DK1254240T3 - Hybrid protease med reduceret antigenicitet og dens anvendelse - Google Patents
Hybrid protease med reduceret antigenicitet og dens anvendelseInfo
- Publication number
- DK1254240T3 DK1254240T3 DK01908667T DK01908667T DK1254240T3 DK 1254240 T3 DK1254240 T3 DK 1254240T3 DK 01908667 T DK01908667 T DK 01908667T DK 01908667 T DK01908667 T DK 01908667T DK 1254240 T3 DK1254240 T3 DK 1254240T3
- Authority
- DK
- Denmark
- Prior art keywords
- reduced antigenicity
- hybrid protease
- protease
- hybrid
- antigenicity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/500,135 US6838269B1 (en) | 1998-04-15 | 2000-02-08 | Proteins producing an altered immunogenic response and methods of making and using the same |
PCT/US2001/002204 WO2001059130A2 (en) | 2000-02-08 | 2001-01-22 | Proteins producing an altered immunogenic response and methods of making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1254240T3 true DK1254240T3 (da) | 2007-07-02 |
Family
ID=23988185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01908667T DK1254240T3 (da) | 2000-02-08 | 2001-01-22 | Hybrid protease med reduceret antigenicitet og dens anvendelse |
Country Status (12)
Country | Link |
---|---|
US (1) | US6838269B1 (es) |
EP (1) | EP1254240B1 (es) |
JP (1) | JP5112587B2 (es) |
KR (1) | KR20020073582A (es) |
CN (3) | CN101906464B (es) |
AR (1) | AR027358A1 (es) |
AT (1) | ATE355377T1 (es) |
AU (1) | AU3651201A (es) |
CA (1) | CA2399019A1 (es) |
DE (1) | DE60126915T2 (es) |
DK (1) | DK1254240T3 (es) |
WO (1) | WO2001059130A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6967080B1 (en) * | 1990-12-05 | 2005-11-22 | Novozymes A/S | Proteins with changed epitopes and methods for the production thereof |
US6936249B1 (en) * | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
CA2249648A1 (en) * | 1998-11-04 | 2000-05-04 | Nabil G. Seidah | Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity |
RU2003125638A (ru) * | 2001-02-06 | 2005-03-10 | Мерк Патент ГмбХ (DE) | Модифицированный лептин с уменьшенной иммуногенностью |
CA2471972A1 (en) * | 2001-12-31 | 2003-07-17 | Genencor International, Inc. | Proteases producing an altered immunological response and methods of making and using the same |
BR0306956A (pt) * | 2002-01-16 | 2006-04-11 | Genencor Int | variantes de protease multiplamente substituìdas |
WO2003072746A2 (en) * | 2002-02-26 | 2003-09-04 | Genencor International, Inc. | Subtilisin carlsberg proteins with reduced immunogenicity |
CN101597601B (zh) * | 2002-06-26 | 2013-06-05 | 诺维信公司 | 具有改变的免疫原性的枯草杆菌酶和枯草杆菌酶变体 |
EP2500423B1 (en) * | 2003-02-26 | 2015-06-17 | Danisco US Inc. | Amylases producing an altered immunogenic response and methods of making and using the same |
AU2003213273A1 (en) * | 2003-02-26 | 2004-09-28 | Genencor International, Inc. | Amylases producing an altered immunogenic response and methods of making and using the same |
AR053833A1 (es) | 2005-03-23 | 2007-05-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenetica |
WO2006113209A1 (en) * | 2005-04-15 | 2006-10-26 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen |
KR101696727B1 (ko) | 2006-07-17 | 2017-01-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 인플루엔자 백신 |
JP5230397B2 (ja) * | 2008-12-18 | 2013-07-10 | 独立行政法人科学技術振興機構 | 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法 |
WO2011084496A1 (en) | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
US10626388B2 (en) | 2014-07-04 | 2020-04-21 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
EP3327122B1 (en) | 2014-07-04 | 2021-02-17 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
