DE69939651D1 - Behandlung hyperproliferativer erkrankungen - Google Patents

Behandlung hyperproliferativer erkrankungen

Info

Publication number
DE69939651D1
DE69939651D1 DE69939651T DE69939651T DE69939651D1 DE 69939651 D1 DE69939651 D1 DE 69939651D1 DE 69939651 T DE69939651 T DE 69939651T DE 69939651 T DE69939651 T DE 69939651T DE 69939651 D1 DE69939651 D1 DE 69939651D1
Authority
DE
Germany
Prior art keywords
inhibitor
ceramide
treatment
preferred
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939651T
Other languages
English (en)
Inventor
Barry James Maurer
C Patrick Reynolds
Myles Cabot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital Los Angeles
Original Assignee
Childrens Hospital Los Angeles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hospital Los Angeles filed Critical Childrens Hospital Los Angeles
Application granted granted Critical
Publication of DE69939651D1 publication Critical patent/DE69939651D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/15—Suppositories

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69939651T 1998-06-29 1999-06-28 Behandlung hyperproliferativer erkrankungen Expired - Lifetime DE69939651D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9113898P 1998-06-29 1998-06-29
PCT/US1999/014591 WO2000000207A1 (en) 1998-06-29 1999-06-28 Treatment of hyperproliferative disorders

Publications (1)

Publication Number Publication Date
DE69939651D1 true DE69939651D1 (de) 2008-11-13

Family

ID=22226266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939651T Expired - Lifetime DE69939651D1 (de) 1998-06-29 1999-06-28 Behandlung hyperproliferativer erkrankungen

Country Status (12)

Country Link
US (1) US6352844B1 (de)
EP (1) EP1091745B1 (de)
JP (1) JP4965764B2 (de)
CN (1) CN100358529C (de)
AT (1) ATE409486T1 (de)
AU (1) AU4724599A (de)
BR (1) BR9912501A (de)
CA (1) CA2335941C (de)
DE (1) DE69939651D1 (de)
DK (1) DK1091745T3 (de)
ES (1) ES2316188T3 (de)
WO (1) WO2000000207A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6098631A (en) * 1998-01-21 2000-08-08 The Regents Of The University Of Michigan Compositions and methods for treating autoimmune disease
US6368831B1 (en) * 1998-06-29 2002-04-09 Childrens Hospital Los Angeles Treatment of hyperproliferative disorders
GB0006539D0 (en) * 2000-03-17 2000-05-10 Oxford Glycosciences Uk Ltd Therapies
AUPQ744700A0 (en) * 2000-05-11 2000-06-01 Medvet Science Pty. Ltd. A method of treatment and agents useful for same
EP1195604A1 (de) * 2000-09-29 2002-04-10 Warner-Lambert Company Verfahren und Zusammensetzungen zum Screenen von Modulatoren von Lipidkinasen
DE60136648D1 (de) * 2000-12-05 2009-01-02 Los Angeles Childrens Hospital Pharmazeutische zusammensetzungen von fenretinid mit erhöhter bioverfügbarkeit und verfahren zu deren verwendung
WO2002051439A2 (en) * 2000-12-22 2002-07-04 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
US20040097587A1 (en) * 2002-03-27 2004-05-20 Arbiser Jack L Compositions and methods of treatment of ulcerating diseases, burns, and related conditions
US20030226181P1 (en) * 2002-05-31 2003-12-04 Mason Harleigh C. Apple tree named 'Rosy Glow'
JP3405981B1 (ja) * 2002-06-26 2003-05-12 日本財経株式会社 酢酸セルロースの製造方法
AU2002357644A1 (en) * 2002-09-20 2004-04-08 Medisyn Technologies, Inc. Therapeutic agents and corresponding treatments
PT1594544T (pt) * 2003-01-31 2016-07-14 Los Angeles Childrens Hospital Composições orais de fenretinida tendo biodisponibilidade aumentada e métodos de utilização das mesmas
JP4842800B2 (ja) * 2003-02-21 2011-12-21 ザ・ガヴァメント・オブ・ザ・ユナイテッド・ステイツ・オブ・アメリカ，アズ・リプレゼンテッド・バイ・ザ・セクレタリー・オブ・ザ・デパートメント・オブ・ヘルス・アンド・ヒューマン・サーヴィシーズ サフィンゴールの医薬組成物およびその使用方法
US20050101674A1 (en) * 2003-11-12 2005-05-12 Maurer Barry J. PPMP as a ceramide catabolism inhibitor for cancer treatment
US20070258970A1 (en) * 2003-12-09 2007-11-08 Robert Blumenthal Methods for Inhibiting Hiv and Other Viral Infections by Modulating Ceramide Metabolism
CA2558429C (en) 2004-03-02 2011-02-01 Mcgill University Compositions and methods for preventing or treating an inflammatory response
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090111812A1 (en) * 2004-06-14 2009-04-30 Musc Foundation For Research Development Methods for treating inflammatory disorders
WO2006010127A2 (en) * 2004-07-09 2006-01-26 Medisyn Technologies, Inc. Therapeutic compound and treatments
SI1812797T1 (sl) * 2004-10-28 2013-06-28 Lpath, Inc. Pripravki in metode zdravljenja ter preprečevanja hiperprolifetarivnih bolezni
US20060257493A1 (en) * 2005-04-28 2006-11-16 Amiji Mansoor M Nanoparticulate delivery systems for treating multi-drug resistance
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US8709379B2 (en) 2006-03-29 2014-04-29 Scitech Development, Llc Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
US9274129B2 (en) * 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9217749B2 (en) * 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8796429B2 (en) * 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
JP5795833B2 (ja) 2006-10-27 2015-10-14 エルパス・インコーポレイテッドＬｐａｔｈ， Ｉｎｃ． スフィンゴシン−１−リン酸と結合させるための組成物および方法
US8614103B2 (en) * 2006-10-27 2013-12-24 Lpath, Inc. Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
WO2009045345A1 (en) * 2007-09-28 2009-04-09 Childrens Hospital Los Angeles Research Institute Metabolic degradation inhibitors for anti-hyperproliferative agents
US8361465B2 (en) * 2007-10-26 2013-01-29 Lpath, Inc. Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents
GB0803352D0 (en) 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
US20090253733A1 (en) * 2008-04-02 2009-10-08 Biointeractions, Ltd. Rapamycin carbonate esters
CN101623277B (zh) * 2008-07-08 2014-07-16 上海交通大学医学院附属瑞金医院 芬维a胺及其活性衍生物的新用途及其药物组合物
US8088822B2 (en) * 2008-07-08 2012-01-03 Ji Zhang Use of fenretinide or bioactive derivatives thereof and pharmaceutical compositions comprising the same
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate
CA2817198C (en) * 2009-11-12 2018-05-01 Texas Tech University Compositions and methods for treating hyperproliferative disorders
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US20120121691A1 (en) * 2010-11-15 2012-05-17 Texas Tech University System Method for Increasing the Production of a Specific ACYL-Chain Dihydroceramide(s) for Improving the Effectiveness of Cancer Treatments

