DK1147117T3 - Immunologiske adjuvansforbindelser - Google Patents

Immunologiske adjuvansforbindelser

Info

Publication number
DK1147117T3
DK1147117T3 DK00907124T DK00907124T DK1147117T3 DK 1147117 T3 DK1147117 T3 DK 1147117T3 DK 00907124 T DK00907124 T DK 00907124T DK 00907124 T DK00907124 T DK 00907124T DK 1147117 T3 DK1147117 T3 DK 1147117T3
Authority
DK
Denmark
Prior art keywords
compounds
adjuvant compounds
novel
immunological adjuvant
adjuvant
Prior art date
Application number
DK00907124T
Other languages
English (en)
Inventor
Lynn D Hawkins
Sally T Ishizaka
Michael Lewis
Jeffrey Rose
Pamela Mcguiness
Anneliese Nault
Daniel P Rossignol
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DK1147117T3 publication Critical patent/DK1147117T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
DK00907124T 1999-02-01 2000-02-01 Immunologiske adjuvansforbindelser DK1147117T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11813199P 1999-02-01 1999-02-01
PCT/US2000/002755 WO2000044758A1 (en) 1999-02-01 2000-02-01 Immunological adjuvant compound

Publications (1)

Publication Number Publication Date
DK1147117T3 true DK1147117T3 (da) 2004-10-25

Family

ID=22376670

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00907124T DK1147117T3 (da) 1999-02-01 2000-02-01 Immunologiske adjuvansforbindelser

Country Status (21)

Country Link
US (1) US6290973B1 (da)
EP (2) EP1147117B1 (da)
JP (1) JP4698027B2 (da)
KR (1) KR100711561B1 (da)
AT (2) ATE269341T1 (da)
AU (2) AU768574B2 (da)
BR (1) BRPI0007936B8 (da)
CA (1) CA2361582C (da)
DE (2) DE60044570D1 (da)
DK (1) DK1147117T3 (da)
ES (2) ES2223464T3 (da)
FI (1) FI120689B (da)
HK (2) HK1043132B (da)
HU (1) HU226869B1 (da)
IL (3) IL144671A0 (da)
MX (1) MXPA01007760A (da)
NO (1) NO329111B1 (da)
NZ (1) NZ513259A (da)
PT (1) PT1147117E (da)
WO (1) WO2000044758A1 (da)
ZA (1) ZA200106487B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835721B2 (en) 1999-02-01 2004-12-28 Eisai Co., Ltd. Immunomodulatory compounds and methods of use thereof
US20040006242A1 (en) * 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
US6551600B2 (en) * 1999-02-01 2003-04-22 Eisai Co., Ltd. Immunological adjuvant compounds compositions and methods of use thereof
US7915238B2 (en) 1999-02-01 2011-03-29 Eisai R & D Management Co., Ltd. Immunomodulatory compounds and methods of use thereof
EP1177187B1 (en) 1999-04-28 2007-07-25 Sanofi-Aventis Deutschland GmbH Di-aryl acid derivatives as ppar receptor ligands
EP1307466B1 (en) * 2000-07-31 2005-11-16 Eisai Co., Ltd. Immunological adjuvant compounds
CA2435681C (en) * 2001-01-23 2011-06-21 Aventis Pasteur Multivalent meningococcal polysaccharide-protein conjugate vaccine
ATE510547T1 (de) * 2001-03-08 2011-06-15 Univ Pennsylvania Faciale amphiphile polymere als infektionsbekämpfende mittel
US8481043B2 (en) * 2001-06-22 2013-07-09 Cpex Pharmaceuticals, Inc. Nasal immunization
EA200401565A1 (ru) * 2002-05-24 2005-04-28 Неофарм, Инк. Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
WO2003099830A2 (en) * 2002-05-24 2003-12-04 Neopharm, Inc. Cardiolipin compositions, methods of preparation and use
JP3900343B2 (ja) * 2002-09-05 2007-04-04 株式会社トリケミカル研究所 （ｒｏ）（ｒ’ｏ）（ｒ’’ｏ）ｍ＝ｏの製造方法
US20050277611A1 (en) * 2002-10-16 2005-12-15 Neopharm, Inc. Cationic cardiolipin analoges and its use thereof
WO2004060396A2 (en) * 2002-12-27 2004-07-22 Chiron Corporation Immunogenic compositions containing phospholpid
JP2006521355A (ja) * 2003-03-17 2006-09-21 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア・センター・フオー・テクノロジー・トランスフアー 表面的に両親媒性のポリマー及びオリゴマーならびにそれらの使用
WO2005020964A1 (en) 2003-06-02 2005-03-10 Chiron Corporation Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
EP1697389A4 (en) * 2003-10-24 2008-12-24 Eisai R&D Man Co Ltd COMPOUNDS AND METHODS FOR TREATING ILLNESS AND SUFFERING TOLL-LIKE RECEPTOR 2 RELATED DISORDERS
FR2863890B1 (fr) * 2003-12-19 2006-03-24 Aventis Pasteur Composition immunostimulante
CN1922133A (zh) * 2004-01-23 2007-02-28 宾夕法尼亚州大学理事会 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
JP2008531585A (ja) * 2005-02-25 2008-08-14 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用
US20070292418A1 (en) * 2005-04-26 2007-12-20 Eisai Co., Ltd. Compositions and methods for immunotherapy
EP1874342B1 (en) 2005-04-26 2018-06-06 Eisai R&D Management Co., Ltd. Compositions and methods for cancer immunotherapy
CN103012304B (zh) 2005-06-30 2014-07-23 卫材R&D管理有限公司 用于制备免疫佐剂的化合物
EP2244695A1 (en) 2007-12-07 2010-11-03 Novartis AG Compositions for inducing immune responses
EP2240435B1 (en) * 2007-12-18 2012-08-01 Eisai R&D Management Co., Ltd. Reagents and methods for the beta-keto amide synthesis of a synthetic precursor to immunological adjuvant e6020
WO2009147980A1 (ja) 2008-06-04 2009-12-10 財団法人化学及血清療法研究所 不活化日本脳炎ウイルス粒子をアジュバントとして使用する方法
EP2758411A2 (en) 2011-09-19 2014-07-30 Gencia Corporation Modified creatine compounds
US20150133551A1 (en) 2012-05-03 2015-05-14 Beth Israel Deaconess Medical Center, Inc. Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
WO2014144777A2 (en) * 2013-03-15 2014-09-18 Beth Israel Deaconess Medical Center, Inc. Lipids that increase insulin sensitivity and methods of using the same
CN105555756B (zh) 2013-06-28 2018-12-07 奥克兰联合服务有限公司 氨基酸缀合物和肽缀合物及缀合方法
KR20170094449A (ko) 2014-12-23 2017-08-17 마가렛 앤 브림블 아미노산 및 펩타이드 접합체 및 이들의 용도
CA3014515A1 (en) 2016-02-26 2017-08-31 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process
US11013711B2 (en) 2016-06-10 2021-05-25 Beth Israel Deaconess Medical Center, Inc. Fatty acid esters of hydroxy fatty acids (FAHFAs) for use in the treatment of type 1 diabetes
AU2021211012A1 (en) 2020-01-24 2022-08-25 Aim Immunotech Inc. Methods, compositions, and vaccines for treating a virus infection
CN113307824B (zh) * 2021-04-26 2022-05-27 浙江大学 一种双亲性材料及其在制备脂质体中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004672A1 (en) 1991-09-11 1993-03-18 Pitman-Moore, Inc. Method for enhancing the immune system in a host employing liposome-encapsulated polypeptides
WO1995011700A1 (en) * 1993-10-29 1995-05-04 Pharmos Corp. Submicron emulsions as vaccine adjuvants
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
EP0732936B1 (de) * 1993-12-09 2000-03-29 Heinrich Exner Adjuvans für antigene, verfahren zur herstellung und verwendung
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6180111B1 (en) * 1995-05-18 2001-01-30 University Of Maryland Vaccine delivery system
US5834015A (en) * 1996-09-11 1998-11-10 Albany Medical College Protein-lipid vesicles and autogenous vaccine comprising the same
US6551600B2 (en) * 1999-02-01 2003-04-22 Eisai Co., Ltd. Immunological adjuvant compounds compositions and methods of use thereof
US20040006242A1 (en) * 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof

