DK119880B - Process for the preparation of sedatives for the central nervous system in the form of derivatives of 4-oxo-1,3,8-triazaspiro- (4,5) -decane. - Google Patents

Process for the preparation of sedatives for the central nervous system in the form of derivatives of 4-oxo-1,3,8-triazaspiro- (4,5) -decane.

Info

Publication number
DK119880B
DK119880B DK297763AA DK297763A DK119880B DK 119880 B DK119880 B DK 119880B DK 297763A A DK297763A A DK 297763AA DK 297763 A DK297763 A DK 297763A DK 119880 B DK119880 B DK 119880B
Authority
DK
Denmark
Prior art keywords
triazaspiro
sedatives
decane
oxo
derivatives
Prior art date
Application number
DK297763AA
Other languages
Danish (da)
Inventor
P Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK119880B publication Critical patent/DK119880B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Wire Processing (AREA)
  • Hydrogenated Pyridines (AREA)
DK297763AA 1962-06-22 1963-06-22 Process for the preparation of sedatives for the central nervous system in the form of derivatives of 4-oxo-1,3,8-triazaspiro- (4,5) -decane. DK119880B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20462362A 1962-06-22 1962-06-22

Publications (1)

Publication Number Publication Date
DK119880B true DK119880B (en) 1971-03-08

Family

ID=22758700

Family Applications (1)

Application Number Title Priority Date Filing Date
DK297763AA DK119880B (en) 1962-06-22 1963-06-22 Process for the preparation of sedatives for the central nervous system in the form of derivatives of 4-oxo-1,3,8-triazaspiro- (4,5) -decane.

Country Status (9)

Country Link
BE (1) BE633914A (en)
CH (1) CH462835A (en)
DE (1) DE1470125C3 (en)
DK (1) DK119880B (en)
FI (1) FI46967C (en)
FR (6) FR1573808A (en)
GB (1) GB1043141A (en)
NO (1) NO117368B (en)
SE (1) SE311019B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154950B (en) * 1975-07-21 1989-01-09 Janssen Pharmaceutica Nv METHOD OF ANALOGUE FOR THE PREPARATION OF 1- (BENZAZOLYLALKYL) -PIPERIDE INGREDIENTS OR THE PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080328A (en) * 1971-07-13 1978-03-21 Sumitomo Chemical Company, Limited N-substituted heterocyclic derivatives and preparation thereof
BE792187A (en) * 1971-12-03 1973-03-30 Sumitomo Chemical Co NEW ALKYLAMINE DERIVATIVES
US4066772A (en) * 1975-07-21 1978-01-03 Janssen Pharmaceutica N.V. 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
DK139684A (en) * 1983-04-11 1984-10-12 Janssen Pharmaceutica Nv N-aryl-alpha-amino carboxamides
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5244902A (en) * 1989-08-21 1993-09-14 Beth Israel Hospital Association Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
DE19610397A1 (en) * 1996-03-16 1997-09-18 Krewel Meuselbach Gmbh Production of fluspirilene suspensions
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
EP1080091A1 (en) * 1998-05-18 2001-03-07 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ES2237047T3 (en) * 1998-10-23 2005-07-16 Pfizer Inc. 1,3,8-TRIAZAESPIRO (4,5) DECANONE COMPOUNDS AS ORL1 RECEIVER AGONISTS.
US7459461B2 (en) 2001-10-19 2008-12-02 Ortho-Mcneil Pharmaceutical, Inc. Phosphonic acid compounds as inhibitors of serine proteases
DE102005038141A1 (en) * 2005-08-12 2007-02-15 Grünenthal GmbH Substituted 8- (3-aminopropyl) -1-phenyl-1,3,8-triaza-spiro [4.5] decan-4-one derivatives
KR101601383B1 (en) * 2010-06-18 2016-03-08 알토스 세라퓨틱스, 엘엘씨 D2 antagonists, methods of synthesis and methods of use
IT201800007580A1 (en) * 2018-07-27 2020-01-27 Maria Cecilia Hospital Spa 1,3,8-triazaspiro compounds and their use as medicaments

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154950B (en) * 1975-07-21 1989-01-09 Janssen Pharmaceutica Nv METHOD OF ANALOGUE FOR THE PREPARATION OF 1- (BENZAZOLYLALKYL) -PIPERIDE INGREDIENTS OR THE PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS

Also Published As

Publication number Publication date
DE1470125B2 (en) 1979-10-31
CH462835A (en) 1968-09-30
NO117368B (en) 1969-08-04
FR3059M (en) 1965-01-11
FR2986M (en) 1964-12-07
FI46967B (en) 1973-05-02
DE1470125C3 (en) 1980-07-10
FR2988M (en) 1964-12-07
SE311019B (en) 1969-05-27
FI46967C (en) 1973-08-10
FR3043M (en) 1965-01-04
DE1470125A1 (en) 1969-05-08
FR2987M (en) 1964-12-07
GB1043141A (en) 1966-09-21
BE633914A (en)
FR1573808A (en) 1969-07-11

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