DK1091745T3 - Behandling af hyperproliferative forstyrrelser - Google Patents
Behandling af hyperproliferative forstyrrelserInfo
- Publication number
- DK1091745T3 DK1091745T3 DK99930790T DK99930790T DK1091745T3 DK 1091745 T3 DK1091745 T3 DK 1091745T3 DK 99930790 T DK99930790 T DK 99930790T DK 99930790 T DK99930790 T DK 99930790T DK 1091745 T3 DK1091745 T3 DK 1091745T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor
- ceramide
- treatment
- preferred
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9113898P | 1998-06-29 | 1998-06-29 | |
PCT/US1999/014591 WO2000000207A1 (en) | 1998-06-29 | 1999-06-28 | Treatment of hyperproliferative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1091745T3 true DK1091745T3 (da) | 2008-12-15 |
Family
ID=22226266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99930790T DK1091745T3 (da) | 1998-06-29 | 1999-06-28 | Behandling af hyperproliferative forstyrrelser |
Country Status (12)
Country | Link |
---|---|
US (1) | US6352844B1 (da) |
EP (1) | EP1091745B1 (da) |
JP (1) | JP4965764B2 (da) |
CN (1) | CN100358529C (da) |
AT (1) | ATE409486T1 (da) |
AU (1) | AU4724599A (da) |
BR (1) | BR9912501A (da) |
CA (1) | CA2335941C (da) |
DE (1) | DE69939651D1 (da) |
DK (1) | DK1091745T3 (da) |
ES (1) | ES2316188T3 (da) |
WO (1) | WO2000000207A1 (da) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6098631A (en) * | 1998-01-21 | 2000-08-08 | The Regents Of The University Of Michigan | Compositions and methods for treating autoimmune disease |
US6368831B1 (en) * | 1998-06-29 | 2002-04-09 | Childrens Hospital Los Angeles | Treatment of hyperproliferative disorders |
GB0006539D0 (en) * | 2000-03-17 | 2000-05-10 | Oxford Glycosciences Uk Ltd | Therapies |
AUPQ744700A0 (en) * | 2000-05-11 | 2000-06-01 | Medvet Science Pty. Ltd. | A method of treatment and agents useful for same |
EP1195604A1 (en) * | 2000-09-29 | 2002-04-10 | Warner-Lambert Company | Methods and compositions for screening modulators of lipid kinases |
JP4384409B2 (ja) * | 2000-12-05 | 2009-12-16 | チルドレンズ・ホスピタル・ロス・アンジエルス | バイオアベイラビリティが増加したフェンレチニドの医薬組成物、およびその使用方法 |
CA2432978C (en) * | 2000-12-22 | 2012-08-28 | Medlyte, Inc. | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor |
US20040097587A1 (en) * | 2002-03-27 | 2004-05-20 | Arbiser Jack L | Compositions and methods of treatment of ulcerating diseases, burns, and related conditions |
US20030226181P1 (en) * | 2002-05-31 | 2003-12-04 | Mason Harleigh C. | Apple tree named 'Rosy Glow' |
JP3405981B1 (ja) * | 2002-06-26 | 2003-05-12 | 日本財経株式会社 | 酢酸セルロースの製造方法 |
JP4469720B2 (ja) * | 2002-09-20 | 2010-05-26 | メディシン テクノロジーズ インコーポレーテッド | 治療薬及び対応する治療 |
JP2006518384A (ja) * | 2003-01-31 | 2006-08-10 | チルドレンズ・ホスピタル・ロス・アンジエルス | 改善されたバイオアベイラビリティを有するフェンレチニドの経口組成物、およびその使用方法 |
MXPA05008860A (es) * | 2003-02-21 | 2005-10-05 | Los Angeles Childrens Hospital | Composiciones farmaceuticas estabilizadas de safingol y metodos para utilizar las mismas. |
US20050101674A1 (en) * | 2003-11-12 | 2005-05-12 | Maurer Barry J. | PPMP as a ceramide catabolism inhibitor for cancer treatment |
US20070258970A1 (en) * | 2003-12-09 | 2007-11-08 | Robert Blumenthal | Methods for Inhibiting Hiv and Other Viral Infections by Modulating Ceramide Metabolism |
ES2459750T3 (es) | 2004-03-02 | 2014-05-12 | Mcgill University | Composiciones y métodos para prevenir o tratar una respuesta inflamatoria |
US7794713B2 (en) * | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
US7652029B2 (en) * | 2004-07-09 | 2010-01-26 | Medisyn Technologies, Inc. | Therapeutic compound and treatments |
WO2006078336A2 (en) * | 2004-10-28 | 2006-07-27 | Lpath Therapeutics, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
US20060257493A1 (en) * | 2005-04-28 | 2006-11-16 | Amiji Mansoor M | Nanoparticulate delivery systems for treating multi-drug resistance |
US20090074720A1 (en) * | 2005-10-28 | 2009-03-19 | Sabbadini Roger A | Methods for decreasing immune response and treating immune conditions |
US20080213274A1 (en) * | 2005-10-28 | 2008-09-04 | Sabbadini Roger A | Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye |
WO2007115134A2 (en) | 2006-03-29 | 2007-10-11 | Wayne State University | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
US9274129B2 (en) * | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
US20080138334A1 (en) * | 2006-05-31 | 2008-06-12 | Sabbadini Roger A | Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same |
US9274130B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
US8796429B2 (en) * | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
US7862812B2 (en) * | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
