DK1117676T3 - Propanolaminderivater bundet til galdesyrer til behandling af forstyrrelser i lipidstofskiftet - Google Patents

Propanolaminderivater bundet til galdesyrer til behandling af forstyrrelser i lipidstofskiftet

Info

Publication number
DK1117676T3
DK1117676T3 DK99947385T DK99947385T DK1117676T3 DK 1117676 T3 DK1117676 T3 DK 1117676T3 DK 99947385 T DK99947385 T DK 99947385T DK 99947385 T DK99947385 T DK 99947385T DK 1117676 T3 DK1117676 T3 DK 1117676T3
Authority
DK
Denmark
Prior art keywords
lipid metabolism
bile acids
treat disorders
derivatives bound
propanolamine derivatives
Prior art date
Application number
DK99947385T
Other languages
Danish (da)
English (en)
Inventor
Alfons Enhsen
Heiner Glombik
Werner Kramer
Eugen Falk
Siegfried Stengelin
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Application granted granted Critical
Publication of DK1117676T3 publication Critical patent/DK1117676T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK99947385T 1998-10-02 1999-09-18 Propanolaminderivater bundet til galdesyrer til behandling af forstyrrelser i lipidstofskiftet DK1117676T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845403A DE19845403B4 (de) 1998-10-02 1998-10-02 Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP99947385A EP1117676B1 (de) 1998-10-02 1999-09-18 Mit gallensäuren verknüpfte propanolaminderivate zur behandlung von lipidstoffwechselstörungen

Publications (1)

Publication Number Publication Date
DK1117676T3 true DK1117676T3 (da) 2004-12-20

Family

ID=7883185

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99947385T DK1117676T3 (da) 1998-10-02 1999-09-18 Propanolaminderivater bundet til galdesyrer til behandling af forstyrrelser i lipidstofskiftet

Country Status (22)

Country Link
US (1) US6180618B1 (pt)
EP (1) EP1117676B1 (pt)
JP (1) JP4598953B2 (pt)
KR (1) KR20010075511A (pt)
CN (1) CN1227259C (pt)
AR (1) AR035003A1 (pt)
AT (1) ATE273991T1 (pt)
AU (1) AU757366B2 (pt)
BR (1) BR9915019A (pt)
CA (1) CA2346085A1 (pt)
DE (2) DE19845403B4 (pt)
DK (1) DK1117676T3 (pt)
ES (1) ES2226440T3 (pt)
HK (1) HK1040717A1 (pt)
HU (1) HUP0103570A3 (pt)
ID (1) ID29353A (pt)
PL (1) PL347106A1 (pt)
PT (1) PT1117676E (pt)
RU (1) RU2234512C2 (pt)
TR (1) TR200100897T2 (pt)
WO (1) WO2000020437A1 (pt)
ZA (1) ZA200102586B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
GB0817969D0 (en) * 2008-10-01 2008-11-05 Axcess Ltd Pharmaceutical composition
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
MX369466B (es) 2011-10-28 2019-11-08 Lumena Pharmaceuticals Inc Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas.
KR20190135545A (ko) 2011-10-28 2019-12-06 루메나 파마수티컬즈, 인코포레이티드 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제
JP2016514684A (ja) 2013-03-15 2016-05-23 ルメナ ファーマシューティカルズ エルエルシー 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤
MX2015013196A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores de reciclaje de acidos biliares para el tratamiento de la enfermedad de reflujo gastroesofagico y esofago de barrett.
KR20210137046A (ko) 2019-02-12 2021-11-17 미룸 파마슈티컬스, 인크. 담즙정체의 치료 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI892341A (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
GB2250634A (en) * 1990-12-04 1992-06-10 Marconi Gec Ltd Point contact diodes
US5250524A (en) * 1990-12-06 1993-10-05 Hoechst Aktiengesellschaft Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
JP2616845B2 (ja) * 1991-02-21 1997-06-04 清水化学株式会社 システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
DK0557879T3 (da) * 1992-02-22 1997-06-16 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse
EP0624593A3 (de) * 1993-05-08 1995-06-07 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
TW289021B (pt) * 1993-05-08 1996-10-21 Hoechst Ag
ATE268758T1 (de) * 1997-04-04 2004-06-15 Aventis Pharma Gmbh Hypolipidämische propanolaminderivate

Also Published As

Publication number Publication date
AR035003A1 (es) 2004-04-14
HK1040717A1 (zh) 2002-06-21
KR20010075511A (ko) 2001-08-09
BR9915019A (pt) 2001-08-14
WO2000020437A1 (de) 2000-04-13
CN1227259C (zh) 2005-11-16
TR200100897T2 (tr) 2001-10-22
PL347106A1 (en) 2002-03-25
DE19845403B4 (de) 2005-02-10
EP1117676A1 (de) 2001-07-25
AU757366B2 (en) 2003-02-20
DE59910300D1 (de) 2004-09-23
ATE273991T1 (de) 2004-09-15
ID29353A (id) 2001-08-23
ES2226440T3 (es) 2005-03-16
US6180618B1 (en) 2001-01-30
JP4598953B2 (ja) 2010-12-15
JP2002526550A (ja) 2002-08-20
HUP0103570A2 (hu) 2002-02-28
HUP0103570A3 (en) 2003-01-28
PT1117676E (pt) 2004-11-30
EP1117676B1 (de) 2004-08-18
CA2346085A1 (en) 2000-04-13
CN1321166A (zh) 2001-11-07
ZA200102586B (en) 2001-10-03
RU2234512C2 (ru) 2004-08-20
DE19845403A1 (de) 2000-04-13
AU6085599A (en) 2000-04-26

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