DK1044364T3 - Fremgangmåde og reagenser til kvantificering af fastfasereaktioner ved anvendelse af fluor-NMR - Google Patents

Fremgangmåde og reagenser til kvantificering af fastfasereaktioner ved anvendelse af fluor-NMR

Info

Publication number
DK1044364T3
DK1044364T3 DK98966876T DK98966876T DK1044364T3 DK 1044364 T3 DK1044364 T3 DK 1044364T3 DK 98966876 T DK98966876 T DK 98966876T DK 98966876 T DK98966876 T DK 98966876T DK 1044364 T3 DK1044364 T3 DK 1044364T3
Authority
DK
Denmark
Prior art keywords
reagents
methods
solid phase
phase reactions
fluorine nmr
Prior art date
Application number
DK98966876T
Other languages
Danish (da)
English (en)
Inventor
Vasant K Nagulapalli
Edward Orton
John E Airey
Paul H Krolikowski
Original Assignee
Aventis Pharm Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/023920 external-priority patent/WO1998029376A1/en
Application filed by Aventis Pharm Prod Inc filed Critical Aventis Pharm Prod Inc
Application granted granted Critical
Publication of DK1044364T3 publication Critical patent/DK1044364T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/12Hydrolysis
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/14Esterification
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/18Introducing halogen atoms or halogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/18Introducing halogen atoms or halogen-containing groups
    • C08F8/20Halogenation
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/26Removing halogen atoms or halogen-containing groups from the molecule
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/30Introducing nitrogen atoms or nitrogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/34Introducing sulfur atoms or sulfur-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/20Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00Chemical modification of a polymer
    • C08F2810/20Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Catalysts (AREA)
DK98966876T 1997-12-17 1998-12-14 Fremgangmåde og reagenser til kvantificering af fastfasereaktioner ved anvendelse af fluor-NMR DK1044364T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US1997/023920 WO1998029376A1 (en) 1996-12-19 1997-12-17 Process for the solid phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds
US9055898P 1998-06-24 1998-06-24
US9056398P 1998-06-24 1998-06-24
PCT/US1998/026512 WO1999031491A1 (en) 1997-12-17 1998-12-14 Method and reagents for the quantification of solid-phase reactions using fluorine nmr

Publications (1)

Publication Number Publication Date
DK1044364T3 true DK1044364T3 (da) 2007-09-24

Family

ID=27376603

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98966876T DK1044364T3 (da) 1997-12-17 1998-12-14 Fremgangmåde og reagenser til kvantificering af fastfasereaktioner ved anvendelse af fluor-NMR

Country Status (16)

Country Link
EP (1) EP1044364B8 (pl)
JP (1) JP2003522934A (pl)
CN (1) CN1205468C (pl)
AT (1) ATE364837T1 (pl)
AU (1) AU748529C (pl)
BG (1) BG65184B1 (pl)
BR (1) BR9813701A (pl)
CA (1) CA2315152A1 (pl)
DE (1) DE69837936T2 (pl)
DK (1) DK1044364T3 (pl)
ES (1) ES2288310T3 (pl)
HU (1) HUP0200726A2 (pl)
IL (1) IL136718A0 (pl)
MX (1) MXPA00006050A (pl)
PL (1) PL197620B1 (pl)
WO (1) WO1999031491A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1106902A (en) * 2000-09-27 2002-04-08 Univ Leiden Method for applying nmr for ligand discovery or as a drug screening tool
FR2955862B1 (fr) * 2010-02-02 2012-07-13 Commissariat Energie Atomique Materiau polymere fluorocarbone et procede de synthese
CN103487455B (zh) * 2013-09-24 2016-04-27 上海大学 一种快速定量检测橄榄油中含羟基化合物的方法
CN108593696B (zh) * 2018-04-26 2020-11-03 南京明捷生物医药检测有限公司 一种利用定量核磁测定多肽中三氟乙酸残留的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5566324A (en) * 1992-12-24 1996-10-15 Ncr Corporation Computer apparatus including a main memory prefetch cache and method of operation thereof
GB9515070D0 (en) * 1995-07-22 1995-09-20 Zeneca Ltd Label
US6355490B1 (en) * 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis

Also Published As

Publication number Publication date
PL341357A1 (en) 2001-04-09
BG104614A (en) 2001-10-31
JP2003522934A (ja) 2003-07-29
IL136718A0 (en) 2001-06-14
ATE364837T1 (de) 2007-07-15
WO1999031491A1 (en) 1999-06-24
HUP0200726A2 (en) 2002-06-29
MXPA00006050A (es) 2004-05-21
ES2288310T3 (es) 2008-01-01
DE69837936T2 (de) 2008-02-28
AU2556999A (en) 1999-07-05
CN1284165A (zh) 2001-02-14
AU748529B2 (en) 2002-06-06
BR9813701A (pt) 2000-12-12
EP1044364B1 (en) 2007-06-13
EP1044364B8 (en) 2008-01-02
PL197620B1 (pl) 2008-04-30
AU748529C (en) 2002-10-17
CA2315152A1 (en) 1999-06-24
EP1044364A1 (en) 2000-10-18
CN1205468C (zh) 2005-06-08
EP1044364A4 (en) 2004-10-06
BG65184B1 (bg) 2007-05-31
DE69837936D1 (de) 2007-07-26

Similar Documents

Publication Publication Date Title
NO20003107L (no) FremgangsmÕte og reagenter for kvantifisering av fastfasereaksjoner ved bruk av fluor NMR
DK1712623T3 (da) Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner
DK199901821A (da) Forbedret multikomponentkøleproces til fortætning af naturgas
IS5124A (is) Aðferð til rafgreiningarframleiðslu málma
DK0983059T3 (da) Fremgangsmåde til fremstilling af flurbiprofen sugetabletter
IS5100A (is) Meðferð á nýrnabólguhelluroða (lupus nephritis) með efnasamböndum sem eru mótefni gegn CD40L
ATE309980T1 (de) Zubereitungen zur verwendung als therapeutische und nachweismittel
DK0698093T3 (da) Von Hippel-Lindau-(VHL)-sygdomsgen og tilsvarende cDNA og metoder til påvisning af bærere af VHL-sygdomsgenet
Gillard et al. A novel fluorine-containing [2] catenane
DK1044364T3 (da) Fremgangmåde og reagenser til kvantificering af fastfasereaktioner ved anvendelse af fluor-NMR
EP0330041A3 (de) Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung und ihre Verwendung
NO984445D0 (no) Tetrahydro-<beta>-karbolinforbindelser
ES2134910T3 (es) Sintesis de bisindolilmaleimidas.
DK1042228T3 (da) Fremgangsmåde til behandling af cementslam
DK499586A (da) Heterocykliske forbindelser, fremgangsmaade til fremstilling af samme samt anvendelse af disse forbindelser
NO892189D0 (no) Trijodbenzenforbindelser og kontrastmidler for radiografiinneholdende disse.
CY1106850T1 (el) Μεθοδος και αντιδραστηρια για την ποσοτικοποιηση των αντιδρασεων στερεας - φασης χρησιμοποιωντας nmr φθοριου
DK1023292T3 (da) Fremgangsmåde til syntese af chlorpurinintermediater
KR970054744U (ko) 용광로의 출선용구 고정소켓
DK0614890T3 (da) Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler.
ATE219476T1 (de) Zusammensetzung feuerfester kohlenstoffmassen
PT832883E (pt) Compostos de tetrahidrobenzo(a)fluoreno e metodos de uso
ZA9811577B (en) Method and reagents for the quantification of solid-phase reactions using fluorine NMR.
Kolb et al. Time-resolved fluorescent assay technology
FI971253A (fi) Lyoluminesenssin käyttö analyyttisiin tarkoituksiin