AU2007329759B2 (en) | 2006-10-27 | 2013-05-30 | Lpath, Inc. | Compositions and methods for binding sphingosine-1-phosphate |
CN101687031B (zh) * | 2006-10-27 | 2014-05-14 | 勒帕斯公司 | 用于治疗眼疾和眼病的组合物及方法 |
US20100311765A1 (en) * | 2007-09-28 | 2010-12-09 | Barry James Maurer | Metabolic degradation inhibitors for anti-hyperproliferative agents |
US8361465B2 (en) * | 2007-10-26 | 2013-01-29 | Lpath, Inc. | Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents |
GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
US20090253733A1 (en) * | 2008-04-02 | 2009-10-08 | Biointeractions, Ltd. | Rapamycin carbonate esters |
US8088822B2 (en) * | 2008-07-08 | 2012-01-03 | Ji Zhang | Use of fenretinide or bioactive derivatives thereof and pharmaceutical compositions comprising the same |
CN101623277B (zh) * | 2008-07-08 | 2014-07-16 | 上海交通大学医学院附属瑞金医院 | 芬维a胺及其活性衍生物的新用途及其药物组合物 |
US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
WO2011060332A2 (en) | 2009-11-12 | 2011-05-19 | Texas Tech University | Compositions and methods for treating hyperproliferative disorders |
US8450350B2 (en) * | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
CA2817957C (en) * | 2010-11-15 | 2016-05-10 | Texas Tech University | Substance for increasing the production of a specific acyl-chain dihydroceramide(s) for improving the effectiveness of cancer treatments |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190594A (en) | 1975-11-03 | 1980-02-26 | Johnson & Johnson | Retinoic acid derivatives |
US4323581A (en) | 1978-07-31 | 1982-04-06 | Johnson & Johnson | Method of treating carcinogenesis |
US4665098A (en) | 1985-03-28 | 1987-05-12 | Mcneilab, Inc. | Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide having increased bioavailability |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
US5041441A (en) | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
US5190876A (en) * | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
EP0671953A4 (en) | 1992-11-13 | 1996-01-10 | Univ Ohio State Res Found | ANALOGS OF N- (4-HYDROXYPHENYL) RETINAMIDE-O-GLUCURONIDE ARYLAMIDE. |
US5302609A (en) | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
US5464870A (en) * | 1993-02-10 | 1995-11-07 | Ortho Pharmaceutical Corporation | Methods of inhibiting development of leukoplakia with fenretinide |
HUT73527A (en) | 1993-08-13 | 1996-08-28 | Seikagaku Kogyo Co Ltd | Remedy for nervous diseases |
US5635536A (en) | 1994-12-07 | 1997-06-03 | Pharmacia & Upjohn Aktiebolag | Emulsion suitable for administering a sphingolipid |
US5821254A (en) * | 1995-02-17 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer |
US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
JPH09176083A (ja) | 1995-12-28 | 1997-07-08 | Sankyo Co Ltd | 新規化合物f−12509a |
US5821072A (en) | 1996-02-20 | 1998-10-13 | Sloan-Kettering Institute For Cancer Research | Combinations of PKC inhibitors and therapaeutic agents for treating cancers |
US5885786A (en) | 1996-04-19 | 1999-03-23 | John Wayne Cancer Institute | Methods for screening of substances for inhibition of multidrug resistance |
-
1999
- 1999-06-28 AT AT99930790T patent/ATE409486T1/de not_active IP Right Cessation
- 1999-06-28 AU AU47245/99A patent/AU4724599A/en not_active Abandoned
- 1999-06-28 DK DK99930790T patent/DK1091745T3/da active
- 1999-06-28 DE DE69939651T patent/DE69939651D1/de not_active Expired - Lifetime
- 1999-06-28 US US09/342,019 patent/US6352844B1/en not_active Expired - Lifetime
- 1999-06-28 CA CA2335941A patent/CA2335941C/en not_active Expired - Lifetime
- 1999-06-28 BR BR9912501-3A patent/BR9912501A/pt not_active IP Right Cessation
- 1999-06-28 JP JP2000556792A patent/JP4965764B2/ja not_active Expired - Lifetime
- 1999-06-28 EP EP99930790A patent/EP1091745B1/en not_active Expired - Lifetime
- 1999-06-28 CN CNB998081426A patent/CN100358529C/zh not_active Expired - Fee Related
- 1999-06-28 WO PCT/US1999/014591 patent/WO2000000207A1/en active Application Filing
- 1999-06-28 ES ES99930790T patent/ES2316188T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2002519329A (ja) | 2002-07-02 |
AU4724599A (en) | 2000-01-17 |
ATE409486T1 (de) | 2008-10-15 |
WO2000000207A9 (en) | 2000-05-18 |
WO2000000207A1 (en) | 2000-01-06 |
JP4965764B2 (ja) | 2012-07-04 |
ES2316188T3 (es) | 2009-04-01 |
CN1308538A (zh) | 2001-08-15 |
US6352844B1 (en) | 2002-03-05 |
BR9912501A (pt) | 2001-05-02 |
EP1091745A1 (en) | 2001-04-18 |
CA2335941C (en) | 2011-03-22 |
EP1091745B1 (en) | 2008-10-01 |
EP1091745A4 (en) | 2003-08-27 |
CN100358529C (zh) | 2008-01-02 |
CA2335941A1 (en) | 2000-01-06 |
DE69939651D1 (de) | 2008-11-13 |
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