WO2003040163A3 - Immunomodulating saponins, a method for their preparation and their use for vaccines - Google Patents

Immunomodulating saponins, a method for their preparation and their use for vaccines Download PDF

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Publication number
WO2003040163A3
WO2003040163A3 PCT/PT2002/000016 PT0200016W WO03040163A3 WO 2003040163 A3 WO2003040163 A3 WO 2003040163A3 PT 0200016 W PT0200016 W PT 0200016W WO 03040163 A3 WO03040163 A3 WO 03040163A3
Authority
WO
WIPO (PCT)
Prior art keywords
saponins
present
new
hemi
antigens
Prior art date
Application number
PCT/PT2002/000016
Other languages
French (fr)
Other versions
WO2003040163A2 (en
WO2003040163B1 (en
Inventor
Maria Costa
Luke Green
Richard Schmidt
Steve Ley
Maria Eleuterio
Susana Alves
Concepcion Rubalcava
Original Assignee
Inst Nac De Engenharia E Tecno
Univ Cambridge Tech
Maria Costa
Luke Green
Richard Schmidt
Steve Ley
Maria Eleuterio
Susana Alves
Concepcion Rubalcava
Cardoso Fernando
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nac De Engenharia E Tecno, Univ Cambridge Tech, Maria Costa, Luke Green, Richard Schmidt, Steve Ley, Maria Eleuterio, Susana Alves, Concepcion Rubalcava, Cardoso Fernando filed Critical Inst Nac De Engenharia E Tecno
Priority to AU2002337529A priority Critical patent/AU2002337529A1/en
Publication of WO2003040163A2 publication Critical patent/WO2003040163A2/en
Publication of WO2003040163A3 publication Critical patent/WO2003040163A3/en
Publication of WO2003040163B1 publication Critical patent/WO2003040163B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.
PCT/PT2002/000016 2001-11-07 2002-11-07 Immunomodulating saponins, a method for their preparation and their use for vaccines WO2003040163A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002337529A AU2002337529A1 (en) 2001-11-07 2002-11-07 Immunomodulating saponins, a method for their preparation and their use for vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT102685A PT102685A (en) 2001-11-07 2001-11-07 Immunomodulatory agents, method for their preparation and their use for vaccines
PT102685 2001-11-07

Publications (3)

Publication Number Publication Date
WO2003040163A2 WO2003040163A2 (en) 2003-05-15
WO2003040163A3 true WO2003040163A3 (en) 2003-11-27
WO2003040163B1 WO2003040163B1 (en) 2004-03-25

Family

ID=20086087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PT2002/000016 WO2003040163A2 (en) 2001-11-07 2002-11-07 Immunomodulating saponins, a method for their preparation and their use for vaccines

Country Status (3)

Country Link
AU (1) AU2002337529A1 (en)
PT (1) PT102685A (en)
WO (1) WO2003040163A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038161A1 (en) * 1995-06-02 1996-12-05 Aquila Biopharmaceuticals, Inc. Drug delivery enhancement via modified saponins
JPH09194498A (en) * 1996-01-17 1997-07-29 Pola Chem Ind Inc Suppressor of absorption of carbohydrate and new saponin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038161A1 (en) * 1995-06-02 1996-12-05 Aquila Biopharmaceuticals, Inc. Drug delivery enhancement via modified saponins
JPH09194498A (en) * 1996-01-17 1997-07-29 Pola Chem Ind Inc Suppressor of absorption of carbohydrate and new saponin

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KIM, YOUN CHUL ET AL: "Application of hydrothermolysis to the studies of the constituents of the Merck Saponin", LIEBIGS ANNALEN DER CHEMIE (1992), (9), 941-6, XP001154522 *
LIU, ZIMIN ET AL: "Triterpenoid saponins from Gypsophila oldhamiana.", JOURNAL OF NATURAL PRODUCTS (1995), 58(10), 1632-5, XP009016344 *
NIE, RUILIN ET AL: "Saponins from Chinese medicinal plants. (I). Isolation and structures o hemslosides", PLANTA MEDICA (1984), 50(4), 322-7, XP009016334 *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 11 28 November 1997 (1997-11-28) *
SO H S ET AL: "Effect of a novel saponin adjuvant derived from Quillaja saponaria on the immune response to recombinant hepatitis B surface antigen", MOLECULAR AND CELLS, KOREAN SOCIETY FOR MOLECULAR SOCIETY, KR, vol. 7, no. 2, 1997, pages 178 - 186, XP002128520 *

Also Published As

Publication number Publication date
PT102685A (en) 2003-05-30
WO2003040163A2 (en) 2003-05-15
AU2002337529A1 (en) 2003-05-19
WO2003040163B1 (en) 2004-03-25

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