DK1140888T3 - Optiske molekylære sensorer for cytochrom P450-aktivitet - Google Patents

Optiske molekylære sensorer for cytochrom P450-aktivitet

Info

Publication number
DK1140888T3
DK1140888T3 DK99965226T DK99965226T DK1140888T3 DK 1140888 T3 DK1140888 T3 DK 1140888T3 DK 99965226 T DK99965226 T DK 99965226T DK 99965226 T DK99965226 T DK 99965226T DK 1140888 T3 DK1140888 T3 DK 1140888T3
Authority
DK
Denmark
Prior art keywords
sub
substituted
unsaturated
sup
saturated
Prior art date
Application number
DK99965226T
Other languages
Danish (da)
English (en)
Inventor
Lewis Makings
Gregor Zlokarnik
Original Assignee
Vertex Pharma San Diego Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/301,395 external-priority patent/US6143492A/en
Priority claimed from US09/301,525 external-priority patent/US6420130B1/en
Application filed by Vertex Pharma San Diego Llc filed Critical Vertex Pharma San Diego Llc
Application granted granted Critical
Publication of DK1140888T3 publication Critical patent/DK1140888T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Optical Filters (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK99965226T 1998-12-14 1999-12-10 Optiske molekylære sensorer for cytochrom P450-aktivitet DK1140888T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11225298P 1998-12-14 1998-12-14
US09/301,395 US6143492A (en) 1998-12-14 1999-04-28 Optical molecular sensors for cytochrome P450 activity
US09/301,525 US6420130B1 (en) 1998-12-14 1999-04-28 Optical molecular sensors for cytochrome P450 activity
PCT/US1999/029439 WO2000035900A1 (en) 1998-12-14 1999-12-10 Optical molecular sensors for cytochrome p450 activity

Publications (1)

Publication Number Publication Date
DK1140888T3 true DK1140888T3 (da) 2003-08-25

Family

ID=27381127

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99965226T DK1140888T3 (da) 1998-12-14 1999-12-10 Optiske molekylære sensorer for cytochrom P450-aktivitet

Country Status (11)

Country Link
US (1) US20070072256A1 (de)
EP (1) EP1140888B1 (de)
JP (1) JP2002532487A (de)
AT (1) ATE240310T1 (de)
AU (1) AU3119000A (de)
CA (1) CA2352631A1 (de)
DE (1) DE69907962T2 (de)
DK (1) DK1140888T3 (de)
ES (1) ES2199605T3 (de)
PT (1) PT1140888E (de)
WO (1) WO2000035900A1 (de)

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US6420130B1 (en) 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
JP2003507466A (ja) 1999-08-19 2003-02-25 ジェンテスト・コーポレーション ハイスループットチトクロームｐ４５０阻害アッセイにおけるフルオレセインアリールエーテル類の使用
TWI288745B (en) * 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
AU2001271985A1 (en) * 2000-07-12 2002-01-21 American Home Products Corporation Method for testing for inhibition of drug-metabolizing cytochrome p450 isozymes
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
WO2004027378A2 (en) 2002-09-20 2004-04-01 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
EP2371927B1 (de) * 2004-09-16 2020-03-11 Life Technologies Corporation Floureszierende Farbstoffverbindungen, Konjugate und Verwendungen damit
EP2277872B1 (de) 2005-05-31 2016-03-23 Promega Corporation Luminogene und Fluorogene Verbindungen uind Verfahren für den Nachweis von Molekülen oder Leiden
EP2323996B1 (de) 2008-08-18 2014-10-22 Promega Corporation Luminogene verbindungen und verfahren zum nachweis von cytochrom p450-3a-enzymen
US20120288885A1 (en) * 2009-09-01 2012-11-15 National Institute Of Advanced Industrial Science And Technolgoy Method and kit for measuring enzymatic activities of various cytochrome p450 molecule species comprehensively and with high efficiency
US8788047B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
US8788046B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
US8788048B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
EP2658998B1 (de) 2010-12-29 2015-04-22 Life Technologies Corporation Ddao-verbindungen als fluorezenzreferenzstandards
EP3099683B1 (de) 2014-01-29 2020-08-05 Promega Corporation Chinonmaskierte sonden als markierungsreagenzien für zellaufnahmemessungen
JP6360345B2 (ja) * 2014-04-22 2018-07-18 五稜化薬株式会社 キサンテン化合物及びその用途
US20180305329A1 (en) * 2015-10-21 2018-10-25 Sumitomo Chemical Company, Limited Xanthine compound and use thereof
US11540973B2 (en) 2016-10-21 2023-01-03 Spr Therapeutics, Llc Method and system of mechanical nerve stimulation for pain relief
CN109608427B (zh) * 2018-12-29 2020-06-30 山东师范大学 一种用于定性检测一氧化氮浓度的双光子荧光探针及其合成方法、应用

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US6420130B1 (en) * 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
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Also Published As

Publication number Publication date
DE69907962D1 (de) 2003-06-18
EP1140888B1 (de) 2003-05-14
US20070072256A1 (en) 2007-03-29
CA2352631A1 (en) 2000-06-22
DE69907962T2 (de) 2004-05-19
ATE240310T1 (de) 2003-05-15
WO2000035900A1 (en) 2000-06-22
ES2199605T3 (es) 2004-02-16
EP1140888A1 (de) 2001-10-10
PT1140888E (pt) 2003-09-30
JP2002532487A (ja) 2002-10-02
AU3119000A (en) 2000-07-03

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