19
GB1231783A (en) 1971-05-12
MTP557B (en) 1969-01-04
IL30001A (en) 1973-07-30
IE32174L (en) 1968-11-16

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