CN109715792A (zh) * | 2016-06-03 | 2019-05-03 | 诺维信公司 | 枯草杆菌酶变体和对其进行编码的多核苷酸 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926808A1 (de) | 1978-07-04 | 1980-01-17 | Novo Industri As | Proteaseprodukt mit verringerter allergener wirkung, herstellungsverfahren und waschmittel |
US5763257A (en) * | 1984-05-29 | 1998-06-09 | Genencor International, Inc. | Modified subtilisins having amino acid alterations |
KR100237968B1 (ko) | 1990-12-05 | 2000-01-15 | 한센 핀 베네드 | 변화된 에피토프를 지닌 단백질 및 그 제조방법 |
US5593877A (en) * | 1993-03-11 | 1997-01-14 | The Rockefeller University | Nucleic acid and recombinant production of vespid venom hyaluronidase |
DK96493D0 (da) | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
CU22615A1 (es) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
US5951980A (en) * | 1995-01-06 | 1999-09-14 | Leuven Research & Development Vzw | Identification, production and use of new staphylokinase derivatives with reduced immunogenicity |
US5837517A (en) * | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
CN100387712C (zh) | 1995-05-05 | 2008-05-14 | 诺沃奇梅兹有限公司 | 蛋白酶变体和组合物 |
JP2000506119A (ja) | 1996-02-15 | 2000-05-23 | ノボ ノルディスク アクティーゼルスカブ | ポリペプチドのコンジュゲーション |
ATE409743T1 (de) | 1996-11-04 | 2008-10-15 | Novozymes As | Subtilase varianten und verbindungen |
GB2339430A (en) | 1997-05-21 | 2000-01-26 | Biovation Ltd | Method for the production of non-immunogenic proteins |
AU8595298A (en) | 1997-07-29 | 1999-02-22 | The Administrators Of The Tulane Eductional Fund | Prediction, detection, and design of t cell epitopes |
US6495136B1 (en) * | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
US6835550B1 (en) | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
US6642011B2 (en) * | 1998-04-15 | 2003-11-04 | Genencor International, Inc. | Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins |
CA2238660A1 (en) | 1998-05-22 | 1999-11-22 | Janet Chantler | Gene sequences of rubella virus associated with attenuation |
CN1202128C (zh) | 1998-12-08 | 2005-05-18 | 拜奥威神有限公司 | 修饰蛋白的免疫原性 |
-
2000
- 2000-02-08 US US09/500,135 patent/US6838269B1/en not_active Expired - Fee Related
-
2001
- 2001-01-22 CN CN2010102215832A patent/CN101906464B/zh not_active Expired - Fee Related
- 2001-01-22 AU AU36512/01A patent/AU3651201A/en not_active Abandoned
- 2001-01-22 WO PCT/US2001/002204 patent/WO2001059130A2/en active IP Right Grant
- 2001-01-22 JP JP2001558466A patent/JP5112587B2/ja not_active Expired - Fee Related
- 2001-01-22 CN CNA2005100836207A patent/CN1721442A/zh active Pending
- 2001-01-22 EP EP01908667A patent/EP1254240B1/en not_active Expired - Lifetime
- 2001-01-22 KR KR1020027010234A patent/KR20020073582A/ko not_active Application Discontinuation
- 2001-01-22 DK DK01908667T patent/DK1254240T3/da active
- 2001-01-22 CN CN01804669A patent/CN1418253A/zh active Pending
- 2001-01-22 DE DE60126915T patent/DE60126915T2/de not_active Expired - Lifetime
- 2001-01-22 CA CA002399019A patent/CA2399019A1/en not_active Abandoned
- 2001-01-22 AT AT01908667T patent/ATE355377T1/de not_active IP Right Cessation
- 2001-02-02 AR ARP010100505A patent/AR027358A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001059130A3 (en) | 2002-03-07 |
CN101906464A (zh) | 2010-12-08 |
JP2004500088A (ja) | 2004-01-08 |
DE60126915T2 (de) | 2007-11-15 |
KR20020073582A (ko) | 2002-09-27 |
ATE355377T1 (de) | 2006-03-15 |
AR027358A1 (es) | 2003-03-26 |
EP1254240B1 (en) | 2007-02-28 |
WO2001059130A2 (en) | 2001-08-16 |
CN1418253A (zh) | 2003-05-14 |
CN101906464B (zh) | 2013-03-27 |
AU3651201A (en) | 2001-08-20 |
CA2399019A1 (en) | 2001-08-16 |
JP5112587B2 (ja) | 2013-01-09 |
US6838269B1 (en) | 2005-01-04 |
CN1721442A (zh) | 2006-01-18 |
EP1254240A2 (en) | 2002-11-06 |
DE60126915D1 (de) | 2007-04-12 |
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