DK1044967T3 - 2-pyridinylguanidinurokinaseinhibitor - Google Patents
2-pyridinylguanidinurokinaseinhibitorInfo
- Publication number
- DK1044967T3 DK1044967T3 DK00302778T DK00302778T DK1044967T3 DK 1044967 T3 DK1044967 T3 DK 1044967T3 DK 00302778 T DK00302778 T DK 00302778T DK 00302778 T DK00302778 T DK 00302778T DK 1044967 T3 DK1044967 T3 DK 1044967T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridinylguanidine
- urokinase inhibitor
- urokinase
- inhibitor
- solvate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9908410.5A GB9908410D0 (en) | 1999-04-13 | 1999-04-13 | Pyridines |
EP00302778A EP1044967B1 (fr) | 1999-04-13 | 2000-03-31 | 2-Pyridinylguanidines utilisées en tant qu'inhibiteurs d'urokinase |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1044967T3 true DK1044967T3 (da) | 2004-11-22 |
Family
ID=10851438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00302778T DK1044967T3 (da) | 1999-04-13 | 2000-03-31 | 2-pyridinylguanidinurokinaseinhibitor |
Country Status (11)
Country | Link |
---|---|
US (2) | US6583162B1 (fr) |
EP (1) | EP1044967B1 (fr) |
JP (1) | JP3521347B2 (fr) |
AT (1) | ATE273280T1 (fr) |
BR (1) | BR0001569A (fr) |
CA (1) | CA2305047A1 (fr) |
DE (1) | DE60012809T2 (fr) |
DK (1) | DK1044967T3 (fr) |
ES (1) | ES2221829T3 (fr) |
GB (1) | GB9908410D0 (fr) |
PT (1) | PT1044967E (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
WO2003024931A1 (fr) * | 2001-09-14 | 2003-03-27 | Merck & Co., Inc. | Inhibiteurs de tyrosine kinase |
US7838560B2 (en) * | 2002-03-11 | 2010-11-23 | The Medicines Company (Leipzig) Gmbh | Urokinase inhibitors, production and use thereof |
US20030195192A1 (en) * | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
NZ541861A (en) | 2003-02-26 | 2009-05-31 | Sugen Inc | Aminoheteroaryl compounds as protein kinase inhibitors |
US7592466B2 (en) | 2003-10-09 | 2009-09-22 | Abbott Laboratories | Ureas having antiangiogenic activity |
ES2382876T3 (es) | 2005-05-31 | 2012-06-14 | Pfizer, Inc. | Compuestos de ariloxi-N-biciclometil-acetamida sustituidos como antagonistas de VR1 |
JP2008543900A (ja) | 2005-06-24 | 2008-12-04 | ヴィレックス アクチェンゲゼルシャフト | 神経病理学的疾患の処置及び/又は予防のためのウロキナーゼ阻害剤の使用 |
US9296697B2 (en) | 2005-08-24 | 2016-03-29 | Abbott Laboratories | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors |
NZ568654A (en) | 2005-12-05 | 2012-02-24 | Pfizer Prod Inc | Method of treating abnormal cell growth |
PT1963302E (pt) | 2005-12-05 | 2013-04-09 | Pfizer Prod Inc | Polimorfos de um inibidor de c-met/hgfr |
US20080038783A1 (en) * | 2006-06-29 | 2008-02-14 | Applera Corporation | Compositions and Methods Pertaining to Guanylation of PNA Oligomers |
NZ578744A (en) * | 2007-01-31 | 2012-02-24 | Vertex Pharma | 2-aminopyridine derivatives useful as kinase inhibitors |
WO2008115870A2 (fr) * | 2007-03-16 | 2008-09-25 | Mount Sinai School Of Medicine | Induction et/ou maintenance d'une dormance de tumeur par rupture de l'interaction récepteur d'activateur du plasminogène d'urokinase-intégrine |
MX2010002772A (es) * | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
WO2009073300A1 (fr) * | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | Dérivés de [1h-pyrazolo[3,4-b]pyridin-4-yl]-phényle ou -pyridin-2-yle en tant qu'inhibiteurs de la protéine kinase c-thêta |