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190594A (en) 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4323581A (en) 1978-07-31 1982-04-06 Johnson & Johnson Method of treating carcinogenesis
US4665098A (en) 1985-03-28 1987-05-12 Mcneilab, Inc. Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide having increased bioavailability
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US5041441A (en) 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
US5190876A (en) * 1988-12-27 1993-03-02 Emory University Method of modifying cellular differentiation and function and compositions therefor
EP0671953A4 (de) 1992-11-13 1996-01-10 Univ Ohio State Res Found C-glycosid-analoge des n-(hydroxyphenyl)retinamid-o-glucuronids.
US5302609A (en) 1992-12-16 1994-04-12 The Regents Of The University Of Michigan Treatment of diabetic nephropathy
US5464870A (en) 1993-02-10 1995-11-07 Ortho Pharmaceutical Corporation Methods of inhibiting development of leukoplakia with fenretinide
DE69426331T2 (de) 1993-08-13 2001-06-21 Seikagaku Kogyo Co Ltd Arzneimittel gegen nervöse erkrankungen
US5635536A (en) 1994-12-07 1997-06-03 Pharmacia & Upjohn Aktiebolag Emulsion suitable for administering a sphingolipid
US5821254A (en) * 1995-02-17 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
JPH09176083A (ja) 1995-12-28 1997-07-08 Sankyo Co Ltd 新規化合物ｆ−１２５０９ａ
US5821072A (en) 1996-02-20 1998-10-13 Sloan-Kettering Institute For Cancer Research Combinations of PKC inhibitors and therapaeutic agents for treating cancers
US5885786A (en) 1996-04-19 1999-03-23 John Wayne Cancer Institute Methods for screening of substances for inhibition of multidrug resistance

Also Published As

Publication number Publication date
US6352844B1 (en) 2002-03-05
DK1091745T3 (da) 2008-12-15
CN1308538A (zh) 2001-08-15
EP1091745A1 (de) 2001-04-18
WO2000000207A9 (en) 2000-05-18
JP4965764B2 (ja) 2012-07-04
CN100358529C (zh) 2008-01-02
EP1091745A4 (de) 2003-08-27
WO2000000207A1 (en) 2000-01-06
CA2335941C (en) 2011-03-22
AU4724599A (en) 2000-01-17
ATE409486T1 (de) 2008-10-15
JP2002519329A (ja) 2002-07-02
EP1091745B1 (de) 2008-10-01
BR9912501A (pt) 2001-05-02
ES2316188T3 (es) 2009-04-01
CA2335941A1 (en) 2000-01-06

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Legal Events

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