Also Published As

Publication number Publication date
MXPA01007760A (es) 2003-06-24
KR100711561B1 (ko) 2007-04-27
ES2223464T3 (es) 2005-03-01
EP1439184B1 (en) 2010-06-16
DE60011571T2 (de) 2005-08-18
BRPI0007936B8 (pt) 2021-05-25
NO20013749D0 (no) 2001-07-31
HU226869B1 (en) 2010-01-28
US6290973B1 (en) 2001-09-18
CA2361582C (en) 2010-04-06
HK1043132A1 (en) 2002-09-06
DE60011571D1 (de) 2004-07-22
NO329111B1 (no) 2010-08-30
FI120689B (fi) 2010-01-29
HUP0105473A3 (en) 2003-11-28
EP1439184A1 (en) 2004-07-21
HK1070372A1 (en) 2005-06-17
WO2000044758A1 (en) 2000-08-03
NO20013749L (no) 2001-09-25
PT1147117E (pt) 2004-10-29
ZA200106487B (en) 2002-08-07
NZ513259A (en) 2004-05-28
AU768574B2 (en) 2003-12-18
JP4698027B2 (ja) 2011-06-08
HUP0105473A2 (hu) 2002-04-29
BR0007936A (pt) 2002-04-09
IL174413A0 (en) 2009-02-11
ES2347428T3 (es) 2010-10-29
BR0007936B1 (pt) 2015-03-10
IL144671A (en) 2006-07-05
AU2867500A (en) 2000-08-18
IL144671A0 (en) 2002-05-23
FI20011593A (fi) 2001-07-31
EP1147117A1 (en) 2001-10-24
AU2004201147B2 (en) 2008-04-03
AU2004201147A1 (en) 2004-04-22
KR20010101912A (ko) 2001-11-15
CA2361582A1 (en) 2000-08-03
ATE471328T1 (de) 2010-07-15
JP2002535411A (ja) 2002-10-22
EP1147117B1 (en) 2004-06-16
DE60044570D1 (de) 2010-07-29
ATE269341T1 (de) 2004-07-15
HK1043132B (zh) 2005-04-01

Similar Documents

Publication Publication Date Title
DK1147117T3 (da) Immunologiske adjuvansforbindelser
WO2003011223A3 (en) Immunomodulatory compounds and methods of use thereof
ATE397942T1 (de) Adjuvanszusammensetzungen zur erhöhung der immunantwort bezüglich polynukleotid-basierenden impfstoffen
MXPA04002490A (es) Interleucina-12 como adyuvante de vacuna veterinaria.
PT1104306E (pt) Composicoes de cpg e adjuvantes de saponina e seus metodos
PT2364724E (pt) Composição de vacina compreendendo um adjuvante de saponina
IS4518A (is) Nýtt lyfjaform fyrir bóluefni
AU2001284354A1 (en) Immunological adjuvant compounds, compositions, and methods of use thereof
EA200800917A1 (ru) Адъюванты для вакцин
WO2003083083A3 (en) Methods of using flt3-ligand in immunization protocols
DK1395283T3 (da) Heterolog beskyttelse induceret ved immunisering med Invaplex-vaccine
DK0626008T3 (da) Vaccine, der som en adjuvans indeholder acemannan
MX2009000717A (es) Composicion para vacuna y metodo para inmunizacion.
WO2001035993A3 (en) Compositions and methods for stimulating an immune response against infectious agents
WO2004043286A3 (en) Use of rmlt as a marker antigen for vaccines and as a synergistic adjuvant with amphigen
PL341541A1 (en) Isolated strains of staphyloccoccus aureus and vaccines prepared of them
WO2002085409A3 (en) Methods and compositions for inducing an immune response to an antigen
WO2003040163A3 (en) Immunomodulating saponins, a method for their preparation and their use for vaccines