NZ590784A (en) | 2008-07-23 | 2012-12-21 | Vertex Pharma | Pyrazolopyridine kinase inhibitors |
EP2328896B1 (fr) | 2008-07-23 | 2013-10-23 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de pyrazolopyridine kinase tricylique |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
WO2010017350A1 (fr) * | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d’aminopyridine kinase |
EP2427464A1 (fr) | 2009-05-06 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
JP2013518114A (ja) | 2010-01-27 | 2013-05-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | ピラゾロピリミジンキナーゼ阻害剤 |
AU2011209649A1 (en) | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
JP5769733B2 (ja) | 2010-01-27 | 2015-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ピラゾロピリジンキナーゼ阻害剤 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2713048A (en) * | 1950-03-09 | 1955-07-12 | Abbott Lab | Pyridyl thenylamines |
US2604473A (en) * | 1950-07-17 | 1952-07-22 | Schering Corp | Propylamine type antihistamines |
GB1489879A (en) | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
US4465851A (en) * | 1981-01-22 | 1984-08-14 | Nippon Chemiphar Co., Ltd. | Guanidinocyclohexanecarboxylic acid derivatives |
WO1994026715A1 (fr) | 1993-05-11 | 1994-11-24 | Smithkline Beecham Plc | Derives d'amidine utilises en tant qu'inhibiteurs de secretion d'acide gastrique |
AU687440B2 (en) | 1993-08-24 | 1998-02-26 | Medivir Ab | Compounds and methods for inhibition of HIV and related viruses |
DE19544686A1 (de) * | 1995-11-30 | 1997-06-05 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
JP2000516620A (ja) * | 1996-08-15 | 2000-12-12 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
-
1999
- 1999-04-13 GB GBGB9908410.5A patent/GB9908410D0/en not_active Ceased
-
2000
- 2000-03-31 AT AT00302778T patent/ATE273280T1/de not_active IP Right Cessation
- 2000-03-31 ES ES00302778T patent/ES2221829T3/es not_active Expired - Lifetime
- 2000-03-31 DE DE60012809T patent/DE60012809T2/de not_active Expired - Fee Related
- 2000-03-31 PT PT00302778T patent/PT1044967E/pt unknown
- 2000-03-31 DK DK00302778T patent/DK1044967T3/da active
- 2000-03-31 EP EP00302778A patent/EP1044967B1/fr not_active Expired - Lifetime
- 2000-04-06 JP JP2000104725A patent/JP3521347B2/ja not_active Expired - Fee Related
- 2000-04-07 BR BR0001569-5A patent/BR0001569A/pt not_active IP Right Cessation
- 2000-04-10 US US09/546,410 patent/US6583162B1/en not_active Expired - Fee Related
- 2000-04-12 CA CA002305047A patent/CA2305047A1/fr not_active Abandoned
-
2003
- 2003-03-12 US US10/386,888 patent/US6673789B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20030203914A1 (en) | 2003-10-30 |
EP1044967B1 (fr) | 2004-08-11 |
BR0001569A (pt) | 2001-08-21 |
DE60012809T2 (de) | 2005-08-11 |
ATE273280T1 (de) | 2004-08-15 |
JP2000297074A (ja) | 2000-10-24 |
CA2305047A1 (fr) | 2000-10-13 |
EP1044967A3 (fr) | 2001-02-07 |
US6673789B2 (en) | 2004-01-06 |
US6583162B1 (en) | 2003-06-24 |
GB9908410D0 (en) | 1999-06-09 |
ES2221829T3 (es) | 2005-01-16 |
EP1044967A2 (fr) | 2000-10-18 |
JP3521347B2 (ja) | 2004-04-19 |
DE60012809D1 (de) | 2004-09-16 |
PT1044967E (pt) | 2004-10-29 |
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