DK115474B - Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin. - Google Patents

Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin.

Info

Publication number
DK115474B
DK115474B DK547566AA DK547566A DK115474B DK 115474 B DK115474 B DK 115474B DK 547566A A DK547566A A DK 547566AA DK 547566 A DK547566 A DK 547566A DK 115474 B DK115474 B DK 115474B
Authority
DK
Denmark
Prior art keywords
fluorocytosine
chlorobenzoyl
preparation
analogous process
analogous
Prior art date
Application number
DK547566AA
Other languages
Danish (da)
English (en)
Inventor
R Duschinsky
M Hoffer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK115474B publication Critical patent/DK115474B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK547566AA 1965-10-22 1966-10-21 Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin. DK115474B (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US502586A US3309359A (en) 1965-10-22 1965-10-22 N-mono-acyl-5-fluorocytosine derivatives and process

Publications (1)

Publication Number Publication Date
DK115474B true DK115474B (da) 1969-10-13

Family

ID=23998481

Family Applications (1)

Application Number Title Priority Date Filing Date
DK547566AA DK115474B (da) 1965-10-22 1966-10-21 Analogifremgangsmåde til fremstilling af N-p-chlorbenzoyl-5-fluorcytosin.

Country Status (11)

Country Link
US (1) US3309359A (US08197722-20120612-C00093.png)
BE (1) BE688539A (US08197722-20120612-C00093.png)
BR (1) BR6683864D0 (US08197722-20120612-C00093.png)
CH (1) CH475258A (US08197722-20120612-C00093.png)
DE (1) DE1695160A1 (US08197722-20120612-C00093.png)
DK (1) DK115474B (US08197722-20120612-C00093.png)
FR (1) FR5908M (US08197722-20120612-C00093.png)
GB (1) GB1110357A (US08197722-20120612-C00093.png)
IL (1) IL26726A (US08197722-20120612-C00093.png)
NL (1) NL6614240A (US08197722-20120612-C00093.png)
SE (1) SE330176B (US08197722-20120612-C00093.png)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894000A (en) * 1971-01-27 1975-07-08 Upjohn Co Ara-cytidine derivatives and process of preparation
US3975367A (en) * 1971-06-08 1976-08-17 The Upjohn Company Arabinofuranosyl N4 -aminoacyl cytosine containing compounds
US4022963A (en) * 1972-06-08 1977-05-10 Deutsch Daniel Harold Acetylation process for nucleoside compounds
US3991045A (en) * 1973-05-30 1976-11-09 Asahi Kasei Kogyo Kabushiki Kaisha N4 -acylarabinonucleosides
JPS5159880A (en) * 1974-11-22 1976-05-25 Asahi Chemical Ind N44 ashirunukureoshidojikarubonsanesuteruno seiho
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
JPS59167600A (ja) * 1983-03-14 1984-09-21 Microbial Chem Res Found ２′−デオキシオキザノシンおよびその製造法
KR100978904B1 (ko) 2001-12-14 2010-08-31 파마셋 인코포레이티드 바이러스 감염 치료용 ｎ4-아실사이토신 뉴클레오사이드
JP5749017B2 (ja) * 2008-01-22 2015-07-15 ダウ アグロサイエンシィズ エルエルシー ５−フルオロピリミジン誘導体
RU2536492C2 (ru) * 2008-08-01 2014-12-27 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Применение 5-фторцитозина в качестве фунгицида
PT2462134E (pt) * 2009-08-07 2014-07-28 Dow Agrosciences Llc Derivados de n1-sulfonil-5-fluoropirimidinona
UA106889C2 (uk) * 2009-08-07 2014-10-27 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні n1-ацил-5-фторпіримідинону
UA107671C2 (en) * 2009-08-07 2015-02-10 Dow Agrosciences Llc N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives
UA112284C2 (uk) * 2009-08-07 2016-08-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні 5-фторпіримідинону
EP2521452B1 (en) * 2010-01-07 2014-12-24 Dow AgroSciences LLC THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS
RU2613451C2 (ru) 2011-08-17 2017-03-16 Адама Мактешим Лтд. Производные 5-фтор-4-имино-3-(замещенного)-3, 4-дигидропиримидин-2(1н)она, композиция на их основе и спсоб борьбы с грибковыми заболеваниями
CA2893778A1 (en) 2012-12-28 2014-07-03 Dow Agrosciences Llc N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2h)-carboxylate derivatives
JP6258969B2 (ja) 2012-12-28 2018-01-10 アダマ・マクテシム・リミテッド Ｎ−（置換）−５−フルオロ−４−イミノ−３−メチル−２−オキソ−３，４−ジヒドロピリミジン−１（２ｈ）−カルボキサミド誘導体
CN104994859B (zh) 2012-12-28 2018-10-26 阿达玛马克西姆股份有限公司 1-(取代的苯甲酰基)-5-氟-4-亚氨基-3-甲基-3,4-二氢嘧啶-2(1h)-酮衍生物
AU2013370494B2 (en) 2012-12-31 2017-08-17 Adama Makhteshim Ltd. 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides
BR112016015158A2 (pt) 2013-12-31 2017-08-08 Adama Makhteshim Ltd Misturas fungicidas sinergísticas para controle de fungos em cereais
CA2935601C (en) 2013-12-31 2023-03-14 Adama Makhteshim Ltd. 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation
WO2019038583A1 (en) 2017-07-17 2019-02-28 Adama Makhteshim Ltd. 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2-ONE POLYMORPHS
CN109651467A (zh) * 2019-01-15 2019-04-19 齐鲁天和惠世制药有限公司 一种卡培他滨杂质及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949451A (en) * 1959-04-21 1960-08-16 Hoffmann La Roche Preparation of thymidine and deoxyfluorouridine, and intermediates therefor
NL299755A (US08197722-20120612-C00093.png) * 1959-06-03
GB1070413A (en) * 1962-11-15 1967-06-01 Sankyo Co A process for preparing purine and pyrimidine nucleosides

Also Published As

Publication number Publication date
US3309359A (en) 1967-03-14
CH475258A (de) 1969-07-15
SE330176B (US08197722-20120612-C00093.png) 1970-11-09
NL6614240A (US08197722-20120612-C00093.png) 1967-04-24
DE1695160A1 (de) 1970-12-17
GB1110357A (en) 1968-04-18
IL26726A (en) 1970-06-17
FR5908M (US08197722-20120612-C00093.png) 1968-03-25
BR6683864D0 (pt) 1973-12-26
BE688539A (US08197722-20120612-C00093.png) 1967-04-20

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