ATE309980T1 - Zubereitungen zur verwendung als therapeutische und nachweismittel - Google Patents
Zubereitungen zur verwendung als therapeutische und nachweismittelInfo
- Publication number
- ATE309980T1 ATE309980T1 AT97949046T AT97949046T ATE309980T1 AT E309980 T1 ATE309980 T1 AT E309980T1 AT 97949046 T AT97949046 T AT 97949046T AT 97949046 T AT97949046 T AT 97949046T AT E309980 T1 ATE309980 T1 AT E309980T1
- Authority
- AT
- Austria
- Prior art keywords
- thrag
- tyrx
- therapeutic
- preparations
- drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9625895.9A GB9625895D0 (en) | 1996-12-13 | 1996-12-13 | Novel compound useful as therapeutic agents and assay reagents |
PCT/GB1997/003433 WO1998025886A1 (en) | 1996-12-13 | 1997-12-12 | Novel compounds useful as therapeutic agents and assay reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE309980T1 true ATE309980T1 (de) | 2005-12-15 |
Family
ID=10804381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97949046T ATE309980T1 (de) | 1996-12-13 | 1997-12-12 | Zubereitungen zur verwendung als therapeutische und nachweismittel |
Country Status (7)
Country | Link |
---|---|
US (1) | US6573284B1 (de) |
EP (1) | EP0944583B1 (de) |
AT (1) | ATE309980T1 (de) |
AU (1) | AU748957B2 (de) |
DE (1) | DE69734670T2 (de) |
GB (1) | GB9625895D0 (de) |
WO (1) | WO1998025886A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040014652A1 (en) * | 2000-06-01 | 2004-01-22 | Andre Trouet | Tumor activated prodrug compounds and methods of making and using the same |
EP1303481A1 (de) * | 2000-07-26 | 2003-04-23 | Patrick Anthony Riley | Phenylethylamin-derivate und ihre anwendung in der behandlung von melanomen |
CA2423262A1 (en) * | 2000-09-21 | 2002-03-28 | Pfizer Products Inc. | Resorcinol derivatives |
JP4757633B2 (ja) * | 2003-03-20 | 2011-08-24 | 日本化薬株式会社 | 難水溶性抗癌剤と新規ブロック共重合体を含むミセル調製物 |
CN102258503B (zh) | 2004-01-22 | 2019-08-16 | 迈阿密大学 | 局部辅酶q10制剂及其使用方法 |
EP1792927B1 (de) * | 2004-09-22 | 2013-03-06 | Nippon Kayaku Kabushiki Kaisha | Neues blockcopolymer, micellenzubereitung und antikrebsmittel, das diese als wirkbestandteil enthält |
RU2447095C2 (ru) * | 2006-05-18 | 2012-04-10 | Ниппон Каяку Кабусики Кайся | Высокомолекулярный конъюгат подофиллотоксинов |
JP5548364B2 (ja) * | 2006-10-03 | 2014-07-16 | 日本化薬株式会社 | レゾルシノール誘導体の高分子結合体 |
EP3607937A1 (de) | 2007-03-22 | 2020-02-12 | Berg LLC | Topische formulierungen mit erhöhter bioverfügbarkeit |
US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
WO2009116509A1 (ja) * | 2008-03-18 | 2009-09-24 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
JP6058263B2 (ja) | 2008-04-11 | 2017-01-11 | バーグ リミテッド ライアビリティ カンパニー | 癌細胞においてアポトーシスを誘導する方法および使用 |
JP5366940B2 (ja) * | 2008-05-08 | 2013-12-11 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
US20110020312A1 (en) | 2009-05-11 | 2011-01-27 | Niven Rajin Narain | Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
CN102421827B (zh) | 2009-05-15 | 2014-07-30 | 日本化药株式会社 | 具有羟基的生理活性物质的高分子结合体 |
SG10202010355PA (en) * | 2010-03-12 | 2020-11-27 | Berg Llc | Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof |
CN103221054A (zh) | 2010-11-17 | 2013-07-24 | 日本化药株式会社 | 新的胞苷类代谢拮抗剂的高分子衍生物 |
CN103608323B (zh) | 2011-04-04 | 2016-08-17 | 博格有限责任公司 | 治疗中枢神经系统肿瘤的方法 |
MX351781B (es) | 2011-06-17 | 2017-10-30 | Berg Llc | Composiciones farmaceuticas inhalables. |
EP2754682B1 (de) | 2011-09-11 | 2017-06-07 | Nippon Kayaku Kabushiki Kaisha | Verfahren zur herstellung von blockcopolymer |
AU2014251045B2 (en) | 2013-04-08 | 2019-06-13 | Berg Llc | Treatment of cancer using coenzyme Q10 combination therapies |
SG11201601583TA (en) | 2013-09-04 | 2016-04-28 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme q10 |
EP3129015B1 (de) | 2014-04-08 | 2021-07-14 | The Methodist Hospital | Inos-hemmende zusammensetzungen und deren verwendung als brustkrebs-therapeutika |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1543630A1 (de) | 1966-12-23 | 1969-07-31 | Bayer Ag | Verfahren zur Herstellung von tert. Butyloxycarbonylderivaten von Aminosaeuren |
CH547799A (de) | 1970-10-30 | 1974-04-11 | Hoffmann La Roche | Verfahren zur herstellung von indolinderivaten. |
US3801624A (en) | 1970-12-09 | 1974-04-02 | Aldrich Chem Co Inc | Di-substituted beta-phenethylcarbamic acid esters |
IT1048122B (it) | 1973-05-23 | 1980-11-20 | Simes | Carbammati di ergoline |
DE2448257A1 (de) | 1974-10-10 | 1976-04-22 | Troponwerke Dinklage & Co | Cumarinabkoemmlinge, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4115539A (en) | 1976-05-17 | 1978-09-19 | Union Carbide Corporation | Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives |
US4812590A (en) * | 1987-06-25 | 1989-03-14 | Merck & Co., Inc. | Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma |
IL102645A (en) * | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
FR2699532B1 (fr) | 1992-12-18 | 1995-02-24 | Oreal | Nouveaux composés indolines, compositions tinctoriales à base de ces composés et procédé de teinture des fibres kératiniques. |
JPH0782280A (ja) * | 1993-06-30 | 1995-03-28 | Kanebo Ltd | 新規なプロドラッグおよびその製造方法 |
EP0731106B1 (de) * | 1993-10-01 | 2004-11-17 | Teikoku Hormone Mfg. Co., Ltd. | Dolastatin-derivate |
GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
CA2155448A1 (en) * | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibitors of farnesyl protein transferase |
-
1996
- 1996-12-13 GB GBGB9625895.9A patent/GB9625895D0/en active Pending
-
1997
- 1997-12-12 EP EP97949046A patent/EP0944583B1/de not_active Expired - Lifetime
- 1997-12-12 AT AT97949046T patent/ATE309980T1/de not_active IP Right Cessation
- 1997-12-12 US US09/319,866 patent/US6573284B1/en not_active Expired - Fee Related
- 1997-12-12 AU AU78469/98A patent/AU748957B2/en not_active Ceased
- 1997-12-12 DE DE69734670T patent/DE69734670T2/de not_active Expired - Fee Related
- 1997-12-12 WO PCT/GB1997/003433 patent/WO1998025886A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69734670T2 (de) | 2006-06-29 |
AU748957B2 (en) | 2002-06-13 |
US6573284B1 (en) | 2003-06-03 |
WO1998025886A1 (en) | 1998-06-18 |
EP0944583A1 (de) | 1999-09-29 |
EP0944583B1 (de) | 2005-11-16 |
AU7846998A (en) | 1998-07-03 |
DE69734670D1 (de) | 2005-12-22 |
GB9625895D0 (en) | 1997-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |