DK1202957T3 - Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa - Google Patents
Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfaInfo
- Publication number
- DK1202957T3 DK1202957T3 DK00943702T DK00943702T DK1202957T3 DK 1202957 T3 DK1202957 T3 DK 1202957T3 DK 00943702 T DK00943702 T DK 00943702T DK 00943702 T DK00943702 T DK 00943702T DK 1202957 T3 DK1202957 T3 DK 1202957T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenyl
- alkyl
- hydrogen
- alkoxycarbonyl
- alkylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14416999P | 1999-07-16 | 1999-07-16 | |
EP00943702A EP1202957B1 (fr) | 1999-07-16 | 2000-07-11 | Aminobenzophenones comme inhibiteurs d'il-1beta et de tnf-alpha |
PCT/DK2000/000388 WO2001005745A1 (fr) | 1999-07-16 | 2000-07-11 | AMINOBENZOPHENONES COMME INHIBITEURS D'IL-1β ET DE TNF-$g(a) |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1202957T3 true DK1202957T3 (da) | 2005-01-31 |
Family
ID=22507398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00943702T DK1202957T3 (da) | 1999-07-16 | 2000-07-11 | Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa |
Country Status (18)
Country | Link |
---|---|
US (1) | US6555710B1 (fr) |
EP (1) | EP1202957B1 (fr) |
JP (1) | JP2003505360A (fr) |
KR (1) | KR20020013960A (fr) |
CN (1) | CN1174956C (fr) |
AT (1) | ATE277889T1 (fr) |
AU (1) | AU768816B2 (fr) |
CA (1) | CA2379319A1 (fr) |
CZ (1) | CZ2002158A3 (fr) |
DE (1) | DE60014393T2 (fr) |
DK (1) | DK1202957T3 (fr) |
ES (1) | ES2228557T3 (fr) |
HK (1) | HK1048465B (fr) |
HU (1) | HUP0201909A3 (fr) |
PL (1) | PL353639A1 (fr) |
PT (1) | PT1202957E (fr) |
RU (1) | RU2238933C2 (fr) |
WO (1) | WO2001005745A1 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
ATE515265T1 (de) * | 1998-03-27 | 2011-07-15 | Univ Oregon Health & Science | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen |
MXPA02011376A (es) | 2000-05-22 | 2004-02-26 | Leo Pharma As | Benzofenonas como inhibidores de il-1beta y tnf-alfa. |
EP2070911A2 (fr) * | 2000-07-18 | 2009-06-17 | Bone Care International, Inc. | 1Alpha-hydroxy vitamine D stabilisée |
EP1423356A2 (fr) | 2001-08-28 | 2004-06-02 | Leo Pharma A/S | Nouvelles aminobenzophenones |
IL162213A0 (en) * | 2001-12-03 | 2005-11-20 | Novacea Inc | Pharmaceutical compositions containing active vitamin d compounds |
US20030225089A1 (en) * | 2002-04-10 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors |
CA2492033A1 (fr) | 2002-07-09 | 2004-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nouvelles compositions pharmaceutiques a base de nouveaux anticholinergiques et d'inhibiteurs de la kinase p38 |
US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
KR101128275B1 (ko) | 2003-07-24 | 2012-04-12 | 레오 파마 에이/에스 | 신규한 아미노벤조페논 화합물 |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
AU2005316034B2 (en) | 2004-12-13 | 2012-01-19 | Leo Pharma A/S | Triazole substituted aminobenzophenone compounds |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1992344A1 (fr) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3 |
MX2010011666A (es) | 2008-04-22 | 2010-12-06 | Toyama Chemical Co Ltd | Metodo para usar una combinacion de derivado de benzofenona o sal del mismo y un agente inmunosupresor, y una composicion farmaceutica que consta de estos compuestos. |
EP2206534A1 (fr) | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dérivés de dibenzocycloheptanone et produits pharmaceutiques comprenant ces composés |
EP2766750B1 (fr) | 2011-10-12 | 2016-02-03 | Novartis AG | Procédé de fabrication de lentilles ophtalmiques absorbant les uv par revêtement |
MY172901A (en) | 2012-12-17 | 2019-12-13 | Alcon Inc | Method for making improved uv-absorbing ophthalmic lenses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
-
2000
- 2000-07-11 PT PT00943702T patent/PT1202957E/pt unknown
- 2000-07-11 DE DE60014393T patent/DE60014393T2/de not_active Expired - Fee Related
- 2000-07-11 PL PL00353639A patent/PL353639A1/xx not_active Application Discontinuation
- 2000-07-11 AU AU58071/00A patent/AU768816B2/en not_active Ceased
- 2000-07-11 DK DK00943702T patent/DK1202957T3/da active
- 2000-07-11 ES ES00943702T patent/ES2228557T3/es not_active Expired - Lifetime
- 2000-07-11 AT AT00943702T patent/ATE277889T1/de not_active IP Right Cessation
- 2000-07-11 EP EP00943702A patent/EP1202957B1/fr not_active Expired - Lifetime
- 2000-07-11 CN CNB008115036A patent/CN1174956C/zh not_active Expired - Fee Related
- 2000-07-11 KR KR1020027000614A patent/KR20020013960A/ko not_active Application Discontinuation
- 2000-07-11 RU RU2002103867A patent/RU2238933C2/ru not_active IP Right Cessation
- 2000-07-11 CZ CZ2002158A patent/CZ2002158A3/cs unknown
- 2000-07-11 JP JP2001511406A patent/JP2003505360A/ja active Pending
- 2000-07-11 HU HU0201909A patent/HUP0201909A3/hu unknown
- 2000-07-11 WO PCT/DK2000/000388 patent/WO2001005745A1/fr active IP Right Grant
- 2000-07-11 US US10/031,071 patent/US6555710B1/en not_active Expired - Fee Related
- 2000-07-11 CA CA002379319A patent/CA2379319A1/fr not_active Abandoned
-
2003
- 2003-01-23 HK HK03100589.4A patent/HK1048465B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2003505360A (ja) | 2003-02-12 |
ES2228557T3 (es) | 2005-04-16 |
HK1048465A1 (en) | 2003-04-04 |
CN1368953A (zh) | 2002-09-11 |
WO2001005745A1 (fr) | 2001-01-25 |
KR20020013960A (ko) | 2002-02-21 |
AU5807100A (en) | 2001-02-05 |
EP1202957A1 (fr) | 2002-05-08 |
RU2238933C2 (ru) | 2004-10-27 |
DE60014393T2 (de) | 2006-02-16 |
DE60014393D1 (de) | 2004-11-04 |
EP1202957B1 (fr) | 2004-09-29 |
CN1174956C (zh) | 2004-11-10 |
PT1202957E (pt) | 2005-01-31 |
ATE277889T1 (de) | 2004-10-15 |
HK1048465B (zh) | 2005-04-08 |
PL353639A1 (en) | 2003-12-01 |
US6555710B1 (en) | 2003-04-29 |
CA2379319A1 (fr) | 2001-01-25 |
HUP0201909A2 (en) | 2002-10-28 |
AU768816B2 (en) | 2004-01-08 |
HUP0201909A3 (en) | 2002-11-28 |
CZ2002158A3 (cs) | 2002-08-14 |
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