DK123714B - Fremgangsmåde til fremstilling af ren digoxin-4"'-monothylether. - Google Patents
Fremgangsmåde til fremstilling af ren digoxin-4"'-monothylether.Info
- Publication number
- DK123714B DK123714B DK607471AA DK607471A DK123714B DK 123714 B DK123714 B DK 123714B DK 607471A A DK607471A A DK 607471AA DK 607471 A DK607471 A DK 607471A DK 123714 B DK123714 B DK 123714B
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- monothyl
- ether
- digoxin
- pure
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 2
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 title 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title 1
- 229960005156 digoxin Drugs 0.000 title 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Installation Of Indoor Wiring (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691961034 DE1961034C (de) | 1969-12-05 | Verfahren zur Herstellung von reinen Digoxin-mono-methyläthern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK123714B true DK123714B (da) | 1972-07-24 |
Family
ID=5753066
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK619970AA DK123354B (da) | 1969-12-05 | 1970-12-04 | Fremgangsmåde til fremstilling af ren digoxin-3'''-monomethylether. |
| DK607471AA DK123714B (da) | 1969-12-05 | 1971-12-13 | Fremgangsmåde til fremstilling af ren digoxin-4"'-monothylether. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK619970AA DK123354B (da) | 1969-12-05 | 1970-12-04 | Fremgangsmåde til fremstilling af ren digoxin-3'''-monomethylether. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US3712884A (da) |
| JP (1) | JPS5028957B1 (da) |
| AT (1) | AT302544B (da) |
| BE (1) | BE759912A (da) |
| BG (1) | BG18865A3 (da) |
| CH (1) | CH537378A (da) |
| CS (2) | CS155249B2 (da) |
| DK (2) | DK123354B (da) |
| ES (1) | ES386172A1 (da) |
| FI (2) | FI47183C (da) |
| FR (1) | FR2081328B1 (da) |
| GB (1) | GB1274779A (da) |
| IE (1) | IE34790B1 (da) |
| IL (1) | IL35788A (da) |
| NL (1) | NL166696C (da) |
| NO (1) | NO131297C (da) |
| PL (1) | PL81222B1 (da) |
| RO (1) | RO58835A (da) |
| SE (1) | SE356046B (da) |
| YU (1) | YU34302B (da) |
| ZA (1) | ZA708221B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2233147A1 (de) * | 1972-07-06 | 1974-01-24 | Boehringer Mannheim Gmbh | Dihydrodigoxin-derivate |
| YU39367B (en) * | 1976-08-20 | 1984-10-31 | Lek Tovarna Farmacevtskih | Process for preparing beta-methyl-digoxine |
| DE3146899A1 (de) * | 1981-11-26 | 1983-06-01 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue ketale von 3'''-dehydro-cardenolid-tridigitoxosiden, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4603196A (en) * | 1983-04-27 | 1986-07-29 | Chemie Linz Aktiengesellschaft | Process for the preparation of β-methyldigoxin |
| US4546097A (en) * | 1983-11-04 | 1985-10-08 | The United States Of America As Represented By The Department Of Health And Human Services | Saponin-based polyether polyols, pharmaceutical compositions and a method of using same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1643665B1 (de) * | 1967-09-20 | 1971-02-18 | Boehringer Mannheim Gmbh | Neue Digoxinaether und Verfahren zur Herstellung derselben |
-
0
- BE BE759912D patent/BE759912A/xx not_active IP Right Cessation
-
1970
- 1970-11-19 US US00091171A patent/US3712884A/en not_active Expired - Lifetime
- 1970-12-01 CS CS811370A patent/CS155249B2/cs unknown
- 1970-12-01 CS CS82672*A patent/CS155250B2/cs unknown
- 1970-12-02 CH CH1784070A patent/CH537378A/de not_active IP Right Cessation
- 1970-12-02 YU YU2917/70A patent/YU34302B/xx unknown
- 1970-12-03 IL IL35788A patent/IL35788A/en unknown
- 1970-12-03 NL NL7017664.A patent/NL166696C/xx not_active IP Right Cessation
- 1970-12-03 GB GB57485/70A patent/GB1274779A/en not_active Expired
- 1970-12-03 RO RO65176A patent/RO58835A/ro unknown
- 1970-12-03 BG BG16193A patent/BG18865A3/xx unknown
- 1970-12-04 ZA ZA708221A patent/ZA708221B/xx unknown
- 1970-12-04 FR FR7043635A patent/FR2081328B1/fr not_active Expired
- 1970-12-04 NO NO4658/70A patent/NO131297C/no unknown
- 1970-12-04 PL PL1970144818A patent/PL81222B1/pl unknown
- 1970-12-04 DK DK619970AA patent/DK123354B/da not_active IP Right Cessation
- 1970-12-04 SE SE16441/70A patent/SE356046B/xx unknown
- 1970-12-04 AT AT1093870A patent/AT302544B/de not_active IP Right Cessation
- 1970-12-04 FI FI703275A patent/FI47183C/fi active
- 1970-12-04 ES ES386172A patent/ES386172A1/es not_active Expired
- 1970-12-04 IE IE1556/70A patent/IE34790B1/xx unknown
- 1970-12-05 JP JP45108059A patent/JPS5028957B1/ja active Pending
-
1971
- 1971-12-13 DK DK607471AA patent/DK123714B/da not_active IP Right Cessation
-
1973
- 1973-03-06 FI FI730686A patent/FI47574C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| DE1961034A1 (de) | 1971-06-09 |
| NL166696B (nl) | 1981-04-15 |
| GB1274779A (en) | 1972-05-17 |
| FI47574B (da) | 1973-10-01 |
| YU291770A (en) | 1978-10-31 |
| IE34790B1 (en) | 1975-08-20 |
| IL35788A0 (en) | 1971-02-25 |
| JPS5028957B1 (da) | 1975-09-19 |
| FR2081328B1 (da) | 1974-08-23 |
| FR2081328A1 (da) | 1971-12-03 |
| BG18865A3 (da) | 1975-03-20 |
| CS155250B2 (da) | 1974-05-30 |
| AT302544B (de) | 1972-10-25 |
| NO131297C (da) | 1975-05-07 |
| IE34790L (en) | 1971-06-05 |
| FI47574C (fi) | 1974-01-10 |
| IL35788A (en) | 1973-05-31 |
| NL7017664A (da) | 1971-06-08 |
| ES386172A1 (es) | 1973-03-16 |
| SE356046B (da) | 1973-05-14 |
| DK123354B (da) | 1972-06-12 |
| PL81222B1 (da) | 1975-08-30 |
| FI47183B (da) | 1973-07-02 |
| BE759912A (fr) | 1971-06-04 |
| CS155249B2 (da) | 1974-05-30 |
| CH537378A (de) | 1973-05-31 |
| NL166696C (nl) | 1981-09-15 |
| SU373935A3 (da) | 1973-03-12 |
| YU34302B (en) | 1979-04-30 |
| FI47183C (fi) | 1973-10-10 |
| ZA708221B (en) | 1971-10-27 |
| RO58835A (da) | 1975-11-15 |
| US3712884A (en) | 1973-01-23 |
| NO131297B (da) | 1975-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |