ATE309980T1 - Zubereitungen zur verwendung als therapeutische und nachweismittel - Google Patents

Zubereitungen zur verwendung als therapeutische und nachweismittel

Info

Publication number
ATE309980T1
ATE309980T1 AT97949046T AT97949046T ATE309980T1 AT E309980 T1 ATE309980 T1 AT E309980T1 AT 97949046 T AT97949046 T AT 97949046T AT 97949046 T AT97949046 T AT 97949046T AT E309980 T1 ATE309980 T1 AT E309980T1
Authority
AT
Austria
Prior art keywords
thrag
tyrx
therapeutic
preparations
drugs
Prior art date
Application number
AT97949046T
Other languages
English (en)
Inventor
Patrick Anthony Riley
Andrew Photiou
Tariq Hussain Khan
Helen Mary Isted Osborn
Original Assignee
Patrick Anthony Riley
Andrew Photiou
Tariq Hussain Khan
Helen Mary Isted Osborn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patrick Anthony Riley, Andrew Photiou, Tariq Hussain Khan, Helen Mary Isted Osborn filed Critical Patrick Anthony Riley
Application granted granted Critical
Publication of ATE309980T1 publication Critical patent/ATE309980T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/69Two or more oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43Y being a hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02Monothiocarbamic acids; Derivatives thereof
    • C07C333/04Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97949046T 1996-12-13 1997-12-12 Zubereitungen zur verwendung als therapeutische und nachweismittel ATE309980T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9625895.9A GB9625895D0 (en) 1996-12-13 1996-12-13 Novel compound useful as therapeutic agents and assay reagents
PCT/GB1997/003433 WO1998025886A1 (en) 1996-12-13 1997-12-12 Novel compounds useful as therapeutic agents and assay reagents

Publications (1)

Publication Number Publication Date
ATE309980T1 true ATE309980T1 (de) 2005-12-15

Family

ID=10804381

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97949046T ATE309980T1 (de) 1996-12-13 1997-12-12 Zubereitungen zur verwendung als therapeutische und nachweismittel

Country Status (7)

Country Link
US (1) US6573284B1 (de)
EP (1) EP0944583B1 (de)
AT (1) ATE309980T1 (de)
AU (1) AU748957B2 (de)
DE (1) DE69734670T2 (de)
GB (1) GB9625895D0 (de)
WO (1) WO1998025886A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014652A1 (en) * 2000-06-01 2004-01-22 Andre Trouet Tumor activated prodrug compounds and methods of making and using the same
EP1303481A1 (de) * 2000-07-26 2003-04-23 Patrick Anthony Riley Phenylethylamin-derivate und ihre anwendung in der behandlung von melanomen
CA2423262A1 (en) * 2000-09-21 2002-03-28 Pfizer Products Inc. Resorcinol derivatives
JP4757633B2 (ja) * 2003-03-20 2011-08-24 日本化薬株式会社 難水溶性抗癌剤と新規ブロック共重合体を含むミセル調製物
CN102258503B (zh) 2004-01-22 2019-08-16 迈阿密大学 局部辅酶q10制剂及其使用方法
EP1792927B1 (de) * 2004-09-22 2013-03-06 Nippon Kayaku Kabushiki Kaisha Neues blockcopolymer, micellenzubereitung und antikrebsmittel, das diese als wirkbestandteil enthält
RU2447095C2 (ru) * 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
EP3607937A1 (de) 2007-03-22 2020-02-12 Berg LLC Topische formulierungen mit erhöhter bioverfügbarkeit
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
WO2009116509A1 (ja) * 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
JP6058263B2 (ja) 2008-04-11 2017-01-11 バーグ リミテッド ライアビリティ カンパニー 癌細胞においてアポトーシスを誘導する方法および使用
JP5366940B2 (ja) * 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
US20110020312A1 (en) 2009-05-11 2011-01-27 Niven Rajin Narain Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
CN102421827B (zh) 2009-05-15 2014-07-30 日本化药株式会社 具有羟基的生理活性物质的高分子结合体
SG10202010355PA (en) * 2010-03-12 2020-11-27 Berg Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
CN103221054A (zh) 2010-11-17 2013-07-24 日本化药株式会社 新的胞苷类代谢拮抗剂的高分子衍生物
CN103608323B (zh) 2011-04-04 2016-08-17 博格有限责任公司 治疗中枢神经系统肿瘤的方法
MX351781B (es) 2011-06-17 2017-10-30 Berg Llc Composiciones farmaceuticas inhalables.
EP2754682B1 (de) 2011-09-11 2017-06-07 Nippon Kayaku Kabushiki Kaisha Verfahren zur herstellung von blockcopolymer
AU2014251045B2 (en) 2013-04-08 2019-06-13 Berg Llc Treatment of cancer using coenzyme Q10 combination therapies
SG11201601583TA (en) 2013-09-04 2016-04-28 Berg Llc Methods of treatment of cancer by continuous infusion of coenzyme q10
EP3129015B1 (de) 2014-04-08 2021-07-14 The Methodist Hospital Inos-hemmende zusammensetzungen und deren verwendung als brustkrebs-therapeutika

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543630A1 (de) 1966-12-23 1969-07-31 Bayer Ag Verfahren zur Herstellung von tert. Butyloxycarbonylderivaten von Aminosaeuren
CH547799A (de) 1970-10-30 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von indolinderivaten.
US3801624A (en) 1970-12-09 1974-04-02 Aldrich Chem Co Inc Di-substituted beta-phenethylcarbamic acid esters
IT1048122B (it) 1973-05-23 1980-11-20 Simes Carbammati di ergoline
DE2448257A1 (de) 1974-10-10 1976-04-22 Troponwerke Dinklage & Co Cumarinabkoemmlinge, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4115539A (en) 1976-05-17 1978-09-19 Union Carbide Corporation Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives
US4812590A (en) * 1987-06-25 1989-03-14 Merck & Co., Inc. Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma
IL102645A (en) * 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
FR2699532B1 (fr) 1992-12-18 1995-02-24 Oreal Nouveaux composés indolines, compositions tinctoriales à base de ces composés et procédé de teinture des fibres kératiniques.
JPH0782280A (ja) * 1993-06-30 1995-03-28 Kanebo Ltd 新規なプロドラッグおよびその製造方法
EP0731106B1 (de) * 1993-10-01 2004-11-17 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
CA2155448A1 (en) * 1994-08-11 1996-02-12 Katerina Leftheris Inhibitors of farnesyl protein transferase

Also Published As

Publication number Publication date
DE69734670T2 (de) 2006-06-29
AU748957B2 (en) 2002-06-13
US6573284B1 (en) 2003-06-03
WO1998025886A1 (en) 1998-06-18
EP0944583A1 (de) 1999-09-29
EP0944583B1 (de) 2005-11-16
AU7846998A (en) 1998-07-03
DE69734670D1 (de) 2005-12-22
GB9625895D0 (en) 1997-01